Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIα promoter and modulation of gene expression in cells

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6161-6164

  Le, N Minh ^a   Sielaff, Alan M ^b   Cooper, Amanda J ^b   Mackay, Hilary ^b   Brown, Toni ^a,b   Kotecha, Minal ^c   O'Hare, Caroline ^c   Hochhauser, Daniel ^c   Lee, Moses ^a,b   Hartley, John A ^c  

^a FURMAN UNIVERSITY   (United States)

^b HOPE COLLEGE   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Achiral; CC 1065; Dimer; Duocarmycins; Footprinting; Gene control; Polyamides; Pyrrolobenzodiazepines; sec amino CBI; Sequence specificity; SPR; Topoisomerase

Indexed keywords

DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); IMIDAZOLE DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; EMBRYO; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROMOTER REGION; PROTEIN DNA INTERACTION; WESTERN BLOTTING;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CIRCULAR DICHROISM; DEOXYRIBONUCLEASE I; DISTAMYCINS; DNA FOOTPRINTING; DNA TOPOISOMERASES, TYPE II; GENE EXPRESSION REGULATION, NEOPLASTIC; IMIDAZOLES; MICE; PROMOTER REGIONS (GENETICS); PYRROLES;

EID: 33750701787     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.043     Document Type: Article

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