Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest

Annals of Hematology

Volumn 92, Issue 9, 2013, Pages 1207-1220

  Hassani, Saeed ^a,b   Ghaffari, Seyed H ^a   Zaker, Farhad ^b   Mirzaee, Rohellah ^c   Mardani, Hajar ^b   Bashash, Davood ^d   Zekri, Ali ^e   Yousefi, Meysam ^a   Zaghal, Azam ^a   Alimoghaddam, Kamran ^a   Ghavamzadeh, Ardeshir ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acute promyelocytic leukemia; Apoptosis; Arsenic trioxide; Azidothymidine; Cell cycle arrest; P21

Indexed keywords

ARSENIC TRIOXIDE; CASPASE 3; MYC PROTEIN; PROTEIN P21; REACTIVE OXYGEN METABOLITE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; ZIDOVUDINE;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SEQUENCE; DNA SYNTHESIS; DOWN REGULATION; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN INDUCTION; QUANTITATIVE REAL TIME POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION;

APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; M PHASE CELL CYCLE CHECKPOINTS; OXIDES; ZIDOVUDINE;

EID: 84883135863     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-013-1763-8     Document Type: Article

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