Comparative analysis of the neurophysiological profile of group II metabotropic glutamate receptor activators and diazepam: Effects on hippocampal and cortical EEG patterns in rats

Neuropharmacology

Volumn 62, Issue 1, 2012, Pages 226-236

  Siok, Chester J ^a   Cogan, Shawn M ^b   Shifflett, Lauren B ^b   Doran, Angela C ^a   Kocsis, Bernat ^b   Hajós, Mihály ^a  

^a PFIZER INC   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anxiety; Diazepam; Hippocampus; mGlu2 3; REM sleep; Theta

Indexed keywords

4 AMINO 2 THIABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID 2,2 DIOXIDE; DIAZEPAM; EGLUMETAD; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR AGONIST 2; METABOTROPIC RECEPTOR AGONIST 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN STEM; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC POTENTIAL; ELECTROCORTICOGRAPHY; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; HIPPOCAMPUS THETA RHYTHM; MALE; NEUROPHYSIOLOGY; NONHUMAN; OSCILLATION; PONTINE NUCLEUS; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP PARAMETERS; SLOW WAVE SLEEP; TRANQUILIZING ACTIVITY; WAKEFULNESS;

ANIMALS; ANTI-ANXIETY AGENTS; BRAIN WAVES; CEREBRAL CORTEX; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EXCITATORY AMINO ACID AGONISTS; FOURIER ANALYSIS; HIPPOCAMPUS; MALE; NEURAL PATHWAYS; PONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SLEEP, REM; WAKEFULNESS;

EID: 80054109355     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.07.011     Document Type: Conference Paper

References (51)

1. 2) elicits common changes in rat and mice sleep-wake architecture Eur. J. Pharmacol. 603 2009 62 72
2. R. Anwyl Metabotropic glutamate receptors: electrophysiological properties and role in plasticity Brain Res. Rev. 29 1999 83 120 (Pubitemid 29016081)
3. G. Buzsaki Theta oscillations in the hippocampus Neuron 33 2002 325 340 (Pubitemid 34158839)
4. J. Cartmell, and D.D. Schoepp Regulation of neurotransmitter release by metabotropic glutamate receptors J. Neurochem. 75 2000 889 907 (Pubitemid 30660476)
5. E. Dunayevich, J. Erickson, L. Levine, R. Landbloom, D.D. Shoepp, and G.D. Tollefson Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder Neuropsyphopharmacology 33 2008 1603 1610 (Pubitemid 351684700)
6. E. Engin, D. Treit, and C.T. Dickson Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models Neuroscience 161 2 2009 359 369
7. E. Engin, J. Stellbrink, D. Treit, and C.T. Dickson Anxiolytic and antidepressant effects of intracerebroventricularly administered somatostatin: behavioral and neurophysiological evidence Neuroscience 157 3 2008 666 676
8. I. Feinberg, I.G. Campbell, D.D. Schoepp, and K. Anderson The selective group 2/3 receptor agonist LY379268 suppresses REM sleep and fast EEG in the rat Pharmacol. Biochem. Behav. 73 2002 467 474 (Pubitemid 34765584)
9. M.J. Fell, J.M. Witkin, J.F. Falcone, J.S. Katner, K.W. Perry, J. Hart, L. Rorick-Kehn, C.D. Overshiner, K. Rasmussen, S.F. Chaney, M.J. Benvenga, X. Li, D.L. Marlow, L.K. Thompson, S.K. Luecke, K.A. Wafford, W.F. Seidel, D.M. Edgar, A.T. Quets, C.C. Felder, X. Wang, B.A. Heinz, A. Nikolayev, M.-S. Kuo, D. Mayhugh, A. Khilevich, D. Zhang, P.J. Ebert, J.A. Ecksstein, B.L. Ackermann, S.P. Swanson, J.T. Catlow, R.A. Dean, K. Jackson, S. Tauscher-Wisniewski, G.J. Marek, J.M. Schkeryantz, and K.A. Svensson N-(4((2-(trifluoromethyl)-3-hydroxy- 4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1 H-imidazole-4-carboamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes J. Pharmacol. Exp. Ther. 336 2011 165 177
10. R. Galici, C.K. Jones, K. Hemstapat, Y. Nong, N.G. Echemendia, L.C. Williams, T. de Paulis, and P.J. Conn Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice J. Pharmacol. Exp. Ther. 318 2006 173 185
11. J.A. Gordon, C.O. Lacefield, C.G. Kentros, and R. Hen State-dependent alterations in hippocampal oscillations in serotonin 1a receptor-deficient mice J. Neurosci. 25 2005 6509 6519 (Pubitemid 40995283)
12. C. Gottesmann, G. Gandolfo, C. Arnaud, and P. Gauthier The intermediate stage and paradoxical sleep in the rat: influence of three generations of hypnotics Eur. J. Neurosci. 10 2 1998 409 414 (Pubitemid 28325464)
13. J.A. Gray, and N. McNaughton The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System 2000 Oxford University Press Oxford
14. C. Grillon, J. Cordova, L.R. Levine, and C.A. Morgan Anxiolytic affects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans Psychopharmacology 168 4 2003 446 454 (Pubitemid 36994028)
15. M. Hajos, C.J. Siok, W.E. Hoffmann, S. Li, and B. Kocsis Modulation of hippocampal theta oscillation by histamine H3 receptors J. Pharmacol. Exp. Ther. 324 1 2008 391 398 (Pubitemid 350294183)
16. M.E. Hasselmo, C. Bodelon, and B.P. Wyble A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning Neural Comput. 14 2002 793 817
17. D.R. Helton, J.P. Tizzano, J.A. Monn, D.D. Schoepp, and M.J. Kallman Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors J. Pharmacol. Exp. Therapeut. 284 1998 651 660 (Pubitemid 28086655)
18. R.B. Hildago, L.A. Tupler, and J.R. Davidson Pregabalin augmentation of quetiapine therapy in the treatment of fibromyagia: an open label, prospective trial Pharmacopsychiatry 40 2 2007 68 71
19. P.J. Johnson, D. Barda, T.C. Britton, R. Emkey, W.J. Hornbac, G.E. Jagdmann, D.L. McKinzie, E.S. Nisenbaum, J.P. Tizzano, and D.D. Shoepp Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity and efficacy in preclinical anxiety and psychosis model(s) Psychopharmacology 179 2005 271 283 (Pubitemid 40576715)
20. J.C. Kalvass, and T.S. Maurer Influence of nonspecific brain and plasma binding on CNS exposure: Implications for rational drug discovery Biopharm. Drug Dispos. 23 2002 327 338 (Pubitemid 36124162)
21. G.G. Kinney, P. Patino, Y. Mermet-Bouvier, J.E. Starrett, and V.K. Gribkoff Cognition-enhancing drugs increase stimulated hippocampal theta rhythm amplitude in the urethane-anesthetized rat J. Pharmacol. Exp. Ther. 291 1999 99 106 (Pubitemid 29451578)
22. B. Kocsis, S. Li, and M. Hajos Behavior-dependent modulation of hippocampal EEG activity by the selective norepinephrine reuptake inhibitor reboxetine in rats Hippocampus 17 8 2007 627 633 (Pubitemid 47292033)
23. T. Kubota, J. Fang, L.T. Meltzer, and J.M. Krueger Pregabalin enhances nonrapid eye movement sleep J. Pharmacol. Exp. Ther. 299 2001 1095 1105 (Pubitemid 33104981)
24. B.C. Lega, J. Jacobs, and M. Kahana Human hippocampal theta oscillations and the formation of episodic memories Hippocampus 2011 Apr 27 10.1002/hipo.20937 (Epub ahead of print)
25. C.-H. Lin, C.-C. Lee, Y.-C. Huang, S.-J. Wang, and P.-W. Gean Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats Learn. Mem. 12 2005 130 137 (Pubitemid 40517079)
26. A.-M. Linden, H. Shannon, M. Baez, J.L. Yu, A. Koester, and D.D. Schoepp Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice Psychopharmacology 179 2005 284 291 (Pubitemid 40576716)
27. J. Lisman Working memory: the importance of theta and gamma oscillations Curr. Biol. 20 11 2010 R490 R492
28. H.S. Lo, C.M. Yang, H.G. Lo, C.Y. Lee, H. Ting, and B.S. Tzang Treatment effects of gabapentin for primary insomnia Clin. Neuropharmacol. 33 2 2010 84 90
29. T.A. Macek, D.G. Winder, R.W. Gereau, C.O. Ladd, and P.J. Conn Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses J. Neurophysiol. 76 1996 3798 3806 (Pubitemid 27009683)
30. B.A. Mander, K.J. Reid, K.G. Baron, T. Tjoa, T.B. Parrish, K.A. Paller, D.R. Gitelman, and P.C. Zee EEG measures index neural and cognitive recovery from sleep deprivation J. Neurosci. 30 7 2010 2686 2693
31. N. McNaughton, B. Kocsis, and M. Hajos Elicited hippocampal theta rhythm: a screen for anxiolytic and procognitive drugs through changes in hippocampal function? Behav. Pharmacol. 18 2007 329 346 (Pubitemid 47356363)
32. S.A. Montgomery, K. Tobias, G.L. Zornberg, S. Kasper, and A.C. Pande Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine J. Clin. Psychiatry 67 2006 771 782 (Pubitemid 43946184)
33. E.C. Muly, I. Mania, J.D. Guo, and D.G. Rainnie Group II metabotropic glutamate receptors in anxiety circuitry: correspondence of physiological response and subcellular distribution Comp. Neurol. 505 6 2007 682 700 (Pubitemid 350247133)
34. J.W. Papez A proposed mechanism of emotion Arch. Neurol. Psychiatry 38 1937 725 743
35. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates second ed. 1986 Academic Press New York, NY
36. J. Quintero, D.J. Dooley, F. Pomerleau, P. Huettl, and G. Gerhardt Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ alpha2delta-1 subunit J. Pharmacol. Exp. Ther. 338 1 2011 240 245
37. G. Richards, J. Messer, P. Malherbe, R. Pink, M. Brockhaus, H. Stadler, J. Wichmann, H. Schaffhauser, and V. Mutel J. Comp. Neurol. 487 2005 15 27
38. L.M. Rorick-Kehn, B.G. Johnson, K.M. Knitowski, C.R. Salhoff, J.M. Witkin, K.W. Perry, K.I. Griffey, J.P. Tizzano, J.A. Monn, D.L. McKinzei, and D.D. Schoepp in vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders Psychopharmacology 193 2007 121 136 (Pubitemid 46906627)
39. D.D. Schoepp, R.A. Wright, L.R. Levine, B. Gaydos, and W.Z. Potter LY354740 an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress Stress 6 3 2003 189 197 (Pubitemid 37210425)
40. C.J. Siok, J.A. Rogers, B. Kocsis, and M. Hajos Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation Eur. J. Neurosci. 23 2 2006 570 574
41. C.J. Siok, C.P. Taylor, and M. Hajos Anxiolytic profile of pregabalin on elicited hippocampal theta oscillation Neuropharmacology 56 2009 379 385
42. C.J. Swanson, C. Bures, M.P. Johnson, A.-M. Linden, J.A. Monn, and D.D. Schoepp Metabotropic glutamate receptors as novel targets for anxiety and stress disorders Nat. Rev. Drug Discov. 4 2005 131 144 (Pubitemid 40277494)
43. 2-delta) subunit as a target for antiepileptic drug discovery Epilepsy Res. 73 2007 137 150 (Pubitemid 46329329)
44. 2/3 receptor agonist, LY354740 in the fear-potentiated startle model in rats is mechanistically distinct from diazepam Pharmacol. Biochem. Behav. 73 2002 367 374 (Pubitemid 34773438)
45. H. van Lier, W.H. Drinenburg, Y.J. van Eeten, and A.M. Coenen Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats Neuropharmacology 47 2 2004 163 174 (Pubitemid 38824640)
46. R.P. Vertes Brain stem generation of the hippocampal EEG Prog. Neurobiol. 19 3 1982 159 186
47. R.P. Vertes Hippocampal theta rhythm: a tag for short-term memory Hippocampus 15 7 2005 923 935 (Pubitemid 41556422)
48. D.L. Walker, L.M. Rattiner, and M. Davis Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats Behav. Neurosci. 116 6 2002 1075 1083 (Pubitemid 35429642)
49. R.A. Wright, M.B. Arnold, W.J. Wheeler, P.L. Ornstein, and D.D. Schoepp [3H]LY3341495 binding to group II metabotropic glutamate receptors in rat brain J Pharmacol. Exp. Ther. 298 2001 453 460 (Pubitemid 32673394)
50. M.-C. Xi, F.R. Morales, and M.H. Chase Interactions between GABAergic and cholinergic processes in the nucleus Pontis Oralis: neuronal mechanisms controlling active (rapid eye movement) sleep and wakefulness J. Neurosci. 24 7 2004 10670 10678 (Pubitemid 39557640)
51. L. Zhang, M.A. Brodney, J. Candler, A.C. Doran, A.J. Duplantier, I.V. Efremov, E. Evrard, K. Kraus, A.H. Ganong, J.A. Haas, A.N. Hanks, K. Jenza, J.T. Lazzar, N. Maklad, S.A. McCarthy, W. Qian, B.N. Rogers, M.D. Rottas, C.J. Schmidt, J.A. Siuciak, F.D. Tingley, and A.Q. Zhang 1-[(1-Methyl-1 H-imidazol-2-yl)methyl]-4-pphenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis J. Med. Chem. 54 2011 1724 1739