Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with ef hands (PPEF-1 and PPEF-2)

Molecular and Cellular Biology

Volumn 21, Issue 24, 2001, Pages 8605-8614

  Ramulu, P ^a   Kennedy, M ^a   Xiong, W H ^a   Williams, J ^a   Cowan, M ^a   Blesh, D ^a   Yau, K W ^a   Hurley, J B ^a   Nathans, J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GENE PRODUCT; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN PPEF 1; PROTEIN PPEF 2; RHODOPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DEPHOSPHORYLATION; DROSOPHILA; GENE DISRUPTION; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETINA; RETINA DEGENERATION; RETINA ROD; VERTEBRATE;

ALLELES; ANIMALS; CALCIUM-BINDING PROTEINS; CLONING, MOLECULAR; DNA PRIMERS; DROSOPHILA PROTEINS; GENETIC VECTORS; IMMUNOBLOTTING; LIGHT; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PHOTONS; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHODOPSIN; TIME FACTORS;

ANIMALIA; VERTEBRATA;

EID: 0035193015     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.24.8605-8614.2001     Document Type: Article

References (53)

1. Interactions between a minimal protein serine/threonine phosphatase and its phosphopeptide substrate sequence
2. Light-dependent antibody labelling of photoreceptors
3. The membrane current of single rod outer segments
4. Inactivation of photoexcited rhodopsin in retinal rods: The roles of rhodopsin kinase and 48-kDa protein (arrestin)
5. Analysis of ERG a-wave amplification and kinetics in terms of the G-protein cascade of phototransduction
6. Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell
7. Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy
8. Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase
9. Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant
10. Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration
11. Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo
12. Interplay of phosphorylation and dephosphorylation in vision: Protein phosphatases of bovine rod outer segments
13. Phosphorylation modulates the affinity of light-activated rhodopsin for G protein and arrestin
14. Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin
15. Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
16. Rhodopsin phosphorylation and its role in photoreceptor function
17. Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation
18. A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila
19. Retinal degeneration caused by dominant rhodopsin mutations in Drosophila
20. Calcium-activated opsin phosphatase activity in retinal rod outer segments
21. The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits
22. Clathrin-mediated endocytosis of the β-adrenergic receptor is regulated by phosphorylation/dephosphorylation of β-arrestinI
23. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
24. Recovery phase of the murine rod photoresponse reconstructed from electroretinographic recordings
25. Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites
26. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin
27. Rhodopsin phosphorylation and dephosphorylation in vivo
28. Localization of guanylate cyclase-activating protein 2 in mammalian retinas
29. The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin
30. The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction
31. Membrane biosynthesis in the frog retina: Opsin transport in the photoreceptor cell
32. Vesicular transport of newly synthesized opsin from the Golgi apparatus toward the rod outer segment. Ultrastructural immunocytochemical and autoradiographic evidence in Xenopus retinas
33. Spermatid-specific expression of protamine 1 in transgenic mice
34. Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands
35. Signal transduction in Drosophila photoreceptors
36. Molecular genetics of human retinal disease
37. Mechanisms and genetics of photoreceptors desensitization in Drosophila flies
38. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C
39. The a-wave of the human electroretinogram recorded with a minimally invasive technique
40. Distribution of membrane proteins in mechanically dissociated retinal rods
41. Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant
42. Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase
43. Cyclic GMP cascade of vision
44. A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment
45. Light adaptation and dark adaptation of human rod photoreceptors measured from the a-wave of the electroretinogram
46. Ultracytochemical study of Ca++-ATPase and K+-NPPase activities in retinal photoreceptors of the guinea pig
47. Localization of ATPases in retinal receptor cells
48. Three types of photoreceptors in the pineal and frontal organs of frogs: Ultrastructure and opsin immunoreactivity
49. A G protein-coupled receptor phosphatase required for rhodopsin function
50. Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments
51. Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2
52. The renewal of the photoreceptor cell outer segments
53. Rhodopsin phosphorylation sites and their role in arrestin binding