Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins

Handbook of Cell Signaling, Second Edition

Volumn 2, Issue , 2009, Pages 659-675

  Cohen, Patricia T W ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882918966     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374145-5.00085-1     Document Type: Chapter

References (69)

1. AK Das, NR Helps, PTW Cohen and D Barford (1996) Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J 15 6798-6809.
2. LW Guddat, AS McAlpine, D Hume, S Hamilton, J de Jersey and JL Martin (1999) Crystal structure of mammalian purple acid phosphatase. Structure 7 757-767.
3. MS Kobor, J Archambault, W Lester, FCP Holstege, O Gileadi, DB Jansma, EG Jennings, F Kouyoumdjian, AR Davidson, RA Young and J Greenblatt (1999) An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S-cerevisiae. Mol Cell 4 55-62.
4. AM Burroughs, KN Allen, D Dunaway-Mariano and L Aravind (2006) Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes. J Mol Biol 361 1003-1034.
5. WD Wosilait and EW Sutherland (1956) The relationship of epinephrine and glucagon to liver phosphorylase: II. Enzymatic inactivation of liver phosphorylase. J Biol Chem 218 469-481.
6. TS Ingebritsen and P Cohen (1983) Protein phosphatases: properties and role in cellular regulation. Science 221 331-338.
7. AA Stewart, TS Ingebritsen, A Manalan, CB Klee and P Cohen (1982) Discovery of a Ca2+-dependent and calmodulin-dependent protein phosphatase – probable identity with calcineurin (CAM-BP80). FEBS Letts 137 80-84.
8. N Berndt, DG Campbell, FB Caudwell, P Cohen, EF da Cruz e Silva, OB da Cruz e Silva and PTW Cohen (1987) Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A. FEBS Letts 223 340-346.
9. S Tamura, KR Lynch, J Larner, J Fox, A Yasui, K Kikuchi, Y Suzuki and S Tsuiki (1989) Molecular cloning of rat type 2C (1A) protein phosphatase mRNA. Proc Natl Acad Sci 86 1796-1800.
10. PJ Kennelly (2002) Protein kinases and protein phosphatases in prokaryotes: a genomic perspective. FEMS Microbiol Letts 206 1-8.
11. GJ Barton, PTW Cohen and D Barford (1994) Conservation analysis and structure prediction of the protein serine/threonine phosphatases: sequence similarity with diadenosine tetraphosphatase from E. coli suggests homology to the protein phosphatases. Eur J Biochem 220 225-237.
12. I Farkas, V Dombradi, M Miskei, L Szabados and C Koncz (2007) Arabidopsis PPP family of serine/threonine phosphatases. Trends Plant Sci 12 169-176.
13. D Kerk, G Templeton and GB Moorhead (2008) Evolutionary radiation pattern of novel protein phosphatases revealed by analysis of protein data from the completely sequenced genomes of humans, green algae, and higher plants. Plant Physiol 146 351-367.
14. MJR Stark (1996) Yeast protein serine/threonine phosphatases: multiple roles and diverse regulation. Yeast 12 1647-1675.
15. AV Andreeva and MA Kutuzov (1999) RdgC/PP5-related phosphatases: novel components in signal transduction. Cell Signal 11 555-562.
16. PTW Cohen (2002) Protein phosphatase 1-targeted in many directions. J Cell Sci 115 241-256.
17. H Ceulemans and M Bollen (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev 84 1-39.
18. H Meiselbach, H Sticht and R Enz (2006) Structural analysis of the protein phosphatase 1 docking motif: molecular description of the binding specificities identifies interacting proteins. Chem Biol 13 49-59.
19. M Terrak, F Kerff, K Langsetmo, T Tao and R Dominguez (2004) Structural basis of protein phosphatase 1 regulation. Nature 429 780-784.
20. V Janssens and J Goris (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353 417-439.
21. X Li and D Virshup (2002) Two conserved domains in the regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Eur J Biochem 269 546-552.
22. PTW Cohen, A Philp and C Vázquez-Martin (2005) Protein phosphatase 4 – from obscurity to vital functions. FEBS Letts 579 3278-3286.
23. B Stefansson, T Ohama, AE Daugherty and DL Brautigan (2008) Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry 47 1442-1451.
24. DM Virshup (2000) Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol 12 180-185.
25. JL McConnell, RJ Gomez, LR McCorvey, BK Law and BE Wadzinski (2007) Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway. Oncogene 26 6021-6030.
26. T Pawson and JD Scott (1998) Signaling through scaffold, anchoring and adaptor proteins. Science 278 2075-2080.
27. M Chinkers (2001) Protein phosphatase 5 in signal transduction. Trends Endocrinol Metab 12 28-32.
28. J Yang, SM Roe, MJ Cliff, MA Williams, JE Ladbury, PTW Cohen and D Barford (2005) Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO J 24 1-10.
29. CB Klee, H Ren and X Wang (1998) Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273 13,367-13,370.
30. MA Kutuzov, OV Solov’eva, AV Andreeva and N Bennett (2002) Protein Ser/Thr phosphatases PPEF interact with calmodulin. Biochem Biophys Res Commun 293 1047-1052.
31. P Cohen (1989) The structure and regulation of protein phosphatases. Annu Rev Biochem 58 453-508.
32. LA Pinna and A Donella-Deana (1994) Phosphorylated synthetic peptides as tools for studying protein phosphatases. Biochim Biophys Acta 1222 415-431.
33. Y Kim, J Huang, P Cohen and HR Matthews (1993) Protein phosphatases 1, 2A and 2C are protein histidine phosphatases. J Biol Chem 268 18,513-18,518.
34. C MacKintosh, AJ Garton, A McDonnell, D Barford, PTW Cohen, P Cohen and NK Tonks (1996) Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation. FEBS Letts 397 235-238.
35. DR Alessi, AJ Street, P Cohen and PTW Cohen (1993) Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. Eur J Biochem 213 1055-1066.
36. T Tolstykh, J Lee, S Vafai and JB Stock (2000) Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 19 5682-5691.
37. S Longin, K Zwaenepoel, JV Louis, S Dilworth, J Goris and V Janssens (2007) Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit. J Biol Chem 282 26,971-26,980.
38. H Hombauer, D Weismann, I Mudrak, C Stanzel, T Fellner, DH Lackner and E Ogris (2007) Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. PLoS Biol 5 e155.
39. G Moorhead, D Johnson, N Morrice and P Cohen (1998) The major myosin phosphatase in skeletal muscle is a complex between the β-isoform of protein phosphatase 1 and the MYPT2 gene product. FEBS Letts 438 141-144.
40. BJ Toole and PTW Cohen (2007) The skeletal muscle-specific glycogen-targeted protein phosphatase 1 plays a major role in the regulation of glycogen metabolism by adrenaline in vivo. Cell Signal 19 1044-1055.
41. S Varmuza, A Jurisicova, K Okano, J Hudson, K Boekelheide and EB Shipp (1999) Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene. Dev Biol 205 98-110.
42. L Trinkle-Mulcahy, J Andersen, YW Lam, G Moorhead, M Mann and AI Lamond (2006) Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol 172 679-692.
43. CW Liu, RH Wang and N Berndt (2006) Protein phosphatase 1α activity prevents oncogenic transformation. Mol Carcinog 45 648-656.
44. MR Junttila, P Puustinen, M Niemela, R Ahola, H Arnold, T Bottzauw, R Ala-aho, C Nielsen, J Ivaska, Y Taya, SL Lu, S Lin, EK Chan, XJ Wang, R Grenman, J Kast, T Kallunki, R Sears, VM Kahari and J Westermarck (2007) CIP2A inhibits PP2A in human malignancies. Cell 130 51-62.
45. M Mumby (2007) PP2A: unveiling a reluctant tumor suppressor. Cell 130 21-24.
46. JW Shui, MC Hu and TH Tan (2007) Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol 27 79-91.
47. C Martin-Granados, A Philp, SK Oxenham, AR Prescott and PTW Cohen (2008) Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation and Rho GTPases. Intl J Biochem Cell Biol 40 2315-2332.
48. D Chowdhury, X Xu, X Zhong, F Ahmed, J Zhong, J Liao, DM Dykxhoorn, DM Weinstock, GP Pfeifer and J Lieberman (2008) A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell 31 33-46.
49. S Nakada, GI Chen, AC Gingras and D Durocher (2008) PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep 91 1019-1026.
50. B Stefansson and DL Brautigan (2007) Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle 6 1386-1392.
51. T Kajino, H Ren, S Iemura, T Natsume, B Stefansson, DL Brautigan, K Matsumoto and J Ninomiya-Tsuji (2006) Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem 281 39,891-39,896.
52. TD Hinds Jr and ER Sanchez (2008) Protein phosphatase 5. Intl J Biochem Cell Biol 40 2358-2362.
53. T Golden, M Swingle and RE Honkanen (2008) The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer Metastasis Rev 27 169-178.
54. Z Wang, W Chen, E Kono, T Dang and MJ Garabedian (2007) Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol 21 625-634.
55. T Zeke, N Morrice, C Vázquez Martin and PTW Cohen (2005) Human protein phosphatase 5 dissociates from heat shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule depolymerising drug nocodazole. Biochem J 385 45-56.
56. SK Wandinger, MH Suhre, H Wegele and J Buchner (2006) The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90. EMBO J 25 367-376.
57. W Yong, S Bao, H Chen, D Li, ER Sanchez and W Shou (2007) Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. J Biol Chem 282 14,690-14,694.
58. P Ramulu, M Kennedy, W-H Xiong, J Williams, M Cowan, D Blesh, K-W Yau, JB Hurley and J Nathans (2001) Normal light response, photoreceptor integrity and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Mol Cell Biol 21 8605-8614.
59. IM Mansuy and S Shenolikar (2006) Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory. Trends Neurosci 29 679-686.
60. NR Banner, H Lyster and MH Yacoub (2005) Clinical immunosuppression using the calcineurin-inhibitors cyclosporin and tacrolimus. LA Pinna, PTW Cohen (Eds) Handbook of experimental pharmacology: inhibitors of protein Kinases and protein phosphatases Springer-Verlag Heidelberg 321-359.
61. RE Honkanen (2005) Serine/threonine protein phosphatase inhibitors with antitumour activity. LA Pinna, PTW Cohen (Eds) Handbook of experimental pharmacology: inhibitors of protein kinases and protein phosphatases Springer-Verlag Heidelberg 297-317.
62. T Ammosova, K Washington, Z Debebe, J Brady and S Nekhai (2005) Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription. Retrovirology 2 47.
63. S Saito, H Matsui, M Kawano, K Kumagai, N Tomishige, K Hanada, S Echigo, S Tamura and T Kobayashi (2008) Protein Phosphatase 2C{epsilon} Is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. J Biol Chem 283 6584-6593.
64. T Sugiura, Y Noguchi, K Sakurai and C Hattori (2008) Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L. Cancer Biol Ther 7 285-293.
65. T Lammers and S Lavi (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol 42 437-461.
66. G Sapkota, M Knockaert, C Alarcon, E Montalvo, AH Brivanlou and J Massague (2006) Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-β pathways. J Biol Chem 281 40,412-40,419.
67. KH Wrighton, D Willis, J Long, F Liu, X Lin and XH Feng (2006) Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-β signaling. J Biol Chem 281 38,365-38,375.
68. M Yeo, SK Lee, B Lee, EC Ruiz, SL Pfaff and GN Gill (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science 307 596-600.
69. Y Kim Jr, MS Gentry, TE Harris, SE Wiley, JC Lawrence and JE Dixon (2007) A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci USA 104 6596-6601.