CD4+FoxP3+ T regulatory cells in drug-susceptible and multidrug-resistant tuberculosis

Tuberculosis

Volumn 93, Issue 5, 2013, Pages 523-528

  Lim, Hyo Jeong ^a   Park, Jong Sun ^a   Cho, Young Jae ^a   Yoon, Ho Il ^a   Park, Kyoung Un ^a   Lee, Choon Tack ^a   Lee, Jae Ho ^a  

^a Seoul National University Bundang Hospital   (South Korea)

Author keywords

Disease susceptibility; FoxP3 protein; Multidrug resistant tuberculosis; Regulatory T cells

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; TUBERCULOSTATIC AGENT;

ACID FAST BACTERIUM; ADULT; ARTICLE; BACTERIUM CULTURE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG SENSITIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANT TUBERCULOSIS; PRIORITY JOURNAL;

DISEASE SUSCEPTIBILITY; FOXP3 PROTEIN; MULTIDRUG-RESISTANT TUBERCULOSIS; REGULATORY T-CELLS;

ADULT; ANTITUBERCULAR AGENTS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; SEVERITY OF ILLNESS INDEX; SPUTUM; T-LYMPHOCYTES, REGULATORY; TUBERCULOSIS, MULTIDRUG-RESISTANT; TUBERCULOSIS, PULMONARY;

EID: 84882266402     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2013.06.001     Document Type: Article

References (27)

1. Global tuberculosis report 2012 2012 World Health Organization
2. J.L. Flynn, and J. Chan Immunology of tuberculosis Annu Rev Immunol 19 2001 93 129 10.1146/annurev.immunol.19.1.93
3. J.M. Hougardy, S. Place, M. Hildebrand, A. Drowart, A.S. Debrie, C. Locht, and F. Mascart Regulatory T cells depress immune responses to protective antigens in active tuberculosis Am J Respir Crit Care Med 176 2007 409 416 10.1164/rccm.200701-084OC
4. X.Y. He, L. Xiao, H.B. Chen, J. Hao, J. Li, Y.J. Wang, K. He, Y. Gao, and B.Y. Shi T regulatory cells and Th1/Th2 cytokines in peripheral blood from tuberculosis patients Eur J Clin Microbiol Infect Dis 29 2010 643 650 10.1007/s10096-010-0908-0
5. S. Sakaguchi, K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi Regulatory T cells: how do they suppress immune responses? Int Immunol 21 2009 1105 1111 10.1093/intimm/dxp095
6. V. Guyot-Revol, J.A. Innes, S. Hackforth, T. Hinks, and A. Lalvani Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis Am J Respir Crit Care Med 173 2006 803 810 10.1164/rccm.200508- 1294OC
7. M. Kursar, M. Koch, H.W. Mittrucker, G. Nouailles, K. Bonhagen, T. Kamradt, and S.H. Kaufmann Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis J Immunol 178 2007 2661 2665
8. N.D. Marin, S.C. Paris, V.M. Velez, C.A. Rojas, M. Rojas, and L.F. Garcia Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis Tuberculosis (Edinb) 90 2010 252 261 10.1016/j.tube.2010. 05.003
9. J. Nemeth, H.M. Winkler, L. Boeck, A.A. Adegnika, E. Clement, T.M. Mve, P.G. Kremsner, and S. Winkler Specific cytokine patterns of pulmonary tuberculosis in Central Africa Clin Immunol 138 2011 50 59 10.1016/j.clim.2010. 09.005
10. T. Chiacchio, R. Casetti, O. Butera, V. Vanini, S. Carrara, E. Girardi, D. Di Mitri, L. Battistini, F. Martini, G. Borsellino, and D. Goletti Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis Clin Exp Immunol 156 2009 463 470 10.1111/j.1365-2249.2009.03908.x
11. A.M. Green, J.T. Mattila, C.L. Bigbee, K.S. Bongers, P.L. Lin, and J.L. Flynn CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection J Infect Dis 202 2010 533 541 10.1086/654896
12. J.A. Yeom, Y.J. Jeong, D. Jeon, K.I. Kim, C.W. Kim, H.K. Park, and Y.D. Kim Imaging findings of primary multidrug-resistant tuberculosis: a comparison with findings of drug-sensitive tuberculosis J Comput Assist Tomogr 33 2009 956 960 10.1097/RCT.0b013e31819877ab
13. J.S. Lee, C.H. Song, C.H. Kim, S.J. Kong, M.H. Shon, H.J. Kim, J.K. Park, T.H. Paik, and E.K. Jo Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis Clin Exp Immunol 128 2002 516 524
14. A.S. Shahemabadi, A.Z. Hosseini, S. Shaghsempour, M.R. Masjedi, M. Rayani, and M. Pouramiri Evaluation of T cell immune responses in multi-drug-resistant tuberculosis (MDR-TB) patients to Mycobacterium tuberculosis total lipid antigens Clin Exp Immunol 149 2007 285 294 10.1111/j.1365-2249.2007.03406.x
15. L. Geffner, N. Yokobori, J. Basile, P. Schierloh, L. Balboa, M.M. Romero, V. Ritacco, M. Vescovo, P. Gonzalez Montaner, B. Lopez, L. Barrera, M. Aleman, E. Abatte, M.C. Sasiain, and S. de la Barrera Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains Infect Immun 77 2009 5025 5034 10.1128/IAI.00224-09
16. reg cells after pulmonary resection in the treatment of cavity multidrug-resistant tuberculosis Int J Infect Dis 14 2010 e815 822 10.1016/j.ijid.2010.04.005
17. D.H. Kim, H.J. Kim, S.K. Park, S.J. Kong, Y.S. Kim, T.H. Kim, E.K. Kim, K.M. Lee, S.S. Lee, J.S. Park, W.J. Koh, C.H. Lee, and T.S. Shim Treatment outcomes and survival based on drug resistance patterns in multidrug-resistant tuberculosis Am J Respir Crit Care Med 182 2010 113 119 10.1164/rccm.200911- 1656OC
18. M. Casarini, F. Ameglio, L. Alemanno, P. Zangrilli, P. Mattia, G. Paone, A. Bisetti, and S. Giosue Cytokine levels correlate with a radiologic score in active pulmonary tuberculosis Am J Respir Crit Care Med 159 1999 143 148
19. Diagnostic Standards and Classification of Tuberculosis in Adults and Children. This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. This statement was endorsed by the Council of the Infectious Disease Society of America, September 1999 Am J Respir Crit Care Med 161 2000 1376 1395
20. A. Singh, A.B. Dey, A. Mohan, P.K. Sharma, and D.K. Mitra Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-gamma producing T cells PLoS One 7 2012 e44728 10.1371/journal.pone.0044728
21. C. Baecher-Allan, J.A. Brown, G.J. Freeman, and D.A. Hafler CD4+CD25high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253
22. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061 10.1126/science.1079490
23. G. Roncador, P.J. Brown, L. Maestre, S. Hue, J.L. Martinez-Torrecuadrada, K.L. Ling, S. Pratap, C. Toms, B.C. Fox, V. Cerundolo, F. Powrie, and A.H. Banham Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level Eur J Immunol 35 2005 1681 1691 10.1002/eji.200526189
24. - T cells J Clin Invest 112 2003 1437 1443 10.1172/JCI19441
25. M.S. Suchard, E. Mayne, V.A. Green, S. Shalekoff, S.L. Donninger, W.S. Stevens, C.M. Gray, and C.T. Tiemessen FOXP3 expression is upregulated in CD4T cells in progressive HIV-1 infection and is a marker of disease severity PLoS One 5 2010 e11762 10.1371/journal.pone.0011762
26. E.G. Churina, O.I. Urazova, and V.V. Novitskiy The role of foxp3-expressing regulatory T cells and T helpers in immunopathogenesis of multidrug resistant pulmonary tuberculosis Tuberc Res Treat 2012 2012 931291 10.1155/2012/931291
27. P.K. Sharma, P.K. Saha, A. Singh, S.K. Sharma, B. Ghosh, and D.K. Mitra FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis Am J Respir Crit Care Med 179 2009 1061 1070 10.1164/rccm.200804-529OC