A Human Antibody to the CD4 Binding Site of gp120 Capable of Highly Potent but Sporadic Cross Clade Neutralization of Primary HIV-1

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Gach, Johannes S ^a,b   Quendler, Heribert ^a   Tong, Tommy ^c   Narayan, Kristin M ^d   Du, Sean X ^d   Whalen, Robert G ^d   Binley, James M ^c   Forthal, Donald N ^b   Poignard, Pascal ^a   Zwick, Michael B ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d Altravax Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIBODY; GLYCAN; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1F7; MONOMER; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANTIGEN BINDING; ARTICLE; BINDING COMPETITION; BINDING SITE; CLADISTICS; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; ANTIGENS, CD4; BINDING SITES, ANTIBODY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLYCOSYLATION; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEUTRALIZATION TESTS; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

EID: 84883158359     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072054     Document Type: Article

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