Pregabalin enhances nonrapid eye movement sleep

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 3, 2001, Pages 1095-1105

  Kubota, Takeshi ^a   Fang, Jidong ^a   Meltzer, Leonard T ^b   Krueger, James M ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID DERIVATIVE; HYPNOTIC AGENT; PREGABALIN; TRIAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DELTA RHYTHM; DOSE RESPONSE; DRUG EFFECT; ELECTROENCEPHALOGRAM; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; SLEEP TIME; SLOW WAVE SLEEP;

ANIMALS; EYE MOVEMENTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; MALE; RATS; RATS, SPRAGUE-DAWLEY; SLEEP; TRIAZOLAM;

EID: 0035200319     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Sleep in a sitting position: Effect of triazolam on sleep stages and EEG power spectra
2. Progress report on new antiepileptic drugs: A summary of the fourth Eilat conference (EILAT IV)
3. Sleep homeostasis and models of sleep regulation
4. Hypnotics and sleep physiology: A consensus report
5. Effect of sleep deprivation on sleep and EEG power spectra in the rat
6. 3-Substituted GABA analogs with central nervous system activity: A review
7. 3H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin
8. Triazolam-induced sleep in the rat: Influence of prior sleep, circadian time, and light/dark cycles
9. The GABAA agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans
10. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity
11. Differential effects of flunitrazepam on human sleep in combination with flumazenil
12. Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat
13. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel
14. Localization of [3H]gabapentin to a novel site in rat brain: Autoradiographic studies
15. Sleep spindle and delta changes during chronic use of a short-acting and a long-acting benzodiazepine hypnotic
16. Blockade of thalamic GABAB receptors decreases EEG synchronization
17. The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep
18. Anxiolytic-like effects of pregabalin
19. Management of insomnia
20. Somnogenic cytokines: Methods and overview
21. Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits
22. The GABAA agonist THIP increases non-REM sleep and enhances non-REM sleep-specific delta activity in the rat during the dark period
23. Role of GABAA receptors in the regulation of sleep: Initial sleep responses to peripherally administered modulators and agonists
24. Role of GABAA receptors in sleep regulation. Differential effects of muscimol and midazolam on sleep in rats
25. The GABAA agonist THIP (gaboxadol) increases non-REM sleep and enhances delta activity in the rat
26. Effects of parenterally administered triazolam on sleep in rats with lesions of the preoptic area
27. Do benzodiazepines induce sleep by a GABAergic mechanism?
28. Triazolam: A review of its pharmacological properties and therapeutic efficacy in patients with insomnia
29. Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals
30. The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy
31. Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits
32. Gabapentin decreases monoamine release without affecting acetylcholine release in the brain
33. Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever
34. Characterisation of [3H]gabapentin binding to a novel site in rat brain: Homogenate binding studies
35. Benzodiazepine effects on human sleep EEG spectra: A comparison of triazolam and flunitrazepam
36. 3-Alkyl GABA and 3-alkylglutamic acid analogues: Two new classes of anticonvulsant agents
37. Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin