메뉴 건너뛰기




Volumn 8, Issue 4, 2013, Pages 840-856

Drainage of cells and soluble antigen from the CNS to regional lymph nodes

Author keywords

Antigen presenting cells; Cervical lymph nodes; CSF; Dendritic cells; Immune privilege; Interstitial fluid; Multiple sclerosis; Nasal lymphatics; Perivascular drainage; Regulatory T and B cells; Stroke; Tolerance

Indexed keywords

ACID PHOSPHATASE; ALBUMIN; ANTIGEN; AUTOANTIGEN; CD209 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHLORDANE; EPITOPE; HORSERADISH PEROXIDASE; IA ANTIGEN; INTEGRIN; INTERLEUKIN 10; INTERLEUKIN 23; INTERLEUKIN 6; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN; MYELIN BASIC PROTEIN; NANOPARTICLE; POLYSACCHARIDE; SERUM ALBUMIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; UVOMORULIN; VIRUS ANTIGEN; VITAMIN; VITAMIN D;

EID: 84882273124     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-013-9470-8     Document Type: Review
Times cited : (137)

References (121)
  • 1
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
    • 15186921 1:CAS:528:DC%2BD2cXks12qurk%3D 10.1016/j.neuint.2003.11.006
    • Abbott NJ (2004) Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 45:545-552
    • (2004) Neurochem Int , vol.45 , pp. 545-552
    • Abbott, N.J.1
  • 2
    • 0026643572 scopus 로고
    • Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system
    • 1613459 1:CAS:528:DyaK38Xks1yhsLk%3D 10.1084/jem.176.1.255
    • Andersson PB, Perry VH, Gordon S (1992) Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system. J Exp Med 176:255-259
    • (1992) J Exp Med , vol.176 , pp. 255-259
    • Andersson, P.B.1    Perry, V.H.2    Gordon, S.3
  • 3
    • 33846472053 scopus 로고    scopus 로고
    • CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE
    • 10.1038/ni1430 17206145 1:CAS:528:DC%2BD2sXnt1KitQ%3D%3D 10.1038/ni1430
    • Bailey SL, Schreiner B, McMahon EJ, Miller SD (2007) CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE. Nat Immunol 8(2):172-180. doi: 10.1038/ni1430
    • (2007) Nat Immunol , vol.8 , Issue.2 , pp. 172-180
    • Bailey, S.L.1    Schreiner, B.2    McMahon, E.J.3    Miller, S.D.4
  • 4
    • 84862236560 scopus 로고    scopus 로고
    • Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model
    • 10.1186/2045-8118-9-2 22264361 1:CAS:528:DC%2BC38Xjs1eju78%3D 10.1186/2045-8118-9-2
    • Barua NU, Bienemann AS, Hesketh S, Wyatt MJ, Castrique E, Love S, Gill SS (2012) Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model. Fluids Barriers CNS 9:2. doi: 10.1186/2045-8118-9-2
    • (2012) Fluids Barriers CNS , vol.9 , pp. 2
    • Barua, N.U.1    Bienemann, A.S.2    Hesketh, S.3    Wyatt, M.J.4    Castrique, E.5    Love, S.6    Gill, S.S.7
  • 5
    • 33845727067 scopus 로고    scopus 로고
    • What is the blood-brain barrier (not)?
    • 17140851 1:CAS:528:DC%2BD2sXhsFCjtQ%3D%3D 10.1016/j.it.2006.11.007
    • Bechmann I, Galea I, Perry VH (2007) What is the blood-brain barrier (not)? Trends Immunol 28:5-11
    • (2007) Trends Immunol , vol.28 , pp. 5-11
    • Bechmann, I.1    Galea, I.2    Perry, V.H.3
  • 6
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • 10.1038/nature10554 22031325 1:CAS:528:DC%2BC3MXhtlOntbbP 10.1038/nature10554
    • Berer K, Mues M, Koutrolos M, Rasbi ZA, Boziki M, Johner C, Wekerle H, Krishnamoorthy G (2011) Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479(7374):538-541. doi: 10.1038/nature10554
    • (2011) Nature , vol.479 , Issue.7374 , pp. 538-541
    • Berer, K.1    Mues, M.2    Koutrolos, M.3    Rasbi, Z.A.4    Boziki, M.5    Johner, C.6    Wekerle, H.7    Krishnamoorthy, G.8
  • 7
    • 0034804075 scopus 로고    scopus 로고
    • Evolving concepts of cerebrospinal fluid
    • Bergsneider M (2001) Evolving concepts of cerebrospinal fluid. Neurosurg Clin N Am 36:631-638
    • (2001) Neurosurg Clin N Am , vol.36 , pp. 631-638
    • Bergsneider, M.1
  • 8
    • 84873669943 scopus 로고    scopus 로고
    • Neck lymph nodes in chronic autoimmune thyroiditis: The sonographic pattern
    • 10.1089/thy.2012.0375 1:CAS:528:DC%2BC3sXis1Cqsbs%3D 10.1089/thy.2012. 0375
    • Brancato D, Citarrella R, Richiusa P, Amato MC, Vetro C, Galluzzo CG (2013) Neck lymph nodes in chronic autoimmune thyroiditis: the sonographic pattern. Thyroid Off J Am Thyroid Assoc 23(2):173-177. doi: 10.1089/thy.2012. 0375
    • (2013) Thyroid off J Am Thyroid Assoc , vol.23 , Issue.2 , pp. 173-177
    • Brancato, D.1    Citarrella, R.2    Richiusa, P.3    Amato, M.C.4    Vetro, C.5    Galluzzo, C.G.6
  • 10
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • 10508180 1:CAS:528:DyaK1MXmvFaqu7o%3D 10.1093/intimm/11.10.1625
    • Burkhart C, Liu GY, Anderton SM, Metzler B, Wraith DC (1999) Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int Immunol 11(10):1625-1634
    • (1999) Int Immunol , vol.11 , Issue.10 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 12
    • 84882240842 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination-failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy
    • 10.1111/nan.12042 23489283
    • Carare RO, Hawkes CA, Jeffrey M, Kalaria RN, Weller RO (2013) Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination-failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy. Neuropathol Appl Neurobiol. doi: 10.1111/nan.12042
    • (2013) Neuropathol Appl Neurobiol
    • Carare, R.O.1    Hawkes, C.A.2    Jeffrey, M.3    Kalaria, R.N.4    Weller, R.O.5
  • 13
    • 84860327199 scopus 로고    scopus 로고
    • Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection
    • 10.4049/jimmunol.1102422 22407917 1:CAS:528:DC%2BC38XltFKhtbs%3D 10.4049/jimmunol.1102422
    • Cervantes-Barragan L, Firner S, Bechmann I, Waisman A, Lahl K, Sparwasser T, Thiel V, Ludewig B (2012) Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 188(8):3678-3685. doi: 10.4049/jimmunol.1102422
    • (2012) J Immunol , vol.188 , Issue.8 , pp. 3678-3685
    • Cervantes-Barragan, L.1    Firner, S.2    Bechmann, I.3    Waisman, A.4    Lahl, K.5    Sparwasser, T.6    Thiel, V.7    Ludewig, B.8
  • 14
    • 84863726869 scopus 로고    scopus 로고
    • The immunology of acute stroke
    • 10.1038/nrneurol.2012.98 22664787 1:CAS:528:DC%2BC38XhtVSgs7%2FI 10.1038/nrneurol.2012.98
    • Chamorro A, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R (2012) The immunology of acute stroke. Nat Rev Neurol 8(7):401-410. doi: 10.1038/nrneurol.2012.98
    • (2012) Nat Rev Neurol , vol.8 , Issue.7 , pp. 401-410
    • Chamorro, A.1    Meisel, A.2    Planas, A.M.3    Urra, X.4    Van De Beek, D.5    Veltkamp, R.6
  • 15
    • 77957257149 scopus 로고    scopus 로고
    • Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice
    • 10.1097/NEN.0b013e3181edbc1a 20720507 10.1097/NEN.0b013e3181edbc1a
    • Chinnery HR, Ruitenberg MJ, McMenamin PG (2010) Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice. J Neuropathol Exp Neurol 69:896-909. doi: 10.1097/NEN.0b013e3181edbc1a
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 896-909
    • Chinnery, H.R.1    Ruitenberg, M.J.2    McMenamin, P.G.3
  • 16
    • 80555149758 scopus 로고    scopus 로고
    • Innate-adaptive crosstalk: How dendritic cells shape immune responses in the CNS
    • 10.1007/978-1-4614-0106-3-18 21948376 1:CAS:528:DC%2BC38Xhs1GrtLnN 10.1007/978-1-4614-0106-3-18
    • Clarkson BD, Heninger E, Harris MG, Lee J, Sandor M, Fabry Z (2012) Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS. Adv Exp Med Biol 946:309-333. doi: 10.1007/978-1-4614-0106-3-18
    • (2012) Adv Exp Med Biol , vol.946 , pp. 309-333
    • Clarkson, B.D.1    Heninger, E.2    Harris, M.G.3    Lee, J.4    Sandor, M.5    Fabry, Z.6
  • 18
    • 0026476657 scopus 로고
    • Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
    • 1463583 1:STN:280:DyaK3s%2FpvVyksw%3D%3D 10.1016/0167-5699(92)90027-5
    • Cserr HF, Knopf PM (1992) Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol Today 13(12):507-512
    • (1992) Immunol Today , vol.13 , Issue.12 , pp. 507-512
    • Cserr, H.F.1    Knopf, P.M.2
  • 19
    • 0026929035 scopus 로고
    • Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance
    • 1341962 1:STN:280:DyaK2c%2Fptlyhtg%3D%3D 10.1111/j.1750-3639.1992. tb00703.x
    • Cserr HF, Harling-Berg CJ, Knopf PM (1992) Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 2:269-276
    • (1992) Brain Pathol , vol.2 , pp. 269-276
    • Cserr, H.F.1    Harling-Berg, C.J.2    Knopf, P.M.3
  • 22
    • 84857225543 scopus 로고    scopus 로고
    • Viral and inflammatory triggers of neurodegenerative diseases
    • 10.1126/scitranslmed.3003492 10.1126/scitranslmed.3003492 1:CAS:528:DC%2BC38Xlt1Cjurk%3D
    • Deleidi M, Isacson O (2012) Viral and inflammatory triggers of neurodegenerative diseases. Sci Transl Med 4(121):121ps123. doi: 10.1126/scitranslmed.3003492
    • (2012) Sci Transl Med , vol.4 , Issue.121
    • Deleidi, M.1    Isacson, O.2
  • 23
    • 68949149048 scopus 로고    scopus 로고
    • CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis
    • 10.4049/jimmunol.0900169 19542451 1:CAS:528:DC%2BD1MXnsVOqsr0%3D 10.4049/jimmunol.0900169
    • Dunne PJ, Moran B, Cummins RC, Mills KH (2009) CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. J Immunol 183(1):400-410. doi: 10.4049/jimmunol.0900169
    • (2009) J Immunol , vol.183 , Issue.1 , pp. 400-410
    • Dunne, P.J.1    Moran, B.2    Cummins, R.C.3    Mills, K.H.4
  • 24
    • 53049110581 scopus 로고    scopus 로고
    • Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines
    • 18573502 1:CAS:528:DC%2BD1cXht1eitr3J 10.1016/j.jns.2008.05.019
    • Engelhardt B (2008) Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neurol Sci 274:23-26
    • (2008) J Neurol Sci , vol.274 , pp. 23-26
    • Engelhardt, B.1
  • 25
    • 80051762728 scopus 로고    scopus 로고
    • Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle
    • 21349152 10.1186/2045-8118-8-4
    • Engelhardt B, Coisne C (2011) Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS 8:4-9
    • (2011) Fluids Barriers CNS , vol.8 , pp. 4-9
    • Engelhardt, B.1    Coisne, C.2
  • 26
    • 14844337878 scopus 로고    scopus 로고
    • In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
    • 15748959 1:CAS:528:DC%2BD2MXhvVCisr0%3D 10.1016/j.jneuroim.2004.12.018
    • Fabriek BO, Zwemmer JN, Teunissen CE, Dijkstra CD, Polman CH, Laman JD, Castelijns JA (2005) In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology. J Neuroimmunol 161:190-194
    • (2005) J Neuroimmunol , vol.161 , pp. 190-194
    • Fabriek, B.O.1    Zwemmer, J.N.2    Teunissen, C.E.3    Dijkstra, C.D.4    Polman, C.H.5    Laman, J.D.6    Castelijns, J.A.7
  • 28
    • 58149294030 scopus 로고    scopus 로고
    • Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
    • 18802067 1:CAS:528:DC%2BD1cXhtFarurzP
    • Furtado GC, Marcondes MC, Latkowski JA, Tsai J, Wensky A, Lafaille JJ (2008) Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis. J Immunol 181:4648-4655
    • (2008) J Immunol , vol.181 , pp. 4648-4655
    • Furtado, G.C.1    Marcondes, M.C.2    Latkowski, J.A.3    Tsai, J.4    Wensky, A.5    Lafaille, J.J.6
  • 29
    • 33845628839 scopus 로고    scopus 로고
    • What is immune privilege (not)?
    • 17129764 1:CAS:528:DC%2BD2sXhsFCjsA%3D%3D 10.1016/j.it.2006.11.004
    • Galea I, Bechmann I, Perry VH (2007) What is immune privilege (not)? Trends Immunol 28:12-18
    • (2007) Trends Immunol , vol.28 , pp. 12-18
    • Galea, I.1    Bechmann, I.2    Perry, V.H.3
  • 30
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • 10.1093/brain/awl075 16632554 10.1093/brain/awl075
    • Gold R, Linington C, Lassmann H (2006) Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129(Pt 8):1953-1971. doi: 10.1093/brain/awl075
    • (2006) Brain , vol.129 , Issue.PART 8 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 31
    • 33751503037 scopus 로고    scopus 로고
    • T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa
    • 10.1189/jlb.0306176 16885505 1:CAS:528:DC%2BD28XhtV2hsL3J 10.1189/jlb.0306176
    • Goldmann J, Kwidzinski E, Brandt C, Mahlo J, Richter D, Bechmann I (2006) T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa. J Leukoc Biol 80:797-801. doi: 10.1189/jlb.0306176
    • (2006) J Leukoc Biol , vol.80 , pp. 797-801
    • Goldmann, J.1    Kwidzinski, E.2    Brandt, C.3    Mahlo, J.4    Richter, D.5    Bechmann, I.6
  • 32
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • 7679952 1:CAS:528:DyaK3sXhvV2rsbo%3D 10.1016/0092-8674(93)90074-Z
    • Goverman J, Woods A, Larson L, Weiner LP, Hood L, Zaller DM (1993) Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72(4):551-560
    • (1993) Cell , vol.72 , Issue.4 , pp. 551-560
    • Goverman, J.1    Woods, A.2    Larson, L.3    Weiner, L.P.4    Hood, L.5    Zaller, D.M.6
  • 33
    • 84864553199 scopus 로고    scopus 로고
    • Reversal of paralysis and reduced inflammation from peripheral administration of beta-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis
    • 10.1126/scitranslmed.3004145 22855462 10.1126/scitranslmed.3004145 1:CAS:528:DC%2BC38Xht1anur3M
    • Grant JL, Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Steinman L (2012) Reversal of paralysis and reduced inflammation from peripheral administration of beta-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis. Sci Transl Med 4(145):145ra105. doi: 10.1126/scitranslmed.3004145
    • (2012) Sci Transl Med , vol.4 , Issue.145
    • Grant, J.L.1    Ghosn, E.E.2    Axtell, R.C.3    Herges, K.4    Kuipers, H.F.5    Woodling, N.S.6    Andreasson, K.7    Herzenberg, L.A.8    Steinman, L.9
  • 34
    • 16244380177 scopus 로고    scopus 로고
    • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    • 15735653 1:CAS:528:DC%2BD2MXhvVSqsr4%3D 10.1038/nm1197
    • Greter M, Heppner FL, Lemos MP, Odermatt BM, Goebels N, Laufer T, Noelle RJ, Becher B (2005) Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat Med 11:328-334
    • (2005) Nat Med , vol.11 , pp. 328-334
    • Greter, M.1    Heppner, F.L.2    Lemos, M.P.3    Odermatt, B.M.4    Goebels, N.5    Laufer, T.6    Noelle, R.J.7    Becher, B.8
  • 35
    • 33947503696 scopus 로고    scopus 로고
    • Corneal antigen-presenting cells
    • 10.1159/000099254 17264483 1:CAS:528:DC%2BD1MXhslyqsr0%3D 10.1159/000099254
    • Hamrah P, Dana MR (2007) Corneal antigen-presenting cells. Chem Immunol Allergy 92:58-70. doi: 10.1159/000099254
    • (2007) Chem Immunol Allergy , vol.92 , pp. 58-70
    • Hamrah, P.1    Dana, M.R.2
  • 36
    • 39549115661 scopus 로고    scopus 로고
    • Detecting and treating cancer with nanotechnology
    • 18288878 1:CAS:528:DC%2BD1cXks1Cns7Y%3D 10.1007/BF03256264
    • Hartman KB, Wilson LJ, Rosenblum MG (2008) Detecting and treating cancer with nanotechnology. Mol Diagn Ther 12(1):1-14
    • (2008) Mol Diagn Ther , vol.12 , Issue.1 , pp. 1-14
    • Hartman, K.B.1    Wilson, L.J.2    Rosenblum, M.G.3
  • 37
    • 30444445129 scopus 로고    scopus 로고
    • How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes
    • 16204309 1:CAS:528:DC%2BD28Xms1eqtQ%3D%3D 10.1182/blood-2005-01-0154
    • Hatterer E, Davoust N, Didier-Bazes M, Vuaillat C, Malcus C, Belin MF, Nataf S (2006) How to drain without lymphatics? dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107:806-812
    • (2006) Blood , vol.107 , pp. 806-812
    • Hatterer, E.1    Davoust, N.2    Didier-Bazes, M.3    Vuaillat, C.4    Malcus, C.5    Belin, M.F.6    Nataf, S.7
  • 38
    • 54149118016 scopus 로고    scopus 로고
    • Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions
    • 10.1371/journal.pone.0003321 18830405 10.1371/journal.pone.0003321 1:CAS:528:DC%2BD1cXht1ygtrfO
    • Hatterer E, Touret M, Belin MF, Honnorat J, Nataf S (2008) Cerebrospinal fluid dendritic cells infiltrate the brain parenchyma and target the cervical lymph nodes under neuroinflammatory conditions. PLoS One 3:e3321. doi: 10.1371/journal.pone.0003321
    • (2008) PLoS One , vol.3 , pp. 3321
    • Hatterer, E.1    Touret, M.2    Belin, M.F.3    Honnorat, J.4    Nataf, S.5
  • 39
    • 59049104731 scopus 로고    scopus 로고
    • Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy
    • 19164591 1:CAS:528:DC%2BD1MXhsFyisLw%3D 10.1073/pnas.0805453106
    • Hawkes CA, McLaurin J (2009) Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy. Proc Natl Acad Sci U S A 106:1261-1266
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1261-1266
    • Hawkes, C.A.1    McLaurin, J.2
  • 40
    • 79954623282 scopus 로고    scopus 로고
    • Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy
    • 10.1007/s00401-011-0801-7 21259015 10.1007/s00401-011-0801-7
    • Hawkes CA, Hartig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathol 121:431-443. doi: 10.1007/s00401-011-0801-7
    • (2011) Acta Neuropathol , vol.121 , pp. 431-443
    • Hawkes, C.A.1    Hartig, W.2    Kacza, J.3    Schliebs, R.4    Weller, R.O.5    Nicoll, J.A.6    Carare, R.O.7
  • 41
    • 84864691664 scopus 로고    scopus 로고
    • Disruption of arterial perivascular drainage of amyloid-beta from the brains of mice expressing the human APOE epsilon4 allele
    • 10.1371/journal.pone.0041636 22848551 1:CAS:528:DC%2BC38XhtFanu7nM 10.1371/journal.pone.0041636
    • Hawkes CA, Sullivan PM, Hands S, Weller RO, Nicoll JA, Carare RO (2012) Disruption of arterial perivascular drainage of amyloid-beta from the brains of mice expressing the human APOE epsilon4 allele. PLoS One 7:e41636. doi: 10.1371/journal.pone.0041636
    • (2012) PLoS One , vol.7 , pp. 41636
    • Hawkes, C.A.1    Sullivan, P.M.2    Hands, S.3    Weller, R.O.4    Nicoll, J.A.5    Carare, R.O.6
  • 42
    • 57149083873 scopus 로고    scopus 로고
    • After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream
    • 18974305 1:CAS:528:DC%2BD1MXkt1CrsA%3D%3D 10.2353/ajpath.2008.080234
    • Hochmeister S, Zeitelhofer M, Bauer J, Nicolussi EM, Fischer MT, Heinke B, Selzer E, Lassmann H, Bradl M (2008) After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream. Am J Pathol 173:1669-1681
    • (2008) Am J Pathol , vol.173 , pp. 1669-1681
    • Hochmeister, S.1    Zeitelhofer, M.2    Bauer, J.3    Nicolussi, E.M.4    Fischer, M.T.5    Heinke, B.6    Selzer, E.7    Lassmann, H.8    Bradl, M.9
  • 43
    • 0022492576 scopus 로고
    • Anatomical relationships of the pia mater to cerebral blood vessels in man
    • 3734882 1:STN:280:DyaL283otVKqsQ%3D%3D 10.3171/jns.1986.65.3.0316
    • Hutchings M, Weller RO (1986) Anatomical relationships of the pia mater to cerebral blood vessels in man. J Neurosurg 65:316-325
    • (1986) J Neurosurg , vol.65 , pp. 316-325
    • Hutchings, M.1    Weller, R.O.2
  • 45
    • 61349199500 scopus 로고    scopus 로고
    • Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats
    • 10.1038/jcbfm.2008.153 1:CAS:528:DC%2BD1MXisVSgtbk%3D 10.1038/jcbfm.2008.153
    • Ishibashi S, Maric D, Mou Y, Ohtani R, Ruetzler C, Hallenbeck JM (2009) Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 29(3):606-620. doi: 10.1038/jcbfm.2008.153
    • (2009) J Cereb Blood Flow Metab off J Int Soc Cereb Blood Flow Metab , vol.29 , Issue.3 , pp. 606-620
    • Ishibashi, S.1    Maric, D.2    Mou, Y.3    Ohtani, R.4    Ruetzler, C.5    Hallenbeck, J.M.6
  • 46
    • 77953758560 scopus 로고    scopus 로고
    • Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
    • 10.1038/ni.1888 20526343 1:CAS:528:DC%2BC3cXntVSrsb8%3D 10.1038/ni.1888
    • Ji Q, Perchellet A, Goverman JM (2010) Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat Immunol 11(7):628-634. doi: 10.1038/ni.1888
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 628-634
    • Ji, Q.1    Perchellet, A.2    Goverman, J.M.3
  • 47
    • 85027956704 scopus 로고    scopus 로고
    • MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8(+) T cells
    • 10.1038/ni.2513 23291597 1:CAS:528:DC%2BC3sXjslaksg%3D%3D 10.1038/ni.2513
    • Ji Q, Castelli L, Goverman JM (2013) MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8(+) T cells. Nat Immunol 14(3):254-261. doi: 10.1038/ni.2513
    • (2013) Nat Immunol , vol.14 , Issue.3 , pp. 254-261
    • Ji, Q.1    Castelli, L.2    Goverman, J.M.3
  • 49
    • 84863495639 scopus 로고    scopus 로고
    • Migration of monocytes after intracerebral injection at entorhinal cortex lesion site
    • 22291210 1:CAS:528:DC%2BC38XhtVOrsbzP 10.1189/jlb.0511241
    • Kaminski M, Bechmann I, Pohland M, Kiwit J, Nitsch R, Glumm J (2012) Migration of monocytes after intracerebral injection at entorhinal cortex lesion site. J Leukoc Biol 92:31-39
    • (2012) J Leukoc Biol , vol.92 , pp. 31-39
    • Kaminski, M.1    Bechmann, I.2    Pohland, M.3    Kiwit, J.4    Nitsch, R.5    Glumm, J.6
  • 50
    • 4043144986 scopus 로고    scopus 로고
    • Initiation of immune responses in brain is promoted by local dendritic cells
    • 15294948 1:CAS:528:DC%2BD2cXmt1Ols7o%3D
    • Karman J, Ling C, Sandor M, Fabry Z (2004) Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 173:2353-2361
    • (2004) J Immunol , vol.173 , pp. 2353-2361
    • Karman, J.1    Ling, C.2    Sandor, M.3    Fabry, Z.4
  • 51
    • 80355146169 scopus 로고    scopus 로고
    • PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity
    • 10.1371/journal.pone.0026684 22073184 1:CAS:528:DC%2BC3MXhsFSrtb3I 10.1371/journal.pone.0026684
    • Keijzer C, Slutter B, van der Zee R, Jiskoot W, van Eden W, Broere F (2011) PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity. PLoS One 6(11):e26684. doi: 10.1371/journal.pone.0026684
    • (2011) PLoS One , vol.6 , Issue.11 , pp. 26684
    • Keijzer, C.1    Slutter, B.2    Van Der Zee, R.3    Jiskoot, W.4    Van Eden, W.5    Broere, F.6
  • 52
    • 0027740941 scopus 로고
    • CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance
    • 7510047 1:STN:280:DyaK2c7ms12gug%3D%3D 10.1111/j.1365-2990.1993.tb00476.x
    • Kida S, Pantazis A, Weller RO (1993a) CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance. Neuropathol Appl Neurobiol 19:480-488
    • (1993) Neuropathol Appl Neurobiol , vol.19 , pp. 480-488
    • Kida, S.1    Pantazis, A.2    Weller, R.O.3
  • 53
    • 0027170019 scopus 로고
    • Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages
    • 8337943 1:STN:280:DyaK3szjtFyltA%3D%3D 10.1007/BF00334675
    • Kida S, Steart PV, Zhang ET, Weller RO (1993b) Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages. Acta Neuropathol 85:646-652
    • (1993) Acta Neuropathol , vol.85 , pp. 646-652
    • Kida, S.1    Steart, P.V.2    Zhang, E.T.3    Weller, R.O.4
  • 54
    • 65349144858 scopus 로고    scopus 로고
    • Abundant extracellular myelin in the meninges of patients with multiple sclerosis
    • 10.1111/j.1365-2990.2008.00986.x 19473295 1:CAS:528:DC%2BD1MXmt1Gkurg%3D 10.1111/j.1365-2990.2008.00986.x
    • Kooi EJ, van Horssen J, Witte ME, Amor S, Bo L, Dijkstra CD, van der Valk P, Geurts JJ (2009) Abundant extracellular myelin in the meninges of patients with multiple sclerosis. Neuropathol Appl Neurobiol 35(3):283-295. doi: 10.1111/j.1365-2990.2008.00986.x
    • (2009) Neuropathol Appl Neurobiol , vol.35 , Issue.3 , pp. 283-295
    • Kooi, E.J.1    Van Horssen, J.2    Witte, M.E.3    Amor, S.4    Bo, L.5    Dijkstra, C.D.6    Van Der Valk, P.7    Geurts, J.J.8
  • 55
    • 0032961659 scopus 로고    scopus 로고
    • Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE
    • 10365103 1:STN:280:DyaK1M3ptlCgtQ%3D%3D 10.1002/(SICI)1096-9896(199901) 187:2<259: AID-PATH212>3.0.CO;2-H
    • Lake J, Weller RO, Phillips MJ, Needham M (1999) Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE. J Pathol 187(2):259-265
    • (1999) J Pathol , vol.187 , Issue.2 , pp. 259-265
    • Lake, J.1    Weller, R.O.2    Phillips, M.J.3    Needham, M.4
  • 56
    • 84863474380 scopus 로고    scopus 로고
    • Editorial: Route by which monocytes leave the brain is revealed
    • 22745459 10.1189/jlb.0212110
    • Laman JD, Weller RO (2012) Editorial: route by which monocytes leave the brain is revealed. J Leukoc Biol 92:6-9
    • (2012) J Leukoc Biol , vol.92 , pp. 6-9
    • Laman, J.D.1    Weller, R.O.2
  • 57
    • 84862153245 scopus 로고    scopus 로고
    • Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer
    • 10.1002/eji.201142286 22678899 1:CAS:528:DC%2BC38Xot1Kgtbg%3D 10.1002/eji.201142286
    • Lieberman SM, Kim JS, Corbo-Rodgers E, Kambayashi T, Maltzman JS, Behrens EM, Turka LA (2012) Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer. Eur J Immunol 42(6):1429-1435. doi: 10.1002/eji.201142286
    • (2012) Eur J Immunol , vol.42 , Issue.6 , pp. 1429-1435
    • Lieberman, S.M.1    Kim, J.S.2    Corbo-Rodgers, E.3    Kambayashi, T.4    Maltzman, J.S.5    Behrens, E.M.6    Turka, L.A.7
  • 58
    • 0142075723 scopus 로고    scopus 로고
    • In situ processing and distribution of intracerebrally injected OVA in the CNS
    • 12965258 1:CAS:528:DC%2BD3sXntVygtbY%3D 10.1016/S0165-5728(03)00249-2
    • Ling C, Sandor M, Fabry Z (2003) In situ processing and distribution of intracerebrally injected OVA in the CNS. J Neuroimmunol 141:90-98
    • (2003) J Neuroimmunol , vol.141 , pp. 90-98
    • Ling, C.1    Sandor, M.2    Fabry, Z.3
  • 60
    • 0037320017 scopus 로고    scopus 로고
    • Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection
    • 12552021 1:CAS:528:DC%2BD3sXpvVGrsw%3D%3D 10.1128/JVI.77.4.2775-2778.2003
    • Marten NW, Stohlman SA, Zhou J, Bergmann CC (2003) Kinetics of virus-specific CD8+ -T-cell expansion and trafficking following central nervous system infection. J Virol 77(4):2775-2778
    • (2003) J Virol , vol.77 , Issue.4 , pp. 2775-2778
    • Marten, N.W.1    Stohlman, S.A.2    Zhou, J.3    Bergmann, C.C.4
  • 61
    • 80054903500 scopus 로고    scopus 로고
    • Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice
    • 10.1038/mi.2011.28 21775981 1:CAS:528:DC%2BC3MXhtlartr3K 10.1038/mi.2011.28
    • Mascarell L, Saint-Lu N, Moussu H, Zimmer A, Louise A, Lone Y, Ladant D, Leclerc C, Tourdot S, Van Overtvelt L, Moingeon P (2011) Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice. Mucosal Immunol 4(6):638-647. doi: 10.1038/mi.2011.28
    • (2011) Mucosal Immunol , vol.4 , Issue.6 , pp. 638-647
    • Mascarell, L.1    Saint-Lu, N.2    Moussu, H.3    Zimmer, A.4    Louise, A.5    Lone, Y.6    Ladant, D.7    Leclerc, C.8    Tourdot, S.9    Van Overtvelt, L.10    Moingeon, P.11
  • 63
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • 10.1038/nm1202 15735651 1:CAS:528:DC%2BD2MXhvVSqsrs%3D 10.1038/nm1202
    • McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD (2005) Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med 11(3):335-339. doi: 10.1038/nm1202
    • (2005) Nat Med , vol.11 , Issue.3 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 66
    • 84855162428 scopus 로고    scopus 로고
    • Induction of tolerance via the sublingual route: Mechanisms and applications
    • 10.1155/2012/623474 22110534 10.1155/2012/623474 1:CAS:528: DC%2BC3MXhs1entrnO
    • Moingeon P, Mascarell L (2012) Induction of tolerance via the sublingual route: mechanisms and applications. Clin Dev Immunol 2012:623474. doi: 10.1155/2012/623474
    • (2012) Clin Dev Immunol , vol.2012 , pp. 623474
    • Moingeon, P.1    Mascarell, L.2
  • 67
    • 77956943528 scopus 로고    scopus 로고
    • Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-beta
    • 10.4049/jimmunol.1000359 20639482 1:CAS:528:DC%2BC3cXpslWnuro%3D 10.4049/jimmunol.1000359
    • Monteiro M, Almeida CF, Caridade M, Ribot JC, Duarte J, Agua-Doce A, Wollenberg I, Silva-Santos B, Graca L (2010) Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-beta. J Immunol 185(4):2157-2163. doi: 10.4049/jimmunol.1000359
    • (2010) J Immunol , vol.185 , Issue.4 , pp. 2157-2163
    • Monteiro, M.1    Almeida, C.F.2    Caridade, M.3    Ribot, J.C.4    Duarte, J.5    Agua-Doce, A.6    Wollenberg, I.7    Silva-Santos, B.8    Graca, L.9
  • 70
    • 84865820981 scopus 로고    scopus 로고
    • A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue
    • 10.1126/scitranslmed.3003594 22932224 1:CAS:528:DC%2BC38XhtlyqtbfI 10.1126/scitranslmed.3003594
    • Nance EA, Woodworth GF, Sailor KA, Shih TY, Xu Q, Swaminathan G, Xiang D, Eberhart C, Hanes J (2012) A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med 4(149):149ra119. doi: 10.1126/scitranslmed.3003594
    • (2012) Sci Transl Med , vol.4 , Issue.149
    • Nance, E.A.1    Woodworth, G.F.2    Sailor, K.A.3    Shih, T.Y.4    Xu, Q.5    Swaminathan, G.6    Xiang, D.7    Eberhart, C.8    Hanes, J.9
  • 71
    • 77955139236 scopus 로고    scopus 로고
    • Transient peripheral immune response and central nervous system leaky compartmentalization in a viral model for multiple sclerosis
    • 10.1111/j.1750-3639.2010.00383.x 20331618 1:CAS:528:DC%2BC3cXhtFKht7bO
    • Navarrete-Talloni MJ, Kalkuhl A, Deschl U, Ulrich R, Kummerfeld M, Rohn K, Baumgartner W, Beineke A (2010) Transient peripheral immune response and central nervous system leaky compartmentalization in a viral model for multiple sclerosis. Brain Pathol 20(5):890-901. doi: 10.1111/j.1750-3639.2010.00383.x
    • (2010) Brain Pathol , vol.20 , Issue.5 , pp. 890-901
    • Navarrete-Talloni, M.J.1    Kalkuhl, A.2    Deschl, U.3    Ulrich, R.4    Kummerfeld, M.5    Rohn, K.6    Baumgartner, W.7    Beineke, A.8
  • 72
    • 0023686551 scopus 로고
    • The fine anatomy of the human spinal meninges. A light and scanning electron microscopy study
    • 3392571 1:STN:280:DyaL1c3nsVGhsQ%3D%3D 10.3171/jns.1988.69.2.0276
    • Nicholas DS, Weller RO (1988) The fine anatomy of the human spinal meninges. A light and scanning electron microscopy study. J Neurosurg 69:276-282
    • (1988) J Neurosurg , vol.69 , pp. 276-282
    • Nicholas, D.S.1    Weller, R.O.2
  • 73
    • 77249096486 scopus 로고    scopus 로고
    • Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis
    • 10.4049/jimmunol.0900747 19841183 1:CAS:528:DC%2BD1MXhtlKhsbvO 10.4049/jimmunol.0900747
    • Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH (2009) Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol 183(10):6041-6050. doi: 10.4049/jimmunol.0900747
    • (2009) J Immunol , vol.183 , Issue.10 , pp. 6041-6050
    • Ochoa-Reparaz, J.1    Mielcarz, D.W.2    Ditrio, L.E.3    Burroughs, A.R.4    Foureau, D.M.5    Haque-Begum, S.6    Kasper, L.H.7
  • 74
    • 77958119730 scopus 로고    scopus 로고
    • Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression
    • 10.4049/jimmunol.1001443 20817872 1:CAS:528:DC%2BC3cXhtFyisrnO 10.4049/jimmunol.1001443
    • Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH (2010a) Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression. J Immunol 185(7):4101-4108. doi: 10.4049/jimmunol.1001443
    • (2010) J Immunol , vol.185 , Issue.7 , pp. 4101-4108
    • Ochoa-Reparaz, J.1    Mielcarz, D.W.2    Ditrio, L.E.3    Burroughs, A.R.4    Begum-Haque, S.5    Dasgupta, S.6    Kasper, D.L.7    Kasper, L.H.8
  • 75
    • 77955913743 scopus 로고    scopus 로고
    • A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
    • 10.1038/mi.2010.29 20531465 1:CAS:528:DC%2BC3cXhtVCntr3I 10.1038/mi.2010.29
    • Ochoa-Reparaz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, Kasper LH (2010b) A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol 3(5):487-495. doi: 10.1038/mi.2010.29
    • (2010) Mucosal Immunol , vol.3 , Issue.5 , pp. 487-495
    • Ochoa-Reparaz, J.1    Mielcarz, D.W.2    Wang, Y.3    Begum-Haque, S.4    Dasgupta, S.5    Kasper, D.L.6    Kasper, L.H.7
  • 77
    • 79251524590 scopus 로고    scopus 로고
    • Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis
    • 10.1002/nbm.1536 20665906 10.1002/nbm.1536
    • Oude Engberink RD, Blezer EL, Dijkstra CD, van der Pol SM, van der Toorn A, de Vries HE (2010) Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis. NMR Biomed 23(9):1087-1096. doi: 10.1002/nbm.1536
    • (2010) NMR Biomed , vol.23 , Issue.9 , pp. 1087-1096
    • Oude Engberink, R.D.1    Blezer, E.L.2    Dijkstra, C.D.3    Van Der Pol, S.M.4    Van Der Toorn, A.5    De Vries, H.E.6
  • 78
    • 84864464545 scopus 로고    scopus 로고
    • Immune surveillance in the central nervous system
    • 10.1038/nn.3161 22837040 1:CAS:528:DC%2BC38XhtV2hsr3I 10.1038/nn.3161
    • Ousman SS, Kubes P (2012) Immune surveillance in the central nervous system. Nat Neurosci 15(8):1096-1101. doi: 10.1038/nn.3161
    • (2012) Nat Neurosci , vol.15 , Issue.8 , pp. 1096-1101
    • Ousman, S.S.1    Kubes, P.2
  • 79
    • 0037942601 scopus 로고    scopus 로고
    • The blood-brain barrier and its role in immune privilege in the central nervous system
    • 12834104 1:CAS:528:DC%2BD3sXlt1yqurk%3D
    • Pachter JS, de Vries HE, Fabry Z (2003) The blood-brain barrier and its role in immune privilege in the central nervous system. J Neuropathol Exp Neurol 62:593-604
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 593-604
    • Pachter, J.S.1    De Vries, H.E.2    Fabry, Z.3
  • 80
    • 0030799954 scopus 로고    scopus 로고
    • Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat
    • 9306968 1:STN:280:DyaK2svlt1WqtQ%3D%3D 10.1002/(SICI)1096-9896(199708) 182:4<457: AID-PATH870>3.0.CO;2-Y
    • Phillips MJ, Needham M, Weller RO (1997) Role of cervical lymph nodes in autoimmune encephalomyelitis in the Lewis rat. J Pathol 182:457-464
    • (1997) J Pathol , vol.182 , pp. 457-464
    • Phillips, M.J.1    Needham, M.2    Weller, R.O.3
  • 81
    • 84857469217 scopus 로고    scopus 로고
    • Brain-derived antigens in lymphoid tissue of patients with acute stroke
    • 10.4049/jimmunol.1102289 22287710 1:CAS:528:DC%2BC38XisVGkur8%3D 10.4049/jimmunol.1102289
    • Planas AM, Gomez-Choco M, Urra X, Gorina R, Caballero M, Chamorro A (2012) Brain-derived antigens in lymphoid tissue of patients with acute stroke. J Immunol 188(5):2156-2163. doi: 10.4049/jimmunol.1102289
    • (2012) J Immunol , vol.188 , Issue.5 , pp. 2156-2163
    • Planas, A.M.1    Gomez-Choco, M.2    Urra, X.3    Gorina, R.4    Caballero, M.5    Chamorro, A.6
  • 82
    • 79957884570 scopus 로고    scopus 로고
    • CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection
    • 10.1016/j.bbi.2010.09.014 20868739 1:CAS:528:DC%2BC3MXntlGksr8%3D 10.1016/j.bbi.2010.09.014
    • Ploix CC, Noor S, Crane J, Masek K, Carter W, Lo DD, Wilson EH, Carson MJ (2011) CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection. Brain Behav Immun 25(5):883-896. doi: 10.1016/j.bbi.2010.09.014
    • (2011) Brain Behav Immun , vol.25 , Issue.5 , pp. 883-896
    • Ploix, C.C.1    Noor, S.2    Crane, J.3    Masek, K.4    Carter, W.5    Lo, D.D.6    Wilson, E.H.7    Carson, M.J.8
  • 83
    • 0037385370 scopus 로고    scopus 로고
    • Capillary and arterial amyloid angiopathy in Alzheimer's disease: Defining the perivascular route for the elimination of amyloid beta from the human brain
    • 12662319 1:CAS:528:DC%2BD3sXjtlKhu7c%3D 10.1046/j.1365-2990.2003.00424.x
    • Preston SD, Steart PV, Wilkinson A, Nicoll JAR, Weller RO (2003) Capillary and arterial amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 29:106-117
    • (2003) Neuropathol Appl Neurobiol , vol.29 , pp. 106-117
    • Preston, S.D.1    Steart, P.V.2    Wilkinson, A.3    Nicoll, J.A.R.4    Weller, R.O.5
  • 84
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • 10.1038/nn.2923 21952260 1:CAS:528:DC%2BC3MXht1anu7vE 10.1038/nn.2923
    • Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011) Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 14(10):1227-1235. doi: 10.1038/nn.2923
    • (2011) Nat Neurosci , vol.14 , Issue.10 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 85
    • 77953791503 scopus 로고    scopus 로고
    • Turning over the chance card on MS susceptibility
    • 10.1038/ni0710-570 20562841 1:CAS:528:DC%2BC3cXns1Gjtbs%3D 10.1038/ni0710-570
    • Ransohoff RM (2010) Turning over the chance card on MS susceptibility. Nat Immunol 11(7):570-572. doi: 10.1038/ni0710-570
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 570-572
    • Ransohoff, R.M.1
  • 86
    • 84864446952 scopus 로고    scopus 로고
    • Animal models of multiple sclerosis: The good, the bad and the bottom line
    • 10.1038/nn.3168 22837037 1:CAS:528:DC%2BC38XhtV2iu7nO 10.1038/nn.3168
    • Ransohoff RM (2012) Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat Neurosci 15(8):1074-1077. doi: 10.1038/nn.3168
    • (2012) Nat Neurosci , vol.15 , Issue.8 , pp. 1074-1077
    • Ransohoff, R.M.1
  • 87
    • 84866364390 scopus 로고    scopus 로고
    • The anatomical and cellular basis of immune surveillance in the central nervous system
    • 10.1038/nri3265 22903150 1:CAS:528:DC%2BC38Xht1Wkt7fN 10.1038/nri3265
    • Ransohoff RM, Engelhardt B (2012) The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 12(9):623-635. doi: 10.1038/nri3265
    • (2012) Nat Rev Immunol , vol.12 , Issue.9 , pp. 623-635
    • Ransohoff, R.M.1    Engelhardt, B.2
  • 88
    • 0021959647 scopus 로고
    • Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • 3971148 1:STN:280:DyaL2M7itlyhtg%3D%3D 10.1016/0006-8993(85)91383-6
    • Rennels ML, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA (1985) Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326:47-63
    • (1985) Brain Res , vol.326 , pp. 47-63
    • Rennels, M.L.1    Gregory, T.F.2    Blaumanis, O.R.3    Fujimoto, K.4    Grady, P.A.5
  • 90
    • 14544303998 scopus 로고    scopus 로고
    • Early events in antigen-specific regulatory T cell induction via nasal and oral mucosa
    • 10.1196/annals.1309.045 15681788 1:CAS:528:DC%2BD2MXislWit7c%3D 10.1196/annals.1309.045
    • Samsom JN, Hauet-Broere F, Unger WW, Vanb LA, Kraal G (2004) Early events in antigen-specific regulatory T cell induction via nasal and oral mucosa. Ann N Y Acad Sci 1029:385-389. doi: 10.1196/annals.1309.045
    • (2004) Ann N y Acad Sci , vol.1029 , pp. 385-389
    • Samsom, J.N.1    Hauet-Broere, F.2    Unger, W.W.3    Vanb, L.A.4    Kraal, G.5
  • 93
    • 31744448129 scopus 로고    scopus 로고
    • Mechanisms to explain the reverse perivascular transport of solutes out of the brain
    • 16112683 1:CAS:528:DC%2BD28XhtFSgsbw%3D 10.1016/j.jtbi.2005.07.005
    • Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO (2006) Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol 238:962-974
    • (2006) J Theor Biol , vol.238 , pp. 962-974
    • Schley, D.1    Carare-Nnadi, R.2    Please, C.P.3    Perry, V.H.4    Weller, R.O.5
  • 94
    • 0344019141 scopus 로고
    • Der Arachnoidalraum, ein Lymphraum und sein Zusammenhang mit dem Perichoroidalraum
    • Schwalbe G (1869) Der Arachnoidalraum, ein Lymphraum und sein Zusammenhang mit dem Perichoroidalraum. Zentralb Med Wiss 7:465-467
    • (1869) Zentralb Med Wiss , vol.7 , pp. 465-467
    • Schwalbe, G.1
  • 95
    • 0030787726 scopus 로고    scopus 로고
    • Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium
    • 9223091 1:STN:280:DyaK2szms1arsw%3D%3D 10.1097/00001756-199705260-00039
    • Serot JM, Foliguet B, Bene MC, Faure GC (1997) Ultrastructural and immunohistological evidence for dendritic-like cells within human choroid plexus epithelium. Neuroreport 8:1995-1998
    • (1997) Neuroreport , vol.8 , pp. 1995-1998
    • Serot, J.M.1    Foliguet, B.2    Bene, M.C.3    Faure, G.C.4
  • 97
    • 1842715270 scopus 로고
    • Drainage of interstitial fluid from different regions of rat brain
    • 6742132 1:STN:280:DyaL2c3lsVSlsg%3D%3D
    • Szentistvanyi I, Patlak CS, Ellis RA, Cserr HF (1984) Drainage of interstitial fluid from different regions of rat brain. Am J Physiol 246:F835-F844
    • (1984) Am J Physiol , vol.246
    • Szentistvanyi, I.1    Patlak, C.S.2    Ellis, R.A.3    Cserr, H.F.4
  • 98
    • 77952746516 scopus 로고    scopus 로고
    • Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus
    • 10.4049/jimmunol.0903918 20208000 1:CAS:528:DC%2BC3cXkt1WqtL0%3D 10.4049/jimmunol.0903918
    • Trandem K, Anghelina D, Zhao J, Perlman S (2010) Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus. J Immunol 184(8):4391-4400. doi: 10.4049/jimmunol.0903918
    • (2010) J Immunol , vol.184 , Issue.8 , pp. 4391-4400
    • Trandem, K.1    Anghelina, D.2    Zhao, J.3    Perlman, S.4
  • 99
    • 0016163551 scopus 로고
    • Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid
    • 4369428 1:STN:280:DyaE2czhtVSitw%3D%3D
    • Tripathi BJ, Tripathi RC (1974) Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid. J Physiol 239:195-206
    • (1974) J Physiol , vol.239 , pp. 195-206
    • Tripathi, B.J.1    Tripathi, R.C.2
  • 100
    • 33644965804 scopus 로고    scopus 로고
    • CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS
    • 10.1002/eji.200535123 16437540 1:CAS:528:DC%2BD28XjtVegtro%3D 10.1002/eji.200535123
    • Tschen SI, Stohlman SA, Ramakrishna C, Hinton DR, Atkinson RD, Bergmann CC (2006) CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol 36(3):603-612. doi: 10.1002/eji.200535123
    • (2006) Eur J Immunol , vol.36 , Issue.3 , pp. 603-612
    • Tschen, S.I.1    Stohlman, S.A.2    Ramakrishna, C.3    Hinton, D.R.4    Atkinson, R.D.5    Bergmann, C.C.6
  • 101
    • 6344276959 scopus 로고    scopus 로고
    • Preferential expression of IgG2b in nose draining cervical lymph nodes and its putative role in mucosal tolerance induction
    • 10.1111/j.1398-9995.2004.00510.x 15461604 10.1111/j.1398-9995.2004.00510. x 1:CAS:528:DC%2BD2cXhtVWksbfK
    • van Helvoort JM, Samsom JN, Chantry D, Jansen W, Schadee-Eestermans I, Thepen T, Mebius RE, Kraal G (2004) Preferential expression of IgG2b in nose draining cervical lymph nodes and its putative role in mucosal tolerance induction. Allergy 59(11):1211-1218. doi: 10.1111/j.1398-9995.2004.00510.x
    • (2004) Allergy , vol.59 , Issue.11 , pp. 1211-1218
    • Van Helvoort, J.M.1    Samsom, J.N.2    Chantry, D.3    Jansen, W.4    Schadee-Eestermans, I.5    Thepen, T.6    Mebius, R.E.7    Kraal, G.8
  • 105
    • 84862835769 scopus 로고    scopus 로고
    • Induction of immune tolerance in mice with a novel mucosal nanoemulsion adjuvant and self-antigen
    • 10.2217/nnm.11.187 1:CAS:528:DC%2BC38XptFSqu74%3D 10.2217/nnm.11.187
    • Wang SH, Fan Y, Makidon PE, Cao Z, Baker JR (2012) Induction of immune tolerance in mice with a novel mucosal nanoemulsion adjuvant and self-antigen. Nanomedicine (London) 7(6):867-876. doi: 10.2217/nnm.11.187
    • (2012) Nanomedicine (London) , vol.7 , Issue.6 , pp. 867-876
    • Wang, S.H.1    Fan, Y.2    Makidon, P.E.3    Cao, Z.4    Baker, J.R.5
  • 106
    • 73949137249 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review
    • 10.1038/jcbfm.2009.192 1:CAS:528:DC%2BC3cXos1Wj 10.1038/jcbfm.2009.192
    • Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL, Neuwelt EA (2010) Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 30(1):15-35. doi: 10.1038/jcbfm.2009.192
    • (2010) J Cereb Blood Flow Metab off J Int Soc Cereb Blood Flow Metab , vol.30 , Issue.1 , pp. 15-35
    • Weinstein, J.S.1    Varallyay, C.G.2    Dosa, E.3    Gahramanov, S.4    Hamilton, B.5    Rooney, W.D.6    Muldoon, L.L.7    Neuwelt, E.A.8
  • 107
    • 0031722421 scopus 로고    scopus 로고
    • Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
    • 9786239 1:STN:280:DyaK1M%2FgtVWkug%3D%3D 10.1097/00005072-199810000-00001
    • Weller RO (1998) Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol 57:885-894
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 885-894
    • Weller, R.O.1
  • 108
    • 0000317428 scopus 로고    scopus 로고
    • Reaction of intrathecal and epidural spaces to infection and inflammation
    • T.L. Yaksh (eds) Elsevier Amsterdam
    • Weller RO (1999) Reaction of intrathecal and epidural spaces to infection and inflammation. In: Yaksh TL (ed) Spinal drug delivery. Elsevier, Amsterdam, pp 297-315
    • (1999) Spinal Drug Delivery , pp. 297-315
    • Weller, R.O.1
  • 109
    • 33644874975 scopus 로고    scopus 로고
    • Microscopic morphology and histology of the human meninges
    • 15943078 1:STN:280:DC%2BD2M3pslShtg%3D%3D 10.1016/S1286-0115(05)83235-7
    • Weller RO (2005) Microscopic morphology and histology of the human meninges. Morphologie 89:22-34
    • (2005) Morphologie , vol.89 , pp. 22-34
    • Weller, R.O.1
  • 110
    • 41149157623 scopus 로고    scopus 로고
    • Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease
    • 18363936 1:CAS:528:DC%2BD1cXmtFGqt7s%3D 10.1111/j.1750-3639.2008.00133.x
    • Weller RO, Subash M, Preston SD, Mazanti I, Carare RO (2008) Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 18:253-266
    • (2008) Brain Pathol , vol.18 , pp. 253-266
    • Weller, R.O.1    Subash, M.2    Preston, S.D.3    Mazanti, I.4    Carare, R.O.5
  • 111
    • 57049154546 scopus 로고    scopus 로고
    • Lymphatic drainage of the brain and the pathophysiology of neurological disease
    • 19002474 1:CAS:528:DC%2BD1cXhsVeksrfK 10.1007/s00401-008-0457-0
    • Weller RO, Djuanda E, Yow HY, Carare RO (2009) Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 117:1-14
    • (2009) Acta Neuropathol , vol.117 , pp. 1-14
    • Weller, R.O.1    Djuanda, E.2    Yow, H.Y.3    Carare, R.O.4
  • 112
    • 77955511942 scopus 로고    scopus 로고
    • Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis
    • 1:STN:280:DC%2BC3cfgsF2quw%3D%3D
    • Weller RO, Galea I, Carare RO, Minagar A (2010) Pathophysiology of the lymphatic drainage of the central nervous system: implications for pathogenesis and therapy of multiple sclerosis. Pathophysiol Off J Int Soc Pathophysiol/ISP 17:295-306
    • (2010) Pathophysiol off J Int Soc Pathophysiol/ISP , vol.17 , pp. 295-306
    • Weller, R.O.1    Galea, I.2    Carare, R.O.3    Minagar, A.4
  • 113
    • 73349119409 scopus 로고    scopus 로고
    • The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen
    • 10.1084/jem.20082401 19858325 1:CAS:528:DC%2BD1MXhsV2ltrrP 10.1084/jem.20082401
    • Willart MA, Jan de Heer H, Hammad H, Soullie T, Deswarte K, Clausen BE, Boon L, Hoogsteden HC, Lambrecht BN (2009) The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-2835. doi: 10.1084/jem.20082401
    • (2009) J Exp Med , vol.206 , Issue.12 , pp. 2823-2835
    • Willart, M.A.1    Jan De Heer, H.2    Hammad, H.3    Soullie, T.4    Deswarte, K.5    Clausen, B.E.6    Boon, L.7    Hoogsteden, H.C.8    Lambrecht, B.N.9
  • 114
    • 0033557738 scopus 로고    scopus 로고
    • Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: Studies with OVA and human cartilage gp-39
    • 9973470 1:CAS:528:DyaK1MXhtVOnsLY%3D
    • Wolvers DA, Coenen-de Roo CJ, Mebius RE, van der Cammen MJ, Tirion F, Miltenburg AM, Kraal G (1999) Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39. J Immunol 162:1994-1998
    • (1999) J Immunol , vol.162 , pp. 1994-1998
    • Wolvers, D.A.1    Coenen-De Roo, C.J.2    Mebius, R.E.3    Van Der Cammen, M.J.4    Tirion, F.5    Miltenburg, A.M.6    Kraal, G.7
  • 115
    • 84871345095 scopus 로고    scopus 로고
    • Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation
    • 10.1371/journal.pone.0051665 23272135 1:CAS:528:DC%2BC3sXjvF2ltA%3D%3D 10.1371/journal.pone.0051665
    • Yamazaki S, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T (2012) Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation. PLoS One 7(12):e51665. doi: 10.1371/journal.pone.0051665
    • (2012) PLoS One , vol.7 , Issue.12 , pp. 51665
    • Yamazaki, S.1    Maruyama, A.2    Okada, K.3    Matsumoto, M.4    Morita, A.5    Seya, T.6
  • 117
    • 0025353908 scopus 로고
    • Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum
    • 2254158 1:STN:280:DyaK3M%2Fnt1Sktw%3D%3D
    • Zhang ET, Inman CB, Weller RO (1990) Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat 170:111-123
    • (1990) J Anat , vol.170 , pp. 111-123
    • Zhang, E.T.1    Inman, C.B.2    Weller, R.O.3
  • 118
    • 0026567020 scopus 로고
    • Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain
    • 1373020 1:STN:280:DyaK383hsVSksQ%3D%3D 10.1007/BF00296784
    • Zhang ET, Richards HK, Kida S, Weller RO (1992) Directional and compartmentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain. Acta Neuropathol 83:233-239
    • (1992) Acta Neuropathol , vol.83 , pp. 233-239
    • Zhang, E.T.1    Richards, H.K.2    Kida, S.3    Weller, R.O.4
  • 119
    • 58149286586 scopus 로고    scopus 로고
    • Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis
    • 18802066 1:CAS:528:DC%2BD1cXhtFarurzM
    • Zhang H, Podojil JR, Luo X, Miller SD (2008) Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis. J Immunol 181(7):4638-4647
    • (2008) J Immunol , vol.181 , Issue.7 , pp. 4638-4647
    • Zhang, H.1    Podojil, J.R.2    Luo, X.3    Miller, S.D.4
  • 120
    • 84866734766 scopus 로고    scopus 로고
    • CD4+LAP + and CD4 +CD25 +Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE-/- mice
    • 10.1007/s10875-012-9699-7 22552859 1:CAS:528:DC%2BC38XhtlOlurnJ 10.1007/s10875-012-9699-7
    • Zhong Y, Wang X, Ji Q, Mao X, Tang H, Yi G, Meng K, Yang X, Zeng Q (2012) CD4+LAP + and CD4 +CD25 +Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE-/- mice. J Clin Immunol 32(5):1104-1117. doi: 10.1007/s10875-012-9699-7
    • (2012) J Clin Immunol , vol.32 , Issue.5 , pp. 1104-1117
    • Zhong, Y.1    Wang, X.2    Ji, Q.3    Mao, X.4    Tang, H.5    Yi, G.6    Meng, K.7    Yang, X.8    Zeng, Q.9
  • 121
    • 3543150635 scopus 로고
    • Die Lymphbahnen des oberen Nasalschnittes und deren Beziehungen zu den perimeningealen Lymphraumen
    • Zwillinger H (1912) Die Lymphbahnen des oberen Nasalschnittes und deren Beziehungen zu den perimeningealen Lymphraumen. Arch Laryngol und Rhinol 26:66-78
    • (1912) Arch Laryngol und Rhinol , vol.26 , pp. 66-78
    • Zwillinger, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.