Screening of cationic compounds as an absorption enhancer for nasal drug delivery

International Journal of Pharmaceutics

Volumn 185, Issue 1, 1999, Pages 1-12

  Natsume, Hideshi ^a   Iwata, Satoko ^a   Ohtake, Kazuo ^a   Miyamoto, Misao ^b   Yamaguchi, Masatoshi ^c   Hosoya, Ken Ichi ^d   Kobayashi, Daisuke ^a   Sugibayashi, Kenji ^a   Morimoto, Yasunori ^a  

^a JOSAI UNIVERSITY   (Japan)

^b NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

^c Prefectural Kakizaki Hospital   (Japan)

^d Tohoku University   (Japan)

Author keywords

Absorption enhancer; FITC dextran; Hemolysis; Leaching of membrane components; Nasal peptide and protein delivery; Poly L arginine

Indexed keywords

ARGININE; CETYLPYRIDINIUM SALT; CHITOSAN; DEOXYCHOLATE SODIUM; DODECYL SULFATE SODIUM; EDETIC ACID; FLUORESCEIN ISOTHIOCYANATE; GLYCOCHOLATE SODIUM; LYSOPHOSPHATIDYLCHOLINE; PENETRATION ENHANCING AGENT; POLIDOCANOL; POLYARGININE; POLYSACCHARIDE; TAUROCHOLIC ACID; TAURODIHYDROFUSIDATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; ERYTHROCYTE; HEMOLYSIS; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEACHING; NONHUMAN; NOSE MUCOSA; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ABSORPTION; ADMINISTRATION, INTRANASAL; ANIMALS; AREA UNDER CURVE; ARGININE; CATIONS; CETYLPYRIDINIUM; CHITIN; CHITOSAN; DEXTRANS; DRUG SYNERGISM; ERYTHROCYTES; FLUORESCEIN-5-ISOTHIOCYANATE; HEMOLYSIS; INJECTIONS, INTRAVENOUS; L-LACTATE DEHYDROGENASE; LYSINE; MALE; NASAL MUCOSA; PEPTIDES; PHOSPHOLIPIDS; PROTEINS; RABBITS; RATS; RATS, WISTAR; SURFACE-ACTIVE AGENTS;

EID: 0032810369     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00100-3     Document Type: Article

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