The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury

Neuroscience

Volumn 104, Issue 3, 2001, Pages 863-874

  Abraham, K E ^a   McGinty, J F ^b   Brewer, K L ^c  

^a SHENANDOAH UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

(RS) 1 aminoindan 1; 2,3 Dihydroxy 6 nitro 7 sulfamoylbenzo f quinoxaline; 5 Dicarboxylic acid; Dynorphin; Enkephalin; Pain; Spinal cord injury

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; DIMETHYL SULFOXIDE; EXCITOTOXIN; KAINIC ACID RECEPTOR; MESSENGER RNA; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; OPIATE; PREPRODYNORPHIN; PREPROENKEPHALIN; QUISQUALIC ACID; RECEPTOR SUBTYPE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; IN SITU HYBRIDIZATION; LUMBAR SPINAL CORD; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; THORACIC SPINAL CORD; TISSUE SECTION;

ANIMALS; BEHAVIOR, ANIMAL; DYNORPHINS; ENKEPHALINS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GROOMING; INDANS; MALE; NERVE DEGENERATION; NEURONS; NEUROTOXINS; OPIOID PEPTIDES; PAIN; PAIN MEASUREMENT; PROTEIN PRECURSORS; QUINOXALINES; RATS; RATS, LONG-EVANS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER; SPINAL CORD; SPINAL CORD INJURIES;

EID: 0035859211     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00134-8     Document Type: Article

References (51)

1. Opioid peptide mRNA expression following excitotoxic spinal cord injury
2. Opioid peptide mRNA expression is related to the onset of pain-related behaviors following excitotoxic spinal cord injury
3. Role of group I metabotropic receptors in traumatic spinal cord white matter injury
4. A peripheral mononeuropathy in rats that produces disorders of pain sensation like those seen in human
5. Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology
6. Excitotoxic spinal cord injury induces diencephalic changes in gene expression
7. Neuroprotective effects of IL-10 following excitotoxic spinal cord injury
8. Excitotoxic cell death
9. Mechanical and thermal allodynia in chronic central pain following spinal cord injury
10. The quantity of calcium that appears to induce neuronal death
11. Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury
12. N-Methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: Behavioral, anatomic, and neurochemical studies
13. Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury
14. Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury
15. Protective effect of the NMDA antagonist MK-801 on photochemically induced spinal lesions in the rat
16. Allodynia-like effects in rat after ischemic spinal cord injury photochemically induced by laser irradiation
17. Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats
18. Intrahippocampal NMDA administration alters fos, fos-related antigens, and opioid peptide immunoreactivity and mRNA in rats
19. Opioid peptides and their receptors
20. Differential effects of NBQX on the distal and local toxicity of glutamate agonists administered intra-hippocampally
21. The thalamus and central pain syndromes: Human and animal studies
22. Dysesthesias and self-mutilation in humans and subhumans: A review of clinical and experimental studies
23. Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus
24. Excitatory amino acids rise to toxic levels upon impact injury to the rat spinal cord
25. NMDA and non-NMDA receptor antagonists protect against excitotoxic injury in the rat spinal cord
26. Effects of NMDA receptor antagonists following spinal ischemia in the rabbit
27. Multiple opioid systems and pain
28. Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist
29. Chronic, selective forebrain responses to excitotoxic dorsal horn injury
30. Dynorphin expression and Fos-like immunoreactivity following inflammation induced hyperalgesia are colocalized in spinal cord neurons
31. Alteration in extracellular amino acids after traumatic spinal cord injury
32. (S)-Homoquisqualate: A potent agonist at the glutamate metabotropic receptor
33. Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat
34. Regulation of spinal neuropeptide genes in a rat model of peripheral inflammation and hyperalgesia
35. Dynorphin A content in the rat brain and spinal cord after a localized trauma to the spinal cord and its modification with p-chlorophenylalanine. An experimental study using radioimmunoassay technique
36. Met-Enkephalin-Arg 6-Phe-7 in spinal cord and brain following traumatic injury to the spinal cord: Influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique
37. Allodynia following traumatic spinal cord injury in the rat
38. Acute amphetamine or metamphetamine alters opioid peptide mRNA expression in rat striatum
39. Dynorphin mRNA expression in dorsal horn neurons after traumatic spinal cord injury: Temporal and spatial analysis using in situ hybridization
40. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
41. Can mechanisms of central pain syndromes be investigated in animal models?
42. NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum
43. Dose-dependent alteration in zif-268 and preprodynorphin mRNA expression induced by amphetamine or methampethamine in rat forebrain
44. Evidence that local non-NMDA receptors contribute to functional deficits on contusive spinal cord injury
45. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX
46. Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma
47. Neuronal degeneration and spinal cavitation following intraspinal injections of quisqualic acid in the rat
48. Neuronal damage following the intraspinal injection of a nitric oxide synthase inhibitor in the rat
49. Excitotoxic spinal cord injury: Behavioral and morphological characteristics of a central pain model
50. Secondary injury mechanisms in acute spinal cord injury
51. A practical guide for the use of animal models in the study of neuropathic pain