Oral benzo[a]pyrene: Understanding pharmacokinetics, detoxication, and consequences - Cyp1 knockout mouse lines as a paradigm

Molecular Pharmacology

Volumn 84, Issue 3, 2013, Pages 304-313

  Nebert, Daniel W ^a   Shi, Zhanquan ^a   Gálvez Peralta, Marina ^a,b   Uno, Shigeyuki ^a,c   Dragin, Nadine ^a,d  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1;

CARCINOGENESIS; DETOXIFICATION; ENZYME METABOLISM; GASTROINTESTINAL CARCINOMA; GENE CONTROL; GENOTYPE ENVIRONMENT INTERACTION; IMMUNOCOMPETENT CELL; IMMUNOTOXICITY; INTESTINE EPITHELIUM CELL; KNOCKOUT MOUSE; NONHUMAN; ONCOGENE; PREPUTIAL GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CARCINOGENS, ENVIRONMENTAL; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE-ENVIRONMENT INTERACTION; INTESTINAL NEOPLASMS; METABOLIC DETOXICATION, PHASE II; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; ORGAN SPECIFICITY; SCENT GLANDS; SPECIES SPECIFICITY;

EID: 84883148290     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.086637     Document Type: Review

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