Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Aerts, Laetitia ^a   Hamelin, Marie Ève ^a   Rhéaume, Chantal ^a   Lavigne, Sophie ^b   Couture, Christian ^b   Kim, WooJin ^c   Susan Resiga, Delia ^c   Prat, Annik ^c   Seidah, Nabil G ^c   Vergnolle, Nathalie ^d,e   Riteau, Beatrice ^f,g   Boivin, Guy ^a  

^a LAVAL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d CNRS   (France)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITÉ LYON 1   (France)

^g CEMAGREF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 3 CYCLOPROPYLAMINO 7 (4 ISOPROPYLBENZYL) 7H PYRROLO[3,2 F]QUINAZOLINE; CYTOKINE; FURIN; INTERLEUKIN 6; KC PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 AGONIST; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; VORAPAXAR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFECT; HUMAN METAPNEUMOVIRUS INFECTION; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LUNG; MALE; MORTALITY; MOUSE; NONHUMAN; PNEUMONIA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS REPLICATION; WEIGHT REDUCTION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOKINES; DISEASE MODELS, ANIMAL; FURIN; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; METAPNEUMOVIRUS; MICE; MICE, INBRED BALB C; PARAMYXOVIRIDAE INFECTIONS; RECEPTOR, PAR-1; RESPIRATORY TRACT INFECTIONS; SEVERITY OF ILLNESS INDEX;

EID: 84883162740     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072529     Document Type: Article

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