메뉴 건너뛰기




Volumn 113, Issue 11, 2012, Pages 3547-3558

Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARγ-agonist activity

Author keywords

ADIPONECTIN; AMPK; EMODIN; MULTIMERIZATION; PPAR

Indexed keywords

ADENYLATE KINASE; ADIPONECTIN; BERBERINE; EMODIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 84866518870     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24232     Document Type: Article
Times cited : (58)

References (53)
  • 2
    • 34547609888 scopus 로고    scopus 로고
    • Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: Differential regulation from nondiabetic subjects
    • Basu R, Pajvani UB, Rizza RA, Scherer PE,. 2007. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: Differential regulation from nondiabetic subjects. Diabetes 56: 2174-2177.
    • (2007) Diabetes , vol.56 , pp. 2174-2177
    • Basu, R.1    Pajvani, U.B.2    Rizza, R.A.3    Scherer, P.E.4
  • 6
    • 29244434833 scopus 로고    scopus 로고
    • AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes
    • Dagon Y, Avraham Y, Berry EM,. 2006. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. Biochem Biophys Res Commun 340: 43-47.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 43-47
    • Dagon, Y.1    Avraham, Y.2    Berry, E.M.3
  • 7
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer LG, Parbu-Patel A, Carling D,. 2002. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277: 25226-25232.
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 8
    • 0031821520 scopus 로고    scopus 로고
    • Understanding adipocyte differentiation
    • Gregoire FM, Smas CM, Sul HS,. 1998. Understanding adipocyte differentiation. Physiol Rev 78: 783-809.
    • (1998) Physiol Rev , vol.78 , pp. 783-809
    • Gregoire, F.M.1    Smas, C.M.2    Sul, H.S.3
  • 9
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function
    • Hardie DG,. 2011. AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function. Genes Dev 25: 1895-1908.
    • (2011) Genes Dev , vol.25 , pp. 1895-1908
    • Hardie, D.G.1
  • 11
    • 51849092969 scopus 로고    scopus 로고
    • Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis
    • Heo SK, Yun HJ, Park WH, Park SD,. 2008. Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis. J Cell Biochem 105: 70-80.
    • (2008) J Cell Biochem , vol.105 , pp. 70-80
    • Heo, S.K.1    Yun, H.J.2    Park, W.H.3    Park, S.D.4
  • 13
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E, Liang P, Spiegelman BM,. 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271: 10697-10703.
    • (1996) J Biol Chem , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 16
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K,. 2006. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784-1792.
    • (2006) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 23
    • 79958116611 scopus 로고    scopus 로고
    • Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes
    • Li Y, Wang P, Zhuang Y, Lin H, Liu L, Meng Q, Cui T, Liu J, Li Z,. 2011. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. FEBS Lett 585: 1735-1740.
    • (2011) FEBS Lett , vol.585 , pp. 1735-1740
    • Li, Y.1    Wang, P.2    Zhuang, Y.3    Lin, H.4    Liu, L.5    Meng, Q.6    Cui, T.7    Liu, J.8    Li, Z.9
  • 25
    • 84863364968 scopus 로고    scopus 로고
    • Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro
    • Liu DL, Bu H, Li H, Chen H, Guo HC, Wang ZH, Tong HF, Ni ZL, Liu HB, Lin SZ,. 2012. Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. Int J Oncol 40: 1049-1057.
    • (2012) Int J Oncol , vol.40 , pp. 1049-1057
    • Liu, D.L.1    Bu, H.2    Li, H.3    Chen, H.4    Guo, H.C.5    Wang, Z.H.6    Tong, H.F.7    Ni, Z.L.8    Liu, H.B.9    Lin, S.Z.10
  • 26
    • 72449141637 scopus 로고    scopus 로고
    • Transcriptional and post-translational regulation of adiponectin
    • Liu M, Liu F,. 2010. Transcriptional and post-translational regulation of adiponectin. Biochem J 425: 41-52.
    • (2010) Biochem J , vol.425 , pp. 41-52
    • Liu, M.1    Liu, F.2
  • 28
    • 70349439134 scopus 로고    scopus 로고
    • Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma
    • Liu Y, Jia L, Liu ZC, Zhang H, Zhang PJ, Wan Q, Wang R,. 2009. Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma. Exp Mol Med 41: 648-655.
    • (2009) Exp Mol Med , vol.41 , pp. 648-655
    • Liu, Y.1    Jia, L.2    Liu, Z.C.3    Zhang, H.4    Zhang, P.J.5    Wan, Q.6    Wang, R.7
  • 31
    • 0033251387 scopus 로고    scopus 로고
    • Insights into the transcriptional control of adipocyte differentiation
    • Morrison RF, Farmer SR,. 1999. Insights into the transcriptional control of adipocyte differentiation. J Cell Biochem Suppl 32-33: 59-67.
    • (1999) J Cell Biochem Suppl , vol.3233 , pp. 59-67
    • Morrison, R.F.1    Farmer, S.R.2
  • 32
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP,. 2000. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348: 607-614.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 33
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE,. 2003. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem 278: 9073-9085.
    • (2003) J Biol Chem , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6    Engel, J.7    Brownlee, M.8    Scherer, P.E.9
  • 35
    • 34347338702 scopus 로고    scopus 로고
    • Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha
    • Qiang L, Wang H, Farmer SR,. 2007. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 27: 4698-4707.
    • (2007) Mol Cell Biol , vol.27 , pp. 4698-4707
    • Qiang, L.1    Wang, H.2    Farmer, S.R.3
  • 36
    • 0042330251 scopus 로고    scopus 로고
    • Minireview: The adipocyte-At the crossroads of energy homeostasis, inflammation, and atherosclerosis
    • Rajala MW, Scherer PE,. 2003. Minireview: The adipocyte-At the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144: 3765-3773.
    • (2003) Endocrinology , vol.144 , pp. 3765-3773
    • Rajala, M.W.1    Scherer, P.E.2
  • 37
    • 36348978499 scopus 로고    scopus 로고
    • Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
    • Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D,. 2007. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem 282: 32539-32548.
    • (2007) J Biol Chem , vol.282 , pp. 32539-32548
    • Sanders, M.J.1    Ali, Z.S.2    Hegarty, B.D.3    Heath, R.4    Snowden, M.A.5    Carling, D.6
  • 39
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF,. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746-26749.
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 40
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG,. 2007. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341.
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 41
    • 0347379841 scopus 로고    scopus 로고
    • Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways
    • Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF,. 2003. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem 278: 50810-50817.
    • (2003) J Biol Chem , vol.278 , pp. 50810-50817
    • Tsao, T.S.1    Tomas, E.2    Murrey, H.E.3    Hug, C.4    Lee, D.H.5    Ruderman, N.B.6    Heuser, J.E.7    Lodish, H.F.8
  • 42
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J, Ye JM,. 2008. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 57: 1414-1418.
    • (2008) Diabetes , vol.57 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6    Taketo, M.M.7    Cooney, G.J.8    Kraegen, E.W.9    James, D.E.10    Hu, L.H.11    Li, J.12    Ye, J.M.13
  • 44
    • 38949125405 scopus 로고    scopus 로고
    • Post-translational modifications of adiponectin: Mechanisms and functional implications
    • Wang Y, Lam KS, Yau MH, Xu A,. 2008. Post-translational modifications of adiponectin: Mechanisms and functional implications. Biochem J 409: 623-633.
    • (2008) Biochem J , vol.409 , pp. 623-633
    • Wang, Y.1    Lam, K.S.2    Yau, M.H.3    Xu, A.4
  • 45
    • 34248197560 scopus 로고    scopus 로고
    • Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention
    • Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE,. 2007. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 27: 3716-3731.
    • (2007) Mol Cell Biol , vol.27 , pp. 3716-3731
    • Wang, Z.V.1    Schraw, T.D.2    Kim, J.Y.3    Khan, T.4    Rajala, M.W.5    Follenzi, A.6    Scherer, P.E.7
  • 46
    • 0037983775 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    • Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R, Goldstein BJ,. 2003. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52: 1355-1363.
    • (2003) Diabetes , vol.52 , pp. 1355-1363
    • Wu, X.1    Motoshima, H.2    Mahadev, K.3    Stalker, T.J.4    Scalia, R.5    Goldstein, B.J.6
  • 47
    • 79951931336 scopus 로고    scopus 로고
    • Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines
    • Xie W, Du L,. 2011. Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines. Diabetes Obes Metab 13: 289-301.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 289-301
    • Xie, W.1    Du, L.2
  • 48
    • 75849147916 scopus 로고    scopus 로고
    • Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice
    • Xue J, Ding W, Liu Y,. 2010. Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. Fitoterapia 81: 173-177.
    • (2010) Fitoterapia , vol.81 , pp. 173-177
    • Xue, J.1    Ding, W.2    Liu, Y.3
  • 51
    • 33845723280 scopus 로고    scopus 로고
    • Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells
    • Yang Y, Shang W, Zhou L, Jiang B, Jin H, Chen M,. 2007. Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells. Biochem Biophys Res Commun 353: 225-230.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 225-230
    • Yang, Y.1    Shang, W.2    Zhou, L.3    Jiang, B.4    Jin, H.5    Chen, M.6
  • 52
    • 0029118536 scopus 로고
    • Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin
    • Zhang L, Chang CJ, Bacus SS, Hung MC,. 1995. Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. Cancer Res 55: 3890-3896.
    • (1995) Cancer Res , vol.55 , pp. 3890-3896
    • Zhang, L.1    Chang, C.J.2    Bacus, S.S.3    Hung, M.C.4
  • 53
    • 0032482434 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties
    • Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung MC,. 1998. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene 16: 2855-2863.
    • (1998) Oncogene , vol.16 , pp. 2855-2863
    • Zhang, L.1    Lau, Y.K.2    Xi, L.3    Hong, R.L.4    Kim, D.S.5    Chen, C.F.6    Hortobagyi, G.N.7    Chang, C.8    Hung, M.C.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.