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Volumn 8, Issue 8, 2013, Pages

Theoretical Predictions of Lactate and Hydrogen Ion Distributions in Tumours

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); GAP JUNCTION PROTEIN; LACTIC ACID; PROTON;

EID: 84882634710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072020     Document Type: Article
Times cited : (2)

References (71)
  • 2
    • 52049101546 scopus 로고    scopus 로고
    • Tumor microenvironment and angiogenesis
    • Nyberg P, Salo T, Kalluri R, (2008) Tumor microenvironment and angiogenesis. Front Biosci 1: 6537-6553.
    • (2008) Front Biosci , vol.1 , pp. 6537-6553
    • Nyberg, P.1    Salo, T.2    Kalluri, R.3
  • 3
    • 0042031680 scopus 로고    scopus 로고
    • Tumor microenvironment and the response to anticancer therapy (review)
    • Brown JM, (2002) Tumor microenvironment and the response to anticancer therapy (review). Cancer Biol Ther 1: 453-458.
    • (2002) Cancer Biol Ther , vol.1 , pp. 453-458
    • Brown, J.M.1
  • 4
    • 4344643796 scopus 로고    scopus 로고
    • Relevance of tumor microenvi ronment for progression, therapy and drug development (review)
    • Henning T, Krausb M, Brischweina M, Ottoa AM, Wolfa B, (2004) Relevance of tumor microenvi ronment for progression, therapy and drug development (review). Anti-Cancer Drugs 15: 7-14.
    • (2004) Anti-Cancer Drugs , vol.15 , pp. 7-14
    • Henning, T.1    Krausb, M.2    Brischweina, M.3    Ottoa, A.M.4    Wolfa, B.5
  • 6
    • 0022559226 scopus 로고
    • Intracellular pH regulation in epithelial cells
    • Boron WF, (1986) Intracellular pH regulation in epithelial cells. Annu Rev Physiol 48: 377-388.
    • (1986) Annu Rev Physiol , vol.48 , pp. 377-388
    • Boron, W.F.1
  • 8
    • 0031033146 scopus 로고    scopus 로고
    • The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion
    • Parkins CS, Stratford MRL, Dennis MF, Stubbs M, Chaplin DJ, (1997) The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion. Brit J Cancer 75: 319-323.
    • (1997) Brit J Cancer , vol.75 , pp. 319-323
    • Parkins, C.S.1    Stratford, M.R.L.2    Dennis, M.F.3    Stubbs, M.4    Chaplin, D.J.5
  • 9
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouysségur J, Dayan F, Mazure N, (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.3
  • 10
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood ow in tumours
    • Raghunand N, Gatenby RA, Gillies RJ, (2003) Microenvironmental and cellular consequences of altered blood ow in tumours. Br J Radiol 76: S11-S22.
    • (2003) Br J Radiol , vol.76
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 11
    • 33746149756 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    • Rofstad EK, Mathiesen B, Kindem K, Galappathi K, (2006) Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 66: 6699-6707.
    • (2006) Cancer Res , vol.66 , pp. 6699-6707
    • Rofstad, E.K.1    Mathiesen, B.2    Kindem, K.3    Galappathi, K.4
  • 12
    • 0024379967 scopus 로고
    • Acid pH in tumours and its potenial for therapeutic exploitation
    • Tannock IF, Rotin D, (1989) Acid pH in tumours and its potenial for therapeutic exploitation. Cancer Res 49: 4373-4384.
    • (1989) Cancer Res , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 13
    • 0030739013 scopus 로고    scopus 로고
    • Mammalian cells adapted to growth at pH 6.7 have eleveted HSP27 levels and are resistant to cisplatin
    • Wachsberger PR, Landry J, Storck C, (1997) Mammalian cells adapted to growth at pH 6.7 have eleveted HSP27 levels and are resistant to cisplatin. Int J Hyperther 13: 251-255.
    • (1997) Int J Hyperther , vol.13 , pp. 251-255
    • Wachsberger, P.R.1    Landry, J.2    Storck, C.3
  • 15
    • 0242582266 scopus 로고    scopus 로고
    • Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition
    • Putney LK, Barber DL, (2003) Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem 278: 44645-4469.
    • (2003) J Biol Chem , vol.278 , pp. 44469-44645
    • Putney, L.K.1    Barber, D.L.2
  • 16
    • 4544246352 scopus 로고    scopus 로고
    • Alterations of intracellular pH homeostasis in apoptosis: origins and roles
    • Lagadic-Gossmann D, Huc L, Lecureur V, (2004) Alterations of intracellular pH homeostasis in apoptosis: origins and roles. Cell Death Differ 11: 953-961.
    • (2004) Cell Death Differ , vol.11 , pp. 953-961
    • Lagadic-Gossmann, D.1    Huc, L.2    Lecureur, V.3
  • 17
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
    • Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC, (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2: 318-325.
    • (2000) Nat Cell Biol , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 18
    • 23844449323 scopus 로고    scopus 로고
    • Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange
    • Stock C, Gassner B, Hauck CR, Arnold H, Mally S, et al. (2005) Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange. J Physiol 567: 225-238.
    • (2005) J Physiol , vol.567 , pp. 225-238
    • Stock, C.1    Gassner, B.2    Hauck, C.R.3    Arnold, H.4    Mally, S.5
  • 19
    • 85006768050 scopus 로고
    • The metabolism of tumours in the body
    • Warburg O, Wind F, Negelein E, (1926) The metabolism of tumours in the body. J Gen Physiol 8: 519-530.
    • (1926) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 21
    • 0025771650 scopus 로고
    • Are cancer cells acidic
    • Griffths JR, (1991) Are cancer cells acidic? Br J Cancer 3: 425-427.
    • (1991) Br J Cancer , vol.3 , pp. 425-427
    • Griffths, J.R.1
  • 22
    • 10344261592 scopus 로고    scopus 로고
    • In the beginning, there was the cell: cellular homeostasis
    • Romero MF, (2004) In the beginning, there was the cell: cellular homeostasis. Adv Physiol Educ 28: 135-138.
    • (2004) Adv Physiol Educ , vol.28 , pp. 135-138
    • Romero, M.F.1
  • 23
    • 0030951685 scopus 로고    scopus 로고
    • Acid modulation of HT29 cell growth and differentiation
    • Fitzgerald RC, Omary MB, Triadafilopoulos G, (1997) Acid modulation of HT29 cell growth and differentiation. J Cell Sci 110: 663-671.
    • (1997) J Cell Sci , vol.110 , pp. 663-671
    • Fitzgerald, R.C.1    Omary, M.B.2    Triadafilopoulos, G.3
  • 25
    • 0021922146 scopus 로고
    • Intracellular pH-regulating mechanisms for the squid axons: Relation between the external Na+ and HC dependences
    • Boron WF, (1985) Intracellular pH-regulating mechanisms for the squid axons: Relation between the external Na+ and HC dependences. J Gen Physiol 85: 325-345.
    • (1985) J Gen Physiol , vol.85 , pp. 325-345
    • Boron, W.F.1
  • 26
    • 62149125733 scopus 로고
    • The effect of pH on growth, protein synthesis, and lipid-rich particles of cultured mammalian cells
    • Mackenzie CG, Mackenzie JB, Beck P, (1961) The effect of pH on growth, protein synthesis, and lipid-rich particles of cultured mammalian cells. J Biophys Biochem Cytol 9: 141-156.
    • (1961) J Biophys Biochem Cytol , vol.9 , pp. 141-156
    • Mackenzie, C.G.1    Mackenzie, J.B.2    Beck, P.3
  • 27
    • 0021894461 scopus 로고
    • Kinetic properties of the plasma membrane Na+-H+ exchanger
    • Aronson PS, (1985) Kinetic properties of the plasma membrane Na+-H+ exchanger. Ann Rev Physiol 47: 545-560.
    • (1985) Ann Rev Physiol , vol.47 , pp. 545-560
    • Aronson, P.S.1
  • 28
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastasis, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, et al. (2000) High lactate levels predict likelihood of metastasis, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 16: 916-921.
    • (2000) Cancer Res , vol.16 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfør, K.5
  • 29
    • 0028784650 scopus 로고
    • Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    • Schwickert G, Walenta S, Sundfør K, Rofstad EK, Mueller-Kliesera W, (1995) Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Res 55: 4757-4759.
    • (1995) Cancer Res , vol.55 , pp. 4757-4759
    • Schwickert, G.1    Walenta, S.2    Sundfør, K.3    Rofstad, E.K.4    Mueller-Kliesera, W.5
  • 30
    • 33750716354 scopus 로고    scopus 로고
    • Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice
    • Quennet V, Yaromina A, Zips D, Rosner A, Walenta S, et al. (2006) Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. Radiother Oncol 81: 130-135.
    • (2006) Radiother Oncol , vol.81 , pp. 130-135
    • Quennet, V.1    Yaromina, A.2    Zips, D.3    Rosner, A.4    Walenta, S.5
  • 31
    • 25844528025 scopus 로고    scopus 로고
    • The role of distributed pH dynamics and the Na+/H+ exchanger in metastasis
    • Cardone RA, Casavola V, Reshkin SJ, (2005) The role of distributed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer 5: 786-795.
    • (2005) Nat Rev Cancer , vol.5 , pp. 786-795
    • Cardone, R.A.1    Casavola, V.2    Reshkin, S.J.3
  • 32
    • 52549099935 scopus 로고    scopus 로고
    • Mathematical model of pulsed immunotherapy for superficial bladder cancer
    • Bunimovich-Mendrazitsky S, Byrne H, Stone K, (2008) Mathematical model of pulsed immunotherapy for superficial bladder cancer. Bull Math Biol 70: 2055-2076.
    • (2008) Bull Math Biol , vol.70 , pp. 2055-2076
    • Bunimovich-Mendrazitsky, S.1    Byrne, H.2    Stone, K.3
  • 34
    • 38649104788 scopus 로고    scopus 로고
    • Mathematical modelling of cancer cell invasion of tissue: Local and non-local models and the effect of adhesion
    • Gerisch A, Chaplain MAJ, (2008) Mathematical modelling of cancer cell invasion of tissue: Local and non-local models and the effect of adhesion. J Theor Biol 250: 684-704.
    • (2008) J Theor Biol , vol.250 , pp. 684-704
    • Gerisch, A.1    Chaplain, M.A.J.2
  • 36
    • 0029751950 scopus 로고    scopus 로고
    • A reaction diffusion model of cancer invasion
    • Gatenby RA, Gawlinski ET, (1996) A reaction diffusion model of cancer invasion. Cancer Res 56: 5745-5753.
    • (1996) Cancer Res , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 38
    • 0033380522 scopus 로고    scopus 로고
    • Alterations in proteolytic activity at low pH and its association with invasion: A theoretical model
    • Webb SD, Sherratt JA, Fish RG, (1999) Alterations in proteolytic activity at low pH and its association with invasion: A theoretical model. Clin Exp Metastas 17: 397-407.
    • (1999) Clin Exp Metastas , vol.17 , pp. 397-407
    • Webb, S.D.1    Sherratt, J.A.2    Fish, R.G.3
  • 39
    • 0033590468 scopus 로고    scopus 로고
    • Mathematical modelling of tumour acidity: Regulation of intracellular pH
    • Webb SD, Sherratt JA, Fish RG, (1999) Mathematical modelling of tumour acidity: Regulation of intracellular pH. J Theor Biol 196: 237-250.
    • (1999) J Theor Biol , vol.196 , pp. 237-250
    • Webb, S.D.1    Sherratt, J.A.2    Fish, R.G.3
  • 40
    • 84874392391 scopus 로고    scopus 로고
    • Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate
    • Al-Husari M, Webb SD, (2013) Regulation of tumour intracellular pH: A mathematical model examining the interplay between H+ and lactate. J Theor Biol 322: 58-71.
    • (2013) J Theor Biol , vol.322 , pp. 58-71
    • Al-Husari, M.1    Webb, S.D.2
  • 41
    • 34548038993 scopus 로고    scopus 로고
    • Serial In vivo spectro scopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gilomas shows redistribution of protons away from sites of glycolysis
    • Provent P, Benito M, Hiba B, Farion R, López-Larrubia P, et al. (2007) Serial In vivo spectro scopic nuclear magnetic resonance imaging of lactate and extracellular pH in rat gilomas shows redistribution of protons away from sites of glycolysis. Cancer Res 67: 7638-7645.
    • (2007) Cancer Res , vol.67 , pp. 7638-7645
    • Provent, P.1    Benito, M.2    Hiba, B.3    Farion, R.4    López-Larrubia, P.5
  • 42
    • 79952084540 scopus 로고    scopus 로고
    • The spatial organization of proton and lactate transport in a rat brain tumor
    • Grillon E, Farion R, Fablet K, Waard MD, Tse CM, et al. (2011) The spatial organization of proton and lactate transport in a rat brain tumor. PloS ONE 6: 1-9.
    • (2011) PloS ONE , vol.6 , pp. 1-9
    • Grillon, E.1    Farion, R.2    Fablet, K.3    Waard, M.D.4    Tse, C.M.5
  • 43
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • Halestrap AP, Meredith D, (2004) The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pug Arch Eur J Phy 447: 619-628.
    • (2004) Pug Arch Eur J Phy , vol.447 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2
  • 44
    • 0026795032 scopus 로고
    • Regulation of intracellular pH in tumour cell lines: Inuence of microenvironmental conditions
    • Boyer MJ, Tannock IF, (1992) Regulation of intracellular pH in tumour cell lines: Inuence of microenvironmental conditions. Cancer Res 52: 4441-4447.
    • (1992) Cancer Res , vol.52 , pp. 4441-4447
    • Boyer, M.J.1    Tannock, I.F.2
  • 45
    • 78751680410 scopus 로고    scopus 로고
    • Kinetic analysis and design of experiments to identify the catalytic mechanism of the monocarboxylate transporter isoforms 4 and 1
    • Vinnakota KC, Beard DA, (2011) Kinetic analysis and design of experiments to identify the catalytic mechanism of the monocarboxylate transporter isoforms 4 and 1. Biophys J 100: 369-380.
    • (2011) Biophys J , vol.100 , pp. 369-380
    • Vinnakota, K.C.1    Beard, D.A.2
  • 46
    • 28044442099 scopus 로고    scopus 로고
    • Brain lactate kinetics: modeling evidence for neural lactate uptake upon activation
    • Aubert A, Costalat R, Magistretti PJ, Pellerin L, (2005) Brain lactate kinetics: modeling evidence for neural lactate uptake upon activation. PNAS 102: 16448-16453.
    • (2005) PNAS , vol.102 , pp. 16448-16453
    • Aubert, A.1    Costalat, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 48
    • 0027179546 scopus 로고
    • Lactate transport by skeletal muscle sarcolemmal vesicles
    • McDermott JC, Bonen A, (1993) Lactate transport by skeletal muscle sarcolemmal vesicles. Mol Cell Biochem 122: 113-121.
    • (1993) Mol Cell Biochem , vol.122 , pp. 113-121
    • McDermott, J.C.1    Bonen, A.2
  • 49
    • 34447547148 scopus 로고    scopus 로고
    • Regulation of tumor pH and the role of carbonic anhydrase 9
    • Swietach P, Vaughan-Jones RD, Harris AL, (2007) Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metast Rev 26: 299-310.
    • (2007) Cancer Metast Rev , vol.26 , pp. 299-310
    • Swietach, P.1    Vaughan-Jones, R.D.2    Harris, A.L.3
  • 50
    • 0018092552 scopus 로고
    • The pH-dependence of sugar-transport and glycolysis in cultured ehrlich ascites-tumour cells
    • Kaminskas E, (1978) The pH-dependence of sugar-transport and glycolysis in cultured ehrlich ascites-tumour cells. Biochem J 174: 453-459.
    • (1978) Biochem J , vol.174 , pp. 453-459
    • Kaminskas, E.1
  • 51
    • 0026568374 scopus 로고
    • Variations in tumour cell growth rates and metabolism with oxygen concentrations, glucose concentration, and extracellular pH
    • Casciari JJ, Sotirchos SV, Sutherland RM, (1992) Variations in tumour cell growth rates and metabolism with oxygen concentrations, glucose concentration, and extracellular pH. J Cell Physiol 151: 386-394.
    • (1992) J Cell Physiol , vol.151 , pp. 386-394
    • Casciari, J.J.1    Sotirchos, S.V.2    Sutherland, R.M.3
  • 53
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors
    • Vaupel P, Kallinowski F, Okunieff P, (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors. Cancer Res 49: 6449-6465.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 55
    • 0022860269 scopus 로고
    • Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise
    • Brooks GA (1986) Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise. Fed Proc 45.
    • (1986) Fed Proc , vol.45
    • Brooks, G.A.1
  • 56
    • 0020358505 scopus 로고
    • Amino acid, glucose, and lactic acid utilization in vivo by rat tumors
    • Sauer LA, Stayman JW, Dauchy RT, (1982) Amino acid, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res 42: 4090-4097.
    • (1982) Cancer Res , vol.42 , pp. 4090-4097
    • Sauer, L.A.1    Stayman, J.W.2    Dauchy, R.T.3
  • 58
    • 76449085182 scopus 로고    scopus 로고
    • Necrotic core in EMT6/Ro tumor spheroids: Is it caused by an ATP deficit
    • Bertuzzi A, Fasano A, Gandolfi A, Sinisgalli C, (2010) Necrotic core in EMT6/Ro tumor spheroids: Is it caused by an ATP deficit? J Theor Biol 262: 142-150.
    • (2010) J Theor Biol , vol.262 , pp. 142-150
    • Bertuzzi, A.1    Fasano, A.2    Gandolfi, A.3    Sinisgalli, C.4
  • 60
    • 0035416450 scopus 로고    scopus 로고
    • Determination of molecular self-diffusion coefficient using multiple spin-echo NMR spectroscopy with removal of convection and background gradient artifacts
    • Zhang X, Li CG, Ye CH, Liu ML, (2001) Determination of molecular self-diffusion coefficient using multiple spin-echo NMR spectroscopy with removal of convection and background gradient artifacts. Anal Chem 73: 3528-3534.
    • (2001) Anal Chem , vol.73 , pp. 3528-3534
    • Zhang, X.1    Li, C.G.2    Ye, C.H.3    Liu, M.L.4
  • 62
    • 80054709950 scopus 로고    scopus 로고
    • Dynamic lactate indices as predictors of outcome in critically ill patients
    • Nichol A, Bailey M, Egi M, Pettila V, French C,et al. (2011) Dynamic lactate indices as predictors of outcome in critically ill patients. Critical Care 15.
    • (2011) Critical Care , vol.15
    • Nichol, A.1    Bailey, M.2    Egi, M.3    Pettila, V.4    French, C.5
  • 63
    • 0035153310 scopus 로고    scopus 로고
    • Point-of-care (POC) testing of lactate in the intensive care patient
    • Boldt J, Kumle B, Suttner S, Haisch G, (2001) Point-of-care (POC) testing of lactate in the intensive care patient. Acta Anaesthesiol Scand 45: 194-199.
    • (2001) Acta Anaesthesiol Scand , vol.45 , pp. 194-199
    • Boldt, J.1    Kumle, B.2    Suttner, S.3    Haisch, G.4
  • 65
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis
    • Gatenby RA, Gillies RJ, (2004) Why do cancers have high aerobic glycolysis? Nature Rev 4: 891-899.
    • (2004) Nature Rev , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 66
    • 34447094919 scopus 로고    scopus 로고
    • Glycolysis in cancer: a potential target for therapy
    • Gatenby RA, Gillies RJ, (2007) Glycolysis in cancer: a potential target for therapy. Int J Biochem Cell B 39: 1358-1366.
    • (2007) Int J Biochem Cell B , vol.39 , pp. 1358-1366
    • Gatenby, R.A.1    Gillies, R.J.2
  • 68
    • 0037105721 scopus 로고    scopus 로고
    • Significance of blood vessel leakiness in cancer
    • McDonald DM, Baluk P, (2002) Significance of blood vessel leakiness in cancer. Cancer Res 62: 5381-5385.
    • (2002) Cancer Res , vol.62 , pp. 5381-5385
    • McDonald, D.M.1    Baluk, P.2
  • 69
    • 77958151285 scopus 로고    scopus 로고
    • Leaky vessels as a potential source of stromal acidification in tumours
    • Martin NK, Gaffney EA, Gatenby RA, Maini PK, (2010) Leaky vessels as a potential source of stromal acidification in tumours. J Theor Biol 267: 454-460.
    • (2010) J Theor Biol , vol.267 , pp. 454-460
    • Martin, N.K.1    Gaffney, E.A.2    Gatenby, R.A.3    Maini, P.K.4


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