Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 22, 2009, Pages 9057-9062

  Song, Likai ^a,b   Sun, Zhen Yu J ^b   Coleman, Kate E ^a   Zwick, Michael B ^c   Gach, Johannes S ^c   Wang, Jia Huai ^b   Reinherz, Ellis L ^a,b   Wagner, Gerhard ^b   Kim, Mikyung ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

AIDS; Fusion; Membrane proximal ectodomain region; Neutralizing antibody; Vaccine design

Indexed keywords

EPITOPE; GLYCOPROTEIN; GLYCOPROTEIN 41; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VACCINE; VIRUS FUSION PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HINGE REGION; IMMOBILIZATION; MACROPHAGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; VIRUS ENVELOPE; VIRUS INFECTION;

AMINO ACID SEQUENCE; CELL MEMBRANE; ELECTRON SPIN RESONANCE SPECTROSCOPY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; MEMBRANE FUSION; NEUTRALIZATION TESTS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; VIRUS INTERNALIZATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67049156802     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901474106     Document Type: Article

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