PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B12 deficient rats

Journal of Proteomics

Volumn 91, Issue , 2013, Pages 297-308

  Ahmad, Shadab ^a   Kumar, K Anand ^b   Basak, Trayambak ^a   Bhardwaj, Gourav ^a   Yadav, Dilip K ^c   Lalitha, A ^b   Chandak, Giriraj Ratan ^c   Raghunath, Manchala ^c   Sengupta, Shantanu ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b NATIONAL INSTITUTE OF NUTRITION   (India)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Liver proteome; Micronutrient deficiency; Obesity; PPARs; Vitamin B12

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A DEHYDROGENASE; CHOLESTEROL; CYANOCOBALAMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEOME; TRIACYLGLYCEROL;

AGE; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIRTH; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIABETES MELLITUS; DOWN REGULATION; FATTY ACID OXIDATION; FEMALE; GLUCONEOGENESIS; GLYCOLYSIS; LIPID METABOLISM; LIVER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLIC REGULATION; MOTHER; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEOMICS; RAT; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

2-DIMENSIONAL DIFFERENCE IN-GEL ELECTROPHORESIS; 2D-DIGE; 3-KETOACYL-COA THIOLASE; ACADM; ACETONITRILE; ACN; ALKALINE PHOSPHATASE; ALP; BIOLOGICAL VARIANT ANALYSIS; BVA; DIA; DIFFERENTIAL IN-GEL ANALYSIS; DITHIOTHERITOL; DTT; ECL; EDTA; ENHANCED CHEMILUMINESCENCE; ETHYLENEDIAMINETETRAACETIC ACID; FABPL; FALSE DISCOVERY RATE; FAS; FAT FREE MASS; FATTY ACID BINDING PROTEIN, LIVER; FATTY ACID SYNTHASE; FDR; FFM; HCDH; HORSERADISH PEROXIDASE; HRP; HYDROXYACYL-COENZYME A DEHYDROGENASE; IAA; IDV; IEF; IMMOBILIZED PH GRADIENT; INTEGRATED DENSITY VALUE; IODOACETAMIDE; IPG; ISOELECTRIC FOCUSSING; LBM; LEAN BODY MASS; LIVER PROTEOME; MALDI TOF/TOF; MATRIX ASSISTED LASED DESORPTION IONIZATION, TIME OF FLIGHT; MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE; MICRONUTRIENT DEFICIENCY; NBT-BCIP; NITRO BLUE TETRAZOLIUM-5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; POLYVINYLIDENE FLUORIDE; PPAR; PPARS; PVDF; S-ADENOSYL METHIONINE; SAM; TFA; TG; THIM; TRIFLUROACETIC ACID; TRIGLYCERIDE; VITAMIN B(12);

AMINO ACIDS; ANIMALS; ANIMALS, NEWBORN; CARBOHYDRATES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPIDS; LIVER; MATERNAL EXPOSURE; MICRONUTRIENTS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PREGNANCY; PROTEOME; PROTEOMICS; RATS; SIGNAL TRANSDUCTION; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84882974351     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2013.07.027     Document Type: Article

References (42)

1. Lelievre-Pegorier M., Vilar J., Ferrier M.L., Moreau E., Freund N., Gilbert T., et al. Mild vitamin A deficiency leads to inborn nephron deficit in the rat. Kidney Int 1998, 54:1455-1462.
2. Ashworth C.J., Antipatis C. Micronutrient programming of development throughout gestation. Reproduction 2001, 122:527-535.
3. Hales C.N., Barker D.J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992, 35:595-601.
4. Christian P., Murray-Kolb L.E., Khatry S.K., Katz J., Schaefer B.A., Cole P.M., et al. Prenatal micronutrient supplementation and intellectual and motor function in early school-aged children in Nepal. JAMA 2010, 304:2716-2723.
5. Wang O., Nie M., Hu Y.Y., Zhang K., Li W., Ping F., et al. Association between vitamin D insufficiency and the risk for gestational diabetes mellitus in pregnant Chinese women. Biomed Environ Sci 2012, 25:399-406.
6. Barker D.J. In utero programming of chronic disease. Clin Sci (Lond) 1998, 95:115-128.
7. Nielsen M.J., Rasmussen M.R., Andersen C.B., Nexo E., Moestrup S.K. Vitamin B12 transport from food to the body's cells-a sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol 2012, 9:345-354.
8. Sharma P., Senthilkumar R.D., Brahmachari V., Sundaramoorthy E., Mahajan A., Sharma A., et al. Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies. Lipids Health Dis 2006, 5:1.
9. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006, 5:949-960.
10. Kumar J., Garg G., Sundaramoorthy E., Prasad P.V., Karthikeyan G., Ramakrishnan L., et al. Vitamin B12 deficiency is associated with coronary artery disease in an Indian population. Clin Chem Lab Med 2009, 47:334-338.
11. Vogel T., Dali-Youcef N., Kaltenbach G., Andres E. Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. Int J Clin Pract 2009, 63:1061-1067.
12. Sachdev P.S. Alzheimer disease: homocysteine and alzheimer disease: an intervention study. Nat Rev Neurol 2011, 7:9-10.
13. Refsum H., Ueland P.M., Nygard O., Vollset S.E. Homocysteine and cardiovascular disease. Annu Rev Med 1998, 49:31-62.
14. Jardine M.J., Kang A., Zoungas S., Navaneethan S.D., Ninomiya T., Nigwekar S.U., et al. The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ 2012, 344:e3533.
15. Yajnik C.S., Deshpande S.S., Jackson A.A., Refsum H., Rao S., Fisher D.J., et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008, 51:29-38.
16. Garcia M.M., Gueant-Rodriguez R.M., Pooya S., Brachet P., Alberto J.M., Jeannesson E., et al. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1alpha by PRMT1 and SIRT1. J Pathol 2011, 225:324-335.
17. Pooya S., Blaise S., Moreno Garcia M., Giudicelli J., Alberto J.M., Gueant-Rodriguez R.M., et al. Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver. J Hepatol 2012, 57:344-351.
18. Kumar K.A., Lalitha A., Pavithra D., Padmavathi I.J., Ganeshan M., Rao K.R., et al. Maternal dietary folate and/or vitamin B(12) restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring. J Nutr Biochem 2013, 24:25-31.
19. Choi S.W., Friso S., Ghandour H., Bagley P.J., Selhub J., Mason J.B. Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr 2004, 134:750-755.
20. Kumar J., Garg G., Kumar A., Sundaramoorthy E., Sanapala K.R., Ghosh S., et al. Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia. Circ Cardiovasc Genet 2009, 2:599-606.
21. Albrecht D., Guthke R., Brakhage A.A., Kniemeyer O. Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics 2010, 11:32.
22. Ponnudurai R.P., Basak T., Ahmad S., Bhardwaj G., Chauhan R.K., Singh R.A., et al. Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A. J Proteomics 2012, 75:1004-1017.
23. Chattopadhyay S., Basak T., Nayak M.K., Bhardwaj G., Mukherjee A., Bhowmick R., et al. Identification of cellular calcium binding protein calmodulin as a regulator of rotavirus A infection during comparative proteomic study. PLoS One 2013, 8:e56655.
24. Yadav A.K., Bhardwaj G., Basak T., Kumar D., Ahmad S., Priyadarshini R., et al. A systematic analysis of eluted fraction of plasma post immunoaffinity depletion: implications in biomarker discovery. PLoS One 2011, 6:e24442.
25. Romero-Calvo I., Ocon B., Martinez-Moya P., Suarez M.D., Zarzuelo A., Martinez-Augustin O., et al. Reversible Ponceau staining as a loading control alternative to actin in Western blots. Anal Biochem 2010, 401:318-320.
26. Carmona-Saez P., Chagoyen M., Tirado F., Carazo J.M., Pascual-Montano A. GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol 2007, 8:R3.
27. Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004, 53(Suppl. 1):S43-S50.
28. Martin G., Schoonjans K., Staels B., Auwerx J. PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes. Atherosclerosis 1998, 137:S75-S80. [Suppl.].
29. Feltrin C., Batista de Morais M., de Cassia Freitas K., Beninga de Morais T., Fagundes Neto U., Silverio Amancio O.M. Effect of soluble fiber pectin on growth and intestinal iron absorption in rats during recovery from iron deficiency anemia. Biol Trace Elem Res 2009, 129(1-3):221-228.
30. Baig M.M., Burgin C.W., Cerda J.J. Effect of dietary pectin on iron absorption and turnover in the rat. J Nutr 1983, 113:2385-2389.
31. El-Sammak M., Kandil M., El-Hifni S., Hosni R., Ragab M. Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. Int J Med Sci 2004, 1:181-192.
32. Mayer E.L., Jacobsen D.W., Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol 1996, 27:517-527.
33. Jacques P.F., Rosenberg I.H., Rogers G., Selhub J., Bowman B.A., Gunter E.W., et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999, 69:482-489.
34. Peters J.M., Shah Y.M., Gonzalez F.J. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nat Rev Cancer 2012, 12:181-195.
35. Kersten S., Mandard S., Escher P., Gonzalez F.J., Tafuri S., Desvergne B., et al. The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. FASEB J 2001, 15:1971-1978.
36. Sheikh K., Camejo G., Lanne B., Halvarsson T., Landergren M.R., Oakes N.D. Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat. Am J Physiol Endocrinol Metab 2007, 292:E1157-E1165.
37. Makowski L., Noland R.C., Koves T.R., Xing W., Ilkayeva O.R., Muehlbauer M.J., et al. Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEB J 2009, 23:586-604.
38. Bansal V., Ochoa J.B. Arginine availability, arginase, and the immune response. Curr Opin Clin Nutr Metab Care 2003, 6:223-228.
39. Kim N.N., Christianson D.W., Traish A.M. Role of arginase in the male and female sexual arousal response. J Nutr 2004, 134:2873S-9S. [discussion 2895S].
40. Lange P.S., Langley B., Lu P., Ratan R.R. Novel roles for arginase in cell survival, regeneration, and translation in the central nervous system. J Nutr 2004, 134:2812S-7S. [discussion 2818S-2819S].
41. Minnich A., Tian N., Byan L., Bilder G. A potent PPARalpha agonist stimulates mitochondrial fatty acid beta-oxidation in liver and skeletal muscle. Am J Physiol Endocrinol Metab 2001, 280:E270-E279.
42. Chakravarthy M.V., Lodhi I.J., Yin L., Malapaka R.R., Xu H.E., Turk J., et al. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 2009, 138:476-488.