Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl) -6-pyrrolidinylquinolin-4-one as a potent anticancer lead

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5223-5227

  Cheng, Yung Yi ^a   Liu, Chin Yu ^a   Tsai, Meng Tung ^a   Lin, Hui Yi ^a   Yang, Jai Sing ^a   Wu, Tian Shung ^b   Kuo, Sheng Chu ^a,c   Huang, Li Jiau ^a   Lee, Kuo Hsiung ^c,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

2 (Hydroxyphenyl)quinolin 4 one derivatives; Anticancer lead development; Antiproliferative activity; Prodrug

Indexed keywords

2 (3 HYDROXY 5 METHOXYPHENYL) 6 PYRROLIDINYLQUINOLIN 4 ONE; 5 TRITYL CYSTEINE; 6 DIAZO 5 OXONORLEUCINE; 6 SUBSTITUTED 2 (HYDROXYL SUBSTITUTED PHENYL)QUINOLIN 4 ONE DERIVATIVE; 6,7 SUBSTITUTED 2 (HYDROXYL SUBSTITUTED PHENYL)QUINOLIN 4 ONE DERIVATIVE; ACIVICIN; ANTINEOPLASTIC AGENT; CYSTEINE DERIVATIVE; DIDEMNIN B; MAYTANSINE; QUINOLINE DERIVATIVE; RHIZOXIN; TIAZOFURIN; TRIMETREXATE; UNCLASSIFIED DRUG; VINCRISTINE; VINCRISTINE SULFATE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; STRUCTURE ACTIVITY RELATION;

2-(HYDROXYPHENYL)QUINOLIN-4-ONE DERIVATIVES; ANTICANCER LEAD DEVELOPMENT; ANTIPROLIFERATIVE ACTIVITY; PRODRUG;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PYRROLIDINES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882705514     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.083     Document Type: Article

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