Genetic Polymorphism and Susceptibility to Pesticides

Hayes' Handbook of Pesticide Toxicology

Volumn , Issue , 2010, Pages 525-549

  Peck, Erin C ^a   Eaton, David L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882741833     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374367-1.00017-3     Document Type: Chapter

References (201)

1. Adcock D.M., Koftan C., Crisan D., Kiechle F.L. Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation. Arch. Pathol. Lab. Med. 2004, 128:1360-1363.
2. Adkins S., Gan K.N., Mody M., La Du B.N. Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes. Am. J. Hum. Genet. 1993, 52:598-608.
3. Ahmadi A., Fredrikson M., Jerregard H., Akerback A., Fall P.A., Rannug A., Axelson O., Soderkvist P. GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset. Biochem. Biophys. Res. Commun. 2000, 269:676-680.
4. Akgur S.A., Ozturk P., Solak I., Moral A.R., Ege B. Human serum paraoxonase (PON1) activity in acute organophosphorous insecticide poisoning. Forensic Sci. Int. 2003, 133:136-140.
5. Akhmedova S.N., Yakimovsky A.K., Schwartz E.I. Paraoxonase 1 Met-Leu 54 polymorphism is associated with Parkinson's disease. J. Neurol. Sci. 2001, 184:179-182.
6. Alavanja M.C., Sandler D.P., McMaster S.B., Zahm S.H., McDonnell C.J., Lynch C.F., Pennybacker M., Rothman N., Dosemeci M., Bond A.E., Blair A. The Agricultural Health Study. Environ. Health Perspect. 1996, 104:362-369.
7. Allam M.F., Del Castillo A.S., Navajas R.F. Parkinson's disease risk factors: genetic, environmental, or both?. Neurol. Res. 2005, 27:206-208.
8. Anand S.S., Bruckner J.V., Haines W.T., Muralidhara S., Fisher J.W., Padilla S. Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol. Appl. Pharmacol. 2006, 212:156-166.
9. Anand S.S., Kim K.B., Padilla S., Muralidhara S., Kim H.J., Fisher J.W., Bruckner J.V. Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. Drug Metab. Dispos. 2006, 34:389-397.
10. Au W.W., Sierra-Torres C.H., Cajas-Salazar N., Shipp B.K., Legator M.S. Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility. Environ. Health Perspect. 1999, 107:501-505.
11. 1 promoter region of CYP3A4. Clin. Pharmacol. Ther. 1999, 66:288-294.
12. Bandmann O., Vaughan J., Holmans P., Marsden C.D., Wood N.W. Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease. Lancet 1997, 350:1136-1139.
13. Barker D.J. The origins of the developmental origins theory. J. Intern. Med. 2007, 261:412-417.
14. Barlow B.K., Cory-Slechta D.A., Richfield E.K., Thiruchelvam M. The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod. Toxicol. 2007, 23:457-470.
15. Barr D.B., Barr J.R., Maggio V.L., Whitehead R.D., Sadowski M.A., Whyatt R.M., Needham L.L. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 778:99-111.
16. Barry R.C., Lin Y., Wang J., Liu G., Timchalk C.A. Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures. J. Expo. Sci. Environ. Epidemiol. 2009, 19:1-18.
17. Bartels C.F., Jensen F.S., Lockridge O., van der Spek A.F., Rubinstein H.M., Lubrano T., La Du B.N. DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites. Am. J. Hum. Genet. 1992, 50:1086-1103.
18. Benmoyal-Segal L., Soreq H. Gene-environment interactions in sporadic Parkinson's disease. J. Neurochem. 2006, 97:1740-1755.
19. Benmoyal-Segal L., Vander T., Shifman S., Bryk B., Ebstein R.P., Marcus E.L., Stessman J., Darvasi A., Herishanu Y., Friedman A., Soreq H. Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. FASEB J. 2005, 19:452-454.
20. Berkowitz G.S., Wetmur J.G., Birman-Deych E., Obel J., Lapinski R.H., Godbold J.H., Holzman I.R., Wolff M.S. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ. Health Perspect. 2004, 112:388-391.
21. Bloch A., Ben-Chetrit E., Muszkat M., Caraco Y. Major bleeding caused by warfarin in a genetically susceptible patient. Pharmacotherapy 2002, 22:97-101.
22. Brophy V.H., Hastings M.D., Clendenning J.B., Richter R.J., Jarvik G.P., Furlong C.E. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001, 11:77-84.
23. 1 regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. Am. J. Hum. Genet. 2001, 68:1428-1436.
24. Brophy V.H., Jarvik G.P., Richter R.J., Rozek L.S., Schellenberg G.D., Furlong C.E. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 2000, 10:453-460.
25. Brown T.P., Rumsby P.C., Capleton A.C., Rushton L., Levy L.S. Pesticides and Parkinson's disease"is there a link?. Environ. Health Perspect. 2006, 114:156-164.
26. Browne R.O., Moyal-Segal L.B., Zumsteg D., David Y., Kofman O., Berger A., Soreq H., Friedman A. Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure. FASEB J. 2006, 20:1733-1735.
27. Buratti F.M., Volpe M.T., Meneguz A., Vittozzi L., Testai E. CYP-specific bioactivation of four organophosphorothioate pesticides by human liver microsomes. Toxicol. Appl. Pharmacol. 2003, 186:143-154.
28. Buratti F.M., D'Aniello A., Volpe M.T., Meneguz A., Testai E. Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab. Dispos. 2005, 33:295-302.
29. Calle E.E., Frumkin H., Henley S.J., Savitz D.A., Thun M.J. Organochlorines and breast cancer risk. CA Cancer J. Clin. 2002, 52:301-309.
30. Canalle R., Burim R.V., Tone L.G., Takahashi C.S. Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Environ. Mol. Mutagen. 2004, 43:100-109.
31. Carmine A., Buervenich S., Sydow O., Anvret M., Olson L. Further evidence for an association of the paraoxonase 1 (PON1) Met-54 allele with Parkinson's disease. Mov. Disord. 2002, 17:764-766.
32. Carvey P.M., Punati A., Newman M.B. Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplant. 2006, 15:239-250.
33. Ceravolo R., Sgado P., Frosini D., Corsini G.U. Assessing neuroprotection in Parkinson's disease: from the animal models to molecular neuroimaging in vivo. J. Neural. Transm. Suppl. 2006, 133-141.
34. Chan D.K., Woo J., Ho S.C., Pang C.P., Law L.K., Ng P.W., Hung W.T., Kwok T., Hui E., Orr K., Leung M.F., Kay R. Genetic and environmental risk factors for Parkinson's disease in a Chinese population. J. Neurol. Neurosurg. Psychiatry 1998, 65:781-784.
35. Chen J., Kumar M., Chan W., Berkowitz G., Wetmur J.G. Increased influence of genetic variation on PON1 activity in neonates. Environ. Health Perspect. 2003, 111:1403-1409.
36. Cherry N., Mackness M., Durrington P., Povey A., Dippnall M., Smith T., Mackness B. Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip. Lancet 2002, 359:763-764.
37. Clarimon J., Eerola J., Hellstrom O., Tienari P.J., Singleton A. Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finnish population. Neurosci. Lett. 2004, 367:168-170.
38. Cole T.B., Jampsa R.L., Walter B.J., Arndt T.L., Richter R.J., Shih D.M., Tward A., Lusis A.J., Jack R.M., Costa L.G., Furlong C.E. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 2003, 13:357-364.
39. Cole T.B., Walter B.J., Shih D.M., Tward A.D., Lusis A.J., Timchalk C., Richter R.J., Costa L.G., Furlong C.E. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet. Genom. 2005, 15:589-598.
40. Cory-Slechta D.A., Thiruchelvam M., Barlow B.K., Richfield E.K. Developmental pesticide models of the Parkinson disease phenotype. Environ. Health Perspect. 2005, 113:1263-1270.
41. Costa L.G., Richter R.J., Li W.F., Cole T., Guizzetti M., Furlong C.E. Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003, 8:1-12.
42. Costello S., Cockburn M., Bronstein J., Zhang X., Ritz B. Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. Am. J. Epidemiol. 2009, 169:919-926.
43. Crow J.A., Borazjani A., Potter P.M., Ross M.K. Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol. Appl. Pharmacol. 2007, 221:1-12.
44. Cummings A.M., Kavlock R.J. Gene-environment interactions: a review of effects on reproduction and development. Crit. Rev. Toxicol. 2004, 34:461-485.
45. D'Amelio M., Ricci I., Sacco R., Liu X., D'Agruma L., Muscarella L.A., Guarnieri V., Militerni R., Bravaccio C., Elia M., Schneider C., Melmed R., Trillo S., Pascucci T., Puglisi-Allegra S., Reichelt K.L., Macciardi F., Holden J.J., Persico A.M. Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions. Mol. Psychiatry 2005, 10:1006-1016.
46. da Silva J., Moraes C.R., Heuser V.D., Andrade V.M., Silva F.R., Kvitko K., Emmel V., Rohr P., Bordin D.L., Andreazza A.C., Salvador M., Henriques J.A., Erdtmann B. Evaluation of genetic damage in a Brazilian population occupationally exposed to pesticides and its correlation with polymorphisms in metabolizing genes. Mutagenesis 2008, 23:415-422.
47. Dai D., Tang J., Rose R., Hodgson E., Bienstock R.J., Mohrenweiser H.W., Goldstein J.A. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J. Pharmacol. Exp. Ther. 2001, 299:825-831.
48. Daly A.K. Pharmacogenetics of the cytochromes P450. Curr. Top. Med. Chem. 2004, 4:1733-1744.
49. Davies H.G., Richter R.J., Keifer M., Broomfield C.A., Sowalla J., Furlong C.E. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat. Genet. 1996, 14:334-336.
50. de Boo H.A., Harding J.E. The developmental origins of adult disease (Barker) hypothesis. Aust. N.Z. J. Obstet. Gynaecol. 2006, 46:4-14.
51. Deng Y., Newman B., Dunne M.P., Silburn P.A., Mellick G.D. Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease. Ann. Neurol. 2004, 55:897.
52. Dick F.D., De Palma G., Ahmadi A., Osborne A., Scott N.W., Prescott G.J., Bennett J., Semple S., Dick S., Mozzoni P., Haites N., Wettinger S.B., Mutti A., Otelea M., Seaton A., Soderkvist P., Felice A. Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study. Occup. Environ. Med. 2007, 64:673-680.
53. Dick F.D., De Palma G., Ahmadi A., Scott N.W., Prescott G.J., Bennett J., Semple S., Dick S., Counsell C., Mozzoni P., Haites N., Wettinger S.B., Mutti A., Otelea M., Seaton A., Soderkvist P., Felice A. Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study. Occup. Environ. Med. 2007, 64:666-672.
54. Dinis-Oliveira R.J., Remiao F., Carmo H., Duarte J.A., Navarro A.S., Bastos M.L., Carvalho F. Paraquat exposure as an etiological factor of Parkinson's disease. Neurotoxicology 2006, 27:1110-1122.
55. Dinis-Oliveira R.J., Duarte J.A., Sanchez-Navarro A., Remiao F., Bastos M.L., Carvalho F. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit. Rev. Toxicol. 2008, 38:13-71.
56. Drechsel D.A., Patel M. Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease. Free Radic. Biol. Med. 2008, 44:1873-1886.
57. Drozdzik M., Bialecka M., Mysliwiec K., Honczarenko K., Stankiewicz J., Sych Z. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 2003, 13:259-263.
58. Eaton D.L. Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology 2000, 21:101-111.
59. Eaton D.L., Daroff R.B., Autrup H., Bridges J., Buffler P., Costa L.G., Coyle J., McKhann G., Mobley W.C., Nadel L., Neubert D., Schulte-Hermann R., Spencer P.S. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit. Rev. Toxicol. 2008, 38(suppl 2):1-125.
60. Eckerson H.W., Wyte C.M., La Du B.N. The human serum paraoxonase/arylesterase polymorphism. Am. J. Hum. Genet. 1983, 35:1126-1138.
61. Elbaz A., Moisan F. Update in the epidemiology of Parkinson's disease. Curr. Opin. Neurol. 2008, 21:454-460.
62. Elbaz A., Tranchant C. Epidemiologic studies of environmental exposures in Parkinson's disease. J. Neurol. Sci. 2007, 262:37-44.
63. Elbaz A., Levecque C., Clavel J., Vidal J.S., Richard F., Amouyel P., Alperovitch A., Chartier-Harlin M.C., Tzourio C. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann. Neurol. 2004, 55:430-434.
64. Elbaz A., Dufouil C., Alperovitch A. Interaction between genes and environment in neurodegenerative diseases. C. R. Biol. 2007, 330:318-328.
65. Elwan M.A., Richardson J.R., Guillot T.S., Caudle W.M., Miller G.W. Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicol. Appl. Pharmacol. 2006, 211:188-197.
66. Falck G.C., Hirvonen A., Scarpato R., Saarikoski S.T., Migliore L., Norppa H. Micronuclei in blood lymphocytes and genetic polymorphism for GSTM1, GSTT1 and NAT2 in pesticide-exposed greenhouse workers. Mutat. Res. 1999, 441:225-237.
67. Fenske R.A. State-of-the-art measurement of agricultural pesticide exposures. Scand. J. Work Environ. Health. 2005, 31(suppl 1):67-73.
68. Firestone J.A., Smith-Weller T., Franklin G., Swanson P., Longstreth W.T., Checkoway H. Pesticides and risk of Parkinson disease: a population-based case-control study. Arch. Neurol. 2005, 62:91-95.
69. Fong C.S., Cheng C.W., Wu R.M. Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease. Acta Neurol. Taiwan 2005, 14:55-60.
70. Fong C.S., Wu R.M., Shieh J.C., Chao Y.T., Fu Y.P., Kuao C.L., Cheng C.W. Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. Clin. Chim. Acta 2007, 378:136-141.
71. Furlong C.E., Li W.F., Costa L.G., Richter R.J., Shih D.M., Lusis A.J. Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism. Neurotoxicology 1998, 19:645-650.
72. Furlong C.E., Li W.F., Richter R.J., Shih D.M., Lusis A.J., Alleva E., Costa L.G. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). Neurotoxicology 2000, 21:91-100.
73. Gage B.F., Eby C., Johnson J.A., Deych E., Rieder M.J., Ridker P.M., Milligan P.E., Grice G., Lenzini P., Rettie A.E., Aquilante C.L., Grosso L., Marsh S., Langaee T., Farnett L.E., Voora D., Veenstra D.L., Glynn R.J., Barrett A., McLeod H.L. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin. Pharmacol. Ther. 2008, 84:326-331.
74. Gao H.M., Liu B., Hong J.S. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 2003, 23:6181-6187.
75. Garabrant D.H., Philbert M.A. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology. Crit. Rev. Toxicol. 2002, 32:233-257.
76. Ghiasuddin S.M., Soderlund D.M. Hydrolysis of pyrethroid insecticides by soluble mouse brain esterases. Toxicol. Appl. Pharmacol. 1984, 74:390-396.
77. Gillette J.S., Bloomquist J.R. Differential up-regulation of striatal dopamine transporter and alpha-synuclein by the pyrethroid insecticide permethrin. Toxicol. Appl. Pharmacol. 2003, 192:287-293.
78. Godin S.J., Scollon E.J., Hughes M.F., Potter P.M., DeVito M.J., Ross M.K. Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab. Dispos. 2006, 34:1764-1771.
79. Greenwood T.A., Schork N.J., Eskin E., Kelsoe J.R. Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Mol. Psychiatry 2006, 11:125-133.
80. Gregio D'Arce L.P., Colus I.M. Cytogenetic and molecular biomonitoring of agricultural workers exposed to pesticides in Brazil. Teratogen. Carcinogen. Mutagen. 2000, 20:161-170.
81. Hadjigeorgiou G.M., Malizos K., Dardiotis E., Aggelakis K., Dardioti M., Zibis A., Dimitroulias A., Scarmeas N., Tsezou A., Karantanas A. Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions. J. Orthop. Res. 2007, 25:1087-1093.
82. Hahn M.E., Gasiewicz T.A., Linko P., Goldstein J.A. The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice. Biochem. J. 1988, 254:245-254.
83. Hatcher J.M., Pennell K.D., Miller G.W. Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol. Sci. 2008, 29:322-329.
84. Hayes J.D., Flanagan J.U., Jowsey I.R. Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 2005, 45:51-88.
85. Hernandez A.F., Mackness B., Rodrigo L., Lopez O., Pla A., Gil F., Durrington P.N., Pena G., Parron T., Serrano J.L., Mackness M.I. Paraoxonase activity and genetic polymorphisms in greenhouse workers with long term pesticide exposure. Hum. Exp. Toxicol. 2003, 22:565-574.
86. Hernandez A., Gomez M.A., Pena G., Gil F., Rodrigo L., Villanueva E., Pla A. Effect of long-term exposure to pesticides on plasma esterases from plastic greenhouse workers. J. Toxicol. Environ. Health A 2004, 67:1095-1108.
87. Hernandez A.F., Lopez O., Rodrigo L., Gil F., Pena G., Serrano J.L., Parron T., Alvarez J.C., Lorente J.A., Pla A. Changes in erythrocyte enzymes in humans long-term exposed to pesticides: influence of several markers of individual susceptibility. Toxicol. Lett. 2005, 159:13-21.
88. Hertzman C., Wiens M., Bowering D., Snow B., Calne D. Parkinson's disease: a case-control study of occupational and environmental risk factors. Am. J. Ind. Med. 1990, 17:349-355.
89. Higuchi S., Muramatsu T., Arai H., Hayashida M., Sasaki H., Trojanowski J.Q. Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease. J. Neural. Transm. Park. Dis. Dement. Sect. 1995, 10:107-113.
90. Hoglinger G.U., Oertel W.H., Hirsch E.C. The rotenone model of parkinsonism"the five years inspection. J. Neural. Transm. Suppl. 2006, 269-272.
91. Hu Y., Krausz K., Gelboin H.V., Kupfer D. CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification. Xenobiotica 2004, 34:117-132.
92. Hubble J.P., Kurth J.H., Glatt S.L., Kurth M.C., Schellenberg G.D., Hassanein R.E., Lieberman A., Koller W.C. Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia. Neuroepidemiology 1998, 17:96-104.
93. Huen K., Richter R., Furlong C., Eskenazi B., Holland N. Validation of PON1 enzyme activity assays for longitudinal studies. Clin. Chim. Acta 2009, 402:67-74.
94. Humbert R., Adler D.A., Disteche C.M., Hassett C., Omiecinski C.J., Furlong C.E. The molecular basis of the human serum paraoxonase activity polymorphism. Nat. Genet. 1993, 3:73-76.
95. Ibrahim M.A., Bond G.G., Burke T.A., Cole P., Dost F.N., Enterline P.E., Gough M., Greenberg R.S., Halperin W.E., McConnell E., et al. Weight of the evidence on the human carcinogenicity of 2,4-D. Environ. Health Perspect. 1991, 96:213-222.
96. Infante-Rivard C., Weichenthal S. Pesticides and childhood cancer: an update of Zahm and Ward's 1998 review. J. Toxicol. Environ. Health B Crit. Rev. 2007, 10:81-99.
97. Infante-Rivard C., Labuda D., Krajinovic M., Sinnett D. Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology 1999, 10:481-487.
98. Ingelman-Sundberg M., Oscarson M., Daly A.K., Garte S., Nebert D.W. Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles. Cancer Epidemiol. Biomarkers Prev. 2001, 10:1307-1308.
99. Joost O., Taylor C.A., Thomas C.A., Cupples L.A., Saint-Hilaire M.H., Feldman R.G., Baldwin C.T., Myers R.H. Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease. Mov. Disord. 1999, 14:590-595.
100. Kamel F., Tanner C., Umbach D., Hoppin J., Alavanja M., Blair A., Comyns K., Goldman S., Korell M., Langston J., Ross G., Sandler D. Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am. J. Epidemiol. 2007, 165:364-374.
101. 1 region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. Hum. Mol. Genet. 2006, 15:3055-3062.
102. Kerridge I., Lincz L., Scorgie F., Hickey D., Granter N., Spencer A. Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk. Br. J. Haematol. 2002, 118:477-481.
103. Khan T., Kamali F., Daly A., King B., Wynne H.A. Warfarin sensitivity: be aware of genetic influence. Age Ageing 2003, 32:226-227.
104. Kim J.W., Kim D.H., Kim S.H., Cha J.K. Association of the dopamine transporter gene with Parkinson's disease in Korean patients. J. Korean Med. Sci. 2000, 15:449-451.
105. Kirsch-Volders M., Mateuca R.A., Roelants M., Tremp A., Zeiger E., Bonassi S., Holland N., Chang W.P., Aka P.V., Deboeck M., Godderis L., Haufroid V., Ishikawa H., Laffon B., Marcos R., Migliore L., Norppa H., Teixeira J.P., Zijno A., Fenech M. The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo. Cancer Epidemiol. Biomarkers Prev. 2006, 15:1038-1042.
106. Kracht T., Schrappe M., Strehl S., Reiter A., Elsner H.A., Trka J., Cario G., Viehmann S., Harbott J., Borkhardt A., Metzler M., Langer T., Repp R., Marschalek R., Welte K., Haas O.A., Stanulla M. NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms. Haematologica 2004, 89:1492-1497.
107. Krajinovic M., Sinnett H., Richer C., Labuda D., Sinnett D. Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int. J. Cancer. 2002, 97:230-236.
108. Laden F., Ishibe N., Hankinson S.E., Wolff M.S., Gertig D.M., Hunter D.J., Kelsey K.T. Polychlorinated biphenyls, cytochrome P450 1A1, and breast cancer risk in the Nurses' Health Study. Cancer Epidemiol. Biomarkers Prev. 2002, 11:1560-1565.
109. Langston J.W., Ballard P.A. Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N. Engl. J. Med. 1983, 309:310.
110. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983, 219:979-980.
111. Langston J.W., Irwin I., Langston E.B., Forno L.S. 1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci. Lett. 1984, 48:87-92.
112. Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 1999, 46:598-605.
113. Lankas G.R., Wise L.D., Cartwright M.E., Pippert T., Umbenhauer D.R. Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reprod. Toxicol. 1998, 12:457-463.
114. Le Couteur D.G., McLean A.J., Taylor M.C., Woodham B.L., Board P.G. Pesticides and Parkinson's disease. Biomed. Pharmacother. 1999, 53:122-130.
115. Leduc V., Poirier J. Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels. Neurodegener. Dis. 2008, 5:225-227.
116. Lee B.W., London L., Paulauskis J., Myers J., Christiani D.C. Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers. J. Occup. Environ. Med. 2003, 45:118-122.
117. Lee C.H., Kamijima M., Kim H., Shibata E., Ueyama J., Suzuki T., Takagi K., Saito I., Gotoh M., Hibi H., Naito H., Nakajima T. 8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype. Int. Arch. Occup. Environ. Health 2007, 80:217-227.
118. Lee S.H., Rhee J., Koh J.K., Lee Y.S. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neurosci. Lett. 1996, 214:199-201.
119. Leng G., Lewalter J., Rohrig B., Idel H. The influence of individual susceptibility in pyrethroid exposure. Toxicol. Lett. 1999, 107:123-130.
120. Li T., Lange L.A., Li X., Susswein L., Bryant B., Malone R., Lange E.M., Huang T.Y., Stafford D.W., Evans J.P. Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation. J. Med. Genet. 2006, 43:740-744.
121. Li W.F., Costa L.G., Richter R.J., Hagen T., Shih D.M., Tward A., Lusis A.J., Furlong C.E. Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000, 10:767-779.
122. Li Y., Millikan R.C., Bell D.A., Cui L., Tse C.K., Newman B., Conway K. Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study. Breast Cancer Res. 2005, 7:R12-R18.
123. Limdi N.A., McGwin G., Goldstein J.A., Beasley T.M., Arnett D.K., Adler B.K., Baird M.F., Acton R.T. Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin. Pharmacol. Ther. 2008, 83:312-321.
124. Lin C.N., Liu H.C., Tsai S.J., Liu T.Y., Hong C.J. Association study for Parkinson's disease and a dopamine transporter gene polymorphism (1215A/G). Eur. Neurol. 2002, 48:207-209.
125. Lin J.J., Yueh K.C., Chang D.C., Chang C.Y., Yeh Y.H., Lin S.Z. The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson's disease for male, but not to female patients. J. Neurol. Sci. 2003, 209:87-92.
126. Liou H.H., Tsai M.C., Chen C.J., Jeng J.S., Chang Y.C., Chen S.Y., Chen R.C. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 1997, 48:1583-1588.
127. Liu Y.J., Huang P.L., Chang Y.F., Chen Y.H., Chiou Y.H., Xu Z.L., Wong R.H. GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. Cancer Epidemiol. Biomarkers Prev. 2006, 15:659-666.
128. Lopez O., Hernandez A.F., Rodrigo L., Gil F., Pena G., Serrano J.L., Parron T., Villanueva E., Pla A. Changes in antioxidant enzymes in humans with long-term exposure to pesticides. Toxicol. Lett. 2007, 171:146-153.
129. Macdonald N., Gledhill A. Potential impact of ABCB1 (p-glycoprotein) polymorphisms on avermectin toxicity in humans. Arch. Toxicol. 2007, 81:553-563.
130. Mackness B., Mackness M.I., Arrol S., Turkie W., Durrington P.N. Effect of the molecular polymorphisms of human paraoxonase (PON1) on the rate of hydrolysis of paraoxon. Br. J. Pharmacol. 1997, 122:265-268.
131. Mackness B., Durrington P., Povey A., Thomson S., Dippnall M., Mackness M., Smith T., Cherry N. Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep. Pharmacogenetics 2003, 13:81-88.
132. Malhi H., Atac B., Daly A.K., Gupta S. Warfarin and celecoxib interaction in the setting of cytochrome P450 (CYP2C9) polymorphism with bleeding complication. Postgrad. Med. J. 2004, 80:107-109.
133. Martin L.J., Woo J.G., Avery C.L., Chen H.S., North K.E., Au K., Broet P., Dalmasso C., Guedj M., Holmans P., Huang B., Kuo P.H., Lam A.C., Li H., Manning A., Nikolov I., Sinha R., Shi J., Song K., Tabangin M., Tang R., Yamada R. Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15. Genet. Epidemiol. 2007, 31(suppl 1):S124-S131.
134. Mealey K.L., Bentjen S.A., Waiting D.K. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States. Am. J. Vet. Res. 2002, 63:479-481.
135. Menegon A., Board P.G., Blackburn A.C., Mellick G.D., Le Couteur D.G. Parkinson's disease, pesticides, and glutathione transferase polymorphisms. Lancet 1998, 352:1344-1346.
136. Metayer C., Buffler P.A. Residential exposures to pesticides and childhood leukaemia. Radiat. Prot. Dosimetry 2008, 132:212-219.
137. Migliore L., Coppede F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat. Res. 2009, 667:82-97.
138. Mikami L.R., Wieseler S., Souza R.L., Schopfer L.M., Nachon F., Lockridge O., Chautard-Freire-Maia E.A. Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population. Pharmacogenet. Genom. 2008, 18:213-218.
139. Miligi L., Costantini A.S., Veraldi A., Benvenuti A., Vineis P. Cancer and pesticides: an overview and some results of the Italian multicenter case-control study on hematolymphopoietic malignancies. Ann. N. Y. Acad. Sci. 2006, 1076:366-377.
140. Miller G.W., Kirby M.L., Levey A.I., Bloomquist J.R. Heptachlor alters expression and function of dopamine transporters. Neurotoxicology 1999, 20:631-637.
141. Miller R.L., James-Kracke M., Sun G.Y., Sun A.Y. Oxidative and inflammatory pathways in Parkinson's disease. Neurochem. Res. 2009, 34:55-65.
142. Morahan J.M., Yu B., Trent R.J., Pamphlett R. A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology 2007, 28:532-540.
143. Mutch E., Williams F.M. Do multiple P450 isoforms contribute to parathion, diazinon and chlorpyrifos metabolism in man?. Drug Metab. Rev. 2004, 36:265.
144. Mutch E., Williams F.M. Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology 2006, 224:22-32.
145. Mutch E., Blain P.G., Williams F.M. The role of metabolism in determining susceptibility to parathion toxicity in man. Toxicol. Lett. 1999, 107:177-187.
146. Mutch E., Daly A.K., Leathart J.B., Blain P.G., Williams F.M. Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?. Arch Toxicol. 2003, 77:313-320.
147. Nelson O.L., Carsten E., Bentjen S.A., Mealey K.L. Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies. J. Vet. Intern. Med. 2003, 17:354-356.
148. Nicholl D.J., Bennett P., Hiller L., Bonifati V., Vanacore N., Fabbrini G., Marconi R., Colosimo C., Lamberti P., Stocchi F., Bonuccelli U., Vieregge P., Ramsden D.B., Meco G., Williams A.C. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism. Neurology 1999, 53:1415-1521.
149. Nishimura M., Kaji R., Ohta M., Mizuta I., Kuno S. Association between dopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan. Mov. Disord. 2002, 17:831-832.
150. Nolan R.J., Rick D.L., Freshour N.L., Saunders J.H. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 1984, 73:8-15.
151. Ossowska K., Wardas J., Kuter K., Nowak P., Dabrowska J., Bortel A., Labus L., Kwiecinski A., Krygowska-Wajs A., Wolfarth S. Influence of paraquat on dopaminergic transporter in the rat brain. Pharmacol. Rep. 2005, 57:330-335.
152. Ozdemir V., Kalow W., Tang B.K., Paterson A.D., Walker S.E., Endrenyi L., Kashuba A.D. Evaluation of the genetic component of variability in
153. Padungtod C., Niu T., Wang Z., Savitz D.A., Christiani D.C., Ryan L.M., Xu X. Paraoxonase polymorphism and its effect on male reproductive outcomes among Chinese pesticide factory workers. Am. J. Ind. Med. 1999, 36:379-387.
154. Paolini M., Biagi G.L., Cantelli-Forti G. Glutathione transferase polymorphism and Parkinson's disease. Lancet 1999, 353:71-72.
155. Perez-Herrera N., Polanco-Minaya H., Salazar-Arredondo E., Solis-Heredia M.J., Hernandez-Ochoa I., Rojas-Garcia E., Alvarado-Mejia J., Borja-Aburto V.H., Quintanilla-Vega B. PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico. Toxicol. Appl. Pharmacol. 2008, 230:261-268.
156. Perez-Pastene C., Graumann R., Diaz-Grez F., Miranda M., Venegas P., Godoy O.T., Layson L., Villagra R., Matamala J.M., Herrera L., Segura-Aguilar J. Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component. Neurosci. Lett. 2007, 418:181-185.
157. Purkerson-Parker S., McDaniel K.L., Moser V.C. Dopamine transporter binding in the rat striatum is increased by gestational, perinatal, and adolescent exposure to heptachlor. Toxicol Sci. 2001, 64:216-223.
158. Ramachandiran S., Hansen J.M., Jones D.P., Richardson J.R., Miller G.W. Divergent mechanisms of paraquat, MPP +, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicol. Sci. 2007, 95:163-171.
159. Raza H., Robin M.A., Fang J.K., Avadhani N.G. Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem. J. 2002, 366:45-55.
160. Richardson J.R., Quan Y., Sherer T.B., Greenamyre J.T., Miller G.W. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol. Sci. 2005, 88:193-201.
161. Richter R.J., Jarvik G.P., Furlong C.E. Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol. Appl. Pharmacol. 2009, 235:1-9.
162. Ross M.K., Crow J.A. Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. J. Biochem. Mol. Toxicol. 2007, 21:187-196.
163. Saeed M., Siddique N., Hung W.Y., Usacheva E., Liu E., Sufit R.L., Heller S.L., Haines J.L., Pericak-Vance M., Siddique T. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology 2006, 67:771-776.
164. Saintot M., Malaveille C., Hautefeuille A., Gerber M. Interaction between genetic polymorphism of cytochrome P450-1B1 and environmental pollutants in breast cancer risk. Eur. J. Cancer Prev. 2004, 13:83-86.
165. Sams C., Mason H.J., Rawbone R. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol. Lett. 2000, 116:217-221.
166. Santt O., Baranova H., Albuisson E., Bignon Y.J., Lucotte G. Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease. Eur. J. Neurol. 2004, 11:247-251.
167. Scarpato R., Migliore L., Hirvonen A., Falck G., Norppa H. Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes. Environ. Mol. Mutagen. 1996, 27:263-269.
168. Scarpato R., Hirvonen A., Migliore L., Falck G., Norppa H. Influence of GSTM1 and GSTT1 polymorphisms on the frequency of chromosome aberrations in lymphocytes of smokers and pesticide-exposed greenhouse workers. Mutat. Res. 1997, 389:227-235.
169. Schmidt W.J., Alam M. Controversies on new animal models of Parkinson's disease pro and con: the rotenone model of Parkinson's disease (PD). J. Neural. Transm. Suppl. 2006, 273-276.
170. Schroeder J.C. Metabolic susceptibility to agricultural pesticides and non-Hodgkin's lymphoma. Scand. J. Work Environ. Health 2005, 31(suppl 1):26-32.
171. Searles Nielsen S., Mueller B.A., De Roos A.J., Viernes H.M., Farin F.M., Checkoway H. Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1). Environ. Health Perspect. 2005, 113:909-913.
172. Semchuk K.M., Love E.J., Lee R.G. Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology 1992, 42:1328-1335.
173. Sinclair K.D., Lea R.G., Rees W.D., Young L.E. The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc. Reprod. Fertil. Suppl. 2007, 64:425-443.
174. Singh M., Khan A.J., Shah P.P., Shukla R., Khanna V.K., Parmar D. Polymorphism in environment responsive genes and association with Parkinson disease. Mol. Cell Biochem. 2008, 312:131-138.
175. Sirivarasai J., Kaojarern S., Yoovathaworn K., Sura T. Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects. Chem. Biol. Interact. 2007, 168:184-192.
176. Smith M.T., Skibola C.F., Allan J.M., Morgan G.J. Causal models of leukaemia and lymphoma. IARC Sci. Publ. 2004, 373-392.
177. Smith M.T., McHale C.M., Wiemels J.L., Zhang L., Wiencke J.K., Zheng S., Gunn L., Skibola C.F., Ma X., Buffler P.A. Molecular biomarkers for the study of childhood leukemia. Toxicol. Appl. Pharmacol. 2005, 206:237-245.
178. Sozmen E.Y., Mackness B., Sozmen B., Durrington P., Girgin F.K., Aslan L., Mackness M. Effect of organophosphate intoxication on human serum paraoxonase. Hum. Exp. Toxicol. 2002, 21:247-252.
179. Sram R.J. Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects. Environ. Health Perspect. 1998, 106(suppl 1):231-239.
180. Stok J.E., Huang H., Jones P.D., Wheelock C.E., Morisseau C., Hammock B.D. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J. Biol. Chem. 2004, 279:29863-29869.
181. Storey J.D., Tibshirani R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 2003, 100:9440-9445.
182. Taylor M.C., Le Couteur D.G., Mellick G.D., Board P.G. Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population. J. Neural. Transm. 2000, 107:979-983.
183. Thiruchelvam M., Richfield E.K., Goodman B.M., Baggs R.B., Cory-Slechta D.A. Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype. Neurotoxicology 2002, 23:621-633.
184. Thrash B., Uthayathas S., Karuppagounder S.S., Suppiramaniam V., Dhanasekaran M. Paraquat and maneb induced neurotoxicity. Proc. West Pharmacol. Soc. 2007, 50:31-42.
185. Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., Mattsson J.L. A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol. Sci. 2002, 66:34-53.
186. Umbenhauer D.R., Lankas G.R., Pippert T.R., Wise L.D., Cartwright M.E., Hall S.J., Beare C.M. Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism. Toxicol. Appl. Pharmacol. 1997, 146:88-94.
187. Van Larebeke N.A., Birnbaum L.S., Boogaerts M.A., Bracke M., Davis D.L., Demarini D.M., Hooper K., Huff J., Kleinjans J.C., Legator M.S., Schoeters G., Vahakangas K. Unrecognized or potential risk factors for childhood cancer. Int. J. Occup. Environ. Health 2005, 11:199-201.
188. Vilar R., Coelho H., Rodrigues E., Gama M.J., Rivera I., Taioli E., Lechner M.C. Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease. Eur. J. Neurol. 2007, 14:156-161.
189. Vos R.M., van Welie R.T., Peters W.H., Evelo C.T., Boogaards J.J., Vermeulen N.P., van Bladeren P.J. Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of the mercapturic acids of Z- and E-1,3-dichloropropene. Arch. Toxicol. 1991, 65:95-99.
190. Wadelius M., Pirmohamed M. Pharmacogenetics of warfarin: current status and future challenges. Pharmacogen. J. 2007, 7:99-111.
191. Wang J., Liu Z. No association between paraoxonase 1 (PON1) gene polymorphisms and susceptibility to Parkinson's disease in a Chinese population. Mov. Disord. 2000, 15:1265-1267.
192. Whyatt R.M., Rauh V., Barr D.B., Camann D.E., Andrews H.F., Garfinkel R., Hoepner L.A., Diaz D., Dietrich J., Reyes A., Tang D., Kinney P.L., Perera F.P. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ. Health Perspect. 2004, 112:1125-1132.
193. Whyatt R.M., Camann D., Perera F.P., Rauh V.A., Tang D., Kinney P.L., Garfinkel R., Andrews H., Hoepner L., Barr D.B. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol. Appl. Pharmacol. 2005, 206:246-254.
194. Whyatt R.M., Garfinkel R., Hoepner L.A., Holmes D., Borjas M., Williams M.K., Reyes A., Rauh V., Perera F.P., Camann D.E. Within- and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City. Environ. Health Perspect. 2007, 115:383-389.
195. Wolff T., Strecker M. Endogenous and exogenous factors modifying the activity of human liver cytochrome P-450 enzymes. Exp. Toxicol. Pathol. 1992, 44:263-271.
196. Wong R.H., Chang S.Y., Ho S.W., Huang P.L., Liu Y.J., Chen Y.C., Yeh Y.H., Lee H.S. Polymorphisms in metabolic GSTP1 and DNA-repair XRCC1 genes with an increased risk of DNA damage in pesticide-exposed fruit growers. Mutat. Res. 2008, 654:168-175.
197. Yang D., Pearce R.E., Wang X., Gaedigk R., Wan Y.J., Yan B. Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin. Biochem. Pharmacol. 2009, 77:238-247.
198. Yang W., Tiffany-Castiglioni E. The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. J. Toxicol. Environ. Health A 2005, 68:1939-1961.
199. Zhang Y., Wise J.P., Holford T.R., Xie H., Boyle P., Zahm S.H., Rusiecki J., Zou K., Zhang B., Zhu Y., Owens P.H., Zheng T. Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women. Am. J. Epidemiol. 2004, 160:1177-1183.
200. Zhang Z., Fasco M.J., Huang Z., Guengerich F.P., Kaminsky L.S. Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe. Drug Metab. Dispos. 1995, 23:1339-1346.
201. Zhou Z.J., Zheng J., Wu Q.E., Xie F. Carboxylic esterase and its associations with long-term effects of organophosphorus pesticides. Biomed. Environ. Sci. 2007, 20:284-290.