메뉴 건너뛰기




Volumn 255, Issue 1, 2013, Pages 149-164

Multipronged CD4+ T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus

Author keywords

Cell differentiation; Cytokines; Cytotoxic T cells; Infectious diseases; Memory; T helper cells

Indexed keywords

ALPHA4 INTEGRIN; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CD103 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; GRANZYME B; HLX PROTEIN; INHIBITOR OF DIFFERENTIATION 2; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6 RECEPTOR ALPHA; L SELECTIN; NUCLEAR FACTOR IL3; POU2AF1 PROTEIN; POU6F1 PROTEIN; PROTEIN BCL 6; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

EID: 84881658243     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12088     Document Type: Review
Times cited : (70)

References (107)
  • 1
    • 33846219152 scopus 로고    scopus 로고
    • Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus
    • Powell TJ, et al. Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus. J Immunol 2007;178:1030-1038.
    • (2007) J Immunol , vol.178 , pp. 1030-1038
    • Powell, T.J.1
  • 2
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011;29:621-663.
    • (2011) Annu Rev Immunol , vol.29 , pp. 621-663
    • Crotty, S.1
  • 3
    • 84856226311 scopus 로고    scopus 로고
    • Expanding roles for CD4(+) T cells in immunity to viruses
    • Swain SL, McKinstry KK, Strutt TM. Expanding roles for CD4(+) T cells in immunity to viruses. Nat Rev Immunol 2012;12:136-148.
    • (2012) Nat Rev Immunol , vol.12 , pp. 136-148
    • Swain, S.L.1    McKinstry, K.K.2    Strutt, T.M.3
  • 4
    • 84864746073 scopus 로고    scopus 로고
    • Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms
    • McKinstry KK, et al. Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J Clin Invest 2012;122:2847-2856.
    • (2012) J Clin Invest , vol.122 , pp. 2847-2856
    • McKinstry, K.K.1
  • 5
    • 84866533018 scopus 로고    scopus 로고
    • Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors
    • Strutt TM, McKinstry KK, Kuang Y, Bradley LM, Swain SL. Memory CD4+ T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc Natl Acad Sci USA 2012;109:E2551-E2560.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Strutt, T.M.1    McKinstry, K.K.2    Kuang, Y.3    Bradley, L.M.4    Swain, S.L.5
  • 6
    • 77952240977 scopus 로고    scopus 로고
    • Memory CD4+ T cells induce innate responses independently of pathogen
    • 1p following 564.
    • Strutt TM, et al. Memory CD4+ T cells induce innate responses independently of pathogen. Nat Med 2010;16:558-564, 1p following 564.
    • (2010) Nat Med , vol.16 , pp. 558-564
    • Strutt, T.M.1
  • 7
    • 77956019831 scopus 로고    scopus 로고
    • Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms
    • Teijaro JR, Verhoeven D, Page CA, Turner D, Farber DL. Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol 2010;84:9217-9226.
    • (2010) J Virol , vol.84 , pp. 9217-9226
    • Teijaro, J.R.1    Verhoeven, D.2    Page, C.A.3    Turner, D.4    Farber, D.L.5
  • 8
    • 82755192260 scopus 로고    scopus 로고
    • Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection
    • Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrancois L, Farber DL. Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol 2011;187:5510-5514.
    • (2011) J Immunol , vol.187 , pp. 5510-5514
    • Teijaro, J.R.1    Turner, D.2    Pham, Q.3    Wherry, E.J.4    Lefrancois, L.5    Farber, D.L.6
  • 9
    • 0028229934 scopus 로고
    • Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity
    • Liang S, Mozdzanowska K, Palladino G, Gerhard W. Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity. J Immunol 1994;152:1653-1661.
    • (1994) J Immunol , vol.152 , pp. 1653-1661
    • Liang, S.1    Mozdzanowska, K.2    Palladino, G.3    Gerhard, W.4
  • 10
    • 0031066918 scopus 로고    scopus 로고
    • Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, beta2-microglobulin-deficient, and J chain-deficient mice
    • Epstein SL, et al. Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, beta2-microglobulin-deficient, and J chain-deficient mice. J Immunol 1997;158:1222-1230.
    • (1997) J Immunol , vol.158 , pp. 1222-1230
    • Epstein, S.L.1
  • 11
    • 79251555970 scopus 로고    scopus 로고
    • Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections
    • Sun K, Ye J, Perez DR, Metzger DW. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol 2011;186:987-993.
    • (2011) J Immunol , vol.186 , pp. 987-993
    • Sun, K.1    Ye, J.2    Perez, D.R.3    Metzger, D.W.4
  • 12
    • 78650063715 scopus 로고    scopus 로고
    • T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model
    • Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ. T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. J Virol 2011;85:448-455.
    • (2011) J Virol , vol.85 , pp. 448-455
    • Guo, H.1    Santiago, F.2    Lambert, K.3    Takimoto, T.4    Topham, D.J.5
  • 13
    • 84875129611 scopus 로고    scopus 로고
    • Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    • Bentebibel SE, et al. Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Sci Transl Med 2013;5:176ra32.
    • (2013) Sci Transl Med , vol.5
    • Bentebibel, S.E.1
  • 14
    • 84862776631 scopus 로고    scopus 로고
    • Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
    • Wilkinson TM, et al. Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans. Nat Med 2012;18:274-280.
    • (2012) Nat Med , vol.18 , pp. 274-280
    • Wilkinson, T.M.1
  • 15
    • 33745095922 scopus 로고    scopus 로고
    • CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    • Swain SL, et al. CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev 2006;211:8-22.
    • (2006) Immunol Rev , vol.211 , pp. 8-22
    • Swain, S.L.1
  • 16
    • 84864754092 scopus 로고    scopus 로고
    • Memory CD4+ T cells: beyond "helper" functions
    • Boonnak K, Subbarao K. Memory CD4+ T cells: beyond "helper" functions. J Clin Invest 2012;122:2768-2770.
    • (2012) J Clin Invest , vol.122 , pp. 2768-2770
    • Boonnak, K.1    Subbarao, K.2
  • 17
    • 79954842533 scopus 로고    scopus 로고
    • Hallmarks of CD4 T cell immunity against influenza
    • McKinstry KK, Strutt TM, Swain SL. Hallmarks of CD4 T cell immunity against influenza. J Intern Med 2011;269:507-518.
    • (2011) J Intern Med , vol.269 , pp. 507-518
    • McKinstry, K.K.1    Strutt, T.M.2    Swain, S.L.3
  • 18
    • 0037037542 scopus 로고    scopus 로고
    • CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function
    • Roman E, et al. CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J Exp Med 2002;196:957-968.
    • (2002) J Exp Med , vol.196 , pp. 957-968
    • Roman, E.1
  • 19
    • 27944461748 scopus 로고    scopus 로고
    • Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue
    • Bingaman AW, et al. Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue. Eur J Immunol 2005;35:3173-3186.
    • (2005) Eur J Immunol , vol.35 , pp. 3173-3186
    • Bingaman, A.W.1
  • 20
    • 0027941401 scopus 로고
    • Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection
    • Graham MB, Braciale VL, Braciale TJ. Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J Exp Med 1994;180:1273-1282.
    • (1994) J Exp Med , vol.180 , pp. 1273-1282
    • Graham, M.B.1    Braciale, V.L.2    Braciale, T.J.3
  • 21
    • 33747765545 scopus 로고    scopus 로고
    • CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch
    • Brown DM, Dilzer AM, Meents DL, Swain SL. CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch. J Immunol 2006;177:2888-2898.
    • (2006) J Immunol , vol.177 , pp. 2888-2898
    • Brown, D.M.1    Dilzer, A.M.2    Meents, D.L.3    Swain, S.L.4
  • 22
    • 84863991008 scopus 로고    scopus 로고
    • Multi-functional CD4 cells expressing IFN-gamma and perforin mediate protection against lethal influenza infection
    • Brown DM, Lee S, Garcia-Hernandez MD, Swain SL. Multi-functional CD4 cells expressing IFN-gamma and perforin mediate protection against lethal influenza infection. J Virol 2012;86:6792-6803.
    • (2012) J Virol , vol.86 , pp. 6792-6803
    • Brown, D.M.1    Lee, S.2    Garcia-Hernandez, M.D.3    Swain, S.L.4
  • 23
    • 0029899290 scopus 로고    scopus 로고
    • Interleukin-4 causes delayed virus clearance in influenza virus-infected mice
    • Moran TM, Isobe H, Fernandez-Sesma A, Schulman JL. Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. J Virol 1996;70:5230-5235.
    • (1996) J Virol , vol.70 , pp. 5230-5235
    • Moran, T.M.1    Isobe, H.2    Fernandez-Sesma, A.3    Schulman, J.L.4
  • 24
    • 0032547762 scopus 로고    scopus 로고
    • Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice
    • Karupiah G, Chen JH, Mahalingam S, Nathan CF, MacMicking JD. Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J Exp Med 1998;188:1541-1546.
    • (1998) J Exp Med , vol.188 , pp. 1541-1546
    • Karupiah, G.1    Chen, J.H.2    Mahalingam, S.3    Nathan, C.F.4    MacMicking, J.D.5
  • 25
    • 77954492854 scopus 로고    scopus 로고
    • Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice
    • Tate MD, Pickett DL, van Rooijen N, Brooks AG, Reading PC. Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice. J Virol 2010;84:7569-7580.
    • (2010) J Virol , vol.84 , pp. 7569-7580
    • Tate, M.D.1    Pickett, D.L.2    van Rooijen, N.3    Brooks, A.G.4    Reading, P.C.5
  • 26
    • 77953546692 scopus 로고    scopus 로고
    • IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner
    • Weiss ID, et al. IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner. J Interferon Cytokine Res 2010;30:439-449.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 439-449
    • Weiss, I.D.1
  • 27
    • 73349124131 scopus 로고    scopus 로고
    • Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
    • Tate MD, Deng YM, Jones JE, Anderson GP, Brooks AG, Reading PC. Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J Immunol 2009;183:7441-7450.
    • (2009) J Immunol , vol.183 , pp. 7441-7450
    • Tate, M.D.1    Deng, Y.M.2    Jones, J.E.3    Anderson, G.P.4    Brooks, A.G.5    Reading, P.C.6
  • 28
    • 84859842089 scopus 로고    scopus 로고
    • Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
    • Dienz O, et al. Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. Mucosal Immunol 2012;5:258-266.
    • (2012) Mucosal Immunol , vol.5 , pp. 258-266
    • Dienz, O.1
  • 29
    • 0035139418 scopus 로고    scopus 로고
    • Production of interferon-gamma by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology
    • Wiley JA, Cerwenka A, Harkema JR, Dutton RW, Harmsen AG. Production of interferon-gamma by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology. Am J Pathol 2001;158:119-130.
    • (2001) Am J Pathol , vol.158 , pp. 119-130
    • Wiley, J.A.1    Cerwenka, A.2    Harkema, J.R.3    Dutton, R.W.4    Harmsen, A.G.5
  • 30
    • 0029890233 scopus 로고    scopus 로고
    • In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue
    • Baumgarth N, Kelso A. In vivo blockade of gamma interferon affects the influenza virus-induced humoral and the local cellular immune response in lung tissue. J Virol 1996;70:4411-4418.
    • (1996) J Virol , vol.70 , pp. 4411-4418
    • Baumgarth, N.1    Kelso, A.2
  • 31
    • 33749457089 scopus 로고    scopus 로고
    • Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
    • Huber VC, et al. Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza. Clin Vaccine Immunol 2006;13:981-990.
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 981-990
    • Huber, V.C.1
  • 32
    • 81255214569 scopus 로고    scopus 로고
    • Negative regulation of lung inflammation and immunopathology by TNF-alpha during acute influenza infection
    • Damjanovic D, et al. Negative regulation of lung inflammation and immunopathology by TNF-alpha during acute influenza infection. Am J Pathol 2011;179:2963-2976.
    • (2011) Am J Pathol , vol.179 , pp. 2963-2976
    • Damjanovic, D.1
  • 33
    • 0034807183 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology
    • Hussell T, Pennycook A, Openshaw PJ. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol 2001;31:2566-2573.
    • (2001) Eur J Immunol , vol.31 , pp. 2566-2573
    • Hussell, T.1    Pennycook, A.2    Openshaw, P.J.3
  • 34
    • 78649404732 scopus 로고    scopus 로고
    • Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection
    • Belisle SE, et al. Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection. J Virol 2010;84:12576-12588.
    • (2010) J Virol , vol.84 , pp. 12576-12588
    • Belisle, S.E.1
  • 35
    • 67649226607 scopus 로고    scopus 로고
    • IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge
    • McKinstry KK, et al. IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge. J Immunol 2009;182:7353-7363.
    • (2009) J Immunol , vol.182 , pp. 7353-7363
    • McKinstry, K.K.1
  • 36
    • 65449145937 scopus 로고    scopus 로고
    • Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge
    • Hamada H, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol 2009;182:3469-3481.
    • (2009) J Immunol , vol.182 , pp. 3469-3481
    • Hamada, H.1
  • 37
    • 75949114864 scopus 로고    scopus 로고
    • Critical role of IL-17RA in immunopathology of influenza infection
    • Crowe CR, et al. Critical role of IL-17RA in immunopathology of influenza infection. J Immunol 2009;183:5301-5310.
    • (2009) J Immunol , vol.183 , pp. 5301-5310
    • Crowe, C.R.1
  • 38
    • 84871830494 scopus 로고    scopus 로고
    • Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection
    • Hamada H, et al. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J Immunol 2013;190:296-306.
    • (2013) J Immunol , vol.190 , pp. 296-306
    • Hamada, H.1
  • 39
    • 84875214926 scopus 로고    scopus 로고
    • IL-22 is essential for lung epithelial repair following influenza infection
    • Pociask DA, et al. IL-22 is essential for lung epithelial repair following influenza infection. Am J Pathol 2013;182:1286-1296.
    • (2013) Am J Pathol , vol.182 , pp. 1286-1296
    • Pociask, D.A.1
  • 40
    • 84858587977 scopus 로고    scopus 로고
    • Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages
    • Paget C, et al. Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages. J Biol Chem 2012;287:8816-8829.
    • (2012) J Biol Chem , vol.287 , pp. 8816-8829
    • Paget, C.1
  • 41
    • 84867658823 scopus 로고    scopus 로고
    • IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
    • Kumar P, Thakar MS, Ouyang W, Malarkannan S. IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol 2013;6:69-82.
    • (2013) Mucosal Immunol , vol.6 , pp. 69-82
    • Kumar, P.1    Thakar, M.S.2    Ouyang, W.3    Malarkannan, S.4
  • 42
    • 60549105041 scopus 로고    scopus 로고
    • The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    • Dienz O, et al. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med 2009;206:69-78.
    • (2009) J Exp Med , vol.206 , pp. 69-78
    • Dienz, O.1
  • 43
    • 84870283741 scopus 로고    scopus 로고
    • B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1
    • Karnowski A, et al. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med 2012;209:2049-2064.
    • (2012) J Exp Med , vol.209 , pp. 2049-2064
    • Karnowski, A.1
  • 44
    • 77951490811 scopus 로고    scopus 로고
    • A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infection
    • Sun K, Torres L, Metzger DW. A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infection. J Virol 2010;84:5007-5014.
    • (2010) J Virol , vol.84 , pp. 5007-5014
    • Sun, K.1    Torres, L.2    Metzger, D.W.3
  • 45
    • 76149097491 scopus 로고    scopus 로고
    • ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice
    • Schaefer JS, Montufar-Solis D, Vigneswaran N, Klein JR. ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice. J Leukoc Biol 2010;87:301-308.
    • (2010) J Leukoc Biol , vol.87 , pp. 301-308
    • Schaefer, J.S.1    Montufar-Solis, D.2    Vigneswaran, N.3    Klein, J.R.4
  • 46
    • 84867323527 scopus 로고    scopus 로고
    • Blockade of IL-10 signaling during bacillus Calmette-Guerin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-gamma and IL-17 responses and increases protection to Mycobacterium tuberculosis infection
    • Pitt JM, et al. Blockade of IL-10 signaling during bacillus Calmette-Guerin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-gamma and IL-17 responses and increases protection to Mycobacterium tuberculosis infection. J Immunol 2012;189:4079-4087.
    • (2012) J Immunol , vol.189 , pp. 4079-4087
    • Pitt, J.M.1
  • 47
    • 82755165048 scopus 로고    scopus 로고
    • Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation
    • Zhang L, Yuan S, Cheng G, Guo B. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS ONE 2011;6:e28432.
    • (2011) PLoS ONE , vol.6
    • Zhang, L.1    Yuan, S.2    Cheng, G.3    Guo, B.4
  • 48
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • Huber S, et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3(-) and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011;34:554-565.
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1
  • 49
    • 62049085168 scopus 로고    scopus 로고
    • Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    • Sun J, Madan R, Karp CL, Braciale TJ. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med 2009;15:277-284.
    • (2009) Nat Med , vol.15 , pp. 277-284
    • Sun, J.1    Madan, R.2    Karp, C.L.3    Braciale, T.J.4
  • 50
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov II, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008;4:337-349.
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 51
  • 52
    • 84855533370 scopus 로고    scopus 로고
    • Cytotoxic CD4 T cells in antiviral immunity
    • Marshall NB, Swain SL. Cytotoxic CD4 T cells in antiviral immunity. J Biomed Biotechnol 2011;2011:954602.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 954602
    • Marshall, N.B.1    Swain, S.L.2
  • 53
    • 84863821907 scopus 로고    scopus 로고
    • Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses
    • Boyden AW, Legge KL, Waldschmidt TJ. Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses. PLoS ONE 2012;7:e40733.
    • (2012) PLoS ONE , vol.7
    • Boyden, A.W.1    Legge, K.L.2    Waldschmidt, T.J.3
  • 54
    • 84870272262 scopus 로고    scopus 로고
    • LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection
    • Yoo JK, Fish EN, Braciale TJ. LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection. J Exp Med 2012;209:1853-1867.
    • (2012) J Exp Med , vol.209 , pp. 1853-1867
    • Yoo, J.K.1    Fish, E.N.2    Braciale, T.J.3
  • 55
    • 84875469030 scopus 로고    scopus 로고
    • Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection
    • Brincks EL, et al. Antigen-specific memory regulatory CD4+Foxp3+ T cells control memory responses to influenza virus infection. J Immunol 2013;190:3438-3446.
    • (2013) J Immunol , vol.190 , pp. 3438-3446
    • Brincks, E.L.1
  • 56
    • 0242410712 scopus 로고    scopus 로고
    • Control of effector CD8+ T cell function by the transcription factor Eomesodermin
    • Pearce EL, et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science 2003;302:1041-1043.
    • (2003) Science , vol.302 , pp. 1041-1043
    • Pearce, E.L.1
  • 57
    • 8544234990 scopus 로고    scopus 로고
    • Recent developments in the transcriptional regulation of cytolytic effector cells
    • Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004;4:900-911.
    • (2004) Nat Rev Immunol , vol.4 , pp. 900-911
    • Glimcher, L.H.1    Townsend, M.J.2    Sullivan, B.M.3    Lord, G.M.4
  • 58
    • 80053502126 scopus 로고    scopus 로고
    • CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation
    • Qui HZ, et al. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol 2011;187:3555-3564.
    • (2011) J Immunol , vol.187 , pp. 3555-3564
    • Qui, H.Z.1
  • 59
    • 84863415045 scopus 로고    scopus 로고
    • Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathways
    • Eshima K, et al. Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathways. Immunol Lett 2012;144:7-15.
    • (2012) Immunol Lett , vol.144 , pp. 7-15
    • Eshima, K.1
  • 60
    • 81255144662 scopus 로고    scopus 로고
    • The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets
    • Yang CY, et al. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 2011;12:1221-1229.
    • (2011) Nat Immunol , vol.12 , pp. 1221-1229
    • Yang, C.Y.1
  • 61
    • 27544442994 scopus 로고    scopus 로고
    • Helix-loop-helix proteins and lymphocyte development
    • Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol 2005;6:1079-1086.
    • (2005) Nat Immunol , vol.6 , pp. 1079-1086
    • Murre, C.1
  • 62
    • 33846305724 scopus 로고    scopus 로고
    • Transcriptional regulator Id2 mediates CD8+ T cell immunity
    • Cannarile MA, et al. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat Immunol 2006;7:1317-1325.
    • (2006) Nat Immunol , vol.7 , pp. 1317-1325
    • Cannarile, M.A.1
  • 63
    • 77953749560 scopus 로고    scopus 로고
    • Regulation of CD4+ T-cell contraction during pathogen challenge
    • McKinstry KK, Strutt TM, Swain SL. Regulation of CD4+ T-cell contraction during pathogen challenge. Immunol Rev 2010;236:110-124.
    • (2010) Immunol Rev , vol.236 , pp. 110-124
    • McKinstry, K.K.1    Strutt, T.M.2    Swain, S.L.3
  • 64
    • 27144526101 scopus 로고    scopus 로고
    • Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression
    • Martins GA, Hutchins AS, Reiner SL. Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. J Immunol 2005;175:5981-5985.
    • (2005) J Immunol , vol.175 , pp. 5981-5985
    • Martins, G.A.1    Hutchins, A.S.2    Reiner, S.L.3
  • 65
    • 65549118531 scopus 로고    scopus 로고
    • Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
    • Schulz EG, Mariani L, Radbruch A, Hofer T. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 2009;30:673-683.
    • (2009) Immunity , vol.30 , pp. 673-683
    • Schulz, E.G.1    Mariani, L.2    Radbruch, A.3    Hofer, T.4
  • 66
    • 2942579099 scopus 로고    scopus 로고
    • Epigenetic gene silencing by Runx proteins
    • Taniuchi I, Littman DR. Epigenetic gene silencing by Runx proteins. Oncogene 2004;23:4341-4345.
    • (2004) Oncogene , vol.23 , pp. 4341-4345
    • Taniuchi, I.1    Littman, D.R.2
  • 67
    • 34447568209 scopus 로고    scopus 로고
    • Transcriptional partners in regulatory T cells: Foxp3. Runx and NFAT
    • Hu H, Djuretic I, Sundrud MS, Rao A. Transcriptional partners in regulatory T cells: Foxp3. Runx and NFAT. Trends Immunol 2007;28:329-332.
    • (2007) Trends Immunol , vol.28 , pp. 329-332
    • Hu, H.1    Djuretic, I.2    Sundrud, M.S.3    Rao, A.4
  • 68
    • 18744398397 scopus 로고    scopus 로고
    • Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    • Taniuchi I, et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002;111:621-633.
    • (2002) Cell , vol.111 , pp. 621-633
    • Taniuchi, I.1
  • 69
    • 2942512933 scopus 로고    scopus 로고
    • Structure and regulated expression of mammalian RUNX genes
    • Levanon D, Groner Y. Structure and regulated expression of mammalian RUNX genes. Oncogene 2004;23:4211-4219.
    • (2004) Oncogene , vol.23 , pp. 4211-4219
    • Levanon, D.1    Groner, Y.2
  • 70
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang F, Meng G, Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008;9:1297-1306.
    • (2008) Nat Immunol , vol.9 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 71
    • 84864876877 scopus 로고    scopus 로고
    • Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells
    • Heidari N, Miller AV, Hicks MA, Marking CB, Harada H. Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells. Cell Death Dis 2012;3:e349.
    • (2012) Cell Death Dis , vol.3
    • Heidari, N.1    Miller, A.V.2    Hicks, M.A.3    Marking, C.B.4    Harada, H.5
  • 72
    • 0344198588 scopus 로고    scopus 로고
    • Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
    • Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci USA 2003;100:14175-14180.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14175-14180
    • Pellegrini, M.1    Belz, G.2    Bouillet, P.3    Strasser, A.4
  • 74
    • 0028809840 scopus 로고
    • Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter
    • Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. Mol Cell Biol 1995;15:6055-6063.
    • (1995) Mol Cell Biol , vol.15 , pp. 6055-6063
    • Zhang, W.1    Zhang, J.2    Kornuc, M.3    Kwan, K.4    Frank, R.5    Nimer, S.D.6
  • 75
    • 0030992167 scopus 로고    scopus 로고
    • Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes
    • Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc Natl Acad Sci USA 1997;94:2609-2614.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2609-2614
    • Ikushima, S.1    Inukai, T.2    Inaba, T.3    Nimer, S.D.4    Cleveland, J.L.5    Look, A.T.6
  • 76
    • 73949134616 scopus 로고    scopus 로고
    • Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo
    • Kamizono S, et al. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med 2009;206:2977-2986.
    • (2009) J Exp Med , vol.206 , pp. 2977-2986
    • Kamizono, S.1
  • 77
    • 79954992071 scopus 로고    scopus 로고
    • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    • Motomura Y, et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol 2011;12:450-459.
    • (2011) Nat Immunol , vol.12 , pp. 450-459
    • Motomura, Y.1
  • 78
    • 0034612994 scopus 로고    scopus 로고
    • The virtuoso of versatility: POU proteins that flex to fit
    • Phillips K, Luisi B. The virtuoso of versatility: POU proteins that flex to fit. J Mol Biol 2000;302:1023-1039.
    • (2000) J Mol Biol , vol.302 , pp. 1023-1039
    • Phillips, K.1    Luisi, B.2
  • 80
    • 33645803177 scopus 로고    scopus 로고
    • Btk expression is controlled by Oct and BOB.1/OBF.1
    • Brunner C, Wirth T. Btk expression is controlled by Oct and BOB.1/OBF.1. Nucleic Acids Res 2006;34:1807-1815.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1807-1815
    • Brunner, C.1    Wirth, T.2
  • 81
    • 20444502955 scopus 로고    scopus 로고
    • PU.1 expression delineates heterogeneity in primary Th2 cells
    • Chang HC, et al. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 2005;22:693-703.
    • (2005) Immunity , vol.22 , pp. 693-703
    • Chang, H.C.1
  • 82
    • 68849111429 scopus 로고    scopus 로고
    • PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells
    • Wei F, Zaprazna K, Wang J, Atchison ML. PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol Cell Biol 2009;29:4612-4622.
    • (2009) Mol Cell Biol , vol.29 , pp. 4612-4622
    • Wei, F.1    Zaprazna, K.2    Wang, J.3    Atchison, M.L.4
  • 83
    • 0027290925 scopus 로고
    • A novel POU domain protein which binds to the T-cell receptor beta enhancer
    • Messier H, Brickner H, Gaikwad J, Fotedar A. A novel POU domain protein which binds to the T-cell receptor beta enhancer. Mol Cell Biol 1993;13:5450-5460.
    • (1993) Mol Cell Biol , vol.13 , pp. 5450-5460
    • Messier, H.1    Brickner, H.2    Gaikwad, J.3    Fotedar, A.4
  • 84
    • 0033054998 scopus 로고    scopus 로고
    • Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1
    • Kasibhatla S, Tailor P, Bonefoy-Berard N, Mustelin T, Altman A, Fotedar A. Jun kinase phosphorylates and regulates the DNA binding activity of an octamer binding protein, T-cell factor beta1. Mol Cell Biol 1999;19:2021-2031.
    • (1999) Mol Cell Biol , vol.19 , pp. 2021-2031
    • Kasibhatla, S.1    Tailor, P.2    Bonefoy-Berard, N.3    Mustelin, T.4    Altman, A.5    Fotedar, A.6
  • 85
    • 84875444198 scopus 로고    scopus 로고
    • Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory
    • Choi YS, et al. Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol 2013;190:4014-4026.
    • (2013) J Immunol , vol.190 , pp. 4014-4026
    • Choi, Y.S.1
  • 86
    • 42649120075 scopus 로고    scopus 로고
    • Regulation and functions of Blimp-1 in T and B lymphocytes
    • Martins G, Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 2008;26:133-169.
    • (2008) Annu Rev Immunol , vol.26 , pp. 133-169
    • Martins, G.1    Calame, K.2
  • 87
    • 33645979374 scopus 로고    scopus 로고
    • Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
    • Kallies A, et al. Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol 2006;7:466-474.
    • (2006) Nat Immunol , vol.7 , pp. 466-474
    • Kallies, A.1
  • 88
    • 33646010346 scopus 로고    scopus 로고
    • Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
    • Martins GA, et al. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol 2006;7:457-465.
    • (2006) Nat Immunol , vol.7 , pp. 457-465
    • Martins, G.A.1
  • 89
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J, Dodd H, Moser EK, Sharma R, Braciale TJ. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol 2011;12:327-334.
    • (2011) Nat Immunol , vol.12 , pp. 327-334
    • Sun, J.1    Dodd, H.2    Moser, E.K.3    Sharma, R.4    Braciale, T.J.5
  • 90
    • 84859720726 scopus 로고    scopus 로고
    • T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells
    • Linterman MA, Liston A, Vinuesa CG. T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells. Immunol Rev 2012;247:143-159.
    • (2012) Immunol Rev , vol.247 , pp. 143-159
    • Linterman, M.A.1    Liston, A.2    Vinuesa, C.G.3
  • 91
    • 75649136214 scopus 로고    scopus 로고
    • Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation
    • Crotty S, Johnston RJ, Schoenberger SP. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 2010;11:114-120.
    • (2010) Nat Immunol , vol.11 , pp. 114-120
    • Crotty, S.1    Johnston, R.J.2    Schoenberger, S.P.3
  • 92
    • 84859716676 scopus 로고    scopus 로고
    • Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics
    • Okada T, Moriyama S, Kitano M. Differentiation of germinal center B cells and follicular helper T cells as viewed by tracking Bcl6 expression dynamics. Immunol Rev 2012;247:120-132.
    • (2012) Immunol Rev , vol.247 , pp. 120-132
    • Okada, T.1    Moriyama, S.2    Kitano, M.3
  • 93
  • 94
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994;12:635-673.
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.A.1    Paul, W.E.2
  • 96
    • 84861423126 scopus 로고    scopus 로고
    • Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
    • Ballesteros-Tato A, et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 2012;36:847-856.
    • (2012) Immunity , vol.36 , pp. 847-856
    • Ballesteros-Tato, A.1
  • 97
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011;34:932-946.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1
  • 98
    • 65049090483 scopus 로고    scopus 로고
    • IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
    • Brown DM, Kamperschroer C, Dilzer AM, Roberts DM, Swain SL. IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. Cell Immunol 2009;257:69-79.
    • (2009) Cell Immunol , vol.257 , pp. 69-79
    • Brown, D.M.1    Kamperschroer, C.2    Dilzer, A.M.3    Roberts, D.M.4    Swain, S.L.5
  • 101
    • 84864018939 scopus 로고    scopus 로고
    • Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity
    • Seah SG, et al. Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity. Eur J Immunol 2012;42:1744-1754.
    • (2012) Eur J Immunol , vol.42 , pp. 1744-1754
    • Seah, S.G.1
  • 102
    • 0036889420 scopus 로고    scopus 로고
    • Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    • Belz GT, Wodarz D, Diaz G, Nowak MA, Doherty PC. Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice. J Virol 2002;76:12388-12393.
    • (2002) J Virol , vol.76 , pp. 12388-12393
    • Belz, G.T.1    Wodarz, D.2    Diaz, G.3    Nowak, M.A.4    Doherty, P.C.5
  • 103
    • 0034608650 scopus 로고    scopus 로고
    • Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia
    • Price GE, Ou R, Jiang H, Huang L, Moskophidis D. Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia. J Exp Med 2000;191:1853-1867.
    • (2000) J Exp Med , vol.191 , pp. 1853-1867
    • Price, G.E.1    Ou, R.2    Jiang, H.3    Huang, L.4    Moskophidis, D.5
  • 104
    • 20744433324 scopus 로고    scopus 로고
    • Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus
    • Price GE, Huang L, Ou R, Zhang M, Moskophidis D. Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus. J Virol 2005;79:8545-8559.
    • (2005) J Virol , vol.79 , pp. 8545-8559
    • Price, G.E.1    Huang, L.2    Ou, R.3    Zhang, M.4    Moskophidis, D.5
  • 105
    • 34248178222 scopus 로고    scopus 로고
    • An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4+ T-cells
    • Berkhoff EG, et al. An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4+ T-cells. Virus Res 2007;126:282-287.
    • (2007) Virus Res , vol.126 , pp. 282-287
    • Berkhoff, E.G.1
  • 106
    • 84881103119 scopus 로고    scopus 로고
    • CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination
    • doi: 10.1093/intimm/dxt005. [Epub ahead of print].
    • Yang J, et al. CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination. Int Immunol 2013; doi: 10.1093/intimm/dxt005. [Epub ahead of print].
    • (2013) Int Immunol
    • Yang, J.1
  • 107
    • 78049232343 scopus 로고    scopus 로고
    • Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses
    • Price GE, et al. Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses. PLoS ONE 2010;5:e13162.
    • (2010) PLoS ONE , vol.5
    • Price, G.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.