메뉴 건너뛰기




Volumn 77, Issue 11, 2009, Pages 5025-5034

Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; TRANSCRIPTION FACTOR FOXP3;

EID: 70350442293     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00224-09     Document Type: Article
Times cited : (66)

References (60)
  • 2
    • 0142185336 scopus 로고    scopus 로고
    • Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
    • Betts, M. R., J. M. Brenchley, D. A. Price, S. C. De Rosa, D. C. Douek, M. Roederer, and R. A. Koup. 2003. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281:65-78.
    • (2003) J. Immunol. Methods , vol.281 , pp. 65-78
    • Betts, M.R.1    Brenchley, J.M.2    Price, D.A.3    De Rosa, S.C.4    Douek, D.C.5    Roederer, M.6    Koup, R.A.7
  • 3
    • 0014385564 scopus 로고
    • Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
    • Boyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Investig. 97(Suppl.):77-89.
    • (1968) Scand. J. Clin. Lab. Investig. , vol.97 , Issue.SUPPL. , pp. 77-89
    • Boyum, A.1
  • 4
    • 28044467549 scopus 로고    scopus 로고
    • Abnormal production of transforming growth factor beta and interferon gamma by peripheral blood cells of patients with multidrug-resistant pulmonary tuberculosis in Brazil
    • Castro, A. Z., B. M. Díaz-Bardalez, E. C. Oliveira, R. C. García, J. B. Afiune, I. A. Paschoal, and L. M. Santos. 2005. Abnormal production of transforming growth factor beta and interferon gamma by peripheral blood cells of patients with multidrug-resistant pulmonary tuberculosis in Brazil. J. Infect. 51:318-324.
    • (2005) J. Infect. , vol.51 , pp. 318-324
    • Castro, A.Z.1    Díaz-Bardalez, B.M.2    Oliveira, E.C.3    García, R.C.4    Afiune, J.B.5    Paschoal, I.A.6    Santos, L.M.7
  • 9
    • 0035692530 scopus 로고    scopus 로고
    • The genetics of host resistance and susceptibility to tuberculosis
    • Davies, P., and J. Grange. 2001. The genetics of host resistance and susceptibility to tuberculosis. Ann. N. Y. Acad. Sci. 953:151-156.
    • (2001) Ann. N. Y. Acad. Sci. , vol.953 , pp. 151-156
    • Davies, P.1    Grange, J.2
  • 10
    • 4644254400 scopus 로고    scopus 로고
    • IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients
    • de la Barrera, S., M. Aleman, R. Musella, P. Schierloh, V. Pasquinelli, V. García, E. Abbate, and C. Sasiain Mdel. 2004. IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients. Clin. Exp. Immunol. 138:128-138.
    • (2004) Clin. Exp. Immunol. , vol.138 , pp. 128-138
    • De La Barrera, S.1    Aleman, M.2    Musella, R.3    Schierloh, P.4    Pasquinelli, V.5    García, V.6    Abbate, E.7    Sasiain Mdel, C.8
  • 11
    • 0028967996 scopus 로고
    • Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients
    • de la Barrera, S., S. Fink, M. Finiasz, F. Minnucci, R. Valdez, L. M. Balina, and M. C. Sasiain. 1995. Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients. Clin. Exp. Immunol. 99:90-97.
    • (1995) Clin. Exp. Immunol. , vol.99 , pp. 90-97
    • De La Barrera, S.1    Fink, S.2    Finiasz, M.3    Minnucci, F.4    Valdez, R.5    Balina, L.M.6    Sasiain, M.C.7
  • 13
    • 0033045726 scopus 로고    scopus 로고
    • In vitro synthesis of interferon-gamma, interleukin-4, transforming growth factor-beta and interleukin- 1 beta by peripheral blood mononuclear cells from tuberculosis patients: Relationship with the severity of pulmonary involvement
    • Dlugovitzky, D., M. L. Bay, L. Rateni, L. Urizar, C. F. Rondelli, C. Largacha, M. A. Farroni, O. Molteni, and O. A. Bottasso. 1999. In vitro synthesis of interferon-gamma, interleukin-4, transforming growth factor-beta and interleukin- 1 beta by peripheral blood mononuclear cells from tuberculosis patients: relationship with the severity of pulmonary involvement. Scand. J. Immunol. 49:210-217.
    • (1999) Scand. J. Immunol. , vol.49 , pp. 210-217
    • Dlugovitzky, D.1    Bay, M.L.2    Rateni, L.3    Urizar, L.4    Rondelli, C.F.5    Largacha, C.6    Farroni, M.A.7    Molteni, O.8    Bottasso, O.A.9
  • 14
    • 0034608891 scopus 로고    scopus 로고
    • Criteria for the control of drug-resistant tuberculosis
    • Dye, C., and B. G. Williams. 2000. Criteria for the control of drug-resistant tuberculosis. Proc. Natl. Acad. Sci. USA 97:8180-8185.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8180-8185
    • Dye, C.1    Williams, B.G.2
  • 15
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J. D., M. A. Gavin, and A. Y. Rudensky. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4:330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 17
    • 42249084604 scopus 로고    scopus 로고
    • Mannose-capped lipoarabinomannan- And prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection
    • Garg, A., P. F. Barnes, S. Roy, M. F. Quiroga, S. Wu, V. E. García, S. R. Krutzik, S. E. Weis, and R. Vankayalapati. 2008. Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection. Eur. J. Immunol. 38:459-469.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 459-469
    • Garg, A.1    Barnes, P.F.2    Roy, S.3    Quiroga, M.F.4    Wu, S.5    García, V.E.6    Krutzik, S.R.7    Weis, S.E.8    Vankayalapati, R.9
  • 20
    • 35148887718 scopus 로고    scopus 로고
    • In vitro expansion of CD4+CD25highFOXP3+CD127low/-regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans
    • Hougardy, J. M., V. Verscheure, C. Locht, and F. Mascart. 2007. In vitro expansion of CD4+CD25highFOXP3+CD127low/-regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans. Microbes Infect. 9:1325-1332.
    • (2007) Microbes Infect. , vol.9 , pp. 1325-1332
    • Hougardy, J.M.1    Verscheure, V.2    Locht, C.3    Mascart, F.4
  • 21
    • 57649090701 scopus 로고    scopus 로고
    • Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination
    • Joosten, S. A., and T. H. Ottenhoff. 2008. Human CD4 and CD8 regulatory T cells in infectious diseases and vaccination. Hum. Immunol. 69:760-770.
    • (2008) Hum. Immunol. , vol.69 , pp. 760-770
    • Joosten, S.A.1    Ottenhoff, T.H.2
  • 24
    • 0035495579 scopus 로고    scopus 로고
    • How can immunology contribute to the control of tuberculosis?
    • Kaufmann, S. H. 2001. How can immunology contribute to the control of tuberculosis? Nat. Rev. Immunol. 1:20-30.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 20-30
    • Kaufmann, S.H.1
  • 25
    • 0036277890 scopus 로고    scopus 로고
    • Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis
    • Lee, J. S., C. H. Song, C. H. Kim, S. J. Kong, M. H. Shon, H. J. Kim, J. K. Park, T. H. Paik, and E. K. Jo. 2002. Profiles of IFN-gamma and its regulatory cytokines (IL-12, IL-18 and IL-10) in peripheral blood mononuclear cells from patients with multidrug-resistant tuberculosis. Clin. Exp. Immunol. 128:516-524.
    • (2002) Clin. Exp. Immunol. , vol.128 , pp. 516-524
    • Lee, J.S.1    Song, C.H.2    Kim, C.H.3    Kong, S.J.4    Shon, M.H.5    Kim, H.J.6    Park, J.K.7    Paik, T.H.8    Jo, E.K.9
  • 26
    • 0037505198 scopus 로고    scopus 로고
    • The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with the 30-kDa antigen of Mycobacterium tuberculosis
    • Lee, J. S., C. H. Song, J. H. Lim, H. J. Kim, J. K. Park, T. H. Paik, C. H. Kim, S. J. Kong, M. H. Shon, S. S. Jung, and E. K. Jo. 2003. The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with the 30-kDa antigen of Mycobacterium tuberculosis. Clin. Exp. Immunol. 132:443-449.
    • (2003) Clin. Exp. Immunol. , vol.132 , pp. 443-449
    • Lee, J.S.1    Song, C.H.2    Lim, J.H.3    Kim, H.J.4    Park, J.K.5    Paik, T.H.6    Kim, C.H.7    Kong, S.J.8    Shon, M.H.9    Jung, S.S.10    Jo, E.K.11
  • 27
    • 0036067080 scopus 로고    scopus 로고
    • Strategies against multidrug-resistant tuberculosis
    • Loddenkemper, R., D. Sagebiel, and A. Brendel. 2002. Strategies against multidrug-resistant tuberculosis. Eur. Respir. J. 36(Suppl.):66s-77s.
    • (2002) Eur. Respir. J. , vol.36 , Issue.SUPPL.
    • Loddenkemper, R.1    Sagebiel, D.2    Brendel, A.3
  • 29
    • 70350458874 scopus 로고    scopus 로고
    • Two M. tuberculosis lineages are over represented among new cases of MDR and XDR TB in Argentina
    • López, B. G., C. Latini, M. Ambroggi, E. Gravina, V. Ritacco, and L. Barrera. 2008. Two M. tuberculosis lineages are over represented among new cases of MDR and XDR TB in Argentina. Int. J. Tuberc. Lung Dis. 12(Suppl. 2):S173.
    • (2008) Int. J. Tuberc. Lung Dis. , vol.12 , Issue.SUPPL. 2
    • López, B.G.1    Latini, C.2    Ambroggi, M.3    Gravina, E.4    Ritacco, V.5    Barrera, L.6
  • 30
    • 4544380418 scopus 로고    scopus 로고
    • Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis
    • Manca, C., M. B. Reed, S. Freeman, B. Mathema, B. Kreiswirth, C. E. Barry III, and G. Kaplan. 2004. Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis. Infect. Immun. 72:5511-5514.
    • (2004) Infect. Immun. , vol.72 , pp. 5511-5514
    • Manca, C.1    Reed, M.B.2    Freeman, S.3    Mathema, B.4    Kreiswirth, B.5    Barry III, C.E.6    Kaplan, G.7
  • 31
    • 29444432905 scopus 로고    scopus 로고
    • Hypervirulent M. tuberculosis W/Beijing strains upregulate Type I IFNs and increase expression of negative regulators of the jak-stat pathway
    • DOI 10.1089/jir.2005.25.694
    • Manca, C., L. Tsenova, S. Freeman, A. K. Barczak, M. Tovey, P. J. Murray, C. Barry, and G. Kaplan. 2005. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J. Interferon Cytokine Res. 25:694-701. (Pubitemid 43010524)
    • (2005) Journal of Interferon and Cytokine Research , vol.25 , Issue.11 , pp. 694-701
    • Manca, C.1    Tsenova, L.2    Freeman, S.3    Barczak, A.K.4    Tovey, M.5    Murray, P.J.6    Barry III, C.7    Kaplan, G.8
  • 33
    • 0030636796 scopus 로고    scopus 로고
    • Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses
    • McDyer, J. F., M. N. Hackley, T. E. Walsh, J. L. Cook, and R. A. Seder. 1997. Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses. J. Immunol. 158:492-500.
    • (1997) J. Immunol. , vol.158 , pp. 492-500
    • McDyer, J.F.1    Hackley, M.N.2    Walsh, T.E.3    Cook, J.L.4    Seder, R.A.5
  • 35
    • 3943106044 scopus 로고    scopus 로고
    • Increased interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis
    • Ordway, D. J., L. Costa, M. Martins, H. Silveira, L. Amaral, M. J. Arroz, F. A. Ventura, and H. M. Dockrell. 2004. Increased interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis. J. Infect. Dis. 190:756-766.
    • (2004) J. Infect. Dis. , vol.190 , pp. 756-766
    • Ordway, D.J.1    Costa, L.2    Martins, M.3    Silveira, H.4    Amaral, L.5    Arroz, M.J.6    Ventura, F.A.7    Dockrell, H.M.8
  • 36
    • 29644447018 scopus 로고    scopus 로고
    • Multidrug-resistant tuberculosis (MDR-TB): Epidemiology, prevention and treatment
    • Ormerod, L. P. 2005. Multidrug-resistant tuberculosis (MDR-TB): epidemiology, prevention and treatment. Br. Med. Bull. 73-74:17-24.
    • (2005) Br. Med. Bull. , vol.73-74 , pp. 17-24
    • Ormerod, L.P.1
  • 40
    • 41449085689 scopus 로고    scopus 로고
    • Infection with prevalent clinical strains of Mycobacterium tuberculosis leads to differential maturation of monocyte derived dendritic cells
    • Rajashree, P., and S. D. Das. 2008. Infection with prevalent clinical strains of Mycobacterium tuberculosis leads to differential maturation of monocyte derived dendritic cells. Immunol. Lett. 117:174-180.
    • (2008) Immunol. Lett. , vol.117 , pp. 174-180
    • Rajashree, P.1    Das, S.D.2
  • 41
    • 0345257023 scopus 로고    scopus 로고
    • Cell-mediated immune responses of healthy laboratory volunteers to sonicate antigens prepared from the most prevalent strains of Mycobacterium tuberculosis from South India harboring a single copy of IS6110
    • Rajavelu, P., and S. D. Das. 2003. Cell-mediated immune responses of healthy laboratory volunteers to sonicate antigens prepared from the most prevalent strains of Mycobacterium tuberculosis from South India harboring a single copy of IS6110. Clin. Diagn. Lab. Immunol. 10:1149-1152.
    • (2003) Clin. Diagn. Lab. Immunol. , vol.10 , pp. 1149-1152
    • Rajavelu, P.1    Das, S.D.2
  • 42
    • 20544468352 scopus 로고    scopus 로고
    • Th2-type immune response observed in healthy individuals to sonicate antigen prepared from the most prevalent Mycobacterium tuberculosis strain with single copy of IS6110
    • Rajavelu, P., and S. D. Das. 2005. Th2-type immune response observed in healthy individuals to sonicate antigen prepared from the most prevalent Mycobacterium tuberculosis strain with single copy of IS6110. FEMS Immunol. Med. Microbiol. 45:95-102.
    • (2005) FEMS Immunol. Med. Microbiol. , vol.45 , pp. 95-102
    • Rajavelu, P.1    Das, S.D.2
  • 44
    • 33745607909 scopus 로고    scopus 로고
    • IL-4 influences the differentiation and the susceptibility to activationinduced cell death of human naive CD8+ T cells
    • Riou, C., A. R. Dumont, B. Yassine-Diab, E. K. Haddad, and R. P. Sekaly. 2006. IL-4 influences the differentiation and the susceptibility to activationinduced cell death of human naive CD8+ T cells. Int. Immunol. 18:827-835.
    • (2006) Int. Immunol. , vol.18 , pp. 827-835
    • Riou, C.1    Dumont, A.R.2    Yassine-Diab, B.3    Haddad, E.K.4    Sekaly, R.P.5
  • 46
    • 33847623734 scopus 로고    scopus 로고
    • Immunosuppression during active tuberculosis is characterized by decreased interferon- Gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels
    • Roberts, T., N. Beyers, A. Aguirre, and G. Walzl. 2007. Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels. J. Infect. Dis. 195: 870-878.
    • (2007) J. Infect. Dis. , vol.195 , pp. 870-878
    • Roberts, T.1    Beyers, N.2    Aguirre, A.3    Walzl, G.4
  • 47
    • 34248667663 scopus 로고    scopus 로고
    • Th2 cytokines in susceptibility to tuberculosis
    • Rook, G. A. 2007. Th2 cytokines in susceptibility to tuberculosis. Curr. Mol. Med. 7:327-337.
    • (2007) Curr. Mol. Med. , vol.7 , pp. 327-337
    • Rook, G.A.1
  • 48
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi, S. 2005. Naturally arising Foxp3-expressing CD25CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6:345-352.
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 49
    • 0033955022 scopus 로고    scopus 로고
    • Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis
    • Seah, G. T., G. M. Scott, and G. A. Rook. 2000. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis. J. Infect. Dis. 181:385-389.
    • (2000) J. Infect. Dis. , vol.181 , pp. 385-389
    • Seah, G.T.1    Scott, G.M.2    Rook, G.A.3
  • 50
    • 34447321027 scopus 로고    scopus 로고
    • Evaluation of T cell immune responses in multi-drug-resistant tuberculosis (MDR-TB) patients to Mycobacterium tuberculosis total lipid antigens
    • Shahemabadi, A. S., A. Z. Hosseini, S. Shaghsempour, M. R. Masjedi, M. Rayani, and M. Pouramiri. 2007. Evaluation of T cell immune responses in multi-drug-resistant tuberculosis (MDR-TB) patients to Mycobacterium tuberculosis total lipid antigens. Clin. Exp. Immunol. 149:285-294.
    • (2007) Clin. Exp. Immunol. , vol.149 , pp. 285-294
    • Shahemabadi, A.S.1    Hosseini, A.Z.2    Shaghsempour, S.3    Masjedi, M.R.4    Rayani, M.5    Pouramiri, M.6
  • 51
    • 2442680356 scopus 로고    scopus 로고
    • Identification of a predominant isolate of Mycobacterium tuberculosis using molecular and clinical epidemiology tools and in vitro cytokine responses
    • Sharma, M. K., A. Al-Azem, J. Wolfe, E. Hershfield, and A. Kabani. 2003. Identification of a predominant isolate of Mycobacterium tuberculosis using molecular and clinical epidemiology tools and in vitro cytokine responses. BMC Infect. Dis. 3:3.
    • (2003) BMC Infect. Dis. , vol.3 , pp. 3
    • Sharma, M.K.1    Al-Azem, A.2    Wolfe, J.3    Hershfield, E.4    Kabani, A.5
  • 52
    • 57149108306 scopus 로고    scopus 로고
    • The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age
    • Simone, R., A. Zicca, and D. Saverino. The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age. J. Leukoc. Biol. 84:1454-1461.
    • J. Leukoc. Biol. , vol.84 , pp. 1454-1461
    • Simone, R.1    Zicca, A.2    Saverino, D.3
  • 53
    • 27144544047 scopus 로고    scopus 로고
    • The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors
    • Skapenko, A., J. R. Kalden, P. E. Lipsky, and H. Schulze-Koops. 2005. The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors. J. Immunol. 175:6107-6116.
    • (2005) J. Immunol. , vol.175 , pp. 6107-6116
    • Skapenko, A.1    Kalden, J.R.2    Lipsky, P.E.3    Schulze-Koops, H.4
  • 54
    • 0036239469 scopus 로고    scopus 로고
    • Decreased IFN-gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients
    • Edinburgh
    • Smith, S. M., M. R. Klein, A. S. Malin, J. Sillah, K. P. McAdam, and H. M. Dockrell. 2002. Decreased IFN-gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients. Tuberculosis (Edinburgh) 82:7-13.
    • (2002) Tuberculosis , vol.82 , pp. 7-13
    • Smith, S.M.1    Klein, M.R.2    Malin, A.S.3    Sillah, J.4    McAdam, K.P.5    Dockrell, H.M.6
  • 56
    • 33747724593 scopus 로고    scopus 로고
    • Tuberculosis associated with Mycobacterium tuberculosis Beijing and non-Beijing genotypes: A clinical and immunological comparison
    • Sun, Y. J., T. K. Lim, A. K. Ong, B. C. Ho, G. T. Seah, and N. I. Paton. 2006. Tuberculosis associated with Mycobacterium tuberculosis Beijing and non-Beijing genotypes: a clinical and immunological comparison. BMC Infect. Dis. 6:105.
    • (2006) BMC Infect. Dis. , vol.6 , pp. 105
    • Sun, Y.J.1    Lim, T.K.2    Ong, A.K.3    Ho, B.C.4    Seah, G.T.5    Paton, N.I.6
  • 57
    • 0034113481 scopus 로고    scopus 로고
    • Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities
    • van Crevel, R., E. Karyadi, F. Preyers, M. Leenders, B. J. Kullberg, R. H. Nelwan, and J. W. van der Meer. Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities. J. Infect. Dis. 181:1194-1197.
    • J. Infect. Dis. , vol.181 , pp. 1194-1197
    • Van Crevel, R.1    Karyadi, E.2    Preyers, F.3    Leenders, M.4    Kullberg, B.J.5    Nelwan, R.H.6    Van Der Meer, J.W.7
  • 59
    • 0003493904 scopus 로고    scopus 로고
    • WHO. World Health Organization Global Tuberculosis Programme. WHO/TB/98.258. WHO, Geneva, Switzerland
    • WHO. 1998. World Health Organization Global Tuberculosis Programme. Laboratory services in tuberculosis control. WHO/TB/98.258. WHO, Geneva, Switzerland.
    • (1998) Laboratory Services in Tuberculosis Control
  • 60
    • 1842631484 scopus 로고    scopus 로고
    • Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells
    • Wolint, P., M. R. Betts, R. A. Koup, and A. Oxenius. 2004. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J. Exp. Med. 199:925-936.
    • (2004) J. Exp. Med. , vol.199 , pp. 925-936
    • Wolint, P.1    Betts, M.R.2    Koup, R.A.3    Oxenius, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.