Nitrite and Heme Globins. Reaction Mechanisms and Physiological Targets.

Nitric Oxide

Volumn , Issue , 2010, Pages 605-626

  Shiva, Sruti ^a   Frizzell, Sheila ^b   Gladwin, Mark T ^c  

^a Department of Pharmacology and Chemical Biology ^*  (United States)

^b Vascular Medicine Institute   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882525021     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-373866-0.00019-8     Document Type: Chapter

References (96)

1. Antunes F., Boveris A., Cadenas E. On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc. Natl. Acad. Sci. USA 2004, 101:16774-16779.
2. Baker J.E., Su J., Fu X., Hsu A., Gross G.J., Tweddell J.S., Hogg N. Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J. Mol. Cell Cardiol. 2007, 43:437-444.
3. Balasubramaniam V., Maxey A.M., Fouty B.W., Abman S.H. Nitric oxide augments fetal pulmonary artery endothelial cell angiogenesis in vitro. Am. J. Physiol. Lung Cell Mol. Physiol. 2006, 290:L1111-L1116.
4. Basireddy M., Isbell T.S., Teng X., Patel R.P., Agarwal A. Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney. Am. J. Physiol. Renal. Physiol. 2006, 290:F779-F786.
5. Baskin S.I., Horowitz A.M., Nealley E.W. The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. J. Clin. Pharmacol. 1992, 32:368-375.
6. Basu S., Grubina R., Huang J., Conradie J., Huang Z., Jeffers A., Jiang A., He X., Azarov I., Seibert R., Mehta A., Patel R., King S.B., Hogg N., Ghosh A., Gladwin M.T., Kim-Shapiro D.B. Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. Nat. Chem. Biol. 2007, 3:785-794.
7. Basu S., Azarova N.A., Font M.D., King S.B., Hogg N., Gladwin M.T., Shiva S., Kim-Shapiro D.B. Nitrite reductase activity of cytochrome c. J. Biol. Chem. 2008, 283:32590-32597.
8. Bolanos J.P., Peuchen S., Heales S.J., Land J.M., Clark J.B. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem. 1994, 63:910-916.
9. Brookes P.S., Shiva S., Patel R.P., Darley-Usmar V.M. Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide. Methods Enzymol. 2002, 359:305-319.
10. Brookes P.S., Kraus D.W., Shiva S., Doeller J.E., Barone M.C., Patel R.P., Lancaster J.R., Darley-Usmar V. Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state. J. Biol. Chem. 2003, 278:31603-31609.
11. Brooks J. The action of nitrite on haemoglobin in the absence of oxygen. Proc. R Soc. Lond B Biol. Sci. 1937, 123:368-382.
12. Brown G.C., Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 1994, 356:295-298.
13. Brune B., Zhou J. The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr. Med. Chem. 2003, 10:845-855.
14. Bryan N.S., Rassaf T., Maloney R.E., Rodriguez C.M., Saijo F., Rodriguez J.R., Feelisch M. Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proc. Natl. Acad. Sci. USA 2004, 101:4308-4313.
15. Bryan N.S., Calvert J.W., Elrod J.W., Gundewar S., Ji S.Y., Lefer D.J. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc. Natl. Acad. Sci. USA 2007, 104:19144-19149.
16. Burmester T., Weich B., Reinhardt S., Hankeln T. A vertebrate globin expressed in the brain. Nature 2000, 407:520-523.
17. Cannon R.O., Schechter A.N., Panza J.A., Ognibene F.P., Pease-Fye M.E., Waclawiw M.A., Shelhamer J.H., Gladwin M.T. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J. Clin. Invest. 2001, 108:279-287.
18. Castello P.R., David P.S., McClure T., Crook Z., Poyton R.O. Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab. 2006, 3:277-287.
19. Challis B.C., Kyrtopoulos S.A. Chemistry of nitroso-compounds. 12. Mechanism of nitrosation and nitration of aqueous piperidine by gaseous dinitrogen tetraoxide and dinitrogen trioxide in aqueous alkaline-solutions-evidence for the existence of molecular isomers of dinitrogen tetraoxide and dinitrogen trioxide. J. Chem. Soc. Perkin Trans. 1978, 2:1296-1302.
20. Chen Q., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion. J. Pharmacol. Exp. Ther. 2006, 319:1405-1412.
21. Cleeter M.W., Cooper J.M., Darley-Usmar V.M., Moncada S., Schapira A.H. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 1994, 345:50-54.
22. Cooper C.E., Mason M.G., Nicholls P. A dynamic model of nitric oxide inhibition of mitochondrial cytochrome c oxidase. Biochim. Biophys. Acta 2008, 1777:867-876.
23. Cosby K., Partovi K.S., Crawford J.H., Patel R.P., Reiter C.D., Martyr S., Yang B.K., Waclawiw M.A., Zalos G., Xu X., Huang K.T., Shields H., Kim-Shapiro D.B., Schechter A.N., Cannon R.O., Gladwin M.T. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat. Med. 2003, 9:1498-1505.
24. Crawford J.H., Isbell T.S., Huang Z., Shiva S., Chacko B.K., Schechter A.N., Darley-Usmar V.M., Kerby J.D., Lang J.D., Kraus D., Ho C., Gladwin M.T., Patel R.P. Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood 2006, 107:566-574.
25. Dejam A., Hunter C.J., Pelletier M.M., Hsu L.L., Machado R.F., Shiva S., Power G.G., Kelm M., Gladwin M.T., Schechter A.N. Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood 2005, 106:734-739.
26. Doyle M.P., Pickering R.A., DeWeert T.M., Hoekstra J.W., Pater D. Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. J. Biol. Chem. 1981, 256:12393-12398.
27. Duranski M.R., Greer J.J., Dejam A., Jaganmohan S., Hogg N., Langston W., Patel R.P., Yet S.F., Wang X., Kevil C.G., Gladwin M.T., Lefer D.J. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J. Clin. Invest. 2005, 115:1232-1240.
28. Dweik R.A., Laskowski D., Abu-Soud H.M., Kaneko F., Hutte R., Stuehr D.J., Erzurum S.C. Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism. J. Clin. Invest. 1998, 101:660-666.
29. Eich R.F., Li T., Lemon D.D., Doherty D.H., Curry S.R., Aitken J.F., Mathews A.J., Johnson K.A., Smith R.D., Phillips G.N., Olson J.S. Mechanism of NO induced oxidation of myoglobin and hemoglobin. Biochemistry 1996, 35:6976-6983.
30. Espey M.G., Miranda K.M., Thomas D.D., Wink D.A. Distinction between nitrosating mechanisms within human cells and aqueous solution. J. Biol. Chem. 2001, 276:30085-30091.
31. Fernandez B.O., Ford P.C. Nitrite catalyzes ferriheme protein reductive nitrosylation. J. Am. Chem. Soc. 2003, 125:10510-10511.
32. Flogel U., Merx M.W., Godecke A., Decking U.K., Schrader J. Myoglobin: A scavenger of bioactive NO. Proc. Natl. Acad. Sci. USA 2001, 98:735-740.
33. Flogel U., Godecke A., Klotz L.O., Schrader J. Role of myoglobin in the antioxidant defense of the heart. FASEB J. 2004, 18:1156-1158.
34. Flogel U., Laussmann T., Godecke A., Abanador N., Schafers M., Fingas C.D., Metzger S., Levkau B., Jacoby C., Schrader J. Lack of myoglobin causes a switch in cardiac substrate selection. Circ. Res. 2005, 96:e68-e75.
35. Furchgott R.F., Bhadrakom S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J. Pharmacol. Exp. Ther. 1953, 108:129-143.
36. Giuffre A., Forte E., Brunori M., Sarti P. Nitric oxide, cytochrome c oxidase and myoglobin: competition and reaction pathways. FEBS Lett. 2005, 579:2528-2532.
37. Gladwin M.T., Kim-Shapiro D.B. The functional nitrite reductase activity of the heme-globins. Blood 2008, 112:2636-2647.
38. Gladwin M.T., Shelhamer J.H., Schechter A.N., Pease-Fye M.E., Waclawiw M.A., Panza J.A., Ognibene F.P., Cannon R.O. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Proc. Natl. Acad. Sci. USA 2000, 97:11482-11487.
39. Gladwin M.T., Schechter A.N., Kim-Shapiro D.B., Patel R.P., Hogg N., Shiva S., Cannon R.O., Kelm M., Wink D.A., Espey M.G., Oldfield E.H., Pluta R.M., Freeman B.A., Lancaster J.R., Feelisch M., Lundberg J.O. The emerging biology of the nitrite anion. Nat. Chem. Biol. 2005, 1:308-314.
40. Godecke A., Schrader J. Adaptive mechanisms of the cardiovascular system in transgenic mice-lessons from eNOS and myoglobin knockout mice. Basic Res. Cardiol. 2000, 95:492-498.
41. Godecke A., Flogel U., Zanger K., Ding Z., Hirchenhain J., Decking U.K., Schrader J. Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc. Natl. Acad. Sci. USA 1999, 96:10495-10500.
42. Gonzalez F.M., Shiva S., Vincent P.S., Ringwood L.A., Hsu L.Y., Hon Y.Y., Aletras A.H., Cannon R.O., Gladwin M.T., Arai A.E. Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation 2008, 117:2986-2994.
43. Govoni M., Jansson E.A., Weitzberg E., Lundberg J.O. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide 2008, 19:333-337.
44. Grubina R., Huang Z., Shiva S., Joshi M.S., Azarov I., Basu S., Ringwood L.A., Jiang A., Hogg N., Kim-Shapiro D.B., Gladwin M.T. Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin. J. Biol. Chem. 2007, 282:12916-12927.
45. Grubina R., Basu S., Tiso M., Kim-Shapiro D.B., Gladwin M.T. Nitrite reductase activity of hemoglobin S (sickle) provides insight into contributions of heme redox potential versus ligand affinity. J. Biol. Chem. 2008, 283:3628-3638.
46. Hagen T., Taylor C.T., Lam F., Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 2003, 302:1975-1978.
47. Haldane J. The Red Colour of Salted Meat. J. Hyg. 1901, 1:115-122.
48. Hendgen-Cotta U.B., Merx M.W., Shiva S., Schmitz J., Becher S., Klare J.P., Steinhoff H.J., Goedecke A., Schrader J., Gladwin M.T., Kelm M., Rassaf T. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc. Natl. Acad. Sci. USA 2008, 105:10256-10261.
49. Heusch G., Schulz R., Rahimtoola S.H. Myocardial hibernation: a delicate balance. Am. J. Physiol. Heart Circ. Physiol. 2005, 288:H984-H999.
50. Huang K.T., Keszler A., Patel N., Patel R.P., Gladwin M.T., Kim-Shapiro D.B., Hogg N. The reaction between nitrite and deoxyhemoglobin. Reassessment of reaction kinetics and stoichiometry. J. Biol. Chem. 2005, 280:31126-31131.
51. Huang Z., Shiva S., Kim-Shapiro D.B., Patel R.P., Ringwood L.A., Irby C.E., Huang K.T., Ho C., Hogg N., Schechter A.N., Gladwin M.T. Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J. Clin. Invest. 2005, 115:2099-2107.
52. Hunter C.J., Dejam A., Blood A.B., Shields H., Kim-Shapiro D.B., Machado R.F., Tarekegn S., Mulla N., Hopper A.O., Schechter A.N., Power G.G., Gladwin M.T. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat. Med. 2004, 10:1122-1127.
53. Jeffers A., Xu X.L., Huang K.T., Cho M., Hogg N., Patel R.P., Kim-Shapiro D.B. Hemoglobin mediated nitrite activation of soluble guanylyl cyclase. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2005, 142:130-135.
54. Jung K.H., Chu K., Ko S.Y., Lee S.T., Sinn D.I., Park D.K., Kim J.M., Song E.C., Kim M., Roh J.K. Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury. Stroke 2006, 37:2744-2750.
55. Khan A.A., Wang Y., Sun Y., Mao X.O., Xie L., Miles E., Graboski J., Chen S., Ellerby L.M., Jin K., Greenberg D.A. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc. Natl. Acad. Sci. USA 2006, 103:17944-17948.
56. Khan A.A., Mao X.O., Banwait S., DerMardirossian C.M., Bokoch G.M., Jin K., Greenberg D.A. Regulation of hypoxic neuronal death signaling by neuroglobin. FASEB J. 2008, 22:1737-1747.
57. Kozlov A.V., Staniek K., Nohl H. Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett. 1999, 454:127-130.
58. Kuwabara M., Kakinuma Y., Ando M., Katare R.G., Yamasaki F., Doi Y., Sato T. Nitric oxide stimulates vascular endothelial growth factor production in cardiomyocytes involved in angiogenesis. J. Physiol. Sci. 2006, 56:95-101.
59. Larsen F.J., Weitzberg E., Lundberg J.O., Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol. (Oxf) 2007, 191:59-66.
60. Lauer T., Preik M., Rassaf T., Strauer B.E., Deussen A., Feelisch M., Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc. Natl. Acad. Sci. USA 2001, 98:12814-12819.
61. Lesnefsky E.J., Chen Q., Moghaddas S., Hassan M.O., Tandler B., Hoppel C.L. Blockade of electron transport during ischemia protects cardiac mitochondria. J. Biol. Chem. 2004, 279:47961-47967.
62. Li H., Samouilov A., Liu X., Zweier J.L. Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. J. Biol. Chem. 2001, 276:24482-24489.
63. Lu P., Liu F., Yao Z., Wang C.Y., Chen D.D., Tian Y., Zhang J.H., Wu Y.H. Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia-reperfusion injury. Hepatobiliary Pancreat Dis Int. 2005, 4:350-355.
64. Lundberg J.O., Weitzberg E., Cole J.A., Benjamin N. Nitrate, bacteria and human health. Nat. Rev. Microbiol. 2004, 2:593-602.
65. Lundberg J.O., Weitzberg E., Gladwin M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. Drug Discov. 2008, 7:156-167.
66. Maher A.R., Milsom A.B., Gunaruwan P., Abozguia K., Ahmed I., Weaver R.A., Thomas P., Ashrafian H., Born G.V., James P.E., Frenneaux M.P. Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation 2008, 117:670-677.
67. Merx M.W., Flogel U., Stumpe T., Godecke A., Decking U.K., Schrader J. Myoglobin facilitates oxygen diffusion. FASEB J 2001, 15:1077-1079.
68. Nadtochiy S.M., Burwell L.S., Brookes P.S. Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J. Mol. Cell Cardiol. 2007, 42:812-825.
69. Nisoli E., Clementi E., Paolucci C., Cozzi V., Tonello C., Sciorati C., Bracale R., Valerio A., Francolini M., Moncada S., Carruba M.O. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 2003, 299:896-899.
70. Palacios-Callender M., Hollis V., Mitchison M., Frakich N., Unitt D., Moncada S. Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation. Proc. Natl. Acad. Sci. USA 2007, 104:18508-18513.
71. Pedigo L. Antagonism between amyl nitrite and prussic acid. Trans. Med. Soc. Virginia 1888, 19:124-131.
72. Petersen M.G., Dewilde S., Fago A. Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions. J. Inorg. Biochem. 2008, 102:1777-1782.
73. Poderoso J.J., Carreras M.C., Lisdero C., Riobo N., Schopfer F., Boveris A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 1996, 328:85-92.
74. Rassaf T., Flogel U., Drexhage C., Hendgen-Cotta U., Kelm M., Schrader J. Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function. Circ. Res. 2007, 100:1749-1754.
75. Ridnour L.A., Isenberg J.S., Espey M.G., Thomas D.D., Roberts D.D., Wink D.A. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc. Natl. Acad. Sci. USA 2005, 102:13147-13152.
76. Robinson J.M., Lancaster J.R. Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide - Mechanism(s) and physiologic versus pathophysiologic relevance. Am. J. Respir. Cell Mol. Biol. 2005, 32:257-261.
77. Rodkey F.L. Mechanism for conversion of oxyhemoglobin to methemoglobin by nitrite. Clin. Chem. 1976, 22:1986-1990.
78. Rodriguez J., Maloney R.E., Rassaf T., Bryan N.S., Feelisch M. Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc. Natl. Acad. Sci. USA 2003, 100:336-341.
79. Ross J. Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation. Circulation 1991, 83:1076-1083.
80. Ross J.M., Fairchild H.M., Weldy J., Guyton A.C. Autoregulation of blood flow by oxygen lack. Am. J. Physiol. 1962, 202:21-24.
81. Roy C.S., Brown J. The blood-pressure and its variations in the arterioles, capillaries and smaller veins. J. Physiol. 1880, 2:323-446. 1.
82. Salgado M.T., Nagababu E., Rifkind J.M. Quantification of intermediates formed during the reduction of nitrite by deoxyhemoglobin. J. Biol. Chem. 2009, 284:12710-12718.
83. Schlieper G., Kim J.H., Molojavyi A., Jacoby C., Laussmann T., Flogel U., Godecke A., Schrader J. Adaptation of the myoglobin knockout mouse to hypoxic stress. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 286:R786-R792.
84. Shen W., Xu X., Ochoa M., Zhao G., Wolin M.S., Hintze T.H. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ. Res. 1994, 75:1086-1095.
85. Shiva S., Brookes P.S., Patel R.P., Anderson P.G., Darley-Usmar V.M. Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc. Natl. Acad. Sci. USA 2001, 98:7212-7217.
86. Shiva S., Wang X., Ringwood L.A., Xu X., Yuditskaya S., Annavajjhala V., Miyajima H., Hogg N., Harris Z.L., Gladwin M.T. Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Nat. Chem. Biol. 2006, 2:486-493.
87. Shiva S., Huang Z., Grubina R., Sun J., Ringwood L.A., MacArthur P.H., Xu X., Murphy E., Darley-Usmar V.M., Gladwin M.T. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ. Res. 2007, 100:654-661.
88. Shiva S., Sack M.N., Greer J.J., Duranski M., Ringwood L.A., Burwell L., Wang X., MacArthur P.H., Shoja A., Raghavachari N., Calvert J.W., Brookes P.S., Lefer D.J., Gladwin M.T. Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J. Exp. Med. 2007, 204:2089-2102.
89. Sun Y., Jin K., Mao X.O., Zhu Y., Greenberg D.A. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc. Natl. Acad. Sci. USA 2001, 98:15306-15311.
90. Thomas D.D., Liu X., Kantrow S.P., Lancaster J.R. The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2. Proc. Natl. Acad. Sci. USA 2001, 98:355-360.
91. Tripatara P., Patel N.S., Webb A., Rathod K., Lecomte F.M., Mazzon E., Cuzzocrea S., Yaqoob M.M., Ahluwalia A., Thiemermann C. Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. J. Am. Soc. Nephrol. 2007, 18:570-580.
92. Tsai A.G., Johnson P.C., Intaglietta M. Oxygen gradients in the microcirculation. Physiol. Rev. 2003, 83:933-963.
93. Tune J.D., Gorman M.W., Feigl E.O. Matching coronary blood flow to myocardial oxygen consumption. J. Appl. Physiol. 2004, 97:404-415.
94. Wang X., Tanus-Santos J.E., Reiter C.D., Dejam A., Shiva S., Smith R.D., Hogg N., Gladwin M.T. Biological activity of nitric oxide in the plasmatic compartment. Proc. Natl. Acad. Sci. USA 2004, 101:11477-11482.
95. Webb A., Bond R., McLean P., Uppal R., Benjamin N., Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc. Natl. Acad. Sci. USA 2004, 101:13683-13688.
96. Xu W.L., Wang C.L., Liao Z.Y., Zhang Y.L., Yu L.H., Meng F.W., Wang X.X., Yin Z.Y., Qian L.J., Zhang C.G. [Identification of interaction and interaction domains between neuroglobin and Na(+), K(+)-ATPase beta2 subunit]. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003, 35:823-828.