-
1
-
-
33749251656
-
MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine
-
Aarnoudse AL, van Schaik RH, Dieleman J, Molokhia M, van Riemsdijk MM, Ligthelm RJ, Overbosch D, van der Heiden IP, Stricker BH (2006) MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine. Clin Pharmacol Ther 80:367-374
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 367-374
-
-
Aarnoudse, A.L.1
Van Schaik, R.H.2
Dieleman, J.3
Molokhia, M.4
Van Riemsdijk, M.M.5
Ligthelm, R.J.6
Overbosch, D.7
Van Der Heiden, I.P.8
Stricker, B.H.9
-
2
-
-
18744407592
-
Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African population
-
Allabi AC, Horsmans Y, Issaoui B, Gala JL (2005) Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African population. Eur J Clin Pharmacol 61:97-102
-
(2005)
Eur J Clin Pharmacol
, vol.61
, pp. 97-102
-
-
Allabi, A.C.1
Horsmans, Y.2
Issaoui, B.3
Gala, J.L.4
-
3
-
-
0030297401
-
Interaction of structurally diverse pesticides with the human mdr1 gene product P-glycoprotein
-
Bain LJ, LeBlanc GA (1996) Interaction of structurally diverse pesticides with the human mdr1 gene product P-glycoprotein. Toxicol Appl Pharmacol 141:288-298
-
(1996)
Toxicol Appl Pharmacol
, vol.141
, pp. 288-298
-
-
Bain, L.J.1
Leblanc, G.A.2
-
4
-
-
4944230477
-
Pregnane X receptor upregulation of P-glycoprotein expression and
-
Bauer B, Hartz Am, Fricker G, Miller Ds (2004) Pregnane X receptor upregulation of P-glycoprotein expression and. Mol Pharmacol 66:413-419
-
(2004)
Mol Pharmacol
, vol.66
, pp. 413-419
-
-
Bauer, B.1
Am, H.2
Fricker, G.3
Ds, M.4
-
5
-
-
0036074018
-
Mammalian ABC transporters in health and disease
-
Borst P, Elferink RO (2002) Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537-592
-
(2002)
Annu Rev Biochem
, vol.71
, pp. 537-592
-
-
Borst, P.1
Elferink, R.O.2
-
6
-
-
23444433388
-
Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans
-
Brunner M, Langer O, Sunder-Plassmann R, Dobrozemsky G, Muller U, Wadsak W, Krcal A, Karch R, Mannhalter C, Dudczak R, Kletter K, Steiner I, Baumgartner C, Muller M (2005) Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans. Clin Pharmacol Ther 78:182-190
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 182-190
-
-
Brunner, M.1
Langer, O.2
Sunder-Plassmann, R.3
Dobrozemsky, G.4
Muller, U.5
Wadsak, W.6
Krcal, A.7
Karch, R.8
Mannhalter, C.9
Dudczak, R.10
Kletter, K.11
Steiner, I.12
Baumgartner, C.13
Muller, M.14
-
7
-
-
33748413464
-
P-glycoprotein in the placenta: Expression, localization, regulation and function
-
3
-
Ceckova-Novotna M, Pavek P, Staud F (2006) P-glycoprotein in the placenta: expression, localization, regulation and function. Reprod Toxicol 22(3):400-410
-
(2006)
Reprod Toxicol
, vol.22
, pp. 400-410
-
-
Ceckova-Novotna, M.1
Pavek, P.2
Staud, F.3
-
8
-
-
23044491475
-
Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression
-
Chowbay B, Li H, David M, Cheung YB, Lee EJ (2005) Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression. Br J Clin Pharmacol 60:159-171
-
(2005)
Br J Clin Pharmacol
, vol.60
, pp. 159-171
-
-
Chowbay, B.1
Li, H.2
David, M.3
Cheung, Y.B.4
Lee, E.J.5
-
9
-
-
0032984766
-
Agricultural avermectins: An uncommon but potentially fatal cause of pesticide poisoning
-
Chung K, Yang CC, Wu ML, Deng JF, Tsai WJ (1999) Agricultural avermectins: an uncommon but potentially fatal cause of pesticide poisoning. Ann Emerg Med 34:51-57
-
(1999)
Ann Emerg Med
, vol.34
, pp. 51-57
-
-
Chung, K.1
Yang, C.C.2
Wu, M.L.3
Deng, J.F.4
Tsai, W.J.5
-
10
-
-
33644674142
-
Computational models for identifying potential P-glycoprotein substrates and inhibitors
-
Crivori P, Reinach B, Pezzetta D, Poggesi I (2006) Computational models for identifying potential P-glycoprotein substrates and inhibitors. Mol Pharm 3:33-44
-
(2006)
Mol Pharm
, vol.3
, pp. 33-44
-
-
Crivori, P.1
Reinach, B.2
Pezzetta, D.3
Poggesi, I.4
-
11
-
-
31844452412
-
Insight in eukaryotic ABC transporter function by mutation analysis
-
Frelet A, Klein M (2006) Insight in eukaryotic ABC transporter function by mutation analysis. FEBS Lett 580:1064-1084
-
(2006)
FEBS Lett
, vol.580
, pp. 1064-1084
-
-
Frelet, A.1
Klein, M.2
-
12
-
-
26844575149
-
Ivermectin 20 years on: Maturation of a wonder drug
-
Geary TG (2005) Ivermectin 20 years on: maturation of a wonder drug. Trends Parasitol 21:530-532
-
(2005)
Trends Parasitol
, vol.21
, pp. 530-532
-
-
Geary, T.G.1
-
13
-
-
2442466917
-
Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)
-
Hitzl M, Schaeffeler E, Hocher B, Slowinski T, Halle H, Eichelbaum M, Kaufmann P, Fritz P, Fromm MF, Schwab M (2004) Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1). Pharmacogenetics 14:309-318
-
(2004)
Pharmacogenetics
, vol.14
, pp. 309-318
-
-
Hitzl, M.1
Schaeffeler, E.2
Hocher, B.3
Slowinski, T.4
Halle, H.5
Eichelbaum, M.6
Kaufmann, P.7
Fritz, P.8
Fromm, M.F.9
Schwab, M.10
-
14
-
-
33144478521
-
ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: Discrimination of critical variants using a gene-wide haplotype tagging approach
-
Ho GT, Soranzo N, Nimmo ER, Tenesa A, Goldstein DB, Satsangi J (2006) ABCB1/MDR1 gene determines susceptibility and phenotype in ulcerative colitis: discrimination of critical variants using a gene-wide haplotype tagging approach. Hum Mol Genet 15:797-805
-
(2006)
Hum Mol Genet
, vol.15
, pp. 797-805
-
-
Ho, G.T.1
Soranzo, N.2
Nimmo, E.R.3
Tenesa, A.4
Goldstein, D.B.5
Satsangi, J.6
-
15
-
-
0034724324
-
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
-
Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U (2000) Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 97:3473-3478
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 3473-3478
-
-
Hoffmeyer, S.1
Burk, O.2
Von Richter, O.3
Arnold, H.P.4
Brockmoller, J.5
Johne, A.6
Cascorbi, I.7
Gerloff, T.8
Roots, I.9
Eichelbaum, M.10
Brinkmann, U.11
-
16
-
-
0030610799
-
Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons
-
Huang J, Casida JE (1997) Avermectin B1a binds to high- and low-affinity sites with dual effects on the gamma-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons. J Pharmacol Exp Ther 281:261-266
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 261-266
-
-
Huang, J.1
Casida, J.E.2
-
17
-
-
16644381719
-
Pharmacogenomics of drug transporters: A new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1)
-
Ishikawa T, Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui S (2004) Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1). Biol Pharm Bull 27:939-948
-
(2004)
Biol Pharm Bull
, vol.27
, pp. 939-948
-
-
Ishikawa, T.1
Onishi, Y.2
Hirano, H.3
Oosumi, K.4
Nagakura, M.5
Tarui, S.6
-
18
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano RL, Ling V (1976) A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152-162
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
19
-
-
33644781452
-
Implications of genetic polymorphisms in drug transporters for pharmacotherapy
-
Kerb R (2006) Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 234:4-33
-
(2006)
Cancer Lett
, vol.234
, pp. 4-33
-
-
Kerb, R.1
-
20
-
-
17644445622
-
Transporters and xenobiotic disposition
-
Kim RB (2002) Transporters and xenobiotic disposition. Toxicology 181-182:291-297
-
(2002)
Toxicology
, vol.181-182
, pp. 291-297
-
-
Kim, R.B.1
-
21
-
-
33744547260
-
Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrugresistant epilepsy
-
Kim DW, Kim M, Lee SK, Kang R, Lee SY (2006) Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrugresistant epilepsy. Seizure 15:344-347
-
(2006)
Seizure
, vol.15
, pp. 344-347
-
-
Kim, D.W.1
Kim, M.2
Lee, S.K.3
Kang, R.4
Lee, S.Y.5
-
22
-
-
0036082545
-
Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system
-
Kimchi-Sarfaty C, Gribar JJ, Gottesman MM (2002) Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system. Mol Pharmacol 62:1-6
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1-6
-
-
Kimchi-Sarfaty, C.1
Gribar, J.J.2
Gottesman, M.M.3
-
23
-
-
0030891791
-
Adult and infant abamectin exposures following Avert 310 and pressurized gel crack and crevice treatment
-
Krieger RI, Rosenheck LA, Schuester LL (1997) Adult and infant abamectin exposures following Avert 310 and pressurized gel crack and crevice treatment. Bull Environ Contam Toxicol 58:681-687
-
(1997)
Bull Environ Contam Toxicol
, vol.58
, pp. 681-687
-
-
Krieger, R.I.1
Rosenheck, L.A.2
Schuester, L.L.3
-
24
-
-
10744222684
-
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene
-
Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG (2003) Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics 13:481-494
-
(2003)
Pharmacogenetics
, vol.13
, pp. 481-494
-
-
Kroetz, D.L.1
Pauli-Magnus, C.2
Hodges, L.M.3
Huang, C.C.4
Kawamoto, M.5
Johns, S.J.6
Stryke, D.7
Ferrin, T.E.8
Deyoung, J.9
Taylor, T.10
Carlson, E.J.11
Herskowitz, I.12
Giacomini, K.M.13
Clark, A.G.14
-
25
-
-
0032906888
-
Disposition of ivermectin and cyclosporin a in CF-1 mice deficient in mdr1a P-glycoprotein
-
Kwei GY, Alvaro RF, Chen Q, Jenkins HJ, Hop CE, Keohane CA, Ly VT, Strauss JR, Wang RW, Wang Z, Pippert TR, Umbenhauer DR (1999) Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein. Drug Metab Dispos 27:581-587
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 581-587
-
-
Kwei, G.Y.1
Alvaro, R.F.2
Chen, Q.3
Jenkins, H.J.4
Hop, C.E.5
Keohane, C.A.6
Ly, V.T.7
Strauss, J.R.8
Wang, R.W.9
Wang, Z.10
Pippert, T.R.11
Umbenhauer, D.R.12
-
26
-
-
0024450060
-
Effects of ivermectin on reproduction and neonatal toxicity in rats
-
Lankas GR, Minsker DH, Robertson RT (1989) Effects of ivermectin on reproduction and neonatal toxicity in rats. Food Chem Toxicol 27:523-529
-
(1989)
Food Chem Toxicol
, vol.27
, pp. 523-529
-
-
Lankas, G.R.1
Minsker, D.H.2
Robertson, R.T.3
-
27
-
-
0030972417
-
P-Glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity
-
Lankas GR, Cartwright ME, Umbenhauer D (1997) P-Glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol Appl Pharmacol 143:357-365
-
(1997)
Toxicol Appl Pharmacol
, vol.143
, pp. 357-365
-
-
Lankas, G.R.1
Cartwright, M.E.2
Umbenhauer, D.3
-
28
-
-
0032129118
-
Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice
-
Lankas GR, Wise LD, Cartwright ME, Pippert T, Umbenhauer DR (1998) Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice. Reprod Toxicol 12:457-463
-
(1998)
Reprod Toxicol
, vol.12
, pp. 457-463
-
-
Lankas, G.R.1
Wise, L.D.2
Cartwright, M.E.3
Pippert, T.4
Umbenhauer, D.R.5
-
29
-
-
0542423220
-
Correlation of actual strawberry harvester exposure with that predicted from abamectin dislodgeable foliar residues
-
Lanning CL, Wehner TA, Norton JA, Dunbar DM, Grosso LS (1997) Correlation of actual strawberry harvester exposure with that predicted from abamectin dislodgeable foliar residues. J Agric Food Chem 46:2340-2345
-
(1997)
J Agric Food Chem
, vol.46
, pp. 2340-2345
-
-
Lanning, C.L.1
Wehner, T.A.2
Norton, J.A.3
Dunbar, D.M.4
Grosso, L.S.5
-
30
-
-
31344432977
-
Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein
-
3
-
Lecoeur S, Videmann B, Mazallon M (2006) Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. M Toxicol Lett 161(3):200-209
-
(2006)
M Toxicol Lett
, vol.161
, pp. 200-209
-
-
Lecoeur, S.1
Videmann, B.2
Mazallon, M.3
-
31
-
-
34447541522
-
ABCB1 genotype and PGP expression, function and therapeutic drug response: A critical review and recommendations for future research
-
online publication
-
Leschziner GD, Andrew T, Pirmohamed M, Johnson MR (2006a) ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics J. Advanced online publication
-
(2006)
Pharmacogenomics J. Advanced
-
-
Leschziner, G.D.1
Andrew, T.2
Pirmohamed, M.3
Johnson, M.R.4
-
32
-
-
33744501248
-
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance
-
Leschziner G, Zabaneh D, Pirmohamed M, Owen A, Rogers J, Coffey AJ, Balding DJ, Bentley DB, Johnson MR (2006b) Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenet Genomics 16:439-450
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 439-450
-
-
Leschziner, G.1
Zabaneh, D.2
Pirmohamed, M.3
Owen, A.4
Rogers, J.5
Coffey, A.J.6
Balding, D.J.7
Bentley, D.B.8
Johnson, M.R.9
-
33
-
-
17544368685
-
Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
-
Leslie EM, Deeley RG, Cole SP (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204:216-237
-
(2005)
Toxicol Appl Pharmacol
, vol.204
, pp. 216-237
-
-
Leslie, E.M.1
Deeley, R.G.2
Cole, S.P.3
-
34
-
-
32044453808
-
Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux
-
Loo TW, Clarke DM (2005) Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux. J Membr Biol 206:173-185
-
(2005)
J Membr Biol
, vol.206
, pp. 173-185
-
-
Loo, T.W.1
Clarke, D.M.2
-
35
-
-
1642523162
-
Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
-
Marzolini C, Paus E, Buclin T, Kim RB (2004) Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther 75:13-33
-
(2004)
Clin Pharmacol Ther
, vol.75
, pp. 13-33
-
-
Marzolini, C.1
Paus, E.2
Buclin, T.3
Kim, R.B.4
-
36
-
-
0033526533
-
Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain
-
Matsuoka Y, Okazaki M, Kitamura Y, Taniguchi T (1999) Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain. J Neurobiol 39:383-392
-
(1999)
J Neurobiol
, vol.39
, pp. 383-392
-
-
Matsuoka, Y.1
Okazaki, M.2
Kitamura, Y.3
Taniguchi, T.4
-
37
-
-
0035164622
-
Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene
-
Mealey KL, Bentjen SA, Gay JM, Cantor GH (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11:727-733
-
(2001)
Pharmacogenetics
, vol.11
, pp. 727-733
-
-
Mealey, K.L.1
Bentjen, S.A.2
Gay, J.M.3
Cantor, G.H.4
-
38
-
-
0038323843
-
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities
-
Morita N, Yasumori T, Nakayama K (2003) Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities. Biochem Pharmacol 65:1843-1852
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1843-1852
-
-
Morita, N.1
Yasumori, T.2
Nakayama, K.3
-
39
-
-
10844238220
-
Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects
-
Moriya Y, Nakamura T, Horinouchi M, Sakaeda T, Tamura T, Aoyama N, Shirakawa T, Gotoh A, Fujimoto S, Matsuo M, Kasuga M, Okumura K (2002) Effects of polymorphisms of MDR1, MRP1, and MRP2 genes on their mRNA expression levels in duodenal enterocytes of healthy Japanese subjects. Biol Pharm Bull 25:1356-1359
-
(2002)
Biol Pharm Bull
, vol.25
, pp. 1356-1359
-
-
Moriya, Y.1
Nakamura, T.2
Horinouchi, M.3
Sakaeda, T.4
Tamura, T.5
Aoyama, N.6
Shirakawa, T.7
Gotoh, A.8
Fujimoto, S.9
Matsuo, M.10
Kasuga, M.11
Okumura, K.12
-
40
-
-
33646545352
-
A T3587G germline mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein
-
Mutoh K, Mitsuhashi J, Kimura Y, Tsukahara S, Ishikawa E, Sai K, Ozawa S, Sawada J, Ueda K, Katayama K, Sugimoto Y (2006) A T3587G germline mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein. Mol Cancer Ther 5:877-884
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 877-884
-
-
Mutoh, K.1
Mitsuhashi, J.2
Kimura, Y.3
Tsukahara, S.4
Ishikawa, E.5
Sai, K.6
Ozawa, S.7
Sawada, J.8
Ueda, K.9
Katayama, K.10
Sugimoto, Y.11
-
41
-
-
0041410061
-
Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: Detection of a novel mutation G816A in the human MRP1 gene
-
Oselin K, Mrozikiewicz PM, Gaikovitch E, Pahkla R, Roots I (2003) Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene. Eur J Clin Pharmacol 59:347-350
-
(2003)
Eur J Clin Pharmacol
, vol.59
, pp. 347-350
-
-
Oselin, K.1
Mrozikiewicz, P.M.2
Gaikovitch, E.3
Pahkla, R.4
Roots, I.5
-
42
-
-
0024957514
-
Community-based treatment of onchocerciasis with ivermectin: Acceptability and early adverse reactions
-
Pacque MC, Dukuly Z, Greene BM, Munoz B, Keyvan-Larijani E, Williams PN, Taylor HR (1989) Community-based treatment of onchocerciasis with ivermectin: acceptability and early adverse reactions. Bull World Health Organ 67:721-730
-
(1989)
Bull World Health Organ
, vol.67
, pp. 721-730
-
-
Pacque, M.C.1
Dukuly, Z.2
Greene, B.M.3
Munoz, B.4
Keyvan-Larijani, E.5
Williams, P.N.6
Taylor, H.R.7
-
43
-
-
0035049879
-
The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene
-
Pippert TR, Umbenhauer DR (2001) The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene. J Biochem Mol Toxicol 15:83-89
-
(2001)
J Biochem Mol Toxicol
, vol.15
, pp. 83-89
-
-
Pippert, T.R.1
Umbenhauer, D.R.2
-
44
-
-
8844229534
-
Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
-
Potocnik U, Ferkolj I, Glavac D, Dean M (2004) Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun 5:530-539
-
(2004)
Genes Immun
, vol.5
, pp. 530-539
-
-
Potocnik, U.1
Ferkolj, I.2
Glavac, D.3
Dean, M.4
-
45
-
-
30144438738
-
Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C->T polymorphism at the multidrug resistance gene 1
-
Rodriguez Novoa S, Barreiro P, Rendon A, Barrios A, Corral A, Jimenez-Nacher I, Gonzalez-Lahoz J, Soriano V (2006) Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C->T polymorphism at the multidrug resistance gene 1. Clin Infect Dis 42:291-295
-
(2006)
Clin Infect Dis
, vol.42
, pp. 291-295
-
-
Rodriguez Novoa, S.1
Barreiro, P.2
Rendon, A.3
Barrios, A.4
Corral, A.5
Jimenez-Nacher, I.6
Gonzalez-Lahoz, J.7
Soriano, V.8
-
46
-
-
32044455207
-
MDR1 genotype-related pharmacokinetics: Fact or fiction?
-
Sakaeda T (2005) MDR1 genotype-related pharmacokinetics: fact or fiction? Drug Metab Pharmacokinet 20:391-414
-
(2005)
Drug Metab Pharmacokinet
, vol.20
, pp. 391-414
-
-
Sakaeda, T.1
-
47
-
-
33751082940
-
In-vitro transport characteristics discriminate wild-type ABCB1(MDR1) from ALA893SER and ALA893THR polymorphisms
-
Schaefer M, Roots I, Gerloff T, (2006) In-vitro transport characteristics discriminate wild-type ABCB1(MDR1) from ALA893SER and ALA893THR polymorphisms. Pharmacogenet Genomics 16:855-861
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 855-861
-
-
Schaefer, M.1
Roots, I.2
Gerloff, T.3
-
48
-
-
0035806748
-
Frequency of C3435T polymorphism of MDR1 gene in African people
-
Schaeffeler E, Eichelbaum M, Brinkmann U, Penger A, Asante-Poku S, Zanger UM, Schwab M (2001) Frequency of C3435T polymorphism of MDR1 gene in African people. Lancet 358:383-384
-
(2001)
Lancet
, vol.358
, pp. 383-384
-
-
Schaeffeler, E.1
Eichelbaum, M.2
Brinkmann, U.3
Penger, A.4
Asante-Poku, S.5
Zanger, U.M.6
Schwab, M.7
-
49
-
-
0037457802
-
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
-
Schinkel AH, Jonker JW (2003) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 55:3-29
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 3-29
-
-
Schinkel, A.H.1
Jonker, J.W.2
-
50
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP et al (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.10
-
51
-
-
0030838009
-
The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain
-
Schumacher U, Mollgard K (1997) The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain. Histochem Cell Biol 108:179-182
-
(1997)
Histochem Cell Biol
, vol.108
, pp. 179-182
-
-
Schumacher, U.1
Mollgard, K.2
-
52
-
-
33645993917
-
New light on multidrug binding by an ATP-binding cassette transporter
-
4
-
Shilling RA, Venter H, Velamakanni S, Bapna A, Woebking B, Shahi S, van Veen HW (2006) New light on multidrug binding by an ATP-binding cassette transporter. Trends Pharmacol Sci 27(4):195-203
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 195-203
-
-
Shilling, R.A.1
Venter, H.2
Velamakanni, S.3
Bapna, A.4
Woebking, B.5
Shahi, S.6
Van Veen, H.W.7
-
53
-
-
0037431040
-
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
-
Siddiqui A, Kerb R, Weale ME, Brinkmann U, Smith A, Goldstein DB, Wood NW, Sisodiya SM (2003) Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med 348:1442-1448
-
(2003)
N Engl J Med
, vol.348
, pp. 1442-1448
-
-
Siddiqui, A.1
Kerb, R.2
Weale, M.E.3
Brinkmann, U.4
Smith, A.5
Goldstein, D.B.6
Wood, N.W.7
Sisodiya, S.M.8
-
54
-
-
18244365827
-
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment
-
Sills GJ, Mohanraj R, Butler E, McCrindle S, Collier L, Wilson EA, Brodie MJ (2005) Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment. Epilepsia 46:643-647
-
(2005)
Epilepsia
, vol.46
, pp. 643-647
-
-
Sills, G.J.1
Mohanraj, R.2
Butler, E.3
McCrindle, S.4
Collier, L.5
Wilson, E.A.6
Brodie, M.J.7
-
55
-
-
1242349778
-
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers
-
Skarke C, Jarrar M, Schmidt H, Kauert G, Langer M, Geisslinger G, Lotsch J (2003) Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics 13:651-660
-
(2003)
Pharmacogenetics
, vol.13
, pp. 651-660
-
-
Skarke, C.1
Jarrar, M.2
Schmidt, H.3
Kauert, G.4
Langer, M.5
Geisslinger, G.6
Lotsch, J.7
-
56
-
-
0032701128
-
Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure
-
10
-
Smit JW, Huisman MT, van Tellingen O, Wiltshire HR, Schinkel AH. (1999) Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. J Clin Invest 104(10):1441-1447
-
(1999)
J Clin Invest
, vol.104
, pp. 1441-1447
-
-
Smit, J.W.1
Huisman, M.T.2
Van Tellingen, O.3
Wiltshire, H.R.4
Schinkel, A.H.5
-
57
-
-
33645916733
-
Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation
-
Sun M, Kingdom J, Baczyk D, Lye SJ, Matthews SG, Gibb W (2006) Expression of the multidrug resistance P-glycoprotein, (ABCB1 glycoprotein) in the human placenta decreases with advancing gestation. Placenta 27:602-609
-
(2006)
Placenta
, vol.27
, pp. 602-609
-
-
Sun, M.1
Kingdom, J.2
Baczyk, D.3
Lye, S.J.4
Matthews, S.G.5
Gibb, W.6
-
58
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5:219-234
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
59
-
-
10044270854
-
Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene
-
Takane H, Kobayashi D, Hirota T, Kigawa J, Terakawa N, Otsubo K, Ieiri I (2004) Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene. J Pharmacol Exp Ther 311:1179-1187
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 1179-1187
-
-
Takane, H.1
Kobayashi, D.2
Hirota, T.3
Kigawa, J.4
Terakawa, N.5
Otsubo, K.6
Ieiri, I.7
-
60
-
-
33750587112
-
Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil
-
Takano A, Kusuhara H, Suhara T, Ieiri I, Morimoto T, Lee YJ, Maeda J, Ikoma Y, Ito H, Suzuki K, Sugiyama Y (2006) Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil. J Nucl Med 47:1427-1433
-
(2006)
J Nucl Med
, vol.47
, pp. 1427-1433
-
-
Takano, A.1
Kusuhara, H.2
Suhara, T.3
Ieiri, I.4
Morimoto, T.5
Lee, Y.J.6
Maeda, J.7
Ikoma, Y.8
Ito, H.9
Suzuki, K.10
Sugiyama, Y.11
-
61
-
-
0034997034
-
Expression of P-glycoprotein in human placenta: Relation to genetic
-
Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, Takahashi M, Kurata Y, Kigawa J, Higuchi S, Terakawa N, Otsubo K (2001) Expression of P-glycoprotein in human placenta: relation to genetic. J Pharmacol Exp Ther 297:1137-1143
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 1137-1143
-
-
Tanabe, M.1
Ieiri, I.2
Nagata, N.3
Inoue, K.4
Ito, S.5
Kanamori, Y.6
Takahashi, M.7
Kurata, Y.8
Kigawa, J.9
Higuchi, S.10
Terakawa, N.11
Otsubo, K.12
-
62
-
-
0023447098
-
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
63
-
-
0030963724
-
Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism
-
Umbenhauer DR, Lankas GR, Pippert TR, Wise LD, Cartwright ME, Hall SJ, Beare CM (1997) Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism. Toxicol Appl Pharmacol 146:88-94
-
(1997)
Toxicol Appl Pharmacol
, vol.146
, pp. 88-94
-
-
Umbenhauer, D.R.1
Lankas, G.R.2
Pippert, T.R.3
Wise, L.D.4
Cartwright, M.E.5
Hall, S.J.6
Beare, C.M.7
-
64
-
-
0034700265
-
Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein
-
Urbatsch IL, Julien M, Carrier I, Rousseau ME, Cayrol R, Gros P (2000) Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein. Biochemistry 39:14138-14149
-
(2000)
Biochemistry
, vol.39
, pp. 14138-14149
-
-
Urbatsch, I.L.1
Julien, M.2
Carrier, I.3
Rousseau, M.E.4
Cayrol, R.5
Gros, P.6
-
65
-
-
0037955805
-
Digoxin pharmacokinetics and MDR1 genetic polymorphisms
-
Verstuyft C, Schwab M, Schaeffeler E, Kerb R, Brinkmann U, Jaillon P, Funck-Brentano C, Becquemont L (2003) Digoxin pharmacokinetics and MDR1 genetic polymorphisms. Eur J Clin Pharmacol 58:809-812
-
(2003)
Eur J Clin Pharmacol
, vol.58
, pp. 809-812
-
-
Verstuyft, C.1
Schwab, M.2
Schaeffeler, E.3
Kerb, R.4
Brinkmann, U.5
Jaillon, P.6
Funck-Brentano, C.7
Becquemont, L.8
-
66
-
-
25144433260
-
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C > T affects mRNA stability
-
Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W (2005) Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C > T affects mRNA stability. Pharmacogenet Genomics 15:693-704
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 693-704
-
-
Wang, D.1
Johnson, A.D.2
Papp, A.C.3
Kroetz, D.L.4
Sadee, W.5
-
67
-
-
1442277718
-
The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function
-
Woodahl EL, Ho RJ (2004) The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr Drug Metab 5:11-19
-
(2004)
Curr Drug Metab
, vol.5
, pp. 11-19
-
-
Woodahl, E.L.1
Ho, R.J.2
-
68
-
-
33750454081
-
Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients
-
7
-
Xing Q, Gao R, Li H, Feng G, Xu M, Duan S, Meng J, Zhang A, Qin S, He L (2006) Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics 7(7):987-993
-
(2006)
Pharmacogenomics
, vol.7
, pp. 987-993
-
-
Xing, Q.1
Gao, R.2
Li, H.3
Feng, G.4
Xu, M.5
Duan, S.6
Meng, J.7
Zhang, A.8
Qin, S.9
He, L.10
-
69
-
-
7944236606
-
A variant 2677A allele of the MDR1 gene affects fexofenadine disposition
-
Yi SY, Hong KS, Lim HS, Chung JY, Oh DS, Kim JR, Jung HR, Cho JY, Yu KS, Jang IJ, Shin SG (2004) A variant 2677A allele of the MDR1 gene affects fexofenadine disposition. Clin Pharmacol Ther 76:418-427
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 418-427
-
-
Yi, S.Y.1
Hong, K.S.2
Lim, H.S.3
Chung, J.Y.4
Oh, D.S.5
Kim, J.R.6
Jung, H.R.7
Cho, J.Y.8
Yu, K.S.9
Jang, I.J.10
Shin, S.G.11
-
70
-
-
4644305242
-
Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy
-
Zimprich F, Sunder-Plassmann R, Stogmann E, Gleiss A, Dal-Bianco A, Zimprich A, Plumer S, Baumgartner C, Mannhalter C (2004) Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology 63:1087-1089
-
(2004)
Neurology
, vol.63
, pp. 1087-1089
-
-
Zimprich, F.1
Sunder-Plassmann, R.2
Stogmann, E.3
Gleiss, A.4
Dal-Bianco, A.5
Zimprich, A.6
Plumer, S.7
Baumgartner, C.8
Mannhalter, C.9
|