메뉴 건너뛰기




Volumn 34, Issue 34, 2013, Pages 8835-8842

Design of a multiple drug delivery system directed at periodontitis

Author keywords

Controlled drug release; Drug delivery; Drug release; Periodontium; Sequential drug release

Indexed keywords

ASSOCIATION POLYMERS; CELLULOSE ACETATE PHTHALATE; CHRONIC INFLAMMATORY; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG RELEASE; PERIODONTAL DISEASE; PERIODONTIUM;

EID: 84882928233     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.07.093     Document Type: Article
Times cited : (83)

References (61)
  • 1
    • 0032602042 scopus 로고    scopus 로고
    • Gingival recession, gingival bleeding, and dental calculus in adults 30 years of age and older in the United States, 1988-1994
    • Albandar J.M., Kingman A. Gingival recession, gingival bleeding, and dental calculus in adults 30 years of age and older in the United States, 1988-1994. JPeriodontol 1999, 70:30-43.
    • (1999) JPeriodontol , vol.70 , pp. 30-43
    • Albandar, J.M.1    Kingman, A.2
  • 2
    • 0024697749 scopus 로고
    • Periodontal diseases in the U.S. in 1981: prevalence, severity, extent, and role in tooth mortality
    • Brown L.J., Oliver R.C., Loe H. Periodontal diseases in the U.S. in 1981: prevalence, severity, extent, and role in tooth mortality. JPeriodontol 1989, 60:363-370.
    • (1989) JPeriodontol , vol.60 , pp. 363-370
    • Brown, L.J.1    Oliver, R.C.2    Loe, H.3
  • 3
    • 77953632018 scopus 로고    scopus 로고
    • Periodontal tissue engineering and regeneration: current approaches and expanding opportunities
    • Chen F.M., Jin Y. Periodontal tissue engineering and regeneration: current approaches and expanding opportunities. Tissue Eng Part B Rev 2010, 16:219-255.
    • (2010) Tissue Eng Part B Rev , vol.16 , pp. 219-255
    • Chen, F.M.1    Jin, Y.2
  • 4
    • 0035753516 scopus 로고    scopus 로고
    • The relationship between periodontal diseases and diabetes: an overview
    • Soskolne W.A., Klinger A. The relationship between periodontal diseases and diabetes: an overview. Ann Periodontol 2001, 6:91-98.
    • (2001) Ann Periodontol , vol.6 , pp. 91-98
    • Soskolne, W.A.1    Klinger, A.2
  • 5
    • 0035694213 scopus 로고    scopus 로고
    • Treatment of plaque-induced gingivitis, chronic periodontitis, and other clinical conditions
    • Rosen P.S. Treatment of plaque-induced gingivitis, chronic periodontitis, and other clinical conditions. JPeriodontol 2001, 72:1790-1800.
    • (2001) JPeriodontol , vol.72 , pp. 1790-1800
    • Rosen, P.S.1
  • 6
    • 0038346309 scopus 로고    scopus 로고
    • Locally delivered antimicrobials for the treatment of chronic periodontitis
    • Etienne D. Locally delivered antimicrobials for the treatment of chronic periodontitis. Oral Dis 2003, 9(Suppl.1):45-50.
    • (2003) Oral Dis , vol.9 , Issue.SUPPL.1 , pp. 45-50
    • Etienne, D.1
  • 7
    • 33745327884 scopus 로고    scopus 로고
    • Biology and principles of periodontal wound healing/regeneration
    • Polimeni G., Xiropaidis A.V., Wikesjö U.M.E. Biology and principles of periodontal wound healing/regeneration. Periodontology 2000, 2006(41):30-47.
    • (2000) Periodontology , vol.2006 , Issue.41 , pp. 30-47
    • Polimeni, G.1    Xiropaidis, A.V.2    Wikesjö, U.M.E.3
  • 8
    • 80051711507 scopus 로고    scopus 로고
    • Infection, inflammation, and bone regeneration: a paradoxical relationship
    • Thomas M.V., Puleo D.A. Infection, inflammation, and bone regeneration: a paradoxical relationship. JDent Res 2011, 90:1052-1061.
    • (2011) JDent Res , vol.90 , pp. 1052-1061
    • Thomas, M.V.1    Puleo, D.A.2
  • 10
    • 0034021620 scopus 로고    scopus 로고
    • Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases
    • Vyas S.P., Sihorkar V., Mishra V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. JClin Pharm Ther 2000, 25:21-42.
    • (2000) JClin Pharm Ther , vol.25 , pp. 21-42
    • Vyas, S.P.1    Sihorkar, V.2    Mishra, V.3
  • 11
    • 0034601246 scopus 로고    scopus 로고
    • Local delivery of antimicrobial agents for the treatment of periodontal diseases
    • Schwach-Abdellaoui K., Vivien-Castioni N., Gurny R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur J Pharm Biopharm 2000, 50:83-99.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 83-99
    • Schwach-Abdellaoui, K.1    Vivien-Castioni, N.2    Gurny, R.3
  • 13
    • 60949102238 scopus 로고    scopus 로고
    • Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats
    • Queiroz-Junior C.M., Pacheco C.M., Maltos K.L., Caliari M.V., Duarte I.D., Francischi J.N. Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. JPeriodont Res 2009, 44:153-160.
    • (2009) JPeriodont Res , vol.44 , pp. 153-160
    • Queiroz-Junior, C.M.1    Pacheco, C.M.2    Maltos, K.L.3    Caliari, M.V.4    Duarte, I.D.5    Francischi, J.N.6
  • 14
    • 0033848045 scopus 로고    scopus 로고
    • Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats
    • Binderman I., Adut M., Yaffe A. Effectiveness of local delivery of alendronate in reducing alveolar bone loss following periodontal surgery in rats. JPeriodontol 2000, 71:1236-1240.
    • (2000) JPeriodontol , vol.71 , pp. 1236-1240
    • Binderman, I.1    Adut, M.2    Yaffe, A.3
  • 15
    • 43049103810 scopus 로고    scopus 로고
    • Topical administration of simvastatin recovers alveolar bone loss in rats
    • Seto H., Ohba H., Tokunaga K., Hama H., Horibe M., Nagata T. Topical administration of simvastatin recovers alveolar bone loss in rats. JPeriodont Res 2008, 43:261-267.
    • (2008) JPeriodont Res , vol.43 , pp. 261-267
    • Seto, H.1    Ohba, H.2    Tokunaga, K.3    Hama, H.4    Horibe, M.5    Nagata, T.6
  • 16
    • 17444410838 scopus 로고    scopus 로고
    • Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells
    • Yazawa H., Zimmermann B., Asami Y., Bernimoulin J.P. Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cells. JPeriodontol 2005, 76:295-302.
    • (2005) JPeriodontol , vol.76 , pp. 295-302
    • Yazawa, H.1    Zimmermann, B.2    Asami, Y.3    Bernimoulin, J.P.4
  • 17
    • 0032059556 scopus 로고    scopus 로고
    • Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration invivo
    • King G.N., King N., Hughes F.J. Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration invivo. JPeriodont Res 1998, 33:226-236.
    • (1998) JPeriodont Res , vol.33 , pp. 226-236
    • King, G.N.1    King, N.2    Hughes, F.J.3
  • 18
    • 0036737390 scopus 로고    scopus 로고
    • Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration
    • Selvig K.A., Sorensen R.G., Wozney J.M., Wikesjo U.M. Bone repair following recombinant human bone morphogenetic protein-2 stimulated periodontal regeneration. JPeriodontol 2002, 73:1020-1029.
    • (2002) JPeriodontol , vol.73 , pp. 1020-1029
    • Selvig, K.A.1    Sorensen, R.G.2    Wozney, J.M.3    Wikesjo, U.M.4
  • 19
    • 0027200612 scopus 로고
    • Programmable drug delivery from an erodible association polymer system
    • Xu X., Lee P.I. Programmable drug delivery from an erodible association polymer system. Pharm Res 1993, 10:1144-1152.
    • (1993) Pharm Res , vol.10 , pp. 1144-1152
    • Xu, X.1    Lee, P.I.2
  • 20
    • 0347625643 scopus 로고    scopus 로고
    • Association polymers for modulated release of bioactive proteins
    • Raiche A.T., Puleo D.A. Association polymers for modulated release of bioactive proteins. IEEE Eng Med Biol Mag 2003, 22:35-41.
    • (2003) IEEE Eng Med Biol Mag , vol.22 , pp. 35-41
    • Raiche, A.T.1    Puleo, D.A.2
  • 22
    • 77953650323 scopus 로고    scopus 로고
    • Toward delivery of multiple growth factors in tissue engineering
    • Chen F.M., Zhang M., Wu Z.F. Toward delivery of multiple growth factors in tissue engineering. Biomaterials 2010, 31:6279-6308.
    • (2010) Biomaterials , vol.31 , pp. 6279-6308
    • Chen, F.M.1    Zhang, M.2    Wu, Z.F.3
  • 23
    • 84877969932 scopus 로고    scopus 로고
    • Controlled release strategies for bone, cartilage, and osteochondral engineering-part II: challenges on the evolution from single to multiple bioactive factor delivery
    • Santo V.E., Gomes M.E., Mano J.F., Reis R.L. Controlled release strategies for bone, cartilage, and osteochondral engineering-part II: challenges on the evolution from single to multiple bioactive factor delivery. Tissue Eng Part B Rev 2013, 19:327-352.
    • (2013) Tissue Eng Part B Rev , vol.19 , pp. 327-352
    • Santo, V.E.1    Gomes, M.E.2    Mano, J.F.3    Reis, R.L.4
  • 24
    • 3142703230 scopus 로고    scopus 로고
    • Dual growth factor delivery and controlled scaffold degradation enhance invivo bone formation by transplanted bone marrow stromal cells
    • Simmons C.A., Alsberg E., Hsiong S., Kim W.J., Mooney D.J. Dual growth factor delivery and controlled scaffold degradation enhance invivo bone formation by transplanted bone marrow stromal cells. Bone 2004, 35:562-569.
    • (2004) Bone , vol.35 , pp. 562-569
    • Simmons, C.A.1    Alsberg, E.2    Hsiong, S.3    Kim, W.J.4    Mooney, D.J.5
  • 25
    • 0025834986 scopus 로고
    • The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing
    • Lynch S.E., de Castilla G.R., Williams R.C., Kiritsy C.P., Howell T.H., Reddy M.S., et al. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing. JPeriodontol 1991, 62:458-467.
    • (1991) JPeriodontol , vol.62 , pp. 458-467
    • Lynch, S.E.1    de Castilla, G.R.2    Williams, R.C.3    Kiritsy, C.P.4    Howell, T.H.5    Reddy, M.S.6
  • 26
    • 67849135050 scopus 로고    scopus 로고
    • Invitro cellular responses to scaffolds containing two microencapulated growth factors
    • Chen F.M., Chen R., Wang X.J., Sun H.H., Wu Z.F. Invitro cellular responses to scaffolds containing two microencapulated growth factors. Biomaterials 2009, 30:5215-5224.
    • (2009) Biomaterials , vol.30 , pp. 5215-5224
    • Chen, F.M.1    Chen, R.2    Wang, X.J.3    Sun, H.H.4    Wu, Z.F.5
  • 27
    • 51449094036 scopus 로고    scopus 로고
    • Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model
    • Patel Z.S., Young S., Tabata Y., Jansen J.A., Wong M.E., Mikos A.G. Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 2008, 43:931-940.
    • (2008) Bone , vol.43 , pp. 931-940
    • Patel, Z.S.1    Young, S.2    Tabata, Y.3    Jansen, J.A.4    Wong, M.E.5    Mikos, A.G.6
  • 31
    • 49349102874 scopus 로고    scopus 로고
    • Sequential growth factor delivery from complexed microspheres for bone tissue engineering
    • Buket Basmanav F., Kose G.T., Hasirci V. Sequential growth factor delivery from complexed microspheres for bone tissue engineering. Biomaterials 2008, 29:4195-4204.
    • (2008) Biomaterials , vol.29 , pp. 4195-4204
    • Buket Basmanav, F.1    Kose, G.T.2    Hasirci, V.3
  • 32
    • 33846050010 scopus 로고    scopus 로고
    • Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation
    • Chen R.R., Silva E.A., Yuen W.W., Mooney D.J. Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 2007, 24:258-264.
    • (2007) Pharm Res , vol.24 , pp. 258-264
    • Chen, R.R.1    Silva, E.A.2    Yuen, W.W.3    Mooney, D.J.4
  • 33
    • 38349108489 scopus 로고    scopus 로고
    • Sequential release of bioactive IGF-I and TGF-β from PLGA microsphere-based scaffolds
    • Jaklenec A., Hinckfuss A., Bilgen B., Ciombor D.M., Aaron R., Mathiowitz E. Sequential release of bioactive IGF-I and TGF-β from PLGA microsphere-based scaffolds. Biomaterials 2008, 29:1518-1525.
    • (2008) Biomaterials , vol.29 , pp. 1518-1525
    • Jaklenec, A.1    Hinckfuss, A.2    Bilgen, B.3    Ciombor, D.M.4    Aaron, R.5    Mathiowitz, E.6
  • 34
    • 61549132911 scopus 로고    scopus 로고
    • Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration
    • Kempen D.H., Lu L., Heijink A., Hefferan T.E., Creemers L.B., Maran A., et al. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration. Biomaterials 2009, 30:2816-2825.
    • (2009) Biomaterials , vol.30 , pp. 2816-2825
    • Kempen, D.H.1    Lu, L.2    Heijink, A.3    Hefferan, T.E.4    Creemers, L.B.5    Maran, A.6
  • 35
    • 77955769300 scopus 로고    scopus 로고
    • Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis
    • Tengood J.E., Kovach K.M., Vescovi P.E., Russell A.J., Little S.R. Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. Biomaterials 2010, 31:7805-7812.
    • (2010) Biomaterials , vol.31 , pp. 7805-7812
    • Tengood, J.E.1    Kovach, K.M.2    Vescovi, P.E.3    Russell, A.J.4    Little, S.R.5
  • 36
    • 0028035178 scopus 로고
    • Anew bioerodible polymer insert for the controlled release of metronidazole
    • Gates K.A., Grad H., Birek P., Lee P.I. Anew bioerodible polymer insert for the controlled release of metronidazole. Pharm Res 1994, 11:1605-1609.
    • (1994) Pharm Res , vol.11 , pp. 1605-1609
    • Gates, K.A.1    Grad, H.2    Birek, P.3    Lee, P.I.4
  • 37
    • 46149102201 scopus 로고    scopus 로고
    • Alternating release of different bioactive molecules from a complexation polymer system
    • Jeon J.H., Puleo D.A. Alternating release of different bioactive molecules from a complexation polymer system. Biomaterials 2008, 29:3591-3598.
    • (2008) Biomaterials , vol.29 , pp. 3591-3598
    • Jeon, J.H.1    Puleo, D.A.2
  • 40
    • 80755176469 scopus 로고    scopus 로고
    • Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic periodontitis patients
    • Japoni A., Vasin A., Noushadi S., Kiany F., Japoni S., Alborzi A. Antibacterial susceptibility patterns of Porphyromonas gingivalis isolated from chronic periodontitis patients. Med Oral Patol Oral Cir Bucal 2011, 16:e1031-e1035.
    • (2011) Med Oral Patol Oral Cir Bucal , vol.16
    • Japoni, A.1    Vasin, A.2    Noushadi, S.3    Kiany, F.4    Japoni, S.5    Alborzi, A.6
  • 41
    • 34548479950 scopus 로고    scopus 로고
    • Conjugal transfer of chromosomal DNA contributes to genetic variation in the oral pathogen Porphyromonas gingivalis
    • Tribble G.D., Lamont G.J., Progulske-Fox A., Lamont R.J. Conjugal transfer of chromosomal DNA contributes to genetic variation in the oral pathogen Porphyromonas gingivalis. JBacteriol 2007, 189:6382-6388.
    • (2007) JBacteriol , vol.189 , pp. 6382-6388
    • Tribble, G.D.1    Lamont, G.J.2    Progulske-Fox, A.3    Lamont, R.J.4
  • 42
    • 8744259752 scopus 로고    scopus 로고
    • Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an invitro study
    • Eick S., Pfister W. Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an invitro study. JPeriodontol 2004, 75:1327-1334.
    • (2004) JPeriodontol , vol.75 , pp. 1327-1334
    • Eick, S.1    Pfister, W.2
  • 43
    • 0036801473 scopus 로고    scopus 로고
    • Susceptibility of Porphyromonas gingivalis in biofilms to amoxicillin, doxycycline and metronidazole
    • Larsen T. Susceptibility of Porphyromonas gingivalis in biofilms to amoxicillin, doxycycline and metronidazole. Oral Microbiol Immunol 2002, 17:267-271.
    • (2002) Oral Microbiol Immunol , vol.17 , pp. 267-271
    • Larsen, T.1
  • 44
    • 48249101588 scopus 로고    scopus 로고
    • Metronidazole-containing gel for the treatment of periodontitis: an invivo evaluation
    • Sato S., Fonseca M.J., Ciampo J.O., Jabor J.R., Pedrazzi V. Metronidazole-containing gel for the treatment of periodontitis: an invivo evaluation. Braz Oral Res 2008, 22:145-150.
    • (2008) Braz Oral Res , vol.22 , pp. 145-150
    • Sato, S.1    Fonseca, M.J.2    Ciampo, J.O.3    Jabor, J.R.4    Pedrazzi, V.5
  • 46
    • 0022873593 scopus 로고
    • Metronidazole concentrations in human plasma, saliva, and gingival crevice fluid after a single dose
    • Van Oosten M.A., Notten F.J., Mikx F.H. Metronidazole concentrations in human plasma, saliva, and gingival crevice fluid after a single dose. JDent Res 1986, 65:1420-1423.
    • (1986) JDent Res , vol.65 , pp. 1420-1423
    • Van Oosten, M.A.1    Notten, F.J.2    Mikx, F.H.3
  • 47
    • 0025012996 scopus 로고
    • Periodontal disease
    • Williams R.C. Periodontal disease. NEngl J Med 1990, 322:373-382.
    • (1990) NEngl J Med , vol.322 , pp. 373-382
    • Williams, R.C.1
  • 49
    • 18744406713 scopus 로고    scopus 로고
    • The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases
    • Salvi G.E., Lang N.P. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Curr Pharm Des 2005, 11:1757-1769.
    • (2005) Curr Pharm Des , vol.11 , pp. 1757-1769
    • Salvi, G.E.1    Lang, N.P.2
  • 51
    • 0032223605 scopus 로고    scopus 로고
    • Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis
    • Lawrence H.P., Paquette D.W., Smith P.C., Maynor G., Wilder R., Mann G.L., et al. Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis. JDent Res 1998, 77:1904-1912.
    • (1998) JDent Res , vol.77 , pp. 1904-1912
    • Lawrence, H.P.1    Paquette, D.W.2    Smith, P.C.3    Maynor, G.4    Wilder, R.5    Mann, G.L.6
  • 52
    • 0032196049 scopus 로고    scopus 로고
    • Effects of tetracyclines on bone metabolism
    • Vernillo A.T., Rifkin B.R. Effects of tetracyclines on bone metabolism. Adv Dent Res 1998, 12:56-62.
    • (1998) Adv Dent Res , vol.12 , pp. 56-62
    • Vernillo, A.T.1    Rifkin, B.R.2
  • 53
    • 0018746073 scopus 로고
    • Local tetracycline delivery using hollow fiber devices in periodontal therapy
    • Llindhe J., Heijl L., Goodson J.M., Socransky S.S. Local tetracycline delivery using hollow fiber devices in periodontal therapy. JClin Periodontol 1979, 6:141-149.
    • (1979) JClin Periodontol , vol.6 , pp. 141-149
    • Llindhe, J.1    Heijl, L.2    Goodson, J.M.3    Socransky, S.S.4
  • 54
    • 78650383157 scopus 로고    scopus 로고
    • Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial
    • Griffiths G.S., Ayob R., Guerrero A., Nibali L., Suvan J., Moles D.R., et al. Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: a randomized controlled clinical trial. JClin Periodontol 2011, 38:43-49.
    • (2011) JClin Periodontol , vol.38 , pp. 43-49
    • Griffiths, G.S.1    Ayob, R.2    Guerrero, A.3    Nibali, L.4    Suvan, J.5    Moles, D.R.6
  • 55
    • 0025077819 scopus 로고
    • Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia
    • Todd P.A., Goa K.L. Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs 1990, 40:583-607.
    • (1990) Drugs , vol.40 , pp. 583-607
    • Todd, P.A.1    Goa, K.L.2
  • 56
    • 77952285581 scopus 로고    scopus 로고
    • Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway
    • Chen P.Y., Sun J.S., Tsuang Y.H., Chen M.H., Weng P.W., Lin F.H. Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. Nutr Res 2010, 30:191-199.
    • (2010) Nutr Res , vol.30 , pp. 191-199
    • Chen, P.Y.1    Sun, J.S.2    Tsuang, Y.H.3    Chen, M.H.4    Weng, P.W.5    Lin, F.H.6
  • 57
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formation invitro and in rodents by statins
    • Mundy G., Garrett R., Harris S., Chan J., Chen D., Rossini G., et al. Stimulation of bone formation invitro and in rodents by statins. Science 1999, 286:1946-1949.
    • (1999) Science , vol.286 , pp. 1946-1949
    • Mundy, G.1    Garrett, R.2    Harris, S.3    Chan, J.4    Chen, D.5    Rossini, G.6
  • 58
    • 77649223503 scopus 로고    scopus 로고
    • Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial
    • Pradeep A.R., Thorat M.S. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. JPeriodontol 2010, 81:214-222.
    • (2010) JPeriodontol , vol.81 , pp. 214-222
    • Pradeep, A.R.1    Thorat, M.S.2
  • 59
    • 0027545349 scopus 로고    scopus 로고
    • Development of the biological concept of guided tissue regeneration: animal and human studies
    • Karring T., Nyman S., Gottlow J.A.N., Laurell L. Development of the biological concept of guided tissue regeneration: animal and human studies. Periodontology 2000, 1993(1):26-35.
    • (2000) Periodontology , vol.1993 , Issue.1 , pp. 26-35
    • Karring, T.1    Nyman, S.2    Gottlow, J.A.N.3    Laurell, L.4
  • 60
    • 0036242398 scopus 로고    scopus 로고
    • Statins as modulators of bone formation
    • Edwards C., Spector T. Statins as modulators of bone formation. Arthritis Res 2002, 4:151-153.
    • (2002) Arthritis Res , vol.4 , pp. 151-153
    • Edwards, C.1    Spector, T.2
  • 61
    • 49149115530 scopus 로고    scopus 로고
    • Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats
    • Jeon J.H., Piepgrass W.T., Lin Y.L., Thomas M.V., Puleo D.A. Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats. JPeriodontol 2008, 79:1457-1464.
    • (2008) JPeriodontol , vol.79 , pp. 1457-1464
    • Jeon, J.H.1    Piepgrass, W.T.2    Lin, Y.L.3    Thomas, M.V.4    Puleo, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.