Glycine-induced cytoprotection is mediated by ERK1/2 and AKT in renal cells with ATP depletion

European Journal of Cell Biology

Volumn 90, Issue 4, 2011, Pages 333-341

  Jiang, Linglin ^a   Qin, Xia ^a   Zhong, Xiaozheng ^a   Liu, Li ^a   Jiang, Li ^a   Lu, Yan ^a   Fan, Leming ^a   He, Zhigang ^b   Chen, Qi ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

ATP depletion; Glycine; Glycine receptor; MDCK cell; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING TRANSCRIPTION FACTOR 1; ADENOSINE TRIPHOSPHATE; GLYCINE; GLYCINE RECEPTOR; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR FOXC1;

ARTICLE; CELL DEATH; CELL PROTECTION; CELL STRAIN; CONTROLLED STUDY; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CYTOPROTECTION; DOGS; GLYCINE; HEK293 CELLS; HUMANS; IMIDAZOLES; KIDNEY; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RECEPTORS, GLYCINE; SIGNAL TRANSDUCTION;

EID: 79951671053     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2010.10.003     Document Type: Article

References (45)

1. Andreucci M., Michael A., Kramers C., Park K.M., Chen A., Matthaeus T., Alessandrini A., Haq S., Force T., Bonventre J.V. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney. Int. 2003, 64:1189-1198.
2. Arden K.C. FoxOs in tumor suppression and stem cell maintenance. Cell 2007, 128:235-237.
3. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999, 96:857-868.
4. Burgering B.M., Kops G.J. Cell cycle and death control: long live forkheads. Trends Biochem. Sci. 2002, 27:352-360.
5. Cai B., Chang S.H., Becker E.B., Bonni A., Xia Z. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J. Biol. Chem. 2006, 281:25215-25222.
6. Cascio M., Shenkel S., Grodzicki R.L., Sigworth F.J., Fox R.O. Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors. J. Biol. Chem. 2001, 276:20981-20988.
7. Chang C.W., Tsai W.H., Chuang W.J., Lin Y.S., Wu J.J., Liu C.C., Tsai P.J., Lin M.T. Procaspase 8 and Bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin B-induced apoptosis. J. Biol. Chem. 2009, 284:33195-33205.
8. Cohen-Armon M., Visochek L., Rozensal D., Kalal A., Geistrikh I., Klein R., Bendetz-Nezer S., Yao Z., Seger R. DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation. Mol. Cell. 2007, 25:297-308.
9. Dhanasekaran D.N., Johnson G.L. MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene 2007, 26:3097-3099.
10. Evans-Anderson H.J., Alfieri C.M., Yutzey K.E. Regulation of cardiomyocyte proliferation and myocardial growth during development by FoxO transcription factors. Circ. Res. 2008, 102:686-694.
11. Froh M., Thurman R.G., Wheeler M.D. Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283:G856-863.
12. Gratton J.P., Morales-Ruiz M., Kureishi Y., Fulton D., Walsh K., Sessa W.C. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 2001, 276:30359-30365.
13. Grenningloh G., Rienitz A., Schmitt B., Methfessel C., Zensen M., Beyreuther K., Gundelfinger E.D., Betz H. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature 1987, 328:215-220.
14. Ikejima K., Qu W., Stachlewitz R.F., Thurman R.G. Kuffer cells contain a glycine-gated chloride channel. Am. J. Physiol. 1997, 272:G1581-1586.
15. Jeffrey K.L., Camps M., Rommel C., Mackay C.R. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat. Rev. Drug. Discov. 2007, 6:391-403.
16. Jensen A.A., Kristiansen U. Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay. Biochem. Pharmacol. 2004, 67:1789-1799.
17. Jentsch T.J., Stein V., Weinreich F., Zdebik A.A. Molecular structure and physiological function of chloride channels. Physiol. Rev. 2002, 82:503-568.
18. Kaiser R.A., Lyons J.M., Duffy J.Y., Wagner C.J., McLean K.M., O'Neill T.P., Pearl J.M., Molkentin J.D. Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H2747-H2751.
19. Khurana A., Dey C.S. Involvement of Elk-1 in L6E9 skeletal muscle differentiation. FEBS Lett. 2002, 527:119-124.
20. Kilic E., Kilic U., Soliz J., Bassetti C.L., Gassmann M., Hermann D.M. Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. FASEBJ. 2005, 19:2026-2028.
21. Kim B.J., Ryu S.W., Song B.J. JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J. Biol. Chem. 2006, 281:21256-21265.
22. Kuhse J., Laube B., Magalei D., Betz H. Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 1993, 11:1049-1056.
23. Liao Y., Hung M.C. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Mol. Cell. Biol. 2003, 23:6836-6848.
24. Lynch J.W. Molecular structure and function of the glycine receptor chloride channel. Physiol. Rev. 2004, 84:1051-1095.
25. Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
26. Meizel S., Son J.H. Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction. Mol. Reprod. Dev. 2005, 72:250-258.
27. Omasa M., Fukuse T., Toyokuni S., Mizutani Y., Yoshida H., Ikeyama K., Hasegawa S., Wada H. Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model. Transplantation 2003, 75:591-598.
28. Pan C., Bai X., Fan L., Ji Y., Li X., Chen Q. Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells. Biochem. J. 2005, 390:447-453.
29. Qin X., Cao J., Bai H., Yang Q., Chen Q. Effects of glycine on the ATP depletion-induced autophagy in MDCK cells. Acta Univ. Med. Nanjing 2009, 29:1633-1637.
30. Raman M., Chen W., Cobb M.H. Differential regulation and properties of MAPKs. Oncogene 2007, 26:3100-3112.
31. Ricote M., García-Tuñón I., Bethencourt F., Fraile B., Onsurbe P., Paniagua R., Royuela M. The p38 transduction pathway in prostatic neoplasia. J. Pathol. 2006, 208:401-407.
32. Sharrocks A.D. Complexities in ETS-domain transcription factor function and regulation: lessons from the TCF (ternary complex factor) subfamily. Biochem. Soc. Trans. 2002, 30:1-9.
33. Tang W., Xie J., Shaikh Z.A. Protection of renal tubular cells against the cytotoxicity of cadmium by glycine. Toxicology 2006, 223:202-208.
34. Uehara T., Bennett B., Sakata S.T., Satoh Y., Bilter G.K., Westwick J.K., Brenner D.A. JNK mediates hepatic ischemia reperfusion injury. J. Hepatol. 2005, 42:850-859.
35. Vikman P., Ansar S., Edvinsson L. Transcriptional regulation of inflammatory and extracellular matrix-regulating genes in cerebral arteries following experimental subarachnoid hemorrhage in rats. J. Neurosurg. 2007, 107:1015-1022.
36. Warny M., Keates A.C., Keates S., Castagliuolo I., Zacks J.K., Aboudola S., Qamar A., Pothoulakis C., LaMont J.T., Kelly C.P. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J. Clin. Invest. 2000, 105:1147-1156.
37. Xu X., Chua C.C., Gao J., Chua K.W., Wang H., Hamdy R.C., Chua B.H. Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain. Res. 2008, 1227:12-18.
38. Yadid G., Youdim M.B., Zinder O. High-affinity strychnine binding to adrenal medulla chromaffin cell membranes. Eur. J. Pharmacol. 1990, 175:365-366.
39. Yang S.H., Whitmarsh A.J., Davis R.J., Sharrocks A.D. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 1998, 17:1740-1749.
40. Yin M., Zhong Z., Connor H.D., Bunzendahl H., Finn W.F., Rusyn I., Li X., Raleigh J.A., Mason R.P., Thurman R.G. Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. Am. J. Physiol. Renal Physiol. 2002, 282:F417-423.
41. Yu P.J., Ferrari G., Pirelli L., Gulkarov I., Galloway A.C., Mignatti P., Pintucci G. Vascular injury and modulation of MAPKs: a targeted approach to therapy of restenosis. Cell. Signal. 2007, 19:1359-1371.
42. Zarubin T., Han J. Activation and signaling of the p38 MAP kinase pathway. Cell. Res. 2005, 15:11-18.
43. Zhang K., Weinberg J.M., Venkatachalam M.A., Dong Z. Glycine protection of PC-12 cells against injury by ATP-depletion. Neurochem. Res. 2003, 28:893-901.
44. Zhong Z., Wheeler M.D., Li X., Froh M., Schemmer P., Yin M., Bunzendaul H., Bradford B., Lemasters J.J. l-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr. Opin. Clin. Nutr. Metab. Care 2003, 6:229-240.
45. Zhu.M., Feng J., Lucchinetti E., Fischer G., Xu L., Pedrazzini T., Schaub M.C., Zaugg M. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc. Res. 2006, 72:152-162.