메뉴 건너뛰기




Volumn 6, Issue , 2013, Pages 309-315

Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects

Author keywords

Adiposity; Body composition; Caloric restriction; Fat loss; Leucine; Pyridoxine; Vitamin B6; Weight loss

Indexed keywords

LEUCINE; NUSHAPE; NUTRACEUTICAL; PLACEBO; PYRIDOXINE; UNCLASSIFIED DRUG;

EID: 84882801522     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S49623     Document Type: Article
Times cited : (15)

References (35)
  • 1
    • 34247579321 scopus 로고    scopus 로고
    • Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells
    • Sun X, Zemel M. Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids. 2007; 42:297-305.
    • (2007) Lipids. , vol.42 , pp. 297-305
    • Sun, X.1    Zemel, M.2
  • 2
    • 68149162719 scopus 로고    scopus 로고
    • Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes
    • Sun X, Zemel MB. Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes. Nutr Metab (Lond). 2009;6:26.
    • (2009) Nutr Metab (Lond). , vol.6 , pp. 26
    • Sun, X.1    Zemel, M.B.2
  • 3
    • 79959453305 scopus 로고    scopus 로고
    • Dietary leucine-an envrionmental modifier of insulin resistance acting on multiple levels of metabolism
    • Macotela Y, Emanuelli B, Bang AM, et al. Dietary leucine-an envrionmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One. 2011;6:e21187.
    • (2011) PLoS One. , vol.6
    • Macotela, Y.1    Emanuelli, B.2    Bang, A.M.3
  • 4
    • 33645996993 scopus 로고    scopus 로고
    • Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction
    • Donato J Jr, Pedrosa RG, Cruzat VF, Pires IS, Tirapegui J. Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. Nutrition. 2006;22:520-527.
    • (2006) Nutrition. , vol.22 , pp. 520-527
    • Donato Jr., J.1    Pedrosa, R.G.2    Cruzat, V.F.3    Pires, I.S.4    Tirapegui, J.5
  • 5
    • 34249680883 scopus 로고    scopus 로고
    • Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms
    • Zhang Y, Guo K, LeBlanc RE, Loh D, Schwartz GJ, Yu YH. Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes. 2007;56:1647-1654.
    • (2007) Diabetes. , vol.56 , pp. 1647-1654
    • Zhang, Y.1    Guo, K.2    LeBlanc, R.E.3    Loh, D.4    Schwartz, G.J.5    Yu, Y.H.6
  • 6
    • 83655197747 scopus 로고    scopus 로고
    • Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
    • Bruckbauer A, Zemel MB. Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells. Nutr Metab (Lond). 2011;8:91.
    • (2011) Nutr Metab (Lond). , vol.8 , pp. 91
    • Bruckbauer, A.1    Zemel, M.B.2
  • 7
    • 84865296096 scopus 로고    scopus 로고
    • Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
    • Bruckbauer A, Zemel MB, Thorpe T, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012;9:77.
    • (2012) Nutr Metab (Lond). , vol.9 , pp. 77
    • Bruckbauer, A.1    Zemel, M.B.2    Thorpe, T.3
  • 8
    • 84865278230 scopus 로고    scopus 로고
    • Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects
    • Zemel MB, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on fat oxidation, and oxidative and inflammatory stress in overweight and obese subjects. Nutrients. 2012;4:529-541.
    • (2012) Nutrients. , vol.4 , pp. 529-541
    • Zemel, M.B.1    Bruckbauer, A.2
  • 9
    • 0033808267 scopus 로고    scopus 로고
    • Relationship between human adipose tissue agouti and fatty acid synthase (FAS)
    • Xue B, Zemel M. Relationship between human adipose tissue agouti and fatty acid synthase (FAS). J Nutr. 2000;130:2478-2481.
    • (2000) J Nutr. , vol.130 , pp. 2478-2481
    • Xue, B.1    Zemel, M.2
  • 10
    • 0030993448 scopus 로고    scopus 로고
    • Agouti regulation of intracellular calcium: Role of melanocortin receptors
    • Kim J, Kiefer L, Woychik R, et al. Agouti regulation of intracellular calcium: role of melanocortin receptors. Am J Physiol. 1997;272: E379-E384.
    • (1997) Am J Physiol. , vol.272
    • Kim, J.1    Kiefer, L.2    Woychik, R.3
  • 11
    • 0035513842 scopus 로고    scopus 로고
    • Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes
    • Xue B, Greenberg A, Kraemer F, Zemel M. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. FASEB J. 2001;15:2527-2529.
    • (2001) FASEB J. , vol.15 , pp. 2527-2529
    • Xue, B.1    Greenberg, A.2    Kraemer, F.3    Zemel, M.4
  • 12
    • 0031718256 scopus 로고    scopus 로고
    • The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism
    • Xue B. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB J. 1998;12:1391-1396.
    • (1998) FASEB J. , vol.12 , pp. 1391-1396
    • Xue, B.1
  • 13
    • 0032827036 scopus 로고    scopus 로고
    • Role of the sulfonylurea receptor in regulating human adipocyte metabolism
    • Shi H, Moustaid-Moussa N, Wilkison W, Zemel M. Role of the sulfonylurea receptor in regulating human adipocyte metabolism. FASEB J. 1999;13:1833-1838.
    • (1999) FASEB J. , vol.13 , pp. 1833-1838
    • Shi, H.1    Moustaid-Moussa, N.2    Wilkison, W.3    Zemel, M.4
  • 14
    • 84878221140 scopus 로고    scopus 로고
    • Weight loss improves adipogenic capacity of human preadipocytes and modulates their secretory profile
    • Rossmeislova L, Malisova L, Kracmerova J, et al. Weight loss improves adipogenic capacity of human preadipocytes and modulates their secretory profile. Diabetes. 2013;62:1990-1995.
    • (2013) Diabetes. , vol.62 , pp. 1990-1995
    • Rossmeislova, L.1    Malisova, L.2    Kracmerova, J.3
  • 16
    • 34548321238 scopus 로고    scopus 로고
    • Impact of weight loss on the metabolic syndrome
    • Phelan S, Wadden TA, Berkowitz RI, et al. Impact of weight loss on the metabolic syndrome. Int J Obes (Lond). 2007;31:1442-1448.
    • (2007) Int J Obes (Lond). , vol.31 , pp. 1442-1448
    • Phelan, S.1    Wadden, T.A.2    Berkowitz, R.I.3
  • 18
    • 84865422248 scopus 로고    scopus 로고
    • From excess adiposity to insulin resistance: The role of free fatty acids
    • Capurso C, Capurso A. From excess adiposity to insulin resistance: the role of free fatty acids. Vascul Pharmacol. 2012;57:91-97.
    • (2012) Vascul Pharmacol. , vol.57 , pp. 91-97
    • Capurso, C.1    Capurso, A.2
  • 20
    • 84869481409 scopus 로고    scopus 로고
    • Mitochondria and endocrine function of adipose tissue
    • Medina-Gomez G. Mitochondria and endocrine function of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2012;26:791-804.
    • (2012) Best Pract Res Clin Endocrinol Metab. , vol.26 , pp. 791-804
    • Medina-Gomez, G.1
  • 21
    • 84872141801 scopus 로고    scopus 로고
    • Metabolic syndrome, obesity, and gastrointestinal cancer
    • Fujihara S, Mori H, Kobara H, et al. Metabolic syndrome, obesity, and gastrointestinal cancer. Gastroenterol Res Pract. 2012;2012:483623.
    • (2012) Gastroenterol Res Pract. , vol.2012 , pp. 483623
    • Fujihara, S.1    Mori, H.2    Kobara, H.3
  • 22
    • 84869021501 scopus 로고    scopus 로고
    • AMP-activated protein kinase: An emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases
    • Srivastava RA, Pinkosky SL, Filippov S, Hanselman JC, Cramer CT, Newton RS. AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J Lipid Res. 2012;53:2490-2514.
    • (2012) J Lipid Res. , vol.53 , pp. 2490-2514
    • Srivastava, R.A.1    Pinkosky, S.L.2    Filippov, S.3    Hanselman, J.C.4    Cramer, C.T.5    Newton, R.S.6
  • 23
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta. 2011;1813: 1269-1278.
    • (2011) Biochim Biophys Acta. , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 24
    • 67349276169 scopus 로고    scopus 로고
    • AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    • Canto C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458:1056-1060.
    • (2009) Nature. , vol.458 , pp. 1056-1060
    • Canto, C.1    Gerhart-Hines, Z.2    Feige, J.N.3
  • 25
    • 84872836906 scopus 로고    scopus 로고
    • What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
    • Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol. 2013;24:49-56.
    • (2013) Curr Opin Lipidol. , vol.24 , pp. 49-56
    • Xu, X.J.1    Pories, W.J.2    Dohm, L.G.3    Ruderman, N.B.4
  • 26
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier MS, O'Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011;404: 382-387.
    • (2011) Biochem Biophys Res Commun. , vol.404 , pp. 382-387
    • Gauthier, M.S.1    O'Brien, E.L.2    Bigornia, S.3
  • 27
    • 0035029874 scopus 로고    scopus 로고
    • Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats
    • Bergeron R, Previs SF, Cline GW, Perret P, Russell RR 3rd, Young LH, Shulman GI. Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes. 2001;50:1076-1082.
    • (2001) Diabetes. , vol.50 , pp. 1076-1082
    • Bergeron, R.1    Previs, S.F.2    Cline, G.W.3    Perret, P.4    Russell III, R.R.5    Young, L.H.6    Shulman, G.I.7
  • 28
    • 20144386698 scopus 로고    scopus 로고
    • Long-term AICAR administration and exercise prevents diabetes in ZDF rats
    • Pold R, Jensen LS, Jessen N, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005;54:928-934.
    • (2005) Diabetes. , vol.54 , pp. 928-934
    • Pold, R.1    Jensen, L.S.2    Jessen, N.3
  • 29
    • 33744514139 scopus 로고    scopus 로고
    • Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
    • Cool B, Zinker B, Chiou W, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 2006;3:403-416.
    • (2006) Cell Metab. , vol.3 , pp. 403-416
    • Cool, B.1    Zinker, B.2    Chiou, W.3
  • 30
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-1122.
    • (2006) Cell. , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 31
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • Feige JN, Lagouge M, Canto C, et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008;8:347-358.
    • (2008) Cell Metab. , vol.8 , pp. 347-358
    • Feige, J.N.1    Lagouge, M.2    Canto, C.3
  • 33
    • 84876782429 scopus 로고    scopus 로고
    • Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism
    • Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R. Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism. J Nutr Biochem. 2013;24:824-831.
    • (2013) J Nutr Biochem. , vol.24 , pp. 824-831
    • Schriever, S.C.1    Deutsch, M.J.2    Adamski, J.3    Roscher, A.A.4    Ensenauer, R.5
  • 34
    • 84882771337 scopus 로고    scopus 로고
    • Role of mTOR and β-hydroxy-β-methylbutyrate (HMB) in leucine stimulation of muscle mitochondrial biogenesis and fatty acid oxidation
    • 601.1
    • Stancliffe RA, Eades M, Smart K, Zemel MB. Role of mTOR and β-hydroxy-β-methylbutyrate (HMB) in leucine stimulation of muscle mitochondrial biogenesis and fatty acid oxidation. FASEB J. 2011; 25:601.1.
    • (2011) FASEB J. , vol.25
    • Stancliffe, R.A.1    Eades, M.2    Smart, K.3    Zemel, M.B.4
  • 35
    • 84873521814 scopus 로고    scopus 로고
    • Role of β-hydroxy-β-methylbutyrate (HMB) in leucine stimulation of muscle mitochondrial biogenesis
    • 251.6
    • Stancliffe RA, Zemel MB. Role of β-hydroxy-β-methylbutyrate (HMB) in leucine stimulation of muscle mitochondrial biogenesis. FASEB J. 2012;26:251.6.
    • (2012) FASEB J. , vol.26
    • Stancliffe, R.A.1    Zemel, M.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.