Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 7, 2013, Pages 760-768

  Kulminski, Alexander M ^a   Arbeev, Konstantin G ^a   Christensen, Kaare ^b,c   Stallard, Eric ^a   Miljkovic, Iva ^d   Barmada, Michael ^d   Yashin, Anatoliy I ^a  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aging; Disease; Genetics of healthspan; Heritability; Longevity regulation

Indexed keywords

ADULT CHILD; AGED; AGING; ARTICLE; DISEASES; ENVIRONMENT; FEMALE; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; GENETICS OF HEALTHSPAN; GENOTYPE; HERITABILITY; HUMAN; LONGEVITY; LONGEVITY REGULATION; MALE; MIDDLE AGED; PARENT; PHENOTYPE; VERY ELDERLY;

AGING; DISEASE; GENETICS OF HEALTHSPAN; HERITABILITY; LONGEVITY REGULATION;

ADULT CHILDREN; AGED; AGED, 80 AND OVER; AGING; ENVIRONMENT; EPIGENESIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LONGEVITY; MALE; MIDDLE AGED; PARENTS; PHENOTYPE;

EID: 84883042222     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls243     Document Type: Article

References (68)

1. Sierra F, Hadley E, Suzman R, Hodes R. Prospects for life span extension. Annu Rev Med. 2009;60:457-469.
2. Olshansky SJ, Perry D, Miller RA, Butler RN. Pursuing the longevity dividend: scientific goals for an aging world. Ann N Y Acad Sci. 2007;1114:11-13. (Pubitemid 350070416)
3. Robine J-M. Determining health expectancies. Chichester, West Sussex, UK; Hoboken, NJ: Wiley; 2003.
4. Cournil A, Kirkwood TB. If you would live long, choose your parents well. Trends Genet. 2001;17:233-235. (Pubitemid 32378737)
5. Sebastiani P, Hadley EC, Province M, et al. A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol. 2009;170:1555-1562.
6. Brown WM, Beck SR, Lange EM, et al. Age-stratified heritability estimation in the Framingham Heart Study families. BMC Genet. 2003;4 Suppl 1:S32.
7. Herskind AM, McGue M, Holm NV, Sørensen TI, Harvald B, Vaupel JW. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum Genet. 1996;97:319-323. (Pubitemid 26057031)
8. Iachine IA, Holm NV, Harris JR, et al. How heritable is individual susceptibility to death? The results of an analysis of survival data on Danish, Swedish and Finnish twins. Twin Res. 1998;1:196-205. (Pubitemid 128560442)
9. Matteini AM, Fallin MD, Kammerer CM, et al. Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2010;65:1375-1379.
10. Martin GM, Bergman A, Barzilai N. Genetic determinants of human health span and life span: progress and new opportunities. PLoS Genet. 2007;3:e125.
11. Vijg J, Suh Y. Genetics of longevity and aging. Annu Rev Med. 2005;56:193-212. (Pubitemid 40299780)
12. Finch CE, Tanzi RE. Genetics of aging. Science. 1997;278:407-411. (Pubitemid 27454416)
13. Martin GM. Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann N Y Acad Sci. 2007;1100:14-20. (Pubitemid 47092636)
14. Di Rienzo A, Hudson RR. An evolutionary framework for common diseases: the ancestral-susceptibility model. Trends Genet. 2005;21:596-601. (Pubitemid 41429287)
15. Williams GC. Pleiotropy, natural-selection, and the evolution of senescence. Evolution. 1957;11:398-411.
16. Williams PD, Day T. Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution. 2003;57:1478-1488. (Pubitemid 36953637)
17. Kulminski AM, Culminskaya I, Ukraintseva SV, Arbeev KG, Land KC, Yashin AI. Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. Mech Ageing Dev. 2010;131:338-345.
18. Summers K, Crespi BJ. Xmrks the spot: life history tradeoffs, sexual selection and the evolutionary ecology of oncogenesis. Mol Ecol. 2010;19:3022-3024.
19. Alexander DM, Williams LM, Gatt JM, et al. The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biol Psychol. 2007;75:229-238. (Pubitemid 46915557)
20. Kulminski AM, Culminskaya I, Ukraintseva SV, et al. Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. Aging Cell. 2011;10:533-541.
21. Finch CE. Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci USA. 2010;107 Suppl 1:1718-1724.
22. Charlesworth B. Evolution of senescence: Alzheimer's disease and evolution. Curr Biol. 1996;6:20-22. (Pubitemid 126663429)
23. Martin GM. APOE alleles and lipophylic pathogens. Neurobiol Aging. 1999;20:441-443.
24. Kulminski A, Culminskaya I, Arbeev K, Ukraintseva S, Arbeeva L, Yashin AI. Trade-off in the effect of the apoe gene on the ages at onset of cvd and cancer across ages, gender, and human generations. Rejuvenation Res. 2012. October 25 [Epub ahead of print].
25. Murk W, Walsh K, Hsu LI, Zhao L, Bracken MB, Dewan AT. Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. Hum Hered. 2011;71:97-105.
26. Assimes TL, Hólm H, Kathiresan S, et al. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010;56:1552-1563.
27. Dahabreh IJ, Murray S. Lack of replication for the association between HER2 I655V polymorphism and breast cancer risk: a systematic review and meta-analysis. Cancer Epidemiol. 2011;35:503-509.
28. Day-Williams AG, Zeggini E. The effect of next-generation sequencing technology on complex trait research. Eur J Clin Invest. 2011;41:561-567.
29. Arking DE, Chakravarti A. Understanding cardiovascular disease through the lens of genome-wide association studies. Trends Genet. 2009;25:387-394.
30. Bloss CS, Pawlikowska L, Schork NJ. Contemporary human genetic strategies in aging research. Ageing Res Rev. 2011;10:191-200.
31. Rose SP. Commentary: heritability estimates-long past their sell-by date. Int J Epidemiol. 2006;35:525-527. (Pubitemid 43985523)
32. Plomin R, Haworth CM, Davis OS. Common disorders are quantitative traits. Nat Rev Genet. 2009;10:872-878.
33. Fisher RA: The correlation between relatives on the supposition of mendelian inheritance. Transact Royal Soc Edinburgh. 1918;52:399-433.
34. Pedersen CB, Gøtzsche H, Møller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull. 2006;53:441-449. (Pubitemid 44816920)
35. Yashin AI, Arbeev KG, Kulminski A, et al. "Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS). Mech Ageing Dev. 2010;131:215-222.
36. Pierce BA. Transmission and population genetics, 3rd ed. New York; 2009. New York: W. H. Freeman.
37. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-359. (Pubitemid 34251969)
38. Fox CS. Cardiovascular disease risk factors, type 2 diabetes mellitus, and the Framingham Heart Study. Trends Cardiovasc Med. 2010;20:90-95.
39. Preis SR, Pencina MJ, Hwang SJ, et al. Trends in cardiovascular disease risk factors in individuals with and without diabetes mellitus in the Framingham Heart Study. Circulation. 2009;120:212-220.
40. Wilson PW, Meigs JB, Sullivan L, Fox CS, Nathan DM, D'Agostino RB Sr. Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med. 2007;167:1068-1074. (Pubitemid 46835795)
41. Melzer D, Hurst AJ, Frayling T. Genetic variation and human aging: progress and prospects. J Gerontol A Biol Sci Med Sci. 2007;62:301-307. (Pubitemid 47065728)
42. Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Genomics and successful aging: grounds for renewed optimism? J Gerontol A Biol Sci Med Sci. 2012;67:511-519.
43. Kraft P, Bauman L, Yuan JY, Horvath S. Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study. BMC Genet. 2003;4 Suppl 1:S55.
44. Wilk JB, DeStefano AL, Joost O, et al. Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study. Hum Mol Genet. 2003;12:2745-2751. (Pubitemid 37407111)
45. Mathias RA, Roy-Gagnon MH, Justice CM, et al. Comparison of year-of-exam- and age-matched estimates of heritability in the Framingham Heart Study data. BMC Genet. 2003;4 Suppl 1:S36.
46. Wienke A, Herskind AM, Christensen K, Skytthe A, Yashin AI. The heritability of CHD mortality in danish twins after controlling for smoking and BMI. Twin Res Hum Genet. 2005;8:53-59. (Pubitemid 40478172)
47. Karasik D, Demissie S, Cupples LA, Kiel DP. Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures. J Gerontol A Biol Sci Med Sci. 2005;60:574-587. (Pubitemid 40847918)
48. Greenwood PM, Parasuraman R. Normal genetic variation, cognition, and aging. Behav Cogn Neurosci Rev. 2003;2:278-306.
49. Gatz M, Pedersen NL, Berg S, et al. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci. 1997;52:M117-M125. (Pubitemid 27123973)
50. Tiainen K, Sipilä S, Alen M, et al. Heritability of maximal isometric muscle strength in older female twins. J Appl Physiol. 2004;96:173-180. (Pubitemid 38031998)
51. Carmelli D, Kelly-Hayes M, Wolf PA, et al. The contribution of genetic influences to measures of lower-extremity function in older male twins. J Gerontol A Biol Sci Med Sci. 2000;55:B49-B53. (Pubitemid 30140732)
52. Liddell MB, Lovestone S, Owen MJ. Genetic risk of Alzheimer's disease: advising relatives. Br J Psychiatry. 2001;178:7-11. (Pubitemid 32055638)
53. Lewontin RC. Annotation: the analysis of variance and the analysis of causes. Am J Hum Genet. 1974;26:400-411.
54. Kuningas M, Mooijaart SP, van Heemst D, Zwaan BJ, Slagboom PE, Westendorp RG. Genes encoding longevity: from model organisms to humans. Aging Cell. 2008;7:270-280. (Pubitemid 351359659)
55. Neel JV, Weder AB, Julius S. Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med. 1998;42:44-74.
56. Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D'Agostino RB Sr. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006;113:2914-2918. (Pubitemid 44297232)
57. NEEL JV. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet. 1962;14:353-362.
58. Shi G, Gu CC, Kraja AT, et al. Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study. Hypertension. 2009;53:35-41.
59. De Benedictis G, Carotenuto L, Carrieri G, et al. Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Ann Hum Genet. 1998;62(Pt 2):115-122. (Pubitemid 28412361)
60. Ilveskoski E, Perola M, Lehtimäki T, et al. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study. Circulation. 1999;100:608-613. (Pubitemid 29379749)
61. Yashin AI, Ukraintseva SV, De Benedictis G, et al. Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. J Gerontol A Biol Sci Med Sci. 2001;56:B432-B442. (Pubitemid 32954223)
62. Jarvik GP, Goode EL, Austin MA, et al. Evidence that the apolipoprotein E-genotype effects on lipid levels can change with age in males: a longitudinal analysis. Am J Hum Genet. 1997;61:171-181. (Pubitemid 27323337)
63. Medawar PB. An unsolved problem of biology: an inaugural lecture delivered at University College, London, 6 December, 1951. London, UK: H.K. Lewis and Co.; 1952.
64. Holliday R. Aging is no longer an unsolved problem in biology. Ann N Y Acad Sci. 2006;1067:1-9. (Pubitemid 43806303)
65. Bergman A, Atzmon G, Ye K, MacCarthy T, Barzilai N. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput Biol. 2007;3:e170.
66. Kirkwood TB. Systems biology of ageing and longevity. Philos Trans R Soc Lond, B, Biol Sci. 2011;366:64-70.
67. Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabási AL. The human disease network. Proc Natl Acad Sci USA. 2007;104:8685-8690. (Pubitemid 47175372)
68. Kirkwood TB, Cordell HJ, Finch CE. Speed-bumps ahead for the genetics of later-life diseases. Trends Genet. 2011;27:387-388.