Enhanced Nasal Mucosal Delivery and Immunogenicity of Anti-Caries DNA Vaccine through Incorporation of Anionic Liposomes in Chitosan/DNA Complexes

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Chen, Liulin ^a   Zhu, Junming ^a   Li, Yuhong ^b   Lu, Jie ^a   Gao, Li ^a   Xu, Huibi ^a   Fan, Mingwen ^b   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN; DNA VACCINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LIPOSOME; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENZYME DEGRADATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IN VITRO STUDY; LIGHT SCATTERING; MEMBRANE PERMEABILITY; MORPHOLOGY; MOUSE; MUCOSAL ADMINISTRATION; NANOENCAPSULATION; NANOTECHNOLOGY; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, INTRANASAL; ADSORPTION; ANIMALS; ANIONS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; CACO-2 CELLS; CELL SURVIVAL; CHITOSAN; DENTAL CARIES; DNA, BACTERIAL; FEMALE; HEK293 CELLS; HUMANS; IMMUNITY, ACTIVE; IMMUNITY, MUCOSAL; LIPOSOMES; MICE; MICE, INBRED BALB C; MICE, NUDE; MUCINS; NANOCAPSULES; NASAL MUCOSA; PARTICLE SIZE; RATS; SALIVA; STREPTOCOCCUS MUTANS; VACCINATION; VACCINES, DNA;

EID: 84882683926     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071953     Document Type: Article

References (53)

1. Gurunathan S, Klinman DM, Seder RA, (2000) DNA vaccines: Immunology, application, and optimization. Annual Review of Immunology 18: 927-974.
2. Liu MA, (1997) The immunologist's grail: Vaccines that generate cellular immunity. PNAS 94: 10496-10498.
3. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Felgner PL, et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745-1749.
4. Wang B, Ugen KE, Srikantan V, Agadjanyan MG, Dang K, et al. (1993) Gene inoculation generates immune responses against human immunodeficiency virus type 1. PNAS 90: 4156-4160.
5. Barackman JD, Ott G, O'Hagan DT, (1999) Intranasal immunization of mice with influenza vaccine in combination with the adjuvant LT-R72 induces potent mucosal and serum immunity which is stronger than that with traditional intramuscular immunization. Infect Immun 67: 4276-4279.
6. Zhou X, Zhang X, Yu X, Zha X, Fu Q, et al. (2008) The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine. Biomaterials 29: 111-117.
7. Wang X, Zhang XY, Kang YM, Jin HL, Du XG, et al. (2008) Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus. Vaccine 26: 5135-5144.
8. Khatri K, Goyal AK, Gupta PN, Mishra N, Mehta A, et al. (2008) Surface modified liposomes for nasal delivery of DNA vaccine. Vaccine 26: 2225-2233.
9. Debin A, Kravtzoff R, Santiago JV, Cazales L, Sperandio S, et al. (2002) Intranasal immunization with recombinant antigens associated with new cationic particles induces strong mucosal as well as systemic antibody and CTL responses. Vaccine 20: 2752-2763.
10. Guo JH, Jia R, Fan MW, Bian Z, Chen Z, et al. (2004) Construction and immunogenic characterization of a fusion anti-caries DNA vaccine against PAc and glucosyltransferase I of Streptococcus mutans. J Dent Res 83: 266-270.
11. Fan MW, Bian Z, Peng ZX, Zhong Y, Chen Z, et al. (2002) A DNA vaccine encoding a cell-surface protein antigen of Streptococcus mutans protects gnotobiotic rats from caries. J Dent Res 81: 784-787.
12. Jia R, Guo JH, Fan MW, Bian Z, Chen Z, et al. (2006) Immunogenicity of CTLA4 fusion anti-caries DNA vaccine in rabbits and monkeys. Vaccine 24: 5192-5200.
13. Xu QA, Yu F, Fan MW, Bian Z, Guo JH, et al. (2005) Immunogenicity and protective efficacy of a targeted fusion DNA construct against dental caries. Caries Res 39: 422-431.
14. Xu QA, Yu F, Fan MW, Bian Z, Chen Z, et al. (2006) Immunogenicity and persistence of a targeted anti-caries DNA vaccine. J Dent Res 85: 915-918.
15. Wang D, Christopher ME, Nagata LP, Zabielski MA, Li H, et al. (2004) Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses. J Clin Viro 31: 99-106.
16. Liu GX, Xu QA, Jin J, Li YH, Jia R, et al. (2009) Mucosal and systemic immunization with targeted fusion anti-caries DNA plasmid in young rats. Vaccine 27: 2940-2947.
17. Csaba N, Garcia-Fuentes M, Alonso MJ, (2009) Nanoparticles for nasal vaccination. Adv Drug Deliver Rev 61: 140-157.
18. van der Lubben IM, Verhoef JC, Borchard G, Junginger HE, (2001) Chitosan for mucosal vaccination. Adv Drug Deliver Rev 52: 139-144.
19. Khatri K, Goyal AK, Gupta PN, Mishra N, Vyas SP, (2008) Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B. Int J Pharmaceut. 354: 235-241.
20. Raghuwanshi D, Mishra V, Das D, Kaur K, Suresh MR, (2012) Dendritic Cell Targeted Chitosan Nanoparticles for Nasal DNA Immunization against SARS CoV Nucleocapsid Protein. Mol Pharmaceut 9: 946-956.
21. Chae SY, Son S, Lee M, Jang MK, Nah JW, (2005) Deoxycholic acid-conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier. J Control Release 109: 330-344.
22. Mansouri S, Cuie Y, Winnik F, Shi Q, Lavigne P, et al. (2006) Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 27: 2060-2065.
23. Douglas KL, Piccirillo CA, Tabrizian M, (2006) Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release 115: 354-361.
24. Peng SF, Yang MJ, Su CJ, Chen HL, Lee PW, et al. (2009) Effects of incorporation of poly([gamma]-glutamic acid) in chitosan/DNA complex nanoparticles on cellular uptake and transfection efficiency. Biomaterials 30: 1797-1808.
25. Lee PW, Hsu SH, Tsai JS, Chen FR, Huang PJ, et al. (2010) Multifunctional core-shell polymeric nanoparticles for transdermal DNA delivery and epidermal Langerhans cells tracking. Biomaterials 31: 2425-2434.
26. Srinivasan C, Burgess DJ, (2009) Optimization and characterization of anionic lipoplexes for gene delivery. J Control Release 71: 445-462.
27. Fillion P, Desjardins A, Sayasith K, Lagace J, (2001) Encapsulation of DNA in negatively charged liposomes and inhibition of bacterial gene expression with fluid liposome-encapsulated antisense oligonucleotides. BBA-Biomembranes 1515: 44-54.
28. Filion MC, Phillips NC, (1997) Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells. BBA-Biomembranes 1329: 345-356.
29. Aramaki Y, Tomizawa H, Hara T, Yachi K, Kikuchi H, et al. (1993) Stability of Liposomes in Vitro and Their Uptake by Rat Peyer's Patches Following Oral Administration. Pharm Res 10: 1228-1231.
30. He P, Davis SS, Illum L, (1998) In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int J Pharmaceut 166: 75-88.
31. Hagenaars N, Mania M, de Jong P, Que I, Nieuwland R, et al. (2010) Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine. J Control Release144: 17-24.
32. Lavertu M, Methot S, Tran-Khanh N, Buschmann MD, (2006) High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation. Biomaterials 27: 4815-4824.
33. Bot A, Bona C, (2002) Genetic immunization of neonates. Microbes Infect 4: 511-520.
34. Vaughan K, Rhodes GH, Gershwin LJ, (2005) DNA immunization against respiratory syncytial virus (RSV) in infant rhesus monkeys. Vaccine 23: 2928-2942.
35. Liu C, Fan M, Bian Z, Chen Z, Li Y, (2008) Effects of targeted fusion anti-caries DNA vaccine pGJA-P/VAX in rats with caries. Vaccine 26: 6685-6689.
36. Sandén T, Salomonsson L, Brzezinski P, Widengren J, (2010) Surface-coupled proton exchange of a membrane-bound proton acceptor. PNAS 107: 4129-4134.
37. Lin YH, Chen CT, Liang HF, Kulkarni AR, Lee PW, et al. (2007) Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology 18: 10-20.
38. Liao ZX, Ho YC, Chen HL, Peng SF, Hsiao CW, et al. (2010) Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly([gamma]-glutamic acid). Biomaterials 31: 8780-8788.
39. Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA, (2000) Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol Bioeng 67: 598-606.
40. Szoka FC, Xu Y, Zelphati O, (1997) How are nucleic acids released in cells from cationic lipid-nucleic acid complexes? Adv Drug Deliver Rev 24: 291-291.
41. Akita H, Kudo A, Minoura A, Yamaguti M, Khalil IA, et al. (2009) Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process. Biomaterials 30: 2940-2949.
42. England RJA, Homer JJ, Knight LC, Ell SR, (1999) Nasal pH measurement: a reliable and repeatable parameter. Clin Otolaryngol 24: 67-68.
43. Slutter B, Bal SM, Que I, Kaijzel E, Lowik C, et al. (2010) Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles? Mol Pharmaceut 7: 2207-2215.
44. Natsume H, Iwata S, Ohtake K, Miyamoto M, Yamaguchi M, et al. (1999) Screening of cationic compounds as an absorption enhancer for nasal drug delivery. Int J Pharmaceut 185: 1-12.
45. Illum L, (1998) Chitosan and its use as a pharmaceutical excipient. Pharm Res 15: 1326-1331.
46. Hamman JH, Stander M, Kotze AF, (2002) Effect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. Int J Pharmaceut 232: 235-242.
47. Slutter B, Bal SM, Que I, Kaijzel E, Lowik C, et al. (2010) Antigen-djuvant Nanoconjugates for Nasal Vaccination: An Improvement over the Use of Nanoparticles? Mol Pharmaceut 7: 2207-2215.
48. Chavanpatil MD, Khdair A, Panyam J, (2006) Nanoparticles for cellular drug delivery: Mechanisms and factors influencing delivery. J Nanosci Nanotechno 6: 2651-2663.
49. Nam HY, Kwon SM, Chung H, Lee SY, Kwon SH, et al. (2009) Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles. J Control Release 135: 259-267.
50. Illum L, (2007) Nanoparticulate systems for nasal delivery of drugs: A real improvement over simple systems? J Pharm Sci 96: 473-483.
51. Jepson MA, Clark MA, Hirst BH, (2004) M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery. Adv Drug Deliver Rev 56: 511-525.
52. Nguyen DN, Green JJ, Chan JM, Longer R, Anderson DG, (2009) Polymeric Materials for Gene Delivery and DNA Vaccination. Adv Mater 21: 847-867.
53. Palumbo RN, Zhong X, Wang C, (2012) Polymer-mediated DNA vaccine delivery via bystander cells requires a proper balance between transfection efficiency and cytotoxicity. J Control Release 157: 86-93.