메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; SPHINGOMYELIN; APP PROTEIN, HUMAN; BRIDGED COMPOUND; MEMBRANE PROTEIN; NERVE PROTEIN; PHOSPHOTRANSFERASE; SGMS1 PROTEIN, HUMAN; SPHINGOLIPID; THIOKETONE; TRICYCLODECANE-9-YL-XANTHOGENATE;

EID: 84882582316     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074016     Document Type: Article
Times cited : (18)

References (37)
  • 1
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • doi: 10.1038/325733a0
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, et al. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736. doi:10.1038/325733a0. PubMed: 2881207.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3    Salbaum, J.M.4    Masters, C.L.5
  • 2
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • PubMed: 11274343
    • Selkoe DJ, (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766. PubMed: 11274343.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 3
    • 0034611980 scopus 로고    scopus 로고
    • Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E
    • doi: 10.1016/S0197-4580(00)00143-3, discussion 451-423
    • Bales KR, Du Y, Holtzman D, Cordell B, Paul SM, (2000) Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E. Neurobiol Aging 21: 427-432; discussion 451-423 doi:10.1016/S0197-4580(00)00143-3. PubMed: 10858588.
    • (2000) Neurobiol Aging , vol.21 , pp. 427-432
    • Bales, K.R.1    Du, Y.2    Holtzman, D.3    Cordell, B.4    Paul, S.M.5
  • 4
    • 28644451007 scopus 로고    scopus 로고
    • Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin
    • doi: 10.1038/ncb1313
    • Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, et al. (2005) Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol 7: 1118-1123. doi:10.1038/ncb1313. PubMed: 16227967.
    • (2005) Nat Cell Biol , vol.7 , pp. 1118-1123
    • Grimm, M.O.1    Grimm, H.S.2    Pätzold, A.J.3    Zinser, E.G.4    Halonen, R.5
  • 5
    • 34547147090 scopus 로고    scopus 로고
    • The redox chemistry of the Alzheimer's disease amyloid beta peptide
    • doi: 10.1016/j.bbamem.2007.02.002
    • Smith DG, Cappai R, Barnham KJ, (2007) The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim Biophys Acta 1768: 1976-1990. doi:10.1016/j.bbamem.2007.02.002. PubMed: 17433250.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 1976-1990
    • Smith, D.G.1    Cappai, R.2    Barnham, K.J.3
  • 6
    • 0034658615 scopus 로고    scopus 로고
    • Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide
    • doi: 10.1042/0264-6021:3480137
    • Ward RV, Jennings KH, Jepras R, Neville W, Owen DE, et al. (2000) Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide. Biochem J 3481:: 137-144. doi:10.1042/0264-6021:3480137. PubMed: 10794724.
    • (2000) Biochem J , vol.348 , pp. 137-144
    • Ward, R.V.1    Jennings, K.H.2    Jepras, R.3    Neville, W.4    Owen, D.E.5
  • 7
    • 77953235753 scopus 로고    scopus 로고
    • Lipids in Alzheimer's disease: A century-old story
    • doi: 10.1016/j.bbalip.2010.05.004
    • Foley P, (2010) Lipids in Alzheimer's disease: A century-old story. Biochim Biophys Acta 1801: 750-753. doi:10.1016/j.bbalip.2010.05.004. PubMed: 20471492.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 750-753
    • Foley, P.1
  • 8
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • doi: 10.1038/ng.801
    • Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, et al. (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 43: 436-441. doi:10.1038/ng.801. PubMed: 21460841.
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3    Wang, L.S.4    Vardarajan, B.N.5
  • 9
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
    • doi: 10.1038/nrn2620
    • Bu G, (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10: 333-344. doi:10.1038/nrn2620. PubMed: 19339974.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 10
    • 2942535903 scopus 로고    scopus 로고
    • Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer
    • doi: 10.1074/jbc.M311256200
    • Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y, (2004) Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J Biol Chem 279: 25511-25516. doi:10.1074/jbc.M311256200. PubMed: 15054100.
    • (2004) J Biol Chem , vol.279 , pp. 25511-25516
    • Xu, Q.1    Brecht, W.J.2    Weisgraber, K.H.3    Mahley, R.W.4    Huang, Y.5
  • 11
    • 0027931854 scopus 로고
    • Isoform-specific binding of apolipoprotein E to beta-amyloid
    • PubMed: 8089103
    • LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, et al. (1994) Isoform-specific binding of apolipoprotein E to beta-amyloid. J Biol Chem 269: 23403-23406. PubMed: 8089103.
    • (1994) J Biol Chem , vol.269 , pp. 23403-23406
    • LaDu, M.J.1    Falduto, M.T.2    Manelli, A.M.3    Reardon, C.A.4    Getz, G.S.5
  • 12
    • 0034214329 scopus 로고    scopus 로고
    • Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides
    • doi: 10.1042/0264-6021:3480359
    • Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, et al. (2000) Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J 3482:: 359-365. doi:10.1042/0264-6021:3480359. PubMed: 10816430.
    • (2000) Biochem J , vol.348 , pp. 359-365
    • Tokuda, T.1    Calero, M.2    Matsubara, E.3    Vidal, R.4    Kumar, A.5
  • 13
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
    • doi: 10.1038/ng.803
    • Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, et al. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 43: 429-435. doi:10.1038/ng.803. PubMed: 21460840.
    • (2011) Nat Genet , vol.43 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3    Gerrish, A.4    Lambert, J.C.5
  • 14
    • 51649118169 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
    • doi: 10.1111/j.1471-4159.2008.05433.x
    • Chan SL, Kim WS, Kwok JB, Hill AF, Cappai R, et al. (2008) ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. J Neurochem 106: 793-804. doi:10.1111/j.1471-4159.2008.05433.x. PubMed: 18429932.
    • (2008) J Neurochem , vol.106 , pp. 793-804
    • Chan, S.L.1    Kim, W.S.2    Kwok, J.B.3    Hill, A.F.4    Cappai, R.5
  • 15
    • 84874612598 scopus 로고    scopus 로고
    • Deletion of Abca7 Increases Cerebral Amyloid-beta Accumulation in the J20 Mouse Model of Alzheimer's Disease
    • doi: 10.1523/JNEUROSCI.4165-12.2013
    • Kim WS, Li H, Ruberu K, Chan S, Elliott DA, et al. (2013) Deletion of Abca7 Increases Cerebral Amyloid-beta Accumulation in the J20 Mouse Model of Alzheimer's Disease. J Neurosci 33: 4387-4394. doi:10.1523/JNEUROSCI.4165-12.2013. PubMed: 23467355.
    • (2013) J Neurosci , vol.33 , pp. 4387-4394
    • Kim, W.S.1    Li, H.2    Ruberu, K.3    Chan, S.4    Elliott, D.A.5
  • 16
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    • doi: 10.1083/jcb.200207113
    • Ehehalt R, Keller P, Haass C, Thiele C, Simons K, (2003) Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 160: 113-123. doi:10.1083/jcb.200207113. PubMed: 12515826.
    • (2003) J Cell Biol , vol.160 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 17
    • 21844448354 scopus 로고    scopus 로고
    • Spatial segregation of gamma-secretase and substrates in distinct membrane domains
    • doi: 10.1074/jbc.M503570200
    • Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem 280: 25892-25900. doi:10.1074/jbc.M503570200. PubMed: 15886206.
    • (2005) J Biol Chem , vol.280 , pp. 25892-25900
    • Vetrivel, K.S.1    Cheng, H.2    Kim, S.H.3    Chen, Y.4    Barnes, N.Y.5
  • 18
    • 21644474053 scopus 로고    scopus 로고
    • Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator
    • doi: 10.1074/jbc.M413862200
    • Glaros EN, Kim WS, Quinn CM, Wong J, Gelissen I, et al. (2005) Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. J Biol Chem 280: 24515-24523. doi:10.1074/jbc.M413862200. PubMed: 15890646.
    • (2005) J Biol Chem , vol.280 , pp. 24515-24523
    • Glaros, E.N.1    Kim, W.S.2    Quinn, C.M.3    Wong, J.4    Gelissen, I.5
  • 19
    • 0032568552 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    • doi: 10.1073/pnas.95.11.6460
    • Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, et al. (1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A 95: 6460-6464. doi:10.1073/pnas.95.11.6460. PubMed: 9600988.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6460-6464
    • Simons, M.1    Keller, P.2    De Strooper, B.3    Beyreuther, K.4    Dotti, C.G.5
  • 20
    • 23044510465 scopus 로고    scopus 로고
    • Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide
    • doi: 10.1074/jbc.M414525200
    • Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, et al. (2005) Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. J Biol Chem 280: 28110-28117. doi:10.1074/jbc.M414525200. PubMed: 15923191.
    • (2005) J Biol Chem , vol.280 , pp. 28110-28117
    • Tamboli, I.Y.1    Prager, K.2    Barth, E.3    Heneka, M.4    Sandhoff, K.5
  • 21
    • 0032211769 scopus 로고    scopus 로고
    • Signal transduction of stress via ceramide
    • PubMed: 9794783
    • Mathias S, Peña LA, Kolesnick RN, (1998) Signal transduction of stress via ceramide. Biochem J 335(3):: 465-480. PubMed: 9794783.
    • (1998) Biochem J , vol.335 , pp. 465-480
    • Mathias, S.1    Peña, L.A.2    Kolesnick, R.N.3
  • 22
    • 0013881132 scopus 로고
    • The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae
    • doi: 10.1073/pnas.55.2.366
    • Brady RO, Kanfer JN, Mock MB, Fredrickson DS, (1966) The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae. Proc Natl Acad Sci U S A 55: 366-369. doi:10.1073/pnas.55.2.366. PubMed: 5220952.
    • (1966) Proc Natl Acad Sci U S A , vol.55 , pp. 366-369
    • Brady, R.O.1    Kanfer, J.N.2    Mock, M.B.3    Fredrickson, D.S.4
  • 23
    • 1242316279 scopus 로고    scopus 로고
    • Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up
    • doi: 10.1016/S0002-9440(10)63163-X
    • Nixon RA, (2004) Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up. Am J Pathol 164: 757-761. doi:10.1016/S0002-9440(10)63163-X. PubMed: 14982829.
    • (2004) Am J Pathol , vol.164 , pp. 757-761
    • Nixon, R.A.1
  • 24
    • 0030681215 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease
    • doi: 10.1016/S0197-4580(97)00057-2
    • (1997) Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 18: S1-S2. doi:10.1016/S0197-4580(97)00057-2. PubMed: 9330978.
    • (1997) Neurobiol Aging , vol.18
  • 25
    • 33745860362 scopus 로고    scopus 로고
    • Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
    • doi: 10.1074/jbc.M602487200
    • White AR, Du T, Laughton KM, Volitakis I, Sharples RA, et al. (2006) Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. J Biol Chem 281: 17670-17680. doi:10.1074/jbc.M602487200. PubMed: 16648635.
    • (2006) J Biol Chem , vol.281 , pp. 17670-17680
    • White, A.R.1    Du, T.2    Laughton, K.M.3    Volitakis, I.4    Sharples, R.A.5
  • 26
    • 33644777552 scopus 로고    scopus 로고
    • Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine
    • PubMed: 16371647
    • Hojjati MR, Jiang XC, (2006) Rapid, specific, and sensitive measurements of plasma sphingomyelin and phosphatidylcholine. J Lipid Res 47: 673-676. PubMed: 16371647.
    • (2006) J Lipid Res , vol.47 , pp. 673-676
    • Hojjati, M.R.1    Jiang, X.C.2
  • 27
    • 0035892603 scopus 로고    scopus 로고
    • High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide
    • doi: 10.1006/abio.2001.5393
    • Wing DR, Garner B, Hunnam V, Reinkensmeier G, Andersson U, et al. (2001) High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide. Anal Biochem 298: 207-217. doi:10.1006/abio.2001.5393. PubMed: 11700975.
    • (2001) Anal Biochem , vol.298 , pp. 207-217
    • Wing, D.R.1    Garner, B.2    Hunnam, V.3    Reinkensmeier, G.4    Andersson, U.5
  • 28
    • 31944450386 scopus 로고    scopus 로고
    • Differences in regional brain atrophy in genetic forms of Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2005.03.011
    • Gregory GC, Macdonald V, Schofield PR, Kril JJ, Halliday GM, (2006) Differences in regional brain atrophy in genetic forms of Alzheimer's disease. Neurobiol Aging 27: 387-393. doi:10.1016/j.neurobiolaging.2005.03.011. PubMed: 15894410.
    • (2006) Neurobiol Aging , vol.27 , pp. 387-393
    • Gregory, G.C.1    Macdonald, V.2    Schofield, P.R.3    Kril, J.J.4    Halliday, G.M.5
  • 29
    • 84856072382 scopus 로고    scopus 로고
    • Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
    • doi: 10.1074/jbc.M111.274142
    • Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, et al. (2012) Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J Biol Chem 287: 2678-2688. doi:10.1074/jbc.M111.274142. PubMed: 22134919.
    • (2012) J Biol Chem , vol.287 , pp. 2678-2688
    • Chan, R.B.1    Oliveira, T.G.2    Cortes, E.P.3    Honig, L.S.4    Duff, K.E.5
  • 30
    • 84866735448 scopus 로고    scopus 로고
    • Evidence for premature lipid raft aging in APP/PS1 double-transgenic mice, a model of familial Alzheimer disease
    • doi: 10.1097/NEN.0b013e31826be03c
    • Fabelo N, Martin V Marin R, Santpere G, Aso Eet al. (2012) Evidence for premature lipid raft aging in APP/PS1 double-transgenic mice, a model of familial Alzheimer disease. J Neuropathol Exp Neurol 71: 868-881. doi:10.1097/NEN.0b013e31826be03c. PubMed: 22975585.
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 868-881
    • Fabelo, N.1
  • 31
    • 33749576963 scopus 로고    scopus 로고
    • The multigenic sphingomyelin synthase family
    • doi: 10.1074/jbc.R600021200
    • Tafesse FG, Ternes P, Holthuis JC, (2006) The multigenic sphingomyelin synthase family. J Biol Chem 281: 29421-29425. doi:10.1074/jbc.R600021200. PubMed: 16905542.
    • (2006) J Biol Chem , vol.281 , pp. 29421-29425
    • Tafesse, F.G.1    Ternes, P.2    Holthuis, J.C.3
  • 32
    • 0842263750 scopus 로고    scopus 로고
    • Identification of a family of animal sphingomyelin synthases
    • doi: 10.1038/sj.emboj.7600034
    • Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC, (2004) Identification of a family of animal sphingomyelin synthases. EMBO J 23: 33-44. doi:10.1038/sj.emboj.7600034. PubMed: 14685263.
    • (2004) EMBO J , vol.23 , pp. 33-44
    • Huitema, K.1    van den Dikkenberg, J.2    Brouwers, J.F.3    Holthuis, J.C.4
  • 33
    • 77953275293 scopus 로고    scopus 로고
    • Modulation of amyloid precursor protein processing by synthetic ceramide analogues
    • doi: 10.1016/j.bbalip.2010.05.012
    • Li H, Kim WS, Guillemin GJ, Hill AF, Evin G, et al. (2010) Modulation of amyloid precursor protein processing by synthetic ceramide analogues. Biochim Biophys Acta 1801: 887-895. doi:10.1016/j.bbalip.2010.05.012. PubMed: 20599631.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 887-895
    • Li, H.1    Kim, W.S.2    Guillemin, G.J.3    Hill, A.F.4    Evin, G.5
  • 34
    • 27744501797 scopus 로고    scopus 로고
    • Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
    • doi: 10.1074/jbc.M504484200
    • Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, et al. (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem 280: 36815-36823. doi:10.1074/jbc.M504484200. PubMed: 16115865.
    • (2005) J Biol Chem , vol.280 , pp. 36815-36823
    • Kalvodova, L.1    Kahya, N.2    Schwille, P.3    Ehehalt, R.4    Verkade, P.5
  • 35
    • 53049089639 scopus 로고    scopus 로고
    • Direct and potent regulation of gamma-secretase by its lipid microenvironment
    • doi: 10.1074/jbc.M801925200
    • Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ, (2008) Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem 283: 22529-22540. doi:10.1074/jbc.M801925200. PubMed: 18539594.
    • (2008) J Biol Chem , vol.283 , pp. 22529-22540
    • Osenkowski, P.1    Ye, W.2    Wang, R.3    Wolfe, M.S.4    Selkoe, D.J.5
  • 36
    • 38449091842 scopus 로고    scopus 로고
    • The way we view cellular (glyco)sphingolipids
    • doi: 10.1111/j.1471-4159.2007.04721.x
    • Hoetzl S, Sprong H, van Meer G, (2007) The way we view cellular (glyco)sphingolipids. J Neurochem 103 (Suppl 1):: 3-13. doi:10.1111/j.1471-4159.2007.04721.x. PubMed: 17986134.
    • (2007) J Neurochem , vol.103 , Issue.SUPPL. 1 , pp. 3-13
    • Hoetzl, S.1    Sprong, H.2    van Meer, G.3
  • 37
    • 79551552043 scopus 로고    scopus 로고
    • Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation
    • doi: 10.1523/JNEUROSCI.2954-10.2011
    • Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, et al. (2011) Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. J Neurosci 31: 1837-1849. doi:10.1523/JNEUROSCI.2954-10.2011. PubMed: 21289194.
    • (2011) J Neurosci , vol.31 , pp. 1837-1849
    • Tamboli, I.Y.1    Hampel, H.2    Tien, N.T.3    Tolksdorf, K.4    Breiden, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.