Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors

Neuropharmacology

Volumn 75, Issue , 2013, Pages 19-30

  Harvey, B D ^a,d   Siok, C J ^a,b   Kiss, T ^a,b   Volfson, D ^a,b   Grimwood, S ^a,b   Shaffer, C L ^a,b   Hajos M ^a,c  

^a PFIZER INC   (United States)

^b Research Statistics Pfizer Global Research and Development Groton Laboratories ^*  (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BIOGEN   (United States)

Author keywords

Anxiety; mGluR5; Polysomnography; Quantitative electroencephalography; Rat

Indexed keywords

4 DIFLUOROMETHOXY [3 (PYRIDINE 2 YLETHYNYL)PHENYL] 5H PYRROLO[3,4 B]PYRIDINE 6(7H)YL METHANONE; AMINO ACID RECEPTOR AFFECTING AGENT; BIOLOGICAL MARKER; GRN 529; METABOTROPIC RECEPTOR 5; OCTAHYDRO 4 HYDROXY 4 [(3 METHYLPHENYL)ETHYNYL] 1H INDOLE 1 CARBOXYLIC ACID METHYL ESTER; UNCLASSIFIED DRUG;

ALPHA RHYTHM; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN FUNCTION; CONTROLLED STUDY; DELTA RHYTHM; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS THETA RHYTHM; MALE; MOVEMENT (PHYSIOLOGY); NERVE CELL NETWORK; NERVE STIMULATION; NEUROMODULATION; NEUROPHYSIOLOGY; NONHUMAN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ELECTROENCEPHALOGRAPHY; RAT; RECEPTOR OCCUPANCY; REM SLEEP; SLEEP WAKING CYCLE; TRANQUILIZING ACTIVITY; WAKEFULNESS;

METHYL (3AR,4S,7AR)-4-HYDROXY-4-[(3-METHYLPHENYL)ETHYNYL]OCTAHYDRO-1H-INDOLE-1-CARBOXYLATE; 4-DIFLUOROMETHOXY-3-(PYRIDINE-2-YLETHYNYL)PHENYL)5H-PYRROLO[3,4-B]PYRIDINE-6(7H)-YL METHANONE; AFQ056; ANTERIOR POSTERIOR; ANXIETY; AP; DORSAL VENTRAL; DV; EEG; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; EMG; FAST-FOURIER TRANSFORM; FFT; GRN-529; JUGULAR VEIN-CANNULATED; JVC; LLOQ; LOWER LIMIT OF QUANTIFICATION; METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5; MGLUR5; N-METHYL-D-ASPARTATE; NAM; NEGATIVE ALLOSTERIC MODULATOR; NMDA; NON REM SLEEP; NPO; NREM; NUCLEUS PONTIS ORALIS; PET; POLYSOMNOGRAPHY; POSITRON EMISSION TOMOGRAPHY; PSG; QEEG; QUANTITATIVE ELECTROENCEPHALOGRAM; QUANTITATIVE ELECTROENCEPHALOGRAPHY; RAPID EYE MOVEMENT; RAT; RECEPTOR OCCUPANCY; REM; RO; S-R; SIMULATION RESPONSE; STANDARD DEVIATION OF THE EMG AMPLITUDE; UNITED STATES PHARMACOPEIA; USP; Σ(EMG);

ALGORITHMS; ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; BRAIN WAVES; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; EYE MOVEMENTS; INDOLES; MALE; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; TRITIUM;

EID: 84882973073     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.06.020     Document Type: Article

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