Specific cytokine patterns of pulmonary tuberculosis in Central Africa

Clinical Immunology

Volumn 138, Issue 1, 2011, Pages 50-59

  Nemeth, Johannes ^b,c,d   Winkler, Heide Maria ^a,b   Boeck, Lucas ^d   Adegnika, Ayola A ^b,c   Clement, Ella ^e   Mve, Toung M ^e   Kremsner, Peter G ^b,c   Winkler, Stefan ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b ALBERT SCHWEITZER HOSPITAL   (Gabon)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

^e Hôpital de Nkembo   (Gabon)

Author keywords

Cytokines; FoxP3; T cell; Tuberculosis

Indexed keywords

EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CENTRAL AFRICA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG TUBERCULOSIS; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BODY TEMPERATURE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GABON; GENE EXPRESSION; HEMOGLOBINS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; TRANSFORMING GROWTH FACTOR BETA; TUBERCULIN; TUBERCULOSIS, PULMONARY; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 78651350646     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.09.005     Document Type: Article

References (41)

1. World Health Organization. Tuberculosis facts 2007. last assessed 20.7.10. http://www.who.int/tb/en/.
2. Kaufmann S.H., McMichael A.J. Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis. Nat. Med. 2005, 11:33-44. Review.
3. Food and Drug Administration. Safety update on TNF-α Antagonists. last assessed 20.7.10. http://www.fda.gov.
4. Dorman S.E., Picard C., Lammas D., Heyne K., van Dissel J.T., Baretto R., Rosenzweig S.D., Newport M., Levin M., Roesler J., Kumararatne D., Casanova J.L., Holland S.M. Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Lancet 2004, 364:2113-2121.
5. Kaufmann S.H. Tuberculosis: back on the immunologists' agenda. Immunity 2006, 24:351-357. Review.
6. Hirsch C.S., Toossi Z., Othieno C., Johnson J.L., Schwander S.K., Robertson S., Wallis R.S., Edmonds K., Okwera A., Mugerwa R., Peters P., Ellner J.J. Depressed T-cell interferon-gamma responses in pulmonary tuberculosis: analysis of underlying mechanisms and modulation with therapy. J. Infect. Dis. 1999, 180:2069-2073.
7. Hirsch C.S., Toossi Z., Othieno C., Johnson J.L., Schwander S.K., Robertson S., Wallis R.S., Edmonds K., Okwera A., Mugerwa R., Peters P., Ellner J.J. Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis. J. Clin. Immunol. 1986, 6:146-151.
8. Jo E.K., Kim H.J., Lim J.H., Min D., Song Y., Song C.H., Paik T.H., Suhr J.W., Park J.K. Dysregulated production of interferon-gamma, interleukin-4 and interleukin-6 in early tuberculosis patients in response to antigen 85B of Mycobacterium tuberculosis. Scand. J. Immunol. 2000, 51:209-217.
9. Winkler S., Necek M., Winkler H., Adegnika A.A., Perkmann T., Ramharter M., Kremsner P.G. Increased specific T cell cytokine responses in patients with active pulmonary tuberculosis from Central Africa. Microbes Infect. 2005, 7:1161-1169.
10. Ravn P., Munk M.E., Andersen A.B., Lundgren B., Lundgren J.D., Nielsen L.N., Kok-Jensen A., Andersen P., Weldingh K. Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis. Clin. Diagn. Lab. Immunol. 2005, 12:491-496.
11. Lange C., Pai M., Drobniewski F., Migliori G.B. Interferon-gamma release assays for the diagnosis of active tuberculosis: sensible or silly?. Eur. Respir. J. 2009, 33(6):1250-1253.
12. Jafari C., Thijsen S., Sotgiu G., Goletti D., Benítez J.A., Losi M., Eberhardt R., Kirsten D., Kalsdorf B., Bossink A., Latorre I., Migliori G.B., Strassburg A., Winteroll S., Greinert U., Richeldi L., Ernst M., Lange C. Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study. Am. J. Respir. Crit. Care Med. 2009, 180(7):666-673. Tuberculosis Network European Trialsgroup.
13. Nemeth J., Winkler H.M., Zwick R.H., Rumetshofer R., Schenk P., Burghuber O.C., Graninger W., Ramharter M., Winkler S. Recruitment of Mycobacterium tuberculosis specific CD4(+) T cells to the site of infection for diagnosis of active tuberculosis. J. Intern. Med. 2009, 265:163-168.
14. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
15. Gavin M.A., Rasmussen J.P., Fontenot J.D., Vasta V., Manganiello V.C., Beavo J.A., Rudensky A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 2007, 445:771-775.
16. Mendez S., Reckling S.K., Piccirillo C.A., Sacks D., Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J. Exp. Med. 2004, 200:201-210.
17. Hougardy J.M., Verscheure V., Locht C., Mascart F. In vitro expansion of CD4+CD25highFOXP3+CD127low/- regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans. Microbes Infect. 2007, 9:1325-1332.
18. Li L., Lao S.H., Wu C.Y. Increased frequency of CD4(+)CD25(high) Treg cells inhibit BCG-specific induction of IFN-gamma by CD4(+) T cells from TB patients. Tuberculosis 2007, 87:526-534.
19. Hougardy J.M., Place S., Hildebrand M., Drowart A., Debrie A.S., Locht C., Mascart F. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am. J. Respir. Crit. Care Med. 2007, 176:409-416.
20. Roberts T., Beyers N., Aguirre A., Walzl G. Immunosuppression during active tuberculosis is characterized by decreased interferon-gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels. J. Infect. Dis. 2007, 195:870-878.
21. Chen X., Zhou B., Li M., Deng Q., Wu X., Le X., Wu C., et al. CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin. Immunol. 2007, 123:50-59.
22. Gazzola L., Tincati C., Gori A., Saresella M., Marventano I., Zanini F. FoxP3 mRNA expression in regulatory T cells from patients with tuberculosis. Am. J. Respir. Crit. Care Med. 2006, 174:356.
23. Guyot-Revol V., Innes J.A., Hackforth S., Hinks T., Lalvani A. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am. J. Respir. Crit. Care Med. 2006, 173:803-810.
24. Wahl S.M. Transforming growth factor-beta: innately bipolar. Curr. Opin. Immunol. 2007, 19:55-62.
25. Quesniaux V.F., Jacobs M., Allie N., Grivennikov S., Nedospasov S.A., Garcia I., Olleros M.L., Shebzukhov Y., Kuprash D., Vasseur V., Rose S., Court N., Vacher R., Ryffel B. TNF in host resistance to tuberculosis infection. Curr. Dir. Autoimmun. 2010, 11:157-179. Review.
26. Caccamo N., Guggino G., Joosten S.A., Gelsomino G., Di Carlo P., Titone L., Galati D., Bocchino M., Matarese A., Salerno A., Sanduzzi A., Franken W.P., Dieli F. Multifunctional CD4+T cells correlate with active Mycobacterium tuberculosis infection. Eur. J. Immunol. 2010, 40:2211-2220.
27. Biselli R., Mariotti S., Sargentini V., Sauzullo I., Lastilla M., Mengoni F., Vanini V., Girardi E., Goletti D., D' Amelio R., Nisini R. Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls. Clin. Microbiol. Infect. 2010, 16(8):1282-1284.
28. Harari A., Rizzardi G.P., Ellefsen K., Ciuffreda D., Champagne P., Bart P.A., Kaufmann D., Telenti A., Sahli R., Tambussi G., Kaiser L., Lazzarin A., Perrin L., Pantaleo G. Analysis of HIV-1- and CMV-specific memory CD4 T-cell responses during primary and chronic infection. Blood 2002, 100:1381-1387.
29. Boaz M.J., Waters A., Murad S., Easterbrook P.J., Vyakarnam A. Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection. J. Immunol. 2002, 169:6376-6385.
30. Toossi Z., Gogate P., Shiratsuchi H., Young T., Ellner J.J. Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions. J. Immunol. 1995, 154(1):465-473.
31. Ranges G.E., Figari I.S., Espevik T., Palladino M.A. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. J. Exp. Med. 1987, 166:991-998.
32. Swain S.L., Huston G., Tonkonogy S., Weinberg A. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J. Immunol. 1991, 147:2991-3000.
33. Hirsch C.S., Ellner J.J., Blinkhorn R., Toossi Z. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor beta. Proc. Natl Acad. Sci. USA 1997, 94:3926-3931.
34. Flynn J.L. Immunology of tuberculosis and implications in vaccine development. Tuberculosis 2004, 84:93-101.
35. Zhang Y., Broser M., Rom W. Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF IL 6 and NF-kappa B. Proc. Natl Acad. Sci. USA 1995, 92(8):3632.
36. Nagabhushanam V., Solache A., Ting L.M., Escaron C.J., Zhang J.Y., Ernst J.D. Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J. Immunol. 2003, 171(9):4750-4757.
37. Mattos A.M., Almeida C.D., Franken K.L., Alves C.C., Abramo C., Souza M.A., L'hotellier M., Alves M.J., Ferreira A.P., Oliveira S.C., Ottenhoff T.H., Teixeira H.C. Increased IgG1, IFN-{gamma}, TNF-{alpha} and IL-6 responses to Mycobacterium tuberculosis antigens in patients with Tuberculosis are lower after chemotherapy. Int. Immunol. 2010, 22:775-782.
38. Boussiotis V.A., Tsai E.Y., Yunis E.J., Thim S., Delgado J.C., Dascher C.C., Berezovskaya A., Rousset D., Reynes J.M., Goldfeld A.E. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J. Clin. Invest. 2000, 105. 131.-25-30.
39. Chiacchio T., Casetti R., Butera O., Vanini V., Carrara S., Girardi E., Di Mitri D., Battistini L., Martini F., Borsellino G., Goletti D. Characterization of regulatory T cells identified as CD4(+)CD25(high)CD39(+) in patients with active tuberculosis. Clin. Exp. Immunol. 2009, 156:463-470.
40. Sharma P.K., Saha P.K., Singh A., Sharma S.K., Ghosh B. Mitra DK.FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am. J. Respir. Crit. Care Med. 2009, 179:1061-1070.
41. Griffith D.E. Nontuberculous mycobacterial lung disease. Curr. Opin. Infect. Dis. 2010, 23(2):185-190. Review.