L-Glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 1, 2007, Pages

  Schachter, David ^a  

^a Columbia University ^*  (United States)

Author keywords

ketoisocaproate; cGMP; Endothelium; L leucine; Smooth muscle; Thoracic aorta

Indexed keywords

2 OXOACID DEHYDROGENASE; AMINO ACID MIXTURE; GLUTAMIC ACID; GLUTAMINE; LEUCINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

AMINO ACID BLOOD LEVEL; AMINO ACID COMPOSITION; AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; THORACIC AORTA; VASCULAR RING;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLUTAMIC ACID; GLUTAMINE; LEUCINE; MALE; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; TRIAZENES; VASODILATION;

RATTUS;

EID: 34547133741     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00589.2006     Document Type: Article

References (47)

1. Abbott RE, Schachter D. Regional differentiation in rat aorta: L-arginine metabolism and cGMP content in vitro. Am J Physiol Heart Circ Physiol 266: H2287-H2295, 1994.
2. Altman PL, Dittmer DS. Biological Handbooks: Blood and Other Body Fluids. Washington, DC: FASEB, 1961, p. 76-77.
3. Arnal JF, Munzel T, Venema RC, James NL, Bai CL, Mitch WE, Harrison DG. Interactions between L-arginine and L-glutamine change endothelial NO production. J Clin Invest 95: 2565-2572, 1995.
4. Baltrons MA, Pedraza C, Sardon T, Navarra M, Garcia A. Regulation of NO-dependent cyclic GMP formation by inflammatory agents in neural cells. Toxicol Lett 139: 191-198, 2003.
5. Bang L, Nielsen-Kudsk JE, Gruhn N, Theilgaard SA, Olesen SP, Boesgaard S, Aldershvile J. Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production. Scand Cardiovasc J 33: 33-78, 1999.
6. Boelens PG, Nijveldt RJ, Houdijk PJ, Meijer S, van Leeuwen PAM. Glutamine alimentation in catabolic state. J Nutr 131: 2569S-2577S, 2001.
7. Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86: 9030-9033, 1989.
8. Chapman J, Zhou M. Microplate-based fluorometric methods for the enzymatic determination of L-glutamate: application in measuring L-glutamate in food samples. Anal Chim Acta 402: 47-52, 1999.
9. Clarkson PBM, Lim PO, MacDonald TM. Influence of basal nitric oxide secretion on cardiac function in man. Br J Clin Pharmacol 40: 299-305, 1995.
10. Curthoys NP, Watford M. Regulation of glutaminase activity and glutamine metabolism. Annu Rev Nutr 15: 133-159, 1995.
11. Daikhin Y, Yudkoff M. Compartmentation of brain glutamate metabolism in neurons and glia. J Nutr 130: 1026S-1031S, 2000.
12. Danner DJ, Armstrong N, Heffelfinger SC, Sewell ET, Priest JH, Elsas LJ. Absence of branched-chain acyltransferase as a cause of Maple Syrup Urine Disease. J Clin Invest 75: 858-860, 1985.
13. Davis EJ. Pathways of branched-chain amino acid metabolism in mammals. In: Problems and Potential of Branched-Chain Amino Acids in Physiology and Medicine, edited by Odessey R. Amsterdam, The Netherlands: Elsevier, 1986, p. 1-29.
14. Erecinska M, Silver IA. Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 35: 245-296, 1990.
15. Furchgott RF. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol 24: 175-197, 1984.
16. Garthwaite J, Boulton CL. Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57: 683-706, 1995.
17. Gow BS. Circulatory correlates: vascular impedance, resistance and capacity. In: Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle. Bethesda, MD: Am Physiol Soc, 1980, sect. 2, vol. II, chapt. 14, p. 353-408.
18. Harris RA, Paxton R, Powell SM, Goodwin GW, Kuntz MJ, Han AC. Regulation of branched-chain α-ketoacid dehydrogenase complex by covalent modification. Adv Enzyme Regul 25: 219-237, 1986.
19. Haynes WG, Noon JP, Walker BR, Webb DJ. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 11: 1375-1380, 1993.
20. Hecker M, Mitchell JA, Swierkosz TA, Sessa WC, Vane JR. Inhibition by L-glutamine of the release of endothelium-derived relaxing factor from cultured endothelial cells. Br J Pharmacol 101: 237-239, 1990.
21. Hutson SM, Hall TR. Identification of the mitochondrial branched chain aminotransferase as a branched chain α-keto acid transport protein. J Biol Chem 268: 3084-3091, 1993.
22. Ignarro LJ. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 30: 535-560, 1990.
23. 2 may be the endothelium-derived contracting factor released by acetylcholine in the aorta of the rat. Hypertension 15: 475- 481, 1990.
24. Kvamme E. Synthesis of glutamate and its regulation. Prog Brain Res 116: 73-85.
25. Meininger CJ, Guoyao WU. L-Glutamine inhibits nitric oxide synthesis in bovine venular endothelial cells. J Pharmacol Exp Ther 281: 448-453, 1997.
26. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130: 1007S-1015S, 2000.
27. Merritt JE, Williams PB. Vasospasm contributes to monosodium glutamate-induced headache. Headache 30: 575-580, 1990.
28. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142, 1991.
29. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, post-injury, surgery or infection? J Nutr 131: 2515-2522, 2001.
30. Newsholme P, Procopio J, Lima MMR, Pithon-Curi TC, Cur R. Glutamine and glutamate - their central role in cell metabolism and function. Cell Biochem Funct 21: 1-9, 2003.
31. O'Leary MJ, Ferguson CN, Rennie MJ, Hinds CJ, Coakley JH, Preedy VR. Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat. Clin Sci (Lond) 101: 295-304, 2001.
32. 2 in regulating arterial glutamine in metabolic acidosis. Experientia 40: 1144-1146, 1984.
33. Sarchielli P, Alberti A, Floridi A, Gallai V. L-Arginine/ nitric oxide pathway in chronic tension-type headache: relation with serotonin content and secretion and glutamate content. J Neurol Sci 198: 9-15, 2002.
34. Schachter D, Sang JC. Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors. Am J Physiol Heart Circ Physiol 273: H1478-H1483, 1997.
35. Schachter D, Sang JC. Regional differentiation in the rat aorta for a novel signaling pathway: leucine to glutamate. Am J Physiol Heart Circ Physiol 273: H1484-H1492, 1997.
36. Schachter D, Sang JC. Aortic leucine-to-glutamate pathway: metabolic route and regulation of contractile responses. Am J Physiol Heart Circ Physiol 282: H1135-H1148, 2002.
37. Schwerin P, Bessman SP, Waelsch H. The uptake of glutamic acid and glutamine by brain and other tissues of the rat and mouse. J Biol Chem 184: 37-44, 1950.
38. Sessa WC, Hecker M, Mitchell JA, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: L-glutamine inhibits the generation of L-arginine by cultured endothelial cells. Proc Natl Acad Sci USA 87: 8607- 8611, 1990.
39. Shears LL 2nd, Kibbe MR, Murdock AD, Billiar TR, Lizonova A, Kovesdi I, Watkins SC, Tzeng E. Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rat and pigs in vivo. J Am Coll Surg 187: 295-306, 1998.
40. Stamler JS. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell 78: 931-936, 1994.
41. Stumvoll M, Perriello G, Meyer C, Gerich J. Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int 5: 778-779, 1999.
42. Swierkosz TA, Mitchell JA, Sessa WC, Hecker M, Vane JR. L-Glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta. Biochem Biophys Res Commun 172: 143-148, 1990.
43. Tapiero H, Mathe G, Couvreur P, Tew KD. Glutamine and glutamate. Biomed Pharmacother 56: 446-457, 2002.
44. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol Cell Physiol 269: C1371-C1378, 1995.
45. Wischmeyer PE, Vanden Hoek TL, Li C, Shao Z, Ren H, Riehm J, Becker LB. Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury. J Parenter Enteral Nutr 27: 116-122, 2003.
46. Wu G, Haynes TE, Yan W, Meininger CJ. Presence of glutamine: fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: effects of hyperglycaemia and glutamine. Diabetologia 44: 196-202, 2001.
47. Yudkoff M. Brain metabolism of branched-chain amino acids. Glia 21: 92-98, 1997.