CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection

Brain, Behavior, and Immunity

Volumn 25, Issue 5, 2011, Pages 883-896

  Ploix, Corinne C ^a   Noor, Shahani ^b,c   Crane, Janelle ^b   Masek, Kokoechat ^b   Carter, Whitney ^b   Lo, David D ^b   Wilson, Emma H ^b   Carson, Monica J ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmunity; Glia; Lymphopenia; Microglia; Multiple sclerosis; Neurodegeneration; Neuroinflammation; T cell trafficking

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYCLOPHILIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOIMMUNITY; BRAIN VENTRICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CERVICAL LYMPH NODE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRAVASATION; GLIA; HOMEOSTASIS; INFLAMMATORY INFILTRATE; LYMPHOCYTE PROLIFERATION; MENINX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ASTROCYTES; BLOTTING, NORTHERN; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL21; CHEMOTAXIS, LEUKOCYTE; IN SITU HYBRIDIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROGLIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOXOPLASMA; TOXOPLASMOSIS, CEREBRAL;

EID: 79957884570     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2010.09.014     Document Type: Article

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