Effects of glycyl-glutamine dipeptide supplementation on myocardial damage and cardiac function in rats after severe burn injury

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 5, 2013, Pages 821-830

  Zhang, Yong ^a   Yan, Hong ^a   Lv, Shang Gun ^a   Wang, Lin ^a   Liang, Guang Ping ^a   Wan, Qian Xue ^a   Peng, Xi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Burns; Energy metabolism; Glycyl glutamine dipeptide; GSH; Myocardial damage; Rat

Indexed keywords

DIPEPTIDE; GLYCYLGLUTAMINE;

ANIMAL; BURN; COMPLICATION; DRUG EFFECTS; HEART; HEART FUNCTION TEST; HEART MUSCLE; MALE; METABOLISM; MYOCARDIAL ISCHEMIA; PATHOLOGY; PATHOPHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; BURNS; DIPEPTIDES; HEART; HEART FUNCTION TESTS; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RATS; RATS, WISTAR;

EID: 84882974715     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Latenser BA. Critical care of the burn patient: the first 48 hours. Crit Care Med 2009; 37: 2819-2826.
2. Huang Y, Li Z and Yang Z. Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock. Burns 2003; 29: 828-833.
3. Huang YS, Yang ZC, Yan BG, Yang JM, Chen FM, Crowther RS and Li A. Pathogenesis of early cardiac myocyte damage after severe burns. J Trauma 1999; 46: 428-432.
4. Jiang L, Qin X, Zhong X, Liu L, Lu Y, Fan L, He Z and Chen Q. Glycine-induced cytoprotection is mediated by ERK1/2 and AKT in renal cells with ATP depletion. Eur J Cell Biol 2011; 90: 333-341.
5. Sahin MA, Yucel O, Guler A, Doganci S, Jahollari A, Cingoz F, Arslan S, Gamsizkan M, YamanH and Demirkilic U. Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?. J Cardiothorac Surg 2011; 6: 31.
6. Greenberg S, Chernin G, Shapira I, George J, Wollman Y, Laniado S and Keren G. Captopril and L-arginine have a synergistic cardioprotective effect in ischemic-reperfusion injury in the isolated rat heart. J Cardiovasc Pharmacol Ther 2000; 5: 281-290.
7. Ikeda Y, Young LH, Scalia R, Ross CR and Lefer AM. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion. Cardiovasc Res 2001; 49: 69-77.
8. Lomivorotov VV, Efremov SM, Shmirev VA, Ponomarev DN, Lomivorotov VN and Karaskov AM. Glutamine Is Cardioprotective in Patients with Ischemic Heart Disease following Cardiopulmonary Bypass. Heart Surg Forum 2011; 14: E384-388.
9. Ugurlucan M, Erer D, Karatepe O, Ziyade S, Haholu A, Gungor Ugurlucan F, Filizcan U, Tireli E, Dayioglu E and Alpagut U. Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus. Expert Opin Ther Targets 2010; 14: 1143-1156.
10. Venturini A, Ascione R, Lin H, Polesel E, Angelini GD and Suleiman MS. The importance of myocardial amino acids during ischemia and reperfusion in dilated left ventricle of patients with degenerative mitral valve disease. Mol Cell Biochem 2009; 330: 63-70.
11. Vermeulen MA, van de Poll MC, Ligthart-Melis GC, Dejong CH, van den Tol MP, Boelens PG and van Leeuwen PA. Specific amino acids in the critically ill patient--exogenous glutamine/ arginine: a common denominator?. Crit Care Med 2007; 35: S568-576.
12. Bolotin G, Raman J, Williams U, Bacha E, Kocherginsky M and Jeevanandam V. Glutamine improves myocardial function following ischemia-reperfusion injury. Asian Cardiovasc Thorac Ann 2007; 15: 463-467.
13. McGuinness J, Neilan TG, Cummins R, Sharkasi A, Bouchier-Hayes D and Redmond JM. Intravenous glutamine enhances COX-2 activity giving cardioprotection. J Surg Res 2009; 152: 140-147.
14. Liu J, Marchase RB and Chatham JC. Glutamine-induced protection of isolated rat heart from ischemia/reperfusion injury is mediated via the hexosamine biosynthesis pathway and increased protein O-GlcNAc levels. J Mol Cell Cardiol 2007; 42: 177-185.
15. Stottrup NB, Kristiansen SB, Lofgren B, Hansen BF, Kimose HH, Botker HE and Nielsen TT.L-glutamate and glutamine improve haemodynamic function and restore myocardial glycogen content during postischaemic reperfusion: A radioactive tracer study in the rat isolated heart. Clin Exp Pharmacol Physiol 2006; 33: 1099-1103.
16. Pan C, Bai X, Fan L, Ji Y, Li X and Chen Q. Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells. Biochem J 2005; 390: 447-453.
17. Weinberg JM, Davis JA and Venkatachalam MA. Cytosolic-free calcium increases to greater than 100 micromolar in ATP-depleted proximal tubules. J Clin Invest 1997; 100: 713-722.
18. Song JX, Tu XH, Wang L and Li CJ. Glutamine dipeptide-supplemented parenteral nutrition in patients with colorectal cancer. Clinical Nutrition 2004; 1: 49-53.
19. Ludbrook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res 1994; 28: 303-311.
20. Khogali SE, Pringle SD, Weryk BV and Rennie MJ. Is glutamine beneficial in ischemic heart disease? Nutrition 2002; 18: 123-126.
21. Rennie MJ, Khogali SE, Low SY, McDowell HE, Hundal HS, Ahmed A and Taylor PM. Amino acid transport in heart and skeletal muscle and the functional consequences. Biochem Soc Trans 1996; 24: 869-873.
22. Boelens PG, Nijveldt RJ, Houdijk AP, Meijer S and van Leeuwen PA. Glutamine alimentation in catabolic state. J Nutr 2001; 131: 2569S-2577S; discussion 2590S.
23. Rennie MJ, Khogali SE, Low SY, McDowell HE, Hundal HS, Ahmed A and Taylor PM. Amino acid transport in heart and skeletal muscle and the functional consequences. Biochem Soc Trans 1996; 24: 869-873.
24. Schachter D. L-glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses. Am J Physiol Cell Physiol 2007; 293: C142-151.
25. Tsai MS, Sun S, Tang W, Ristagno G, Chen WJ and Weil MH. Free radicals mediate postshock contractile impairment in cardiomyocytes. Crit Care Med 2008; 36: 3213-3219.
26. Ren J, Privratsky JR, Yang X, Dong F and Carlson EC. Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit Care Med 2008; 36: 2106-2116.
27. Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R and Klimberg VS. Oral glutamine protects against cyclophosphamideinduced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition 2009; 25: 812-817.
28. Nabavi SF, Nabavi SM, Abolhasani F, Moghaddam AH and Eslami S. Cytoprotective effects of curcumin on sodium fluoride-induced intoxication in rat erythrocytes. Bull Environ Contam Toxicol 2012; 88: 486-490.
29. Nabavi SM, Nabavi SF, Eslami S and Moghaddam AH. In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue. Food Chemistry 2012; 132: 931-935.