Extracellular signal-regulated kinase mediates stimulation of TGF-β1 and matrix by high glucose in mesangial cells

Journal of the American Society of Nephrology

Volumn 11, Issue 12, 2000, Pages 2222-2230

  Isono, Motohide ^a   Iglesias De La Cruz, M Carmen ^a   Chen, Sheldon ^a   Hong, Soon Won ^a   Ziyadeh, Fuad N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CALPHOSTIN C; COLLAGEN; FIBRONECTIN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; PROLINE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GLUCOSE METABOLISM; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0033662740     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (2)

1. Ziyadeh FN: The extracellular matrix in diabetic nephropathy. Am J Kidney Dis 22: 736-744, 1993
2. Ziyadeh FN, Snipes ER, Watanabe M, Alvarez RJ, Goldfarb S, Haverty TP: High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule. Am J Physiol 259: F704-F714, 1990