Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling

Molecular and Cellular Biology

Volumn 27, Issue 1, 2007, Pages 79-91

  Shui, Jr Wen ^a   Hu, Mickey C T ^b   Tan, Tse Hua ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CALCIUM; CD3 ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; OKADAIC ACID; PHOSPHATASE; PHOSPHOLIPASE C GAMMA1; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2; PRE T CELL RECEPTOR; PROTEIN BCL XL; PROTEIN PHOSPHATASE 4; SERINE; T LYMPHOCYTE RECEPTOR; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL SELECTION; CELLULAR IMMUNITY; CONDITIONAL KNOCKOUT MOUSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DELETION; GENETIC TRANSCRIPTION; IC 50; IMMUNE RESPONSE; IN VIVO STUDY; KNOCKOUT MOUSE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD44; ANTIGENS, CD8; APOPTOSIS; BCL-X PROTEIN; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OKADAIC ACID; PHOSPHOLIPASE C; PHOSPHOPROTEIN PHOSPHATASE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND; TUMOR SUPPRESSOR PROTEINS;

EID: 33845807376     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00799-06     Document Type: Article

References (31)

1. Brenner, D., A. Golks, F. Kiefer, P. H. Krammer, and R. Arnold. 2005. Activation or suppression of NF-κB by HPK1 determines sensitivity to activation-induced cell death. EMBO J. 24:4279-4290.
2. Colombetti, S., V. Basso, D. L. Mueller, and A. Mondino. 2006. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J. Immunol. 176:2730-2738.
3. Dangond, F., D. A. Hafler, J. K. Tong, J. Randall, R. Kojima, N. Utku, and S. R. Gullans. 1998. Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. Biochem. Biophys. Res. Commun. 242:648-652.
4. Fischer, A. M., C. D. Katayama, G. Pages, J. Pouyssegur, and S. M. Hedrick, 2005. The role of ERK1 and ERK2 in multiple stages of T cell development. Immunity 23:431-443.
5. Gingras, A. C., M. Caballero, M. Zarske, A. Sanchez, T. R. Hazbun, S. Fields, N. Sonenberg, E. Hafen, B. Raught, and R. Aebersold. 2005. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol. Cell. Proteomics 4:1725-1740.
6. Gotz, J., A. Probst, E. Ehler, B. Hemmings, and W. Kues. 1998. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Ca. Proc. Natl. Acad. Sci. USA 95:12370-12375.
7. Gu, H., J. D. Marth, P. C. Orban, H. Mossmann, and K. Rajewsky. 1994. Deletion of a DNA polymerase β gene segment in T cells using cell type-specific gene targeting. Science 265:103-106.
8. Haks, M. C., M. A. Oosterwegel, B. Blom, H. M. Spits, and A. M. Kruisbeek. 1999. Cell-fate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR. Semin, Immunol. 11:23-37.
9. Hastie, C. J., and P. T. Cohen. 1998. Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431:357-361.
10. Hayday, A. C., D. F. Barber, N. Douglas, and E. S. Hoffman. 1999. Signals involved in γ/δ T cell versus α/β T cell lineage commitment. Semin. Immunol. 11:239-249.
11. Hu, M. C.-T., J.-W., Shui, K. A. Mihindukulasuriya, and T.-H. Tan. 2001. Genomic structure of the mouse PP4 gene: a developmental regulated protein phosphatase. Gene 278:89-99.
12. Hu, M. C.-T., Q. Tang-Oxley, W. R. Qiu, Y. P. Wang, K. A. Mihindukulasuriya, R. Afshar, and T.-H. Tan. 1998. Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor κB activity. J. Biol. Chem. 273:33561-33565.
13. Hua, D. R., S. Inui, T. Yamashita, K. Maeda, K. Takagi, J. Takeda, and N. Sakaguchi. 2003. T cell-specific gene targeting reveals that α4 is required for early T cell development. Eur. J. Immunol. 33:1899-1906.
14. Kabra, N. H., C. Rang, L. C. Hsing, J. Zhang, and A. Winoto. 2001. T cell-specific FADD-deficient mice: FADD is required for early T cell development. Proc. Natl. Acad. Sci. USA 98:6307-6312.
15. Keogh, M. C., J. A. Kim, M. Downey, J. Fillingham, D. Chowdhury, J. C. Harrison, M. Onishi, N. Datta, S. Galicia, A. Emili, J. Lieberman, X. Shen, S. Buratowski, J. E. Haber, D. Durocher, J. F. Greenblatt, and N. J. Krogan. 2006. A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery. Nature 439:497-501.
16. Kong, M., C. J. Fox, J. Mu, L. Solt, A. Xu, R. M. Cinalli, M. J. Birnbaum, T. Lindsten, and C. B. Thompson. 2004. The PP2A-associated protein a4 is an essential inhibitor of apoptosis. Science 306:695-698.
17. Koyasu, S. 2003. The role of PI3K in immune cells. Nat. Immunol. 4:313-319.
18. Lacroix, I., C. Lipcey, J. Imbert, and B. Kahn-Perles. 2002. Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes. J. Biol. Chem. 277:9598-9605.
19. Lee, P. P., D., R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Perez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, S. R. Cherry, J. H. Tsai, S. M. Tucker, W. M. Weaver, A. Kelso, R. Jaenisch, and C. B. Wilson. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15:763-774.
20. Ling, P., C. F. Meyer, L. P. Redmond, J.-W. Shui, B. Davis, R. R. Rich, M. C.-T. Hu, R. L. Wange, and T.-H. Tan. 2001. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. J. Biol. Chem. 276:18908-18914.
21. Mihindukulasuriya, K. A., G. Zhou, J. Qin, and T.-H. Tan. 2004. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-α stimulation. J. Biol. Chem. 279:46588-46594.
22. Nakayama, T., D. J. Kasprowicz, M. Yamashita, L. A. Schubert, G. Gillard, M. Kimura, A. Didierlaurent, H. Koseki, and S. F. Ziegler. 2002. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168:87-94.
23. Nebl, G., S. C. Meuer, and Y. Samstag. 1998. Cyclosporin A-resistant transactivation of the IL-2 promoter requires activity of okadaic acid-sensitive serine/threonine phosphatases. J. Immunol. 161:1803-1810.
24. Shi, Y. F., R. P. Bissonnette, N. Parfrey, M. Szalay, R. T. Kubo, and D. R. Green. 1991. In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146:3340-3346.
25. Woetmann, A., J. Brockdorff, P. Lovato, M. Nielsen, V. Leick, K. Rieneck, A. S-vejgaard, C. Geisler, and N. Odum. 2003. Protein phosphatase 2A (PP2A) regulates intsrleukm-4-mediated STAT6 signaling. J. Biol. Chem. 278:2787-2791.
26. Woetmann, A., M. Nielsen, S. T. Christensen, J. Brockdorff, K. Kaltoft, A. M. Engel, S. Skov, C. Brender, C. Geisler, A. Svejgaard, J. Rygaard, V. Leick, and N. Odum. 1999. Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3. Proc. Natl. Acad. Sci. USA 96:10620-10625.
27. Wolfer, A., A. Wilson, M. Nemir, H. R. MacDonald, and F. Radtke. 2002. Inactivation of Notchl impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16:869-879.
28. Yeh, P. Y., K. H. Yeh, S. E. Chuang, Y. C. Song, and A. L. Cheng. 2004. Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-κB activation by protein phosphatase 4-mediated NF-κB p65 Thr dephosphorylation. J. Biol. Chem. 279:26143-26148.
29. Zhang, X., Y. Ozawa, H. Lee, Y. D. Wen, T.-H. Tan, B. E. Wadzinski, and E. Seto. 2005. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 19:827-839.
30. Zhou, G., J. S. Boomer, and T.-H. Tan. 2004. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. J. Biol. Chem. 279:49551-49561.
31. Zhou, G., K. A. Mihindukulasuriya, R. A. MacCorkle-Chosnek, A. Van Hooser, M. C.-T. Hu, B. R. Brinkley, and T.-H. Tan. 2002. Protein phosphatase 4 is involved in tumor necrosis factor alpha-induced activation of c-Jun N-terminal kinase. J. Biol. Chem. 277:6391-6398.