Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species

Chemical Research in Toxicology

Volumn 18, Issue 2, 2005, Pages 357-364

  Lesniak, Wojciech ^a,b   Pecoraro, Vincent L ^b   Schacht, Jochen ^a,c  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ARACHIDONIC ACID; FERROUS ION; GENTAMICIN; INOSITOL; IRON; LIPID; LIPID PEROXIDE; MEMBRANE LIPID; OXYGEN; PHOSPHATE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPID DERIVATIVE; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE;

ARTICLE; BINDING ASSAY; BINDING KINETICS; BIOSYNTHESIS; CATALYSIS; CATALYST; CHEMICAL INTERACTION; CHEMICAL REACTION; COMPLEX FORMATION; DRUG BINDING; ELECTRON TRANSPORT; ELECTROSPRAY MASS SPECTROMETRY; IN VITRO STUDY; LIPID DEGRADATION; LIPID MEMBRANE; LIPID PEROXIDATION; MEMBRANE DAMAGE; MOLECULAR MODEL; NEPHROTOXICITY; OTOTOXICITY; OXIDATION; OXIDATION REDUCTION REACTION;

ARACHIDONIC ACID; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CATALYSIS; GENTAMICINS; HYDROGEN-ION CONCENTRATION; IRON; MOLECULAR SEQUENCE DATA; PHOSPHOLIPIDS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 13844269346     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0496946     Document Type: Article

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