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Volumn 144, Issue 5, 2013, Pages

Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice

Author keywords

Digestive Enzyme; Inflammation; Mouse Model; PRSS1

Indexed keywords

CERULETIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR RELA; TRYPSINOGEN;

EID: 84876493374     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.041     Document Type: Article
Times cited : (93)

References (78)
  • 1
    • 77954632792 scopus 로고    scopus 로고
    • Protein digestion
    • K.E. Barrett, S.M. Barman, S. Boitano, 23rd ed. Accessed March 10, 2013
    • K.E. Barrett, S.M. Barman, S. Boitano et al. Protein digestion K.E. Barrett, S.M. Barman, S. Boitano, Ganong's review of medical physiology 23rd ed. 2010 http://www.accessmedicine.com/content.aspx?aID=5242356 Accessed March 10, 2013
    • (2010) Ganong's Review of Medical Physiology
    • Barrett, K.E.1    Barman, S.M.2    Boitano, S.3
  • 2
    • 0002616496 scopus 로고
    • Überdie selbstverdauung des menschlichen pankreas
    • H. Chiari Überdie selbstverdauung des menschlichen pankreas Zeitschrift Heilkunde 17 1896 69 96
    • (1896) Zeitschrift Heilkunde , vol.17 , pp. 69-96
    • Chiari, H.1
  • 3
    • 80051774435 scopus 로고    scopus 로고
    • Molecular mechanisms of pancreatic injury
    • R.P. Sah, A. Saluja Molecular mechanisms of pancreatic injury Curr Opin Gastroenterol 27 2011 444 451
    • (2011) Curr Opin Gastroenterol , vol.27 , pp. 444-451
    • Sah, R.P.1    Saluja, A.2
  • 4
    • 33947376068 scopus 로고    scopus 로고
    • Why does pancreatic overstimulation cause pancreatitis?
    • A.K. Saluja, M.M. Lerch, P.A. Phillips Why does pancreatic overstimulation cause pancreatitis? Annu Rev Physiol 69 2007 249 269
    • (2007) Annu Rev Physiol , vol.69 , pp. 249-269
    • Saluja, A.K.1    Lerch, M.M.2    Phillips, P.A.3
  • 5
    • 0031867966 scopus 로고    scopus 로고
    • Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rats
    • B. Hofbauer, A.K. Saluja, M.M. Lerch Intra-acinar cell activation of trypsinogen during cerulein-induced pancreatitis in rats Am J Physiol 275 1998 G352 G362
    • (1998) Am J Physiol , vol.275
    • Hofbauer, B.1    Saluja, A.K.2    Lerch, M.M.3
  • 6
    • 0024416027 scopus 로고
    • Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization
    • A. Saluja, M. Saluja, A. Villa Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization J Clin Invest 84 1989 1260 1266
    • (1989) J Clin Invest , vol.84 , pp. 1260-1266
    • Saluja, A.1    Saluja, M.2    Villa, A.3
  • 7
    • 0022462341 scopus 로고
    • Human acute pancreatitis: Its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells
    • G. Kloppel, T. Dreyer, S. Willemer Human acute pancreatitis: its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells Virchows Arch A Pathol Anat Histopathol 409 1986 791 803
    • (1986) Virchows Arch A Pathol Anat Histopathol , vol.409 , pp. 791-803
    • Kloppel, G.1    Dreyer, T.2    Willemer, S.3
  • 8
    • 80052589208 scopus 로고    scopus 로고
    • Trypsinogen activation in acute and chronic pancreatitis: Is it a prerequisite?
    • R.P. Sah, A.K. Saluja Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite? Gut 60 2011 1305 1307
    • (2011) Gut , vol.60 , pp. 1305-1307
    • Sah, R.P.1    Saluja, A.K.2
  • 9
    • 81855228093 scopus 로고    scopus 로고
    • Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
    • R. Dawra, R.P. Sah, V. Dudeja Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis Gastroenterology 141 2011 2210 2217
    • (2011) Gastroenterology , vol.141 , pp. 2210-2217
    • Dawra, R.1    Sah, R.P.2    Dudeja, V.3
  • 10
    • 80052586196 scopus 로고    scopus 로고
    • Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis
    • 10.1136/gut.2010.226175 Epub 2011 Apr 6
    • S. Gaiser, J. Daniluk, Y. Liu Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis Gut 60 10 2011 1379 1388 10.1136/gut.2010.226175 Epub 2011 Apr 6
    • (2011) Gut , vol.60 , Issue.10 , pp. 1379-1388
    • Gaiser, S.1    Daniluk, J.2    Liu, Y.3
  • 11
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • W. Halangk, M.M. Lerch, B. Brandt-Nedelev Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis J Clin Invest 106 2000 773 781
    • (2000) J Clin Invest , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3
  • 12
    • 0035109764 scopus 로고    scopus 로고
    • Chronic pancreatitis: Diagnosis, classification, and new genetic developments
    • B. Etemad, D.C. Whitcomb Chronic pancreatitis: diagnosis, classification, and new genetic developments Gastroenterology 120 2001 682 707
    • (2001) Gastroenterology , vol.120 , pp. 682-707
    • Etemad, B.1    Whitcomb, D.C.2
  • 13
    • 77951920963 scopus 로고    scopus 로고
    • Genetic aspects of pancreatitis
    • D.C. Whitcomb Genetic aspects of pancreatitis Annu Rev Med 61 2010 413 424
    • (2010) Annu Rev Med , vol.61 , pp. 413-424
    • Whitcomb, D.C.1
  • 14
    • 70350225542 scopus 로고    scopus 로고
    • Chronic pancreatitis: Genetics and pathogenesis
    • J.M. Chen, C. Ferec Chronic pancreatitis: genetics and pathogenesis Annu Rev Genomics Hum Genet 10 2009 63 87
    • (2009) Annu Rev Genomics Hum Genet , vol.10 , pp. 63-87
    • Chen, J.M.1    Ferec, C.2
  • 16
    • 34247197621 scopus 로고    scopus 로고
    • Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy
    • H. Witt, M.V. Apte, V. Keim Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy Gastroenterology 132 2007 1557 1573
    • (2007) Gastroenterology , vol.132 , pp. 1557-1573
    • Witt, H.1    Apte, M.V.2    Keim, V.3
  • 17
    • 8744256699 scopus 로고    scopus 로고
    • Pathogenesis of chronic pancreatitis: An evidence-based review of past theories and recent developments
    • T. Stevens, D.L. Conwell, G. Zuccaro Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments Am J Gastroenterol 99 2004 2256 2270
    • (2004) Am J Gastroenterol , vol.99 , pp. 2256-2270
    • Stevens, T.1    Conwell, D.L.2    Zuccaro, G.3
  • 18
    • 10144246566 scopus 로고    scopus 로고
    • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
    • D.C. Whitcomb, M.C. Gorry, R.A. Preston Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene Nat Genet 14 1996 141 145
    • (1996) Nat Genet , vol.14 , pp. 141-145
    • Whitcomb, D.C.1    Gorry, M.C.2    Preston, R.A.3
  • 19
    • 84863724208 scopus 로고    scopus 로고
    • Natural history following the first attack of acute pancreatitis
    • D. Yadav, M. O'Connell, G.I. Papachristou Natural history following the first attack of acute pancreatitis Am J Gastroenterol 107 2012 1096 1103
    • (2012) Am J Gastroenterol , vol.107 , pp. 1096-1103
    • Yadav, D.1    O'Connell, M.2    Papachristou, G.I.3
  • 21
    • 0042744006 scopus 로고    scopus 로고
    • Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis
    • A. Canbay, M.E. Guicciardi, H. Higuchi Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis J Clin Invest 112 2003 152 159
    • (2003) J Clin Invest , vol.112 , pp. 152-159
    • Canbay, A.1    Guicciardi, M.E.2    Higuchi, H.3
  • 22
    • 0034741255 scopus 로고    scopus 로고
    • Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal cerulein stimulation
    • A.J. Hietaranta, A.K. Saluja, Bhagat Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal cerulein stimulation Biochem Biophys Res Commun 280 2001 388 395
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 388-395
    • Hietaranta, A.J.1    Saluja, A.K.2    Bhagat3
  • 23
    • 34248345864 scopus 로고    scopus 로고
    • Chronic pancreatitis, pseudotumors and other tumor-like lesions
    • G. Kloppel Chronic pancreatitis, pseudotumors and other tumor-like lesions Mod Pathol 20 Suppl 1 2007 S113 S131
    • (2007) Mod Pathol , vol.20 , Issue.SUPPL. 1
    • Kloppel, G.1
  • 24
    • 77951681488 scopus 로고    scopus 로고
    • Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis
    • S.B. Ko, N. Mizuno, Y. Yatabe Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis Gastroenterology 138 2010 1988 1996
    • (2010) Gastroenterology , vol.138 , pp. 1988-1996
    • Ko, S.B.1    Mizuno, N.2    Yatabe, Y.3
  • 25
    • 0034087517 scopus 로고    scopus 로고
    • Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse
    • B.A. Neuschwander-Tetri, F.R. Burton, M.E. Presti Repetitive self-limited acute pancreatitis induces pancreatic fibrogenesis in the mouse Dig Dis Sci 45 2000 665 674
    • (2000) Dig Dis Sci , vol.45 , pp. 665-674
    • Neuschwander-Tetri, B.A.1    Burton, F.R.2    Presti, M.E.3
  • 26
    • 53049107597 scopus 로고    scopus 로고
    • Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis
    • F. Marrache, S.P. Tu, G. Bhagat Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis Gastroenterology 135 2008 1277 1287
    • (2008) Gastroenterology , vol.135 , pp. 1277-1287
    • Marrache, F.1    Tu, S.P.2    Bhagat, G.3
  • 27
    • 0036934057 scopus 로고    scopus 로고
    • TGFbeta-induced fibrogenesis of the pancreas
    • A. Menke, G. Adler TGFbeta-induced fibrogenesis of the pancreas Int J Gastrointest Cancer 31 2002 41 46
    • (2002) Int J Gastrointest Cancer , vol.31 , pp. 41-46
    • Menke, A.1    Adler, G.2
  • 28
    • 65549164068 scopus 로고    scopus 로고
    • Roles of NF-kappaB in health and disease: Mechanisms and therapeutic potential
    • E.T. Wong, V. Tergaonkar Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential Clin Sci (Lond) 116 2009 451 465
    • (2009) Clin Sci (Lond) , vol.116 , pp. 451-465
    • Wong, E.T.1    Tergaonkar, V.2
  • 29
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • P.J. Barnes, M. Karin Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases N Engl J Med 336 1997 1066 1071
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 30
    • 33747010658 scopus 로고    scopus 로고
    • Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis
    • N. Teich, J. Rosendahl, M. Toth Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis Hum Mutat 27 2006 721 730
    • (2006) Hum Mutat , vol.27 , pp. 721-730
    • Teich, N.1    Rosendahl, J.2    Toth, M.3
  • 31
    • 33646028182 scopus 로고    scopus 로고
    • Biochemical models of hereditary pancreatitis
    • ix
    • M. Sahin-Toth Biochemical models of hereditary pancreatitis Endocrinol Metab Clin North Am 35 2006 303 312 ix
    • (2006) Endocrinol Metab Clin North Am , vol.35 , pp. 303-312
    • Sahin-Toth, M.1
  • 32
    • 58249089866 scopus 로고    scopus 로고
    • The natural history of hereditary pancreatitis: A national series
    • V. Rebours, M.C. Boutron-Ruault, M. Schnee The natural history of hereditary pancreatitis: a national series Gut 58 2009 97 103
    • (2009) Gut , vol.58 , pp. 97-103
    • Rebours, V.1    Boutron-Ruault, M.C.2    Schnee, M.3
  • 33
    • 10744233747 scopus 로고    scopus 로고
    • Clinical and genetic characteristics of hereditary pancreatitis in Europe
    • N. Howes, M.M. Lerch, W. Greenhalf Clinical and genetic characteristics of hereditary pancreatitis in Europe Clin Gastroenterol Hepatol 2 2004 252 261
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 252-261
    • Howes, N.1    Lerch, M.M.2    Greenhalf, W.3
  • 34
    • 33845664588 scopus 로고    scopus 로고
    • A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen
    • H. Archer, N. Jura, J. Keller A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen Gastroenterology 131 2006 1844 1855
    • (2006) Gastroenterology , vol.131 , pp. 1844-1855
    • Archer, H.1    Jura, N.2    Keller, J.3
  • 35
    • 77953699769 scopus 로고    scopus 로고
    • Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations
    • R. Szmola, M. Sahin-Toth Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations J Med Genet 47 2010 348 350
    • (2010) J Med Genet , vol.47 , pp. 348-350
    • Szmola, R.1    Sahin-Toth, M.2
  • 36
    • 77952296674 scopus 로고    scopus 로고
    • Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis
    • J. Rosendahl, N. Teich, P. Kovacs Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis Pancreatology 10 2010 243 249
    • (2010) Pancreatology , vol.10 , pp. 243-249
    • Rosendahl, J.1    Teich, N.2    Kovacs, P.3
  • 37
    • 84870511045 scopus 로고    scopus 로고
    • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
    • D.C. Whitcomb, J. Larusch, A.M. Krasinskas Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis Nat Genet 44 2012 1349 1354
    • (2012) Nat Genet , vol.44 , pp. 1349-1354
    • Whitcomb, D.C.1    Larusch, J.2    Krasinskas, A.M.3
  • 38
    • 70450248392 scopus 로고    scopus 로고
    • Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death
    • E. Kereszturi, M. Sahin-Toth Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death J Biol Chem 284 2009 33392 33399
    • (2009) J Biol Chem , vol.284 , pp. 33392-33399
    • Kereszturi, E.1    Sahin-Toth, M.2
  • 39
    • 63749109353 scopus 로고    scopus 로고
    • Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism
    • E. Kereszturi, R. Szmola, Z. Kukor Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism Hum Mutat 30 2009 575 582
    • (2009) Hum Mutat , vol.30 , pp. 575-582
    • Kereszturi, E.1    Szmola, R.2    Kukor, Z.3
  • 40
    • 77749318543 scopus 로고    scopus 로고
    • Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
    • R. Szmola, M. Sahin-Toth Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells Gut 59 2009 365 372
    • (2009) Gut , vol.59 , pp. 365-372
    • Szmola, R.1    Sahin-Toth, M.2
  • 41
    • 79952310800 scopus 로고    scopus 로고
    • Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage
    • A. Lugea, D. Tischler, J. Nguyen Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage Gastroenterology 140 2011 987 997
    • (2011) Gastroenterology , vol.140 , pp. 987-997
    • Lugea, A.1    Tischler, D.2    Nguyen, J.3
  • 42
    • 34447515863 scopus 로고    scopus 로고
    • Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells
    • C.H. Kubisch, C.D. Logsdon Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells Am J Physiol Gastrointest Liver Physiol 292 2007 G1804 G1812
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Kubisch, C.H.1    Logsdon, C.D.2
  • 43
    • 0036789203 scopus 로고    scopus 로고
    • Tropical calcific pancreatitis: Strong association with SPINK1 trypsin inhibitor mutations
    • E. Bhatia, G. Choudhuri, S.S. Sikora Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations Gastroenterology 123 2002 1020 1025
    • (2002) Gastroenterology , vol.123 , pp. 1020-1025
    • Bhatia, E.1    Choudhuri, G.2    Sikora, S.S.3
  • 44
    • 2342433551 scopus 로고    scopus 로고
    • Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
    • G.R. Chandak, M.M. Idris, D.N. Reddy Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis Gut 53 2004 723 728
    • (2004) Gut , vol.53 , pp. 723-728
    • Chandak, G.R.1    Idris, M.M.2    Reddy, D.N.3
  • 45
    • 0036113792 scopus 로고    scopus 로고
    • Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis
    • J.P. Drenth, R. te Morsche, J.B. Jansen Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis Gut 50 2002 687 692
    • (2002) Gut , vol.50 , pp. 687-692
    • Drenth, J.P.1    Te Morsche, R.2    Jansen, J.B.3
  • 46
    • 33749143421 scopus 로고    scopus 로고
    • Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis
    • S. Keiles, A. Kammesheidt Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis Pancreas 33 2006 221 227
    • (2006) Pancreas , vol.33 , pp. 221-227
    • Keiles, S.1    Kammesheidt, A.2
  • 47
    • 33747773624 scopus 로고    scopus 로고
    • Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
    • S. Mahurkar, M.M. Idris, D.N. Reddy Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis Gut 55 2006 1270 1275
    • (2006) Gut , vol.55 , pp. 1270-1275
    • Mahurkar, S.1    Idris, M.M.2    Reddy, D.N.3
  • 48
    • 84885625347 scopus 로고    scopus 로고
    • Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants
    • Epub ahead of print
    • S. Paliwal, S. Bhaskar, K.R. Mani Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants Gut 2012 May 12 Epub ahead of print
    • (2012) Gut
    • Paliwal, S.1    Bhaskar, S.2    Mani, K.R.3
  • 50
    • 84866345751 scopus 로고    scopus 로고
    • Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis
    • M. Ohmuraya, A. Sugano, M. Hirota Role of intrapancreatic SPINK1/Spink3 expression in the development of pancreatitis Front Physiol 3 2012 126
    • (2012) Front Physiol , vol.3 , pp. 126
    • Ohmuraya, M.1    Sugano, A.2    Hirota, M.3
  • 51
    • 23244447063 scopus 로고    scopus 로고
    • Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    • M. Ohmuraya, M. Hirota, M. Araki Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice Gastroenterology 129 2005 696 705
    • (2005) Gastroenterology , vol.129 , pp. 696-705
    • Ohmuraya, M.1    Hirota, M.2    Araki, M.3
  • 52
    • 80155186900 scopus 로고    scopus 로고
    • Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases
    • M. Ohmuraya, K. Yamamura Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases Exp Anim 60 2011 433 444
    • (2011) Exp Anim , vol.60 , pp. 433-444
    • Ohmuraya, M.1    Yamamura, K.2
  • 53
    • 0038247596 scopus 로고    scopus 로고
    • Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules
    • Y. Tando, H. Algul, G. Schneider Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules Digestion 66 2002 237 245
    • (2002) Digestion , vol.66 , pp. 237-245
    • Tando, Y.1    Algul, H.2    Schneider, G.3
  • 54
    • 15744392747 scopus 로고    scopus 로고
    • Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice
    • J.D. Nathan, J. Romac, R.Y. Peng Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice Gastroenterology 128 2005 717 727
    • (2005) Gastroenterology , vol.128 , pp. 717-727
    • Nathan, J.D.1    Romac, J.2    Peng, R.Y.3
  • 55
    • 74049127271 scopus 로고    scopus 로고
    • Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor
    • J.D. Nathan, J. Romac, R.Y. Peng Protection against chronic pancreatitis and pancreatic fibrosis in mice overexpressing pancreatic secretory trypsin inhibitor Pancreas 39 2010 e24 e30
    • (2010) Pancreas , vol.39
    • Nathan, J.D.1    Romac, J.2    Peng, R.Y.3
  • 56
    • 0032246276 scopus 로고    scopus 로고
    • Early NF-kappaB activation is associated with hormone-induced pancreatitis
    • I. Gukovsky, A.S. Gukovskaya, T.A. Blinman Early NF-kappaB activation is associated with hormone-induced pancreatitis Am J Physiol 275 1998 G1402 G1414
    • (1998) Am J Physiol , vol.275
    • Gukovsky, I.1    Gukovskaya, A.S.2    Blinman, T.A.3
  • 57
    • 0011770646 scopus 로고    scopus 로고
    • CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells
    • B. Han, B. Ji, C.D. Logsdon CCK independently activates intracellular trypsinogen and NF-kappaB in rat pancreatic acinar cells Am J Physiol Cell Physiol 280 2001 C465 C472
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Han, B.1    Ji, B.2    Logsdon, C.D.3
  • 58
    • 67650513305 scopus 로고    scopus 로고
    • Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation
    • B. Ji, S. Gaiser, X. Chen Intracellular trypsin induces pancreatic acinar cell death but not NF-kappaB activation J Biol Chem 284 2009 17488 17498
    • (2009) J Biol Chem , vol.284 , pp. 17488-17498
    • Ji, B.1    Gaiser, S.2    Chen, X.3
  • 59
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • S. Vallabhapurapu, M. Karin Regulation and function of NF-kappaB transcription factors in the immune system Annu Rev Immunol 27 2009 693 733
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 60
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • B. Rayet, C. Gelinas Aberrant rel/nfkb genes and activity in human cancer Oncogene 18 1999 6938 6947
    • (1999) Oncogene , vol.18 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 61
    • 34249879045 scopus 로고    scopus 로고
    • Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
    • H. Algul, M. Treiber, M. Lesina Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis J Clin Invest 117 2007 1490 1501
    • (2007) J Clin Invest , vol.117 , pp. 1490-1501
    • Algul, H.1    Treiber, M.2    Lesina, M.3
  • 62
    • 80053588704 scopus 로고    scopus 로고
    • Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis
    • 85 e1-7
    • M. Treiber, P. Neuhofer, E. Anetsberger Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis Gastroenterology 141 2011 1473 1485 85 e1-7
    • (2011) Gastroenterology , vol.141 , pp. 1473-1485
    • Treiber, M.1    Neuhofer, P.2    Anetsberger, E.3
  • 63
    • 9144220803 scopus 로고    scopus 로고
    • Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB- deficient mice
    • D. Altavilla, C. Famulari, M. Passaniti Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice Lab Invest 83 2003 1723 1732
    • (2003) Lab Invest , vol.83 , pp. 1723-1732
    • Altavilla, D.1    Famulari, C.2    Passaniti, M.3
  • 64
    • 34249887978 scopus 로고    scopus 로고
    • Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo
    • B. Baumann, M. Wagner, T. Aleksic Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo J Clin Invest 117 2007 1502 1513
    • (2007) J Clin Invest , vol.117 , pp. 1502-1513
    • Baumann, B.1    Wagner, M.2    Aleksic, T.3
  • 65
    • 33846994097 scopus 로고    scopus 로고
    • Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2
    • T. Aleksic, B. Baumann, M. Wagner Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2 Gut 56 2007 227 236
    • (2007) Gut , vol.56 , pp. 227-236
    • Aleksic, T.1    Baumann, B.2    Wagner, M.3
  • 66
    • 0036007501 scopus 로고    scopus 로고
    • NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response
    • X. Chen, B. Ji, B. Han NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response Gastroenterology 122 2002 448 457
    • (2002) Gastroenterology , vol.122 , pp. 448-457
    • Chen, X.1    Ji, B.2    Han, B.3
  • 67
    • 84871272183 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice
    • H. Huang, Y. Liu, J. Daniluk Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice Gastroenterology 144 2013 202 210
    • (2013) Gastroenterology , vol.144 , pp. 202-210
    • Huang, H.1    Liu, Y.2    Daniluk, J.3
  • 68
    • 38549084647 scopus 로고    scopus 로고
    • The role of NF-kappaB activation in the pathogenesis of acute pancreatitis
    • Z. Rakonczay Jr, P. Hegyi, T. Takacs The role of NF-kappaB activation in the pathogenesis of acute pancreatitis Gut 57 2008 259 267
    • (2008) Gut , vol.57 , pp. 259-267
    • Rakonczay, Jr.Z.1    Hegyi, P.2    Takacs, T.3
  • 69
    • 0030791042 scopus 로고    scopus 로고
    • Transcription factors as activators of gene transcription: AP-1 and NF-kappa B
    • I.M. Adcock Transcription factors as activators of gene transcription: AP-1 and NF-kappa B Monaldi Arch Chest Dis 52 1997 178 186
    • (1997) Monaldi Arch Chest Dis , vol.52 , pp. 178-186
    • Adcock, I.M.1
  • 70
    • 78651101405 scopus 로고    scopus 로고
    • Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats
    • A. Vonlaufen, P.A. Phillips, Z. Xu Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats Gut 60 2011 238 246
    • (2011) Gut , vol.60 , pp. 238-246
    • Vonlaufen, A.1    Phillips, P.A.2    Xu, Z.3
  • 71
    • 0348041945 scopus 로고    scopus 로고
    • Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis
    • S.V. Shrikhande, M.E. Martignoni, M. Shrikhande Comparison of histological features and inflammatory cell reaction in alcoholic, idiopathic and tropical chronic pancreatitis Br J Surg 90 2003 1565 1572
    • (2003) Br J Surg , vol.90 , pp. 1565-1572
    • Shrikhande, S.V.1    Martignoni, M.E.2    Shrikhande, M.3
  • 72
    • 25444451078 scopus 로고    scopus 로고
    • A mouse model of ethanol dependent pancreatic fibrosis
    • G. Perides, X. Tao, N. West A mouse model of ethanol dependent pancreatic fibrosis Gut 54 2005 1461 1467
    • (2005) Gut , vol.54 , pp. 1461-1467
    • Perides, G.1    Tao, X.2    West, N.3
  • 73
    • 55949100820 scopus 로고    scopus 로고
    • Does chronic ethanol intake cause chronic pancreatitis?: Evidence and mechanism
    • J. Li, M. Guo, B. Hu Does chronic ethanol intake cause chronic pancreatitis?: evidence and mechanism Pancreas 37 2008 189 195
    • (2008) Pancreas , vol.37 , pp. 189-195
    • Li, J.1    Guo, M.2    Hu, B.3
  • 74
    • 0030973673 scopus 로고    scopus 로고
    • Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride
    • G. Sparmann, J. Merkord, A. Jaschke Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride Gastroenterology 112 1997 1664 1672
    • (1997) Gastroenterology , vol.112 , pp. 1664-1672
    • Sparmann, G.1    Merkord, J.2    Jaschke, A.3
  • 75
    • 0029966206 scopus 로고    scopus 로고
    • Induction of chronic pancreatic disease by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts
    • V. Puig-Divi, X. Molero, A. Salas Induction of chronic pancreatic disease by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts Pancreas 13 1996 417 424
    • (1996) Pancreas , vol.13 , pp. 417-424
    • Puig-Divi, V.1    Molero, X.2    Salas, A.3
  • 76
    • 81855228093 scopus 로고    scopus 로고
    • Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis
    • R. Dawra, R.P. Sah, V. Dudeja Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis Gastroenterology 141 2011 2210 2217
    • (2011) Gastroenterology , vol.141 , pp. 2210-2217
    • Dawra, R.1    Sah, R.P.2    Dudeja, V.3
  • 77
    • 0019332357 scopus 로고
    • A zinc metalloendopeptidase associated with dog pancreatic membranes
    • R.A. Mumford, A.W. Strauss, J.C. Powers A zinc metalloendopeptidase associated with dog pancreatic membranes J Biol Chem 255 1980 2227 2230
    • (1980) J Biol Chem , vol.255 , pp. 2227-2230
    • Mumford, R.A.1    Strauss, A.W.2    Powers, J.C.3
  • 78
    • 21244468248 scopus 로고    scopus 로고
    • Simultaneous observation of collagen and elastin in normal and pathological tissues: Analysis of Sirius-red-stained sections by fluorescence microscopy
    • L.F. Borges, S.R. Taboga, P.S. Gutierrez Simultaneous observation of collagen and elastin in normal and pathological tissues: analysis of Sirius-red-stained sections by fluorescence microscopy Cell Tissue Res 320 2005 551 552
    • (2005) Cell Tissue Res , vol.320 , pp. 551-552
    • Borges, L.F.1    Taboga, S.R.2    Gutierrez, P.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.