Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

European Journal of Immunology

Volumn 42, Issue 7, 2012, Pages 1744-1754

  Seah, Shirley G K ^a,b   Carrington, Emma M ^a   Ng, Wy C ^b   Belz, Gabrielle T ^a   Brady, Jamie L ^a   Sutherland, Robyn M ^a   Hancock, Manuela S ^a   La Gruta, Nicole L ^b   Brown, Lorena E ^b   Turner, Stephen J ^b   Zhan, Yifan ^a   Lew, Andrew M ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

CD8+ T cells; Costimulatory molecules; Transgenic models; Virology

Indexed keywords

CD28 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIVISION; GENOTYPE; IMMUNITY; IMMUNOSTIMULATION; INFLUENZA; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRAL CLEARANCE; VIROLOGY; VIRUS LOAD;

ANIMALS; ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CTLA-4 ANTIGEN; FLOW CYTOMETRY; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; ORTHOMYXOVIRIDAE INFECTIONS; SPECIFIC PATHOGEN-FREE ORGANISMS; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84864018939     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201142211     Document Type: Article

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