Effect of intra-cisternal application of kainic acid on the spinal cord and locomotor activity in rats

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 8, 2013, Pages 1505-1515

  Mitra, Nilesh K ^a   Goh, Tiffanie E W ^b   Krishnan, Thalisha Bala ^b   Nadarajah, Vishna D ^c   Vasavaraj, Arun K ^c   Soga, Tomoko ^d  

^a TAYLOR S UNIVERSITY   (Malaysia)

^b Postgraduate and Research Department   (Malaysia)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Amyotrophic lateral sclerosis; Glial fibrillary acidic protein; Kainic acid; Neurofilament protein; Spinal cord; Superoxide dismutase

Indexed keywords

AMINO ACID RECEPTOR STIMULATING AGENT; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; NEUROFILAMENT PROTEIN; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; MALE; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SPINAL CORD; WISTAR RAT;

AMYOTROPHIC LATERAL SCLEROSIS; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; NEUROFILAMENT PROTEIN; SPINAL CORD; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; MOTOR ACTIVITY; NEURONS; RATS; RATS, WISTAR; SPINAL CORD;

EID: 84882963940     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Drexel M, Preidt AP, Sperk G. Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. Neuropharmacology 2012; 63: 806-817.
2. Favaron M, Manev H, Alho H, Bertolino M, Ferret B, Guidotti A, Costa E. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc Natl Acad Sci U S A 1988; 85: 7351-7355.
3. Thonhoff JR, Ojeda L, Wu P. Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis. Curr Stem Cell Res Ther 2009; 4: 178-199.
4. Hugon J, Vallat JM, Dumas M. Role of glutamate and excitotoxicity in neurologic diseases. Rev Neurol (Paris) 1996; 152: 239-248.
5. Zhang XM, Zhu J. Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines. Curr Neuropharmacol 2011; 9: 388-398.
6. Foster AC, Mena EE, Monaghan DT, Cotman CW. Synaptic localization of kainic acid binding sites. Nature 1981; 289: 73-75.
7. Mikulecká A, Hlinák Z, Mares P. Behavioural effects of a subconvulsive dose of kainic acid in rats. Behav Brain Res 1999; 101: 21-28.
8. Tien D, Ohara PT, Larson AA, Jasmin L. Vagal afferents are necessary for the establishment but not the maintenance of kainic acid-induced hyperalgesia in mice. Pain 2003; 102: 39-49.
9. Otani N, Nawashiro H, Fukui S, Ooigawa H, Ohsumi A, Toyooka T, Shima K, Gomi H, Brenner M. Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice. J Clin Neurosci 2006; 13: 934-938.
10. Tovar-Y-Romo LB, Santa-Cruz LD, Tapia R. Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis. Mol Neurodegener 2009; 4: 31.
11. Strong M, Rosenfeld J. Amyotrophic lateral sclerosis: a review of current concepts. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4: 136-143.
12. Dal Canto MC, Gurney ME. Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res 1995; 676: 25-40.
13. Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, Reaume AG, Scott RW, Cleveland DW. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 1998; 281: 1851-1854.
14. Jaarsma D, Haasdijk ED, Grashorn JA, Hawkins R, van Duijn W, Verspaget HW, London J, Holstege JC. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol Dis 2000; 7: 623-643.
15. Chelly J, Kouyoumdjian JC, Mouillé P, Huchet AM, Schmitt H. Effects of L-glutamic acid and kainic acid on central cardiovascular control. Eur J Pharmacol 1979; 60: 91-94.
16. Hirst RA, Gosai B, Rutman A, Andrew PW, O'Callaghan C. Streptococcus pneumoniae damages the ciliated ependyma of the brain during meningitis. Infect Immun 2003; 71: 6095-6100.
17. Leke R, de Oliveira DL, Mussulini BH, Pereira MS, Kazlauckas V, Mazzini G, Hartmann CR, Silveira TR, Simonsen M, Bak LK, Waagepetersen HS, Keiding S, Schousboe A, Portela LV. Impairment of the organization of locomotor and exploratory behaviours in bile duct-ligated rats. PLoS One 2012; 7: e36322.
18. Esposito E, Paterniti I, Mazzon E, Genovese T, Galuppo M, Meli R, Bramanti P, Cuzzocrea S. MK801 attenuates secondary injury in a mouse experimental compression model of spinal cord trauma. BMC Neurosci 2011; 12: 31.
19. Reske-Nielsen E, Oster S, Reintoft I. Astrocytes in the prenatal central nervous system. From 5th to 28th week of gestation. An immunohistochemical study on paraffin-embedded material. Acta Pathol Microbiol Immunol Scand A 1987; 95: 339-346.
20. Morsy MD, Abdel-Razek HA, Osman OM. Effect of vanadium on renal Na+, K+-ATPase activity in diabetic rats: a possible role of leptin. J Physiol Biochem 2011; 67: 61-69.
21. Lepore AC, Tolmie C, O'Donnell J, Wright MC, Dejea C, Rauck B, Hoke A, Ignagni AR, Onders RP, Maragakis NJ. Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats. Neurobiol Dis 2010; 39: 252-264.
22. Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia A, McNamara JO. Neurotransmiter receptor and their effects. In: Purves D, editor. Neuroscience. Sunderland (MA): Sinauer Associates 2001; pp: 143.
23. Abraham KE, McGinty JF, Brewer KL. The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behaviour following excitotoxic spinal cord injury. Neuroscience 2001; 104: 863-874.
24. Liu MY, Su CF, Lin MT. The antinociceptive role of a bulbospinal serotonergic pathway in the rat brain. Pain 1988; 33: 123-129.
25. Pugdahl K, Fuglsang-Frederiksen A, de Carvalho M, Johnsen B, Fawcett PR, Labarre-Vila A, Liguori R, Nix WA, Schofield IS. Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study. J Neurol Neurosurg Psychiatry 2007; 78: 746-749.
26. Franck JE, Schwartzkroin PA. Immature rabbit hippocampus is damaged by systemic but not intraventricular kainic acid. Brain Res 1984; 315: 219-27.
27. Mayer ML, Westbrook GL. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J Physiol 1987; 394: 501-527.
28. Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci 2004; 24: 2143-2155.
29. Norton WT, Aquino DA, Hozumi I, Chiu FC, Brosnan CF. Quantitative aspects of reactive gliosis: a review. Neurochem Res 1992; 17: 877-885.
30. Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR. Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005; 202: 145-156.
31. Yoshii Y, Otomo A, Pan L, Ohtsuka M, Hadano S. Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1 (H46R) transgenic mouse model of ALS. Neurosci Res 2011; 70: 321-329.
32. O'Callaghan JP, Sriram K. Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity. Expert Opin Drug Saf 2005; 4: 433-442.
33. Morrison BM, Shu IW, Wilcox AL, Gordon JW, Morrison JH. Early and selective pathology of light chain neurofilament in the spinal cord and sciatic nerve of G86R mutant superoxide dismutase transgenic mice. Exp Neurol 2000; 165: 207-220.
34. Morrison BM, Hof PR, Morrison JH. Determinants of neuronal vulnerability in neurodegenerative diseases. Ann Neurol 1998; 44: 32-44.
35. Rong Y, Doctrow SR, Tocco G, Baudry M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainite induced neuropathology. Proc Natl Acad Sci USA 1999; 96: 9897-9902.
36. Bowling AC, Schulz JB, Brown RH Jr, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993; 61: 2322-2325.
37. Djukic MM, Jovanovic MD, Ninkovic M, Stevanovic I, Ilic K, Curcic M, Vekic J. Protective role of glutathione reductase in paraquat induced neurotoxicity. Chem Biol Interact 2012; 199: 74-86.