Icariin attenuates high glucose-induced type IV collagen and fibronectin accumulation in glomerular mesangial cells by inhibiting transforming growth factor-β production and signalling through G protein-coupled oestrogen receptor 1

Clinical and Experimental Pharmacology and Physiology

Volumn 40, Issue 9, 2013, Pages 635-643

  Li, Yi Chen ^a   Ding, Xuan Sheng ^a   Li, Hui Mei ^a   Zhang, Cheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Fibronectin; G protein coupled oestrogen receptor 1; Icariin; Mesangial cells; Transforming growth factor ; Type IV collagen

Indexed keywords

CALCIUM; COLLAGEN TYPE 4; CORTICOTROPIN; CYCLINE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR 30; GLUCOSE; ICARIIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

FIBRONECTIN; G PROTEIN-COUPLED OESTROGEN RECEPTOR 1; ICARIIN; MESANGIAL CELLS; TRANSFORMING GROWTH FACTOR-Β; TYPE IV COLLAGEN;

ANIMALS; CELLS, CULTURED; COLLAGEN TYPE IV; FEMALE; FIBRONECTINS; FLAVONOIDS; GLOMERULAR MESANGIUM; GLUCOSE; HUMANS; MAP KINASE SIGNALING SYSTEM; MESANGIAL CELLS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84882955802     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12143     Document Type: Article

References (24)

1. Abboud HE. Mesangial cell biology. Exp. Cell Res. 2012; 318: 979-85.
2. Schnaper HW, Hayashida T, Hubchak SC, Poncelet AC. TGF-beta signal transduction and mesangial cell fibrogenesis. Am. J. Physiol. Renal Physiol. 2003; 284: F243-52.
3. Schrijvers BF, Vriese AS, Flyvbjerg A. From hyperglycemia to diabetic kidney disease: The role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines. Endocr. Rev. 2004; 25: 971-1010.
4. Isono M, Iglesias-de la Cruz MC, Chen S, Hong SW, Ziyadeh FN. Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells. J. Am. Soc. Nephrol. 2000; 11: 2222-30.
5. Abdollah S, Macias-Silva M, Tsukazaki T, Hayashi H, Attisano L, Wrana JL. TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signalling. J. Biol. Chem. 1997; 272: 27678-85.
6. Wrighton KH, Lin X, Feng XH. TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signalling. Cell Res. 2009; 19: 8-20.
7. Zhang YE. Non-Smad pathways in TGF-β signalling. Cell Res. 2009; 19: 128-39.
8. Miyata T, Kikuchi K, Kiyomoto H, Strihou CY. New era for drug discovery and development in renal disease. Nat. Rev. Nephrol. 2011; 7: 469-77.
9. Thomas MC, Cooper ME. Bardoxolone improves kidney function in type 2 diabetes. Nat. Rev. Nephrol. 2011; 7: 552-3.
10. Qi MY, Chen K, Liu HR, Su YH, Yu SQ. Protective effect of Icariin on the early stage of experimental diabetic nephropathy induced by streptozotocin via modulating transforming growth factor β1 and type IV collagen expression in rats. J. Ethnopharmacol. 2011; 138: 731-6.
11. Vivacqua A, Bonofiglio D, Albanito L et al. 17β-estradiol, genistein and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the G-protein-coupled receptor GPR30. Mol. Pharmacol. 2006; 70: 1414-23.
12. Heldring N, Pike A, Andersson S et al. Estrogen receptors: How do they signal and what are their targets. Physiol. Rev. 2007; 87: 905-31.
13. Hofmeister MV, Damkier HH, Christensen BM et al. 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1. Am. J. Physiol. Renal Physiol. 2012; 302: F358-68.
14. Prossnitz ER, Barton M. The G-protein-coupled estrogen receptor GPER in health and disease. Nat. Rev. Endocrinol. 2011; 7: 715-26.
15. Sraer JD, Delarue F, Hagege J et al. Stable cell lines of T-SV40 immortalized human glomerular mesangial cells. Kidney Int. 1996; 49: 267-70.
16. Varghese Z, Fernando R, Moorhead JF, Powis SH, Ruan XZ. Effects of sirolimus on mesangial cell cholesterol homeostasis: A novel mechanism for its action against lipid-mediated injury in renal allografts. Am. J. Physiol. Renal Physiol. 2005; 289: F43-8.
17. Wang Y, Simonson MS, Pouyssegur J, Dunn MJ. Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. Biochem. J. 1992; 287: 589-94.
18. Biederman J, Yee J, Cortes P. Validation of internal control genes for gene expression analysis in diabetic glomerulosclerosis. Kidney Int. 2004; 66: 2308-14.
19. Helmchen F. Calibration of fluorescent calcium indicators. Cold Spring Harb. Protoc. 2011; 923-30.
20. Dennis MK, Burai R, Ramesh C et al. In vivo effects of a GPR30 antagonist. Nat. Chem. Biol. 2009; 5: 421-7.
21. Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 2005; 146: 624-32.
22. Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-β receptor function. Trends Cell Biol. 2009; 19: 385-94.
23. Ming LG, Chen KM, Xian CJ et al. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J. Cell. Physiol. 2013; 228: 513-21.
24. Kleuser B, Malek D, Gust R, Pertz HH, Potteck H. 17-β-estradiol inhibits transforming growth factor-β signalling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30. Mol. Pharmacol. 2008; 74: 1533-43.