-
1
-
-
0026021161
-
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
-
DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes care 1991; 14: 173-94
-
(1991)
Diabetes care
, vol.14
, pp. 173-194
-
-
DeFronzo, R.A.1
Ferrannini, E.2
-
2
-
-
2942675088
-
Obesity, metabolic syndrome, and cardiovascular disease
-
DOI 10.1210/jc.2004-0372
-
Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89: 2595-600 (Pubitemid 38766337)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.6
, pp. 2595-2600
-
-
Grundy, S.M.1
-
3
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn BB, Alquier T, Carling D, Hardie DG. AMP-Activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1: 15-25 (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
4
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang BB, Zhou G, Li C. AMPK: An emerging drug target for diabetes and the metabolic syndrome. Cell Metab 2009; 9: 407-16
-
(2009)
Cell Metab
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
5
-
-
77949471535
-
AMPK activators as novel therapeutics for type 2 diabetes
-
Yu LF, Qiu BY, Nan FJ, Li J. AMPK activators as novel therapeutics for type 2 diabetes. Curr Top Med Chem 2010; 10: 397-410
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 397-410
-
-
Yu, L.F.1
Qiu, B.Y.2
Nan, F.J.3
Li, J.4
-
6
-
-
0029910018
-
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
-
DOI 10.1074/jbc.271.44.27879
-
Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D, et al. Characterization of the AMP-Activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-Activated protein kinase. J Biol Chem 1996; 271: 27879-87 (Pubitemid 26367365)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.44
, pp. 27879-27887
-
-
Hawley, S.A.1
Davison, M.2
Woods, A.3
Davies, S.P.4
Beri, R.K.5
Carling, D.6
Hardie, D.G.7
-
7
-
-
12844281251
-
AMPK, the metabolic syndrome and cancer
-
DOI 10.1016/j.tips.2004.12.011, PII S0165614704003402
-
Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 2005; 26: 69-76 (Pubitemid 40170168)
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, Issue.2
, pp. 69-76
-
-
Luo, Z.1
Saha, A.K.2
Xiang, X.3
Ruderman, N.B.4
-
8
-
-
34248578773
-
Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes
-
Im SS, Kwon SK, Kim TH, Kim HI, Ahn YH. Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes. IUBMB life 2007; 59: 134-45
-
(2007)
IUBMB life
, vol.59
, pp. 134-145
-
-
Im, S.S.1
Kwon, S.K.2
Kim, T.H.3
Kim, H.I.4
Ahn, Y.H.5
-
9
-
-
57749094239
-
AMP-Activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMPresponsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver
-
Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, et al. AMP-Activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMPresponsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 2008; 283: 33902-10
-
(2008)
J Biol Chem
, vol.283
, pp. 33902-33910
-
-
Horike, N.1
Sakoda, H.2
Kushiyama, A.3
Ono, H.4
Fujishiro, M.5
Kamata, H.6
-
10
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
DOI 10.1016/j.cmet.2006.05.005, PII S1550413106001604
-
Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab 2006; 3: 403-16 (Pubitemid 43811782)
-
(2006)
Cell Metabolism
, vol.3
, Issue.6
, pp. 403-416
-
-
Cool, B.1
Zinker, B.2
Chiou, W.3
Kifle, L.4
Cao, N.5
Perham, M.6
Dickinson, R.7
Adler, A.8
Gagne, G.9
Iyengar, R.10
Zhao, G.11
Marsh, K.12
Kym, P.13
Jung, P.14
Camp, H.S.15
Frevert, E.16
-
11
-
-
85047689953
-
5-Aminoimidazole-4-carboxamide ribonucleoside A specific method for activating AMPactivated protein kinase in intact cells?
-
Corton JM, Gillespie JG, Hawley SA, Hardie DG. 5-Aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMPactivated protein kinase in intact cells? FEBS J 1995; 229: 558-65
-
(1995)
FEBS J
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
12
-
-
12944252812
-
5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: A possible role for AMPK
-
DOI 10.1042/BJ20040694
-
Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen KL. 5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: A possible role for AMPK. Biochem J 2005; 385: 485-91 (Pubitemid 40173969)
-
(2005)
Biochemical Journal
, vol.385
, Issue.2
, pp. 485-491
-
-
Walker, J.1
Jijon, H.B.2
Diaz, H.3
Salehi, P.4
Churchill, T.5
Madsen, K.L.6
-
13
-
-
9144271181
-
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
-
DOI 10.1074/jbc.M408149200
-
Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, et al. AMP-Activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem 2004; 279: 47898-905 (Pubitemid 39540941)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.46
, pp. 47898-47905
-
-
Zang, M.1
Zuccollo, A.2
Hou, X.3
Nagata, D.4
Walsh, K.5
Herscovitz, H.6
Brecher, P.7
Ruderman, N.B.8
Cohen, R.A.9
-
14
-
-
33749336146
-
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
-
DOI 10.2337/db06-0006
-
Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-Activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006; 55: 2256-64 (Pubitemid 44743622)
-
(2006)
Diabetes
, vol.55
, Issue.8
, pp. 2256-2264
-
-
Lee, Y.S.1
Kim, W.S.2
Kim, K.H.3
Yoon, M.J.4
Cho, H.J.5
Shen, Y.6
Ye, J.-M.7
Lee, C.H.8
Oh, W.K.9
Kim, C.T.10
Hohnen-Behrens, C.11
Gosby, A.12
Kraegen, E.W.13
James, D.E.14
Kim, J.B.15
-
15
-
-
80255123790
-
Emodin, a naturally occurring anthraquinone derivative, suppresses IgEmediated anaphylactic reaction and mast cell activation
-
Lu Y, Yang JH, Li X, Hwangbo K, Hwang SL, Taketomi Y, et al. Emodin, a naturally occurring anthraquinone derivative, suppresses IgEmediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 2011; 82: 1700-8
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 1700-1708
-
-
Lu, Y.1
Yang, J.H.2
Li, X.3
Hwangbo, K.4
Hwang, S.L.5
Taketomi, Y.6
-
16
-
-
84856098097
-
Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK
-
Niu Y, Li S, Na L, Feng R, Liu L, Li Y, et al. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK. PLoS one 2012; 7: E30782
-
(2012)
PLoS one
, vol.7
-
-
Niu, Y.1
Li, S.2
Na, L.3
Feng, R.4
Liu, L.5
Li, Y.6
-
17
-
-
84872092574
-
Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation
-
Liu J, Zhang JF, Lu JZ, Zhang DL, Li K, Su K, et al. Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation. Acta pharmacol Sin 2013; 34: 137-45
-
(2013)
Acta pharmacol Sin
, vol.34
, pp. 137-145
-
-
Liu, J.1
Zhang, J.F.2
Lu, J.Z.3
Zhang, D.L.4
Li, K.5
Su, K.6
-
18
-
-
0028093329
-
Cell proliferation induced by laxatives and related compounds in the rat intestine
-
DOI 10.1016/0304-3835(94)90297-6
-
Toyoda K, Nishikawa A, Furukawa F, Kawanishi T, Hayashi Y, Takahashi M. Cell proliferation induced by laxatives and related compounds in the rat intestine. Cancer Lett 1994; 83: 43-9 (Pubitemid 24253516)
-
(1994)
Cancer Letters
, vol.83
, Issue.1-2
, pp. 43-49
-
-
Toyoda, K.1
Nishikawa, A.2
Furukawa, F.3
Kawanishi, T.4
Hayashi, Y.5
Takahashi, M.6
-
19
-
-
77953233479
-
Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells
-
Lu HF, Lai TY, Hsia TC, Tang YJ, Yang JS, Chiang JH, et al. Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells. Neurochem Res 2010; 35: 1105-10
-
(2010)
Neurochem Res
, vol.35
, pp. 1105-1110
-
-
Lu, H.F.1
Lai, T.Y.2
Hsia, T.C.3
Tang, Y.J.4
Yang, J.S.5
Chiang, J.H.6
-
20
-
-
77950546062
-
Anthraquinones danthron and quinizarin exert antiproliferative and antimetastatic activity on murine B16-F10 melanoma cells
-
Rossi S, Tabolacci C, Lentini A, Provenzano B, Carlomosti F, Frezzotti S, et al. Anthraquinones danthron and quinizarin exert antiproliferative and antimetastatic activity on murine B16-F10 melanoma cells. Anticancer Res 2010; 30: 445-9
-
(2010)
Anticancer Res
, vol.30
, pp. 445-449
-
-
Rossi, S.1
Tabolacci, C.2
Lentini, A.3
Provenzano, B.4
Carlomosti, F.5
Frezzotti, S.6
-
21
-
-
78751539633
-
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor
-
Zhang H, Zhou R, Li L, Chen J, Chen L, Li C, et al. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem 2011; 286: 1868-75
-
(2011)
J Biol Chem
, vol.286
, pp. 1868-1875
-
-
Zhang, H.1
Zhou, R.2
Li, L.3
Chen, J.4
Chen, L.5
Li, C.6
-
22
-
-
33748924524
-
1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP
-
DOI 10.1093/carcin/bgl043
-
Mantena SK, Sharma SD, Katiyar SK. Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis 2006; 27: 2018-27 (Pubitemid 44530576)
-
(2006)
Carcinogenesis
, vol.27
, Issue.10
, pp. 2018-2027
-
-
Mantena, S.K.1
Sharma, S.D.2
Katiyar, S.K.3
-
23
-
-
84866903943
-
Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists
-
Huang H, Yu Y, Gao Z, Zhang Y, Li C, Xu X, et al. Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists. J Med Chem 2012; 55: 7037-53
-
(2012)
J Med Chem
, vol.55
, pp. 7037-7053
-
-
Huang, H.1
Yu, Y.2
Gao, Z.3
Zhang, Y.4
Li, C.5
Xu, X.6
-
24
-
-
0014314403
-
The effect of phenolphthalein and other purgative drugs on rat intestinal (Na++K+) adenosine triphosphatase
-
Chignell CF. The effect of phenolphthalein and other purgative drugs on rat intestinal (Na++K+) adenosine triphosphatase. Biochem Pharmacol 1968; 17: 1207-12
-
(1968)
Biochem Pharmacol
, vol.17
, pp. 1207-1212
-
-
Chignell, C.F.1
-
25
-
-
77957155442
-
Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells
-
Genvigir FD, Rodrigues AC, Cerda A, Arazi SS, Willrich MA, Oliveira R, et al. Effects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cells. Pharmacogenomics 2010; 11 : 1235-46
-
(2010)
Pharmacogenomics
, vol.11
, pp. 1235-1246
-
-
Genvigir, F.D.1
Rodrigues, A.C.2
Cerda, A.3
Arazi, S.S.4
Willrich, M.A.5
Oliveira, R.6
-
26
-
-
34548487132
-
Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals
-
DOI 10.1007/s00125-007-0760-7
-
Kase ET, Thoresen GH, Westerlund S, Hojlund K, Rustan AC, Gaster M. Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals. Diabetologia 2007; 50: 2171-80 (Pubitemid 47373846)
-
(2007)
Diabetologia
, vol.50
, Issue.10
, pp. 2171-2180
-
-
Kase, E.T.1
Thoresen, G.H.2
Westerlund, S.3
Hojlund, K.4
Rustan, A.C.5
Gaster, M.6
-
27
-
-
33750927892
-
ATP-binding cassette cholesterol transporters and cardiovascular disease
-
DOI 10.1161/01.RES.0000250171.54048.5c, PII 0000301220061110000005
-
Oram JF, Vaughan AM. ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ Res 2006; 99: 1031-43 (Pubitemid 44729927)
-
(2006)
Circulation Research
, vol.99
, Issue.10
, pp. 1031-1043
-
-
Oram, J.F.1
Vaughan, A.M.2
-
28
-
-
77953960882
-
Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction
-
Li D, Zhang Y, Ma J, Ling W, Xia M. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Arterioscler Thromb Vasc Biol 2010; 30: 1354-62
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 1354-1362
-
-
Li, D.1
Zhang, Y.2
Ma, J.3
Ling, W.4
Xia, M.5
-
29
-
-
33846864234
-
Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element
-
DOI 10.1016/j.atherosclerosis.2006.04.018, PII S0021915006002127
-
Uehara Y, Miura S, von Eckardstein A, Abe S, Fujii A, Matsuo Y, et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. Atherosclerosis 2007; 191: 11-21 (Pubitemid 46227424)
-
(2007)
Atherosclerosis
, vol.191
, Issue.1
, pp. 11-21
-
-
Uehara, Y.1
Miura, S.-i.2
Von Eckardstein, A.3
Abe, S.4
Fujii, A.5
Matsuo, Y.6
Rust, S.7
Lorkowski, S.8
Assmann, G.9
Yamada, T.10
Saku, K.11
-
30
-
-
2142655784
-
LXR/RXR ligand activation enhances basolateral efflux of β-sitosterol in CaCo-2 cells
-
DOI 10.1194/jlr.M300473-JLR200
-
Field FJ, Born E, Mathur SN. LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. J Lipid Res 2004; 45: 905-13 (Pubitemid 38552861)
-
(2004)
Journal of Lipid Research
, vol.45
, Issue.5
, pp. 905-913
-
-
Field, F.J.1
Born, E.2
Mathur, S.N.3
-
31
-
-
0036310592
-
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells
-
DOI 10.1194/jlr.M100358-JLR200
-
Murthy S, Born E, Mathur SN, Field FJ. LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. J Lipid Res 2002; 43: 1054-64 (Pubitemid 34760876)
-
(2002)
Journal of Lipid Research
, vol.43
, Issue.7
, pp. 1054-1064
-
-
Murthy, S.1
Born, E.2
Mathur, S.N.3
Field, F.J.4
-
32
-
-
63849311264
-
Regulation of glucose transporter 4 traffic by energy deprivation from mitochondrial compromise
-
Klip A, Schertzer JD, Bilan PJ, Thong F, Antonescu C. Regulation of glucose transporter 4 traffic by energy deprivation from mitochondrial compromise. Acta Physiol (Oxf) 2009; 196: 27-35
-
(2009)
Acta Physiol (Oxf
, vol.196
, pp. 27-35
-
-
Klip, A.1
Schertzer, J.D.2
Bilan, P.J.3
Thong, F.4
Antonescu, C.5
-
33
-
-
84866518870
-
Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARgammaagonist activity
-
Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARgammaagonist activity. J Cell Biochem 2012; 113: 3547-58
-
(2012)
J Cell Biochem
, vol.113
, pp. 3547-3558
-
-
Chen, Z.1
Zhang, L.2
Yi, J.3
Yang, Z.4
Zhang, Z.5
Li, Z.6
|