Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop

Journal of Biological Chemistry

Volumn 288, Issue 33, 2013, Pages 24049-24062

  Németh, Balázs Csaba ^a   Wartmann, Thomas ^b   Halangk, Walter ^b   Sahin Tóth, Miklós ^a  

^a BOSTON UNIVERSITY   (United States)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOACTIVATION; AUTOLYSIS LOOP; BIOCHEMICAL EFFECTS; DIFFERENT MECHANISMS;

BIOCHEMISTRY; BIOLOGY;

MAMMALS;

CHYMOTRYPSIN; CHYMOTRYPSIN B; CHYMOTRYPSIN C; ISOENZYME; SERINE PROTEINASE; TRYPSINOGEN; TRYPSINOGEN 20; TRYPSINOGEN 7; TRYPSINOGEN 8; TRYPSINOGEN 9; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; SEQUENCE ALIGNMENT;

CHYMOTRYPSIN; ENZYMES; HEREDITARY PANCREATITIS; PANCREAS; PROTEIN PROCESSING; PROTEOLYTIC ENZYMES; SERINE PROTEASE; TRYPSIN; TRYPSINOGEN; ZYMOGEN ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; CATIONS; CHROMATOGRAPHY, ION EXCHANGE; CHYMOTRYPSIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME ACTIVATION; GENOME; HUMANS; ISOENZYMES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PANCREAS; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; TRYPSINOGEN;

EID: 84882398089     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.478800     Document Type: Article

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