Double targeting of Survivin and XIAP radiosensitizes 3D grown human colorectal tumor cells and decreases migration

Radiotherapy and Oncology

Volumn 108, Issue 1, 2013, Pages 32-39

  Hehlgans, Stephanie ^a   Petraki, Chrysi ^a   Reichert, Sebastian ^a   Cordes, Nils ^b,c   Rödel, Claus ^a   Rödel, Franz ^a  

^a GOETHE UNIVERSITY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Colorectal cancer; Invasion; Ionizing radiation; Migration; Survivin; Three dimensional cell culture; XIAP

Indexed keywords

CASPASE 3; CASPASE 7; FOCAL ADHESION KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR RELA; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BASAL CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MIGRATION; CELL SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

COLORECTAL CANCER; INVASION; IONIZING RADIATION; MIGRATION; SURVIVIN; THREE-DIMENSIONAL CELL CULTURE; XIAP;

CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; COLORECTAL NEOPLASMS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84883156674     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.06.006     Document Type: Article

References (29)

1. R. Sauer, H. Becker, and W. Hohenberger Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 2004 1731 1740
2. R. Sauer, T. Liersch, and S. Merkel Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years J Clin Oncol 30 2012 1926 1933
3. F. Marquardt, F. Rodel, G. Capalbo, C. Weiss, and C. Rodel Molecular targeted treatment and radiation therapy for rectal cancer Strahlenther Onkol 185 2009 371 378
4. C. Rodel, T. Liersch, and H. Becker Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial Lancet Oncol 13 2012 679 687
5. F. Rodel, J. Hoffmann, and L. Distel Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer Cancer Res 65 2005 4881 4887
6. T. Sprenger, F. Rodel, and T. Beissbarth Failure of downregulation of survivin following neoadjuvant radiochemotherapy in rectal cancer is associated with distant metastases and shortened survival Clin Cancer Res 17 2011 1623 1631
7. D. Moussata, S. Amara, and B. Siddeek XIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma Am J Pathol 181 2012 1271 1278
8. F. Rodel, T. Sprenger, and B. Kaina Survivin as a prognostic/predictive marker and molecular target in cancer therapy Curr Med Chem 19 2012 3679 3688
9. M. Gyrd-Hansen, and P. Meier IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer Nat Rev Cancer 10 2010 561 574
10. D.C. Altieri Survivin, cancer networks and pathway-directed drug discovery Nat Rev Cancer 8 2008 61 70
11. S. Reichert, V. Reinboldt, S. Hehlgans, T. Efferth, C. Rodel, and F. Rodel A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin Radiother Oncol 103 2012 394 401
12. B. Weigelt, J.L. Peterse, and L.J. Van 't Veer Breast cancer metastasis: markers and models Nat Rev Cancer 5 2005 591 602
13. N. Sethi, and Y. Kang Unravelling the complexity of metastasis - molecular understanding and targeted therapies Nat Rev Cancer 11 2011 735 748
14. M.L. Taddei, E. Giannoni, T. Fiaschi, and P. Chiarugi Anoikis: an emerging hallmark in health and diseases J Pathol 226 2012 380 393
15. S. Mehrotra, L.R. Languino, C.M. Raskett, A.M. Mercurio, T. Dohi, and D.C. Altieri IAP regulation of metastasis Cancer Cell 17 2010 53 64
16. J.A. McKenzie, T. Liu, A.G. Goodson, and D. Grossman Survivin enhances motility of melanoma cells by supporting Akt activation and {alpha}5 integrin upregulation Cancer Res 70 2010 7927 7937
17. S. Hehlgans, I. Lange, I. Eke, and N. Cordes 3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226 Radiother Oncol 92 2009 371 378
18. I. Eke, Y. Deuse, and S. Hehlgans Beta(1)integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy J Clin Invest 122 2012 1529 1540
19. S. Hehlgans, I. Eke, and N. Cordes Targeting FAK radiosensitizes 3-dimensional grown human HNSCC cells through reduced Akt1 and MEK1/2 signaling Int J Radiat Oncol Biol Phys 83 2012 e669 e676
20. E.F. Wagner, and A.R. Nebreda Signal integration by JNK and p38 MAPK pathways in cancer development Nat Rev Cancer 9 2009 537 549
21. N. Cordes, J. Seidler, R. Durzok, H. Geinitz, and C. Brakebusch Beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury Oncogene 25 2006 1378 1390
22. T. Dohi, K. Okada, and F. Xia An IAP-IAP complex inhibits apoptosis J Biol Chem 279 2004 34087 34090
23. V. Arora, H.H. Cheung, S. Plenchette, O.C. Micali, P. Liston, and R.G. Korneluk Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex J Biol Chem 282 2007 26202 26209
24. S. Hehlgans, I. Eke, Y. Deuse, and N. Cordes Integrin-linked kinase: dispensable for radiation survival of three-dimensionally cultured fibroblasts Radiother Oncol 86 2008 329 335
25. K. Storch, I. Eke, and K. Borgmann Three-dimensional cell growth confers radioresistance by chromatin density modification Cancer Res 70 2010 3925 3934
26. O. Zschenker, T. Streichert, S. Hehlgans, and N. Cordes Genome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair PLoS One 7 2012 e34279
27. C.D. Roskelley, P.Y. Desprez, and M.J. Bissell Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction Proc Natl Acad Sci USA 91 1994 12378 12382
28. I. Eke, L. Schneider, C. Forster, D. Zips, L.A. Kunz-Schughart, and N. Cordes EGFR/JIP-4/JNK2 signaling attenuates cetuximab-mediated radiosensitization of squamous cell carcinoma cells Cancer Res 73 2013 297 306
29. K. Miura, W. Fujibuchi, and K. Ishida Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer Surg Today 41 2011 175 182