Antioxidant gene therapy can protect hearing and hair cells from ototoxicity

Molecular Therapy

Volumn 9, Issue 2, 2004, Pages 173-181

  Kawamoto, Kohei ^a   Sha, Su Hua ^b   Minoda, Ryosei ^b,c   Izumikawa, Masahiko ^a,b   Kuriyama, Hiromichi ^a   Schacht, Jochen ^b   Raphael, Yehoash ^b,d  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d NONE   (United States)

Author keywords

Aminoglycosides; Antioxidants; Catalase; Cochlea; Gene therapy; Guinea pig; Hair cells; Ototoxicity; Superoxide dismutase

Indexed keywords

ADENOVIRUS VECTOR; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ETACRYNIC ACID; KANAMYCIN; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; AUDITORY THRESHOLD; CHEMICAL ANALYSIS; COCHLEA; CONTROLLED STUDY; ENZYME ACTIVITY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEASIBILITY STUDY; GENE CASSETTE; GENE EXPRESSION; GENE OVEREXPRESSION; GUINEA PIG; HAIR CELL; HEARING IMPAIRMENT; INNER EAR; NONHUMAN; OTOTOXICITY; OXIDATIVE STRESS; PERILYMPH; TOXICITY TESTING; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS TYPING;

ADENOVIRIDAE; ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 1342290226     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.11.020     Document Type: Article

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