Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1

Food and Chemical Toxicology

Volumn 60, Issue , 2013, Pages 369-376

  Tian, Chun Jie ^a   Kim, Seung Won ^a   Kim, Yeon Ju ^a   Lim, Hye Jin ^a   Park, Raekil ^b   So, Hong Seob ^b   Choung, Yun Hoon ^a  

^a Ajou University School of Medicine   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

Author keywords

Apoptosis; Gentamicin; Ginsenoside Rb1; Korean red ginseng; Vestibular

Indexed keywords

ANTIOXIDANT; CASPASE 3; CYTOCHROME C; GENTAMICIN; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIAPOPTOTIC FUNCTION; ANTIOXIDANT ACTIVITY; ARTICLE; AUDITORY THRESHOLD; BALANCE DISORDER; CELL DAMAGE; CELL VIABILITY; COCHLEA; CONTROLLED STUDY; DETERIORATION; DOWN REGULATION; DRUG ACTIVITY; DRUG INDUCED DISEASE; ENZYME ACTIVATION; FEMALE; GINSENG; HAIR CELL; HEAD TILTING; HEARING; HEARING IMPAIRMENT; IN VITRO STUDY; KOREAN RED GINSENG; NONHUMAN; OTOTOXICITY; PLANT AGE; PLANT ROOT; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RAT; SACCULUS; SCANNING ELECTRON MICROSCOPY; SCORING SYSTEM; SWIMMING; UPREGULATION; UTRICLE; VESTIBULAR FUNCTION;

APOPTOSIS; GENTAMICIN; GINSENOSIDE RB1; KOREAN RED GINSENG; VESTIBULAR;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CYTOCHROMES C; DOWN-REGULATION; FEMALE; GENTAMICINS; GINSENOSIDES; HEARING LOSS; PANAX; PLANT EXTRACTS; POSTURAL BALANCE; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; UP-REGULATION; VESTIBULAR DISEASES;

EID: 84883146356     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.07.069     Document Type: Article

References (27)

1. Black F.O., Pesznecker S., Stallings V. Permanent gentamicin vestibulotoxicity. Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society and European Academy of Otology and Neurotology 2004, 25:559-569.
2. Chen Y., Huang W.G., Zha D.J., Qiu J.H., Wang J.L., Sha S.H., Schacht J. Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic. Hearing Research 2007, 226:178-182.
3. Chen Z., Lu T., Yue X., Wei N., Jiang Y., Chen M., Ni G., Liu X., Xu G. Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy. Neuroscience Letters 2010, 482:264-268.
4. Choung Y.H., Taura A., Pak K., Choi S.J., Masuda M., Ryan A.F. Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of Corti treated with gentamicin. Neuroscience 2009, 161:214-226.
5. Choung Y.H., Kim S.W., Tian C., Min J.Y., Lee H.K., Park S.N., Lee J.B., Park K. Korean red ginseng prevents gentamicin-induced hearing loss in rats. The Laryngoscope 2011, 121:1294-1302.
6. Fujita K., Hakuba N., Hata R., Morizane I., Yoshida T., Shudou M., Sakanaka M., Gyo K. Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia. Neuroscience Letters 2007, 415:113-117.
7. Joh E.H., Lee I.A., Jung I.H., Kim D.H. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation-the key step of inflammation. Biochemical Pharmacology 2011, 82:278-286.
8. Kawamoto K., Sha S.H., Minoda R., Izumikawa M., Kuriyama H., Schacht J., Raphael Y. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Molecular Therapy: The Journal of the American Society of Gene Therapy 2004, 9:173-181.
9. Kim J.H., Kim S., Yoon I.S., Lee J.H., Jang B.J., Jeong S.M., Lee B.H., Han J.S., Oh S., Kim H.C., Park T.K., Rhim H., Nah S.Y. Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats. Neuropharmacology 2005, 48:743-756.
10. Lesniak W., Pecoraro V.L., Schacht J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chemical Research in Toxicology 2005, 18:357-364.
11. Li J., Shao Z.H., Xie J.T., Wang C.Z., Ramachandran S., Yin J.J., Aung H., Li C.Q., Qin G., Vanden Hoek T., Yuan C.S. The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes. Archives of Pharmacal Research 2012, 35:1259-1267.
12. Liu J.J., Shin J.H., Hyrc K.L., Liu S., Lei D., Holley M.C., Bao J. Stem cell therapy for hearing loss: Math1 overexpression in VOT-E36 cells. Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society and European Academy of Otology and Neurotology 2006, 27:414-421.
13. Liu J., Yan X., Li L., Zhu Y., Qin K., Zhou L., Sun D., Zhang X., Ye R., Zhao G. Ginsennoside rd attenuates cognitive dysfunction in a rat model of Alzheimer's disease. Neurochemical Research 2012, 37:2738-2747.
14. Lopez M.V., Cuadrado M.P., Ruiz-Poveda O.M., Del Fresno A.M., Accame M.E. Neuroprotective effect of individual ginsenosides on astrocytes primary culture. Biochimica et Biophysica Acta 2007, 1770:1308-1316.
15. Rauch S.D. Vestibular histopathology of the human temporal bone. What can we learn?. Annals of the New York Academy of Sciences 2001, 942:25-33.
16. 2+ channel currents in rat sensory neurons. European Journal of Pharmacology 2002, 436:151-158.
17. Rybak L.P., Ramkumar V. Ototoxicity. Kidney International 2007, 72:931-935.
18. Rybak L.P., Touliatos J., Campbell K. Ototoxicity. Otolaryngology Basic Science and Clinical Review 2006, 129-136. Thieme, New York. T.R. Van De Water, H. Staecker (Eds.).
19. Shibata S., Tanaka O., Shoji J., Saito H. Chemistry and pharmacology of Panax. Economic and Medicinal Plant Research 1994, 217-284. World Scientific, Philadelphia.
20. Shin Y.M., Jung H.J., Choi W.Y., Lim C.J. Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside Rg3 in cultured mammalian cell lines. Molecular Biology Reports 2013, 40:269-279.
21. Staecker H., Praetorius M., Baker K., Brough D.E. Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer. Otology & Neurotology: Official Publication of the American Otological Society, American Neurotology Society and European Academy of Otology and Neurotology 2007, 28:223-231.
22. Sugahara K., Rubel E.W., Cunningham L.L. JNK signaling in neomycin-induced vestibular hair cell death. Hearing Research 2006, 221:128-135.
23. Wall C., Merfeld D.M., Rauch S.D., Black F.O. Vestibular prostheses: the engineering and biomedical issues. Journal of Vestibular Research: Equilibrium & Orientation 2002, 12:95-113.
24. Warchol M.E. Cellular mechanisms of aminoglycoside ototoxicity. Current Opinion in Otolaryngology & Head and Neck Surgery 2010, 18:454-458.
25. Yang C.X., Liu J.X., Sun Z.L., Gao X.Q., Deng L., Yuan Q.L. Effects of Ginsenoside RB1 on neural cell apoptosis and expressions of Bcl-2 and Bax in rats following subjected to cerebral ischemia-reperfusion. Sichuan da xue xue bao. Yi xue ban=Journal of Sichuan University. Medical Science Edition 2008, 39:214-217.
26. Ye R., Han J., Kong X., Zhao L., Cao R., Rao Z., Zhao G. Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide. Biological & Pharmaceutical Bulletin 2008, 31:1923-1927.
27. Zhang B., Hata R., Zhu P., Sato K., Wen T.C., Yang L., Fujita H., Mitsuda N., Tanaka J., Samukawa K., Maeda N., Sakanaka M. Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism 2006, 26:708-721.