PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Keijzer, Chantal ^a   Slütter, Bram ^b   van der Zee, Ruurd ^a   Jiskoot, Wim ^b   van Eden, Willem ^a   Broere, Femke ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHITOSAN DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; HEAT SHOCK PROTEIN 70; N TRIMETHYLCHITOSAN; NANOPARTICLE; OVALBUMIN; PEPTIDE VACCINE; POLYGLACTIN; TRANSCRIPTION FACTOR FOXP3; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG; CHITOSAN; LACTIC ACID; N TRIMETHYL CHITOSAN CHLORIDE; N-TRIMETHYL CHITOSAN CHLORIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYPHOSPHATE; TRIPHOSPHORIC ACID; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN PRESENTATION; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CERVICAL LYMPH NODE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; DRUG ADMINISTRATION ROUTE; FEMALE; HUMORAL IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOID TISSUE; MALE; MOUSE; NASOPHARYNX; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TH1 CELL; TRANSCRIPTION REGULATION; UPREGULATION; ANTIBODY PRODUCTION; CELL PROLIFERATION; DRUG EFFECT; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION;

MUS;

ADMINISTRATION, INTRANASAL; ANTIBODY FORMATION; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHITOSAN; HYPERSENSITIVITY, DELAYED; LACTIC ACID; NANOPARTICLES; POLYGLYCOLIC ACID; POLYPHOSPHATES; VACCINES;

EID: 80355146169     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026684     Document Type: Article

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