CAPE promotes TRAIL-induced apoptosis through the upregulation of TRAIL receptors via activation of p38 and suppression of JNK in SK-Hep1 hepatocellular carcinoma cells

International Journal of Oncology

Volumn 43, Issue 4, 2013, Pages 1291-1300

  Kim, Eun Young ^a   Ryu, Jae Ha ^a   Kim, An Keun ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Caffeic acid phenethyl ester; Combination; Hepatoma; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CAFFEIC ACID PHENETHYL ESTER; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; DEATH RECEPTOR 4; DEATH RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; BEES; CAFFEIC ACIDS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE 4; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLETHYL ALCOHOL; PROPOLIS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UP-REGULATION;

EID: 84882403388     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2018     Document Type: Article

References (36)

1. Schutte K, Bornschein J and Malfertheiner P: Hepatocellular carcinoma-epidemiological trends and risk factors. Dig Dis 27: 80-92, 2009.
2. McGlynn KA, Tsao L, Hsing AW, Devesa SS and Fraumeni JF Jr: International trends and patterns of primary liver cancer. Int J Cancer 94: 290-296, 2001.
3. Harnois DM: Hepatitis C virus infection and the rising incidence of hepatocellular carcinoma. Mayo Clin Proc 87: 7-8, 2012.
4. Paul SB, Manjunatha YC and Acharya SK: Palliative treatment in advanced hepatocellular carcinoma: has it made any difference? Trop Gastroenterol 30: 125-134, 2009.
5. Ashkenazi A, Pai RC, Fong S, et al: Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104: 155-162, 1999.
6. Mucha SR, Rizzani A, Gerbes AL, et al: JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand. Gut 58: 688-698, 2009.
7. Voelkel-Johnson C: TRAIL-mediated signaling in prostate, bladder and renal cancer. Nat Rev Urol 8: 417-427, 2011.
8. Hellwig CT and Rehm M: TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies. Mol Cancer Ther 11: 3-13, 2012.
9. Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B and Russo GL: Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann NY Acad Sci 1259: 95-103, 2012.
10. Stagos D, Amoutzias GD, Matakos A, Spyrou A, Tsatsakis AM and Kouretas D: Chemoprevention of liver cancer by plant polyphenols. Food Chem Toxicol 50: 2155-2170, 2012.
11. Siddiqui IA, Malik A, Adhami VM, et al: Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene 27: 2055-2063, 2008.
12. Jacquemin G, Shirley S and Micheau O: Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells? Cell Mol Life Sci 67: 3115-3130, 2010.
13. Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998.
14. Wang S and El-Deiry WS: TRAIL and apoptosis induction by TNF-family death receptors. Oncogene 22: 8628-8633, 2003.
15. Grunberger D, Banerjee R, Eisinger K, et al: Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Cell Mol Life Sci 44: 230-232, 1988.
16. Ozturk G, Ginis Z, Akyol S, Erden G, Gurel A and Akyol O: The anticancer mechanism of caffeic acid phenethyl ester (CAPE): review of melanomas, lung and prostate cancers. Eur Rev Med Pharmacol Sci 16: 2064-2068, 2012.
17. Khalil ML: Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev 7: 22-31, 2006.
18. Szliszka E, Czuba ZP, Domino M, Mazur B, Zydowicz G and Krol W: Ethanolic extract of propolis (EEP) enhances the apoptosis-inducing potential of TRAIL in cancer cells. Molecules 14: 738-754, 2009.
19. Szliszka E, Czuba ZP, Bronikowska J, Mertas A, Paradysz A and Krol W: Ethanolic extract of propolis augments TRAIL induced apoptotic death in prostate cancer cells. Evid Based Complement Alternat Med 2011: 535172, 2011.
20. Szliszka E, Zydowicz G, Mizgala E and Krol W: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis. Int J Oncol 41: 818-828, 2012.
21. Li X, Wang JN, Huang JM, et al: Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. Toxicol In Vitro 25: 630-635, 2011.
22. Kim EY, Yu JS, Yang M and Kim AK: Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5. Mol Cells 35: 32-40, 2013.
23. Jin CY, Park C, Hwang HJ, et al: Naringenin up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer A549 cells. Mol Nutr Food Res 55: 300-309, 2011.
24. Nicholson DW: Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6: 1028-1042, 1999.
25. Thorburn A: Death receptor-induced cell killing. Cell Signal 16: 139-144, 2004.
26. Kim HE, Du F, Fang M and Wang X: Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1. Proc Natl Acad Sci USA 102: 17545-17550, 2005.
27. Zhang L and Fang B: Mechanisms of resistance to TRAIL induced apoptosis in cancer. Cancer Gene Ther 12: 228-237, 2004.
28. Kauntz H, Bousserouel S, Gosse F and Raul F: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells. Apoptosis 17: 797-809, 2012.
29. Prasad S, Yadav VR, Kannappan R and Aggarwal BB: Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. J Biol Chem 286: 5546-5557, 2011.
30. Kelley RF, Totpal K, Lindstrom SH, et al: Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling. J Biol Chem 280: 2205-2212, 2005.
31. Gupta SC, Reuter S, Phromnoi K, et al: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species-and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem 286: 1134-1146, 2011.
32. Raman M, Chen W and Cobb MH: Differential regulation and properties of MAPKs. Oncogene 26: 3100-3112, 2007.
33. Pimienta G and Pascual J: Canonical and alternative MAPK signaling. Cell Cycle 6: 2628-2632, 2007.
34. Lepage C, Leger DY, Bertrand J, Martin F, Beneytout JL and Liagre B: Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett 301: 193-202, 2011.
35. Lin FL, Hsu JL, Chou CH, Wu WJ, Chang CI and Liu HJ: Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF alpha and p53 pathways. Eur J Pharmacol 650: 120-129, 2011.
36. Lamy V, Bousserouel S, Gosse F, Minker C, Lobstein A and Raul F: Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells. Oncol Rep 26: 109-114, 2011.