-
1
-
-
45849089879
-
Exploring the role of cancer stem cells in radioresistance
-
Baumann M., Krause M., and Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 8 (2008) 545-554
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 545-554
-
-
Baumann, M.1
Krause, M.2
Hill, R.3
-
2
-
-
33745712636
-
Cancer stem cells: redefining the paradigm of cancer treatment strategies
-
Dean M. Cancer stem cells: redefining the paradigm of cancer treatment strategies. Mol Interv 6 (2006) 140-148
-
(2006)
Mol Interv
, vol.6
, pp. 140-148
-
-
Dean, M.1
-
3
-
-
16844368698
-
Tumour stem cells and drug resistance
-
Dean M., Fojo T., and Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 5 (2005) 275-284
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
4
-
-
30544434832
-
Targeting molecular determinants of tumor chemo-radioresistance
-
Milas L., Raju U., Liao Z., and Ajani J. Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol 32 (2005) S78-S81
-
(2005)
Semin Oncol
, vol.32
-
-
Milas, L.1
Raju, U.2
Liao, Z.3
Ajani, J.4
-
5
-
-
34250345258
-
EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms
-
Baumann M., Krause M., Dikomey E., et al. EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms. Radiother Oncol 83 (2007) 238-248
-
(2007)
Radiother Oncol
, vol.83
, pp. 238-248
-
-
Baumann, M.1
Krause, M.2
Dikomey, E.3
-
6
-
-
0037799517
-
Cell adhesion-mediated radioresistance (CAM-RR) extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro
-
Cordes N., and Meineke V. Cell adhesion-mediated radioresistance (CAM-RR) extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlenther Onkol 179 (2003) 337-344
-
(2003)
Strahlenther Onkol
, vol.179
, pp. 337-344
-
-
Cordes, N.1
Meineke, V.2
-
7
-
-
33845329178
-
Signalling via integrins: implications for cell survival and anticancer strategies
-
Hehlgans S., Haase M., and Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775 (2007) 163-180
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 163-180
-
-
Hehlgans, S.1
Haase, M.2
Cordes, N.3
-
8
-
-
43049157995
-
A review of the role of insulin-like growth factor 2 in malignancy and its potential as a modifier of radiation sensitivity
-
Jacobs C.I. A review of the role of insulin-like growth factor 2 in malignancy and its potential as a modifier of radiation sensitivity. Clin Oncol [R Coll Radiol] 20 (2008) 345-352
-
(2008)
Clin Oncol [R Coll Radiol]
, vol.20
, pp. 345-352
-
-
Jacobs, C.I.1
-
9
-
-
33748040450
-
Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin
-
Eke I., Sandfort V., Mischkus A., Baumann M., and Cordes N. Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin. Radiother Oncol 80 (2006) 178-184
-
(2006)
Radiother Oncol
, vol.80
, pp. 178-184
-
-
Eke, I.1
Sandfort, V.2
Mischkus, A.3
Baumann, M.4
Cordes, N.5
-
10
-
-
36849038939
-
Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro
-
Eke I., Sandfort V., Storch K., Baumann M., Roper B., and Cordes N. Pharmacological inhibition of EGFR tyrosine kinase affects ILK-mediated cellular radiosensitization in vitro. Int J Radiat Biol 83 (2007) 793-802
-
(2007)
Int J Radiat Biol
, vol.83
, pp. 793-802
-
-
Eke, I.1
Sandfort, V.2
Storch, K.3
Baumann, M.4
Roper, B.5
Cordes, N.6
-
11
-
-
38949089708
-
Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention
-
Parsons J.T., Slack-Davis J., Tilghman R., and Roberts W.G. Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin Cancer Res 14 (2008) 627-632
-
(2008)
Clin Cancer Res
, vol.14
, pp. 627-632
-
-
Parsons, J.T.1
Slack-Davis, J.2
Tilghman, R.3
Roberts, W.G.4
-
12
-
-
0034715923
-
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics
-
Sastry S.K., and Burridge K. Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261 (2000) 25-36
-
(2000)
Exp Cell Res
, vol.261
, pp. 25-36
-
-
Sastry, S.K.1
Burridge, K.2
-
13
-
-
0034044795
-
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes
-
Cance W.G., Harris J.E., Iacocca M.V., et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 6 (2000) 2417-2423
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2417-2423
-
-
Cance, W.G.1
Harris, J.E.2
Iacocca, M.V.3
-
14
-
-
0028912755
-
Adhesion systems in normal breast and in invasive breast carcinoma
-
Glukhova M., Koteliansky V., Sastre X., and Thiery J.P. Adhesion systems in normal breast and in invasive breast carcinoma. Am J Pathol 146 (1995) 706-716
-
(1995)
Am J Pathol
, vol.146
, pp. 706-716
-
-
Glukhova, M.1
Koteliansky, V.2
Sastre, X.3
Thiery, J.P.4
-
15
-
-
0031112814
-
Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation
-
Han N.M., Fleming R.Y., Curley S.A., and Gallick G.E. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol 4 (1997) 264-268
-
(1997)
Ann Surg Oncol
, vol.4
, pp. 264-268
-
-
Han, N.M.1
Fleming, R.Y.2
Curley, S.A.3
Gallick, G.E.4
-
16
-
-
34548009376
-
Prognostic significance of expression of nm23-H1 and focal adhesion kinase in non-small cell lung cancer
-
Hsu N.Y., Chen C.Y., Hsu C.P., et al. Prognostic significance of expression of nm23-H1 and focal adhesion kinase in non-small cell lung cancer. Oncol Rep 18 (2007) 81-85
-
(2007)
Oncol Rep
, vol.18
, pp. 81-85
-
-
Hsu, N.Y.1
Chen, C.Y.2
Hsu, C.P.3
-
17
-
-
0031750715
-
Focal adhesion kinase expression in oral cancers
-
Kornberg L.J. Focal adhesion kinase expression in oral cancers. Head Neck 20 (1998) 634-639
-
(1998)
Head Neck
, vol.20
, pp. 634-639
-
-
Kornberg, L.J.1
-
18
-
-
0029039421
-
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors
-
Owens L.V., Xu L., Craven R.J., et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55 (1995) 2752-2755
-
(1995)
Cancer Res
, vol.55
, pp. 2752-2755
-
-
Owens, L.V.1
Xu, L.2
Craven, R.J.3
-
19
-
-
58149484784
-
Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
-
Sakurama K., Noma K., Takaoka M., et al. Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor. Mol Cancer Ther 8 (2009) 127-134
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 127-134
-
-
Sakurama, K.1
Noma, K.2
Takaoka, M.3
-
20
-
-
4644315256
-
Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion
-
Sood A.K., Coffin J.E., Schneider G.B., et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol 165 (2004) 1087-1095
-
(2004)
Am J Pathol
, vol.165
, pp. 1087-1095
-
-
Sood, A.K.1
Coffin, J.E.2
Schneider, G.B.3
-
21
-
-
0242551706
-
Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro
-
Beinke C., Van Beuningen D., and Cordes N. Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro. Int J Radiat Biol 79 (2003) 721-731
-
(2003)
Int J Radiat Biol
, vol.79
, pp. 721-731
-
-
Beinke, C.1
Van Beuningen, D.2
Cordes, N.3
-
22
-
-
35348965193
-
Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1
-
Cordes N., Frick S., Brunner T.B., et al. Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Oncogene 26 (2007) 6851-6862
-
(2007)
Oncogene
, vol.26
, pp. 6851-6862
-
-
Cordes, N.1
Frick, S.2
Brunner, T.B.3
-
23
-
-
0036019938
-
Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation
-
Kasahara T., Koguchi E., Funakoshi M., Aizu-Yokota E., and Sonoda Y. Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxid Redox Signal 4 (2002) 491-499
-
(2002)
Antioxid Redox Signal
, vol.4
, pp. 491-499
-
-
Kasahara, T.1
Koguchi, E.2
Funakoshi, M.3
Aizu-Yokota, E.4
Sonoda, Y.5
-
24
-
-
21744435478
-
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
-
McLean G.W., Carragher N.O., Avizienyte E., Evans J., Brunton V.G., and Frame M.C. The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer 5 (2005) 505-515
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 505-515
-
-
McLean, G.W.1
Carragher, N.O.2
Avizienyte, E.3
Evans, J.4
Brunton, V.G.5
Frame, M.C.6
-
25
-
-
0034717285
-
Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60
-
Sonoda Y., Matsumoto Y., Funakoshi M., Yamamoto D., Hanks S.K., and Kasahara T. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem 275 (2000) 16309-16315
-
(2000)
J Biol Chem
, vol.275
, pp. 16309-16315
-
-
Sonoda, Y.1
Matsumoto, Y.2
Funakoshi, M.3
Yamamoto, D.4
Hanks, S.K.5
Kasahara, T.6
-
26
-
-
38949115895
-
Integrin-mediated signalling through the MAP-kinase pathway
-
Yee K.L., Weaver V.M., and Hammer D.A. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol 2 (2008) 8-15
-
(2008)
IET Syst Biol
, vol.2
, pp. 8-15
-
-
Yee, K.L.1
Weaver, V.M.2
Hammer, D.A.3
-
27
-
-
48849089827
-
FERM control of FAK function: implications for cancer therapy
-
Lim S.T., Mikolon D., Stupack D.G., and Schlaepfer D.D. FERM control of FAK function: implications for cancer therapy. Cell Cycle 7 (2008) 2306-2314
-
(2008)
Cell Cycle
, vol.7
, pp. 2306-2314
-
-
Lim, S.T.1
Mikolon, D.2
Stupack, D.G.3
Schlaepfer, D.D.4
-
28
-
-
67651085772
-
Signal transduction by focal adhesion kinase in cancer
-
Zhao J., and Guan J.L. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev (2009)
-
(2009)
Cancer Metastasis Rev
-
-
Zhao, J.1
Guan, J.L.2
-
29
-
-
34250359928
-
N-MYC regulates focal adhesion kinase expression in human neuroblastoma
-
Beierle E.A., Trujillo A., Nagaram A., et al. N-MYC regulates focal adhesion kinase expression in human neuroblastoma. J Biol Chem 282 (2007) 12503-12516
-
(2007)
J Biol Chem
, vol.282
, pp. 12503-12516
-
-
Beierle, E.A.1
Trujillo, A.2
Nagaram, A.3
-
30
-
-
0037064030
-
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells
-
Golubovskaya V., Beviglia L., Xu L.H., Earp III H.S., Craven R., and Cance W. Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells. J Biol Chem 277 (2002) 38978-38987
-
(2002)
J Biol Chem
, vol.277
, pp. 38978-38987
-
-
Golubovskaya, V.1
Beviglia, L.2
Xu, L.H.3
Earp III, H.S.4
Craven, R.5
Cance, W.6
-
31
-
-
29344471438
-
Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells
-
Halder J., Landen Jr. C.N., Lutgendorf S.K., et al. Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin Cancer Res 11 (2005) 8829-8836
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8829-8836
-
-
Halder, J.1
Landen Jr., C.N.2
Lutgendorf, S.K.3
-
32
-
-
0034730632
-
The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways
-
Xu L.H., Yang X., Bradham C.A., et al. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem 275 (2000) 30597-30604
-
(2000)
J Biol Chem
, vol.275
, pp. 30597-30604
-
-
Xu, L.H.1
Yang, X.2
Bradham, C.A.3
-
33
-
-
40949152523
-
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271
-
Roberts W.G., Ung E., Whalen P., et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562, 271. Cancer Res 68 (2008) 1935-1944
-
(2008)
Cancer Res
, vol.68
, pp. 1935-1944
-
-
Roberts, W.G.1
Ung, E.2
Whalen, P.3
-
34
-
-
34447538483
-
Cellular characterization of a novel focal adhesion kinase inhibitor
-
Slack-Davis J.K., Martin K.H., Tilghman R.W., et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem 282 (2007) 14845-14852
-
(2007)
J Biol Chem
, vol.282
, pp. 14845-14852
-
-
Slack-Davis, J.K.1
Martin, K.H.2
Tilghman, R.W.3
-
35
-
-
38949115555
-
TAE226 inhibits human neuroblastoma cell survival
-
Beierle E.A., Trujillo A., Nagaram A., Golubovskaya V.M., Cance W.G., and Kurenova E.V. TAE226 inhibits human neuroblastoma cell survival. Cancer Invest 26 (2008) 145-151
-
(2008)
Cancer Invest
, vol.26
, pp. 145-151
-
-
Beierle, E.A.1
Trujillo, A.2
Nagaram, A.3
Golubovskaya, V.M.4
Cance, W.G.5
Kurenova, E.V.6
-
36
-
-
40749087685
-
TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR
-
Golubovskaya V.M., Virnig C., and Cance W.G. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Mol Carcinog 47 (2008) 222-234
-
(2008)
Mol Carcinog
, vol.47
, pp. 222-234
-
-
Golubovskaya, V.M.1
Virnig, C.2
Cance, W.G.3
-
37
-
-
34250163937
-
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth
-
Shi Q., Hjelmeland A.B., Keir S.T., et al. A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog 46 (2007) 488-496
-
(2007)
Mol Carcinog
, vol.46
, pp. 488-496
-
-
Shi, Q.1
Hjelmeland, A.B.2
Keir, S.T.3
-
38
-
-
59249095408
-
TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells
-
Wang Z.G., Fukazawa T., Nishikawa T., et al. TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncol Rep 20 (2008) 1473-1477
-
(2008)
Oncol Rep
, vol.20
, pp. 1473-1477
-
-
Wang, Z.G.1
Fukazawa, T.2
Nishikawa, T.3
-
39
-
-
51649114600
-
Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo
-
Watanabe N., Takaoka M., Sakurama K., et al. Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo. Clin Cancer Res 14 (2008) 4631-4639
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4631-4639
-
-
Watanabe, N.1
Takaoka, M.2
Sakurama, K.3
-
40
-
-
40249084107
-
Integrin-linked kinase: dispensable for radiation survival of three-dimensionally cultured fibroblasts
-
Hehlgans S., Eke I., Deuse Y., and Cordes N. Integrin-linked kinase: dispensable for radiation survival of three-dimensionally cultured fibroblasts. Radiother Oncol 86 (2008) 329-335
-
(2008)
Radiother Oncol
, vol.86
, pp. 329-335
-
-
Hehlgans, S.1
Eke, I.2
Deuse, Y.3
Cordes, N.4
-
41
-
-
34250314555
-
Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation
-
Yaromina A., Krause M., Thames H., et al. Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation. Radiother Oncol 83 (2007) 304-310
-
(2007)
Radiother Oncol
, vol.83
, pp. 304-310
-
-
Yaromina, A.1
Krause, M.2
Thames, H.3
-
42
-
-
0016409447
-
The effect of dimethyl sulfoxide on the neuronal excitability and cholinergic transmission in aplysia ganglion cells
-
Sawada M., and Sato M. The effect of dimethyl sulfoxide on the neuronal excitability and cholinergic transmission in aplysia ganglion cells. Ann NY Acad Sci 243 (1975) 337-357
-
(1975)
Ann NY Acad Sci
, vol.243
, pp. 337-357
-
-
Sawada, M.1
Sato, M.2
-
43
-
-
0024585002
-
Mechanism of erythropoietin action on the erythroid progenitor cells induced from murine erythroleukemia cells (TSA8)
-
Fukumoto H., Matsui Y., and Obinata M. Mechanism of erythropoietin action on the erythroid progenitor cells induced from murine erythroleukemia cells (TSA8). Development 105 (1989) 109-114
-
(1989)
Development
, vol.105
, pp. 109-114
-
-
Fukumoto, H.1
Matsui, Y.2
Obinata, M.3
-
45
-
-
0021345559
-
Effects of sodium butyrate and dimethylsulfoxide on human pancreatic tumor cell lines
-
McIntyre L.J., and Kim Y.S. Effects of sodium butyrate and dimethylsulfoxide on human pancreatic tumor cell lines. Eur J Cancer Clin Oncol 20 (1984) 265-271
-
(1984)
Eur J Cancer Clin Oncol
, vol.20
, pp. 265-271
-
-
McIntyre, L.J.1
Kim, Y.S.2
-
46
-
-
33644522372
-
New roles for integrins in squamous-cell carcinoma
-
Janes S.M., and Watt F.M. New roles for integrins in squamous-cell carcinoma. Nat Rev Cancer 6 (2006) 175-183
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 175-183
-
-
Janes, S.M.1
Watt, F.M.2
-
47
-
-
0031795119
-
Protein tyrosine kinases: structure, substrate specificity, and drug discovery
-
al-Obeidi F.A., Wu J.J., and Lam K.S. Protein tyrosine kinases: structure, substrate specificity, and drug discovery. Biopolymers 47 (1998) 197-223
-
(1998)
Biopolymers
, vol.47
, pp. 197-223
-
-
al-Obeidi, F.A.1
Wu, J.J.2
Lam, K.S.3
-
48
-
-
0032945675
-
Induction of cell death by radiotherapy
-
Ross G.M. Induction of cell death by radiotherapy. Endocr Relat Cancer 6 (1999) 41-44
-
(1999)
Endocr Relat Cancer
, vol.6
, pp. 41-44
-
-
Ross, G.M.1
|