The biochemistry of Alzheimer disease

Alzheimer Disease and Associated Disorders

Volumn 13, Issue SUPPL. 1, 1999, Pages

  Fine, Richard E ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer disease; Apolipoprotein E; Biochemistry; Presenilin; amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; BIOCHEMISTRY; HUMAN; NERVE CELL NECROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW;

EID: 0032874077     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199904001-00018     Document Type: Review

References (49)

1. Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. Purification and cloning of brain proteases capable of degrading the β-amyloid precursor protein. Ann NY Acad Sci 1992;674:174-9.
2. Bales KR, Verina T, Dodei RC, et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat Genet 1997;17:263-4.
3. Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem Biophys Res Commun 1992;186:944-50.
4. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994;77:817-27.
5. Borchelt DR, Ratovitski T, van Lare J, et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997;19:939-45.
6. Borchelt DR, Thinakaran G, Eckman CB, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 1996;17:1005-13.
7. De Strooper B, Saftig P, Craessaerts K, et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998;391:387-90.
8. Duff K, Eckman C, Zehr C, et al. Increased amyloid β-42(43) in brains of mice expressing mutant presenilin 1. Nature 1996;383:710-3.
9. El Khoury JE, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 1996;382:716-9.
10. Esch FS, Keim PS, Beanie EC, et al. Cleavage of amyloid βA peptide during constitutive processing of its precursor. Science 1990;248: 1122-4.
11. Fine RE, Abraham CR. Hypothesis: β amyloid precursor protein is a key sorting and targeting receptor for neuropeptidases. Amyloid Int J Exp Clin Invest 1997;4:233-9.
12. Fraser SP, Suh Y-H, Djamgoz MBA. Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments. Trends Neurosci 1997;20:67-72.
13. Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995;373:523-7.
14. Geula C, Wu C-K, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med 1998;4:827-31.
15. Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984;122:1131-5.
16. Goate A, Chartier-Harlin M-C, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein with familial Alzheimer's disease. Nature 1991;349:704-6.
17. Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, amyloid plaques in transgenic mice.Science 1996;274:99-102.
18. Hua X, Nohturfft A, Goldstein JL, Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 1996;87:415-26.
19. Hutton M, Lendon CL, Rizzu P, et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 1998;393:702-5.
20. Iwai A, Masliah E, Yoshimoto M, et al. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 1995;14:467-75.
21. Klein A. Beta amyloid injections cause cortical injury and oxidative damage in the mouse cerebral cortex. Ph.D. thesis, Boston University, 1998.
22. Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein, tau, is a major antigenic component of paired helical filaments in Alzheimer's disease. Proc Natl Acad Sci USA 1986;83:4044-8.
23. Kowall NW, Beal MR, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of β-amyloid and protection by substance P. Proc Natl Acad Sci USA 1991;88:7247-51.
24. LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, Frail DE. Isoform-specific binding of apolipoprotein E to beta-amyloid. J Biol Chem 1994;269:23403-6.
25. Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch-type. Science 1990;248:1124-6.
26. Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-7.
27. Mahley RW. Apolipoprotein E: cholesterol transport protein with an expanding role in cell biology. Science 1988;240:622-30.
28. Mattson MP. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev 1997;77:1081-132.
29. Mattson MP, Guo Q. Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease. J Neurosci Res 1997;50:505-13.
30. Mattson MP, Guo Q, Furukawa K, Pedersen WA. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J Neurochem 1998;70:1-14.
31. McKee AC, Kowall NW, Schumacher JS, Beal MF. The neurotoxicity of amyloid beta protein in aged primates. Amyloid Int J Clin Invest 1998;5:1-9.
32. Mullan M, Crawford F, Axelman K, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet 1993;1:345-7.
33. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993;13:1676-87.
34. Polymeropoulos MH, Lavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-7.
35. Roses A, Apolipoprotein E affects the rate of Alzheimer's disease expression: β-amyloid burden is a secondary consequence dependent on Apo E genotype and duration of disease. Neuropathol Exp Neurol 1994;53:429-37.
36. Saunders A, Schmader K, Breitner J, et al. Apolipoprotein E4 distribution in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 1993;342:710-1.
37. Scheuner D, Eckman C, Jensen M, et al. The amyloid β protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med 1996;2:864-70.
38. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 1991;6:487-9.
39. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in presenilin-1-deficient mice. Cell 1997;89:629-39.
40. Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-60.
41. Smith MA, Hirai K, Hsiao K, et al. Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem 1997;70:2212-5.
42. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 1998;95:6469-73.
43. Strittmatter WJ, Weisgraber K, Huang DY, et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:8098-102.
44. Weidemann A, Paliga K, Durrwang U, et al. Formation of stable complexes between two Alzheimer's disease gene products, presenilin-2 and β-amyloid precursor protein. Nat Med 1997;3:328-32.
45. Wolozin B, Iwasaki K, Vito P, et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996;274:1710-3.
46. Yaar M, Zhai S, Pilch PF, et al. Binding of β-amyloid to the p75 neurotrophin receptor induces apoptosis: a possible mechanism for Alzheimer's disease. J Clin Invest 1997;100:2333-40.
47. Yan DS, Chen X, Fu J, et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 1996;382:685-91.
48. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 1996;16:921-32.
49. Yankner BA, Duffy LK, Kirshner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 1990;250:279-82.